Genetica最新文献_第7页

The genotype-phenotype distinction: from Mendelian genetics to 21st century biology. 基因型-表现型的区别:从孟德尔遗传学到21世纪生物学。

IF 1.5 4区生物学

Genetica Pub Date : 2022-08-01 Epub Date: 2022-07-25 DOI: 10.1007/s10709-022-00159-5

Gaëlle Pontarotti, Matteo Mossio, Arnaud Pocheville

{"title":"The genotype-phenotype distinction: from Mendelian genetics to 21st century biology.","authors":"Gaëlle Pontarotti, Matteo Mossio, Arnaud Pocheville","doi":"10.1007/s10709-022-00159-5","DOIUrl":"https://doi.org/10.1007/s10709-022-00159-5","url":null,"abstract":"The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in the wake of late nineteenth century studies about heredity. In this paper, we provide a conceptual analysis that highlights that the G-P distinction was grounded on three pillars: observability, transmissibility, and causality. Originally, the genotype is the non-observable and transmissible cause of its observable and non-transmissible effect, the phenotype. We argue that the current developments of biology have called the validity of such pillars into question. First, molecular biology has unveiled the putative material substrate of the genotype (qua DNA), making it an observable object. Second, numerous findings on non-genetic heredity suggest that some phenotypic traits can be directly transmitted. Third, recent organicist approaches to biological phenomena have emphasized the reciprocal causality between parts of a biological system, which notably applies to the relation between genotypes and phenotypes. As a consequence, we submit that the G-P distinction has lost its general validity, although it can still apply to specific situations. This calls for forging new frameworks and concepts to better describe heredity and development.","PeriodicalId":55121,"journal":{"name":"Genetica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40623939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Special issue on "The relationship between genotype and phenotype: new insight into an old question". “基因型与表现型的关系:一个老问题的新认识”特刊。

IF 1.5 4区生物学

Genetica Pub Date : 2022-08-01 Epub Date: 2022-07-25 DOI: 10.1007/s10709-022-00153-x

Dominique de Vienne, Pierre Capy

引用次数: 0

Solving the grand challenge of phenotypic integration: allometry across scales. 解决表型整合的巨大挑战：跨尺度异构。

IF 1.3 4区生物学

Genetica Pub Date : 2022-08-01 Epub Date: 2022-07-20 DOI: 10.1007/s10709-022-00158-6

François Vasseur, Adrianus Johannes Westgeest, Denis Vile, Cyrille Violle

{"title":"Solving the grand challenge of phenotypic integration: allometry across scales.","authors":"François Vasseur, Adrianus Johannes Westgeest, Denis Vile, Cyrille Violle","doi":"10.1007/s10709-022-00158-6","DOIUrl":"10.1007/s10709-022-00158-6","url":null,"abstract":"Phenotypic integration is a concept related to the cascade of trait relationships from the lowest organizational levels, i.e. genes, to the highest, i.e. whole-organism traits. However, the cause-and-effect linkages between traits are notoriously difficult to determine. In particular, we still lack a mathematical framework to model the relationships involved in the integration of phenotypic traits. Here, we argue that allometric models developed in ecology offer testable mathematical equations of trait relationships across scales. We first show that allometric relationships are pervasive in biology at different organizational scales and in different taxa. We then present mechanistic models that explain the origin of allometric relationships. In addition, we emphasized that recent studies showed that natural variation does exist for allometric parameters, suggesting a role for genetic variability, selection and evolution. Consequently, we advocate that it is time to examine the genetic determinism of allometries, as well as to question in more detail the role of genome size in subsequent scaling relationships. More broadly, a possible-but so far neglected-solution to understand phenotypic integration is to examine allometric relationships at different organizational levels (cell, tissue, organ, organism) and in contrasted species.","PeriodicalId":55121,"journal":{"name":"Genetica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40607472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associating complex traits with genetic variants: polygenic risk scores, pleiotropy and endophenotypes. 将复杂性状与遗传变异联系起来:多基因风险评分、多效性和内表型。

IF 1.5 4区生物学

Genetica Pub Date : 2022-08-01 Epub Date: 2021-10-22 DOI: 10.1007/s10709-021-00138-2

Gene S Fisch

引用次数: 0

Using phenotypic plasticity to understand the structure and evolution of the genotype-phenotype map. 利用表型可塑性了解基因型-表型图谱的结构和进化。

IF 1.5 4区生物学

Genetica Pub Date : 2022-08-01 Epub Date: 2021-10-06 DOI: 10.1007/s10709-021-00135-5

Luis-Miguel Chevin, Christelle Leung, Arnaud Le Rouzic, Tobias Uller

{"title":"Using phenotypic plasticity to understand the structure and evolution of the genotype-phenotype map.","authors":"Luis-Miguel Chevin, Christelle Leung, Arnaud Le Rouzic, Tobias Uller","doi":"10.1007/s10709-021-00135-5","DOIUrl":"https://doi.org/10.1007/s10709-021-00135-5","url":null,"abstract":"Deciphering the genotype-phenotype map necessitates relating variation at the genetic level to variation at the phenotypic level. This endeavour is inherently limited by the availability of standing genetic variation, the rate of spontaneous mutation to novo genetic variants, and possible biases associated with induced mutagenesis. An interesting alternative is to instead rely on the environment as a source of variation. Many phenotypic traits change plastically in response to the environment, and these changes are generally underlain by changes in gene expression. Relating gene expression plasticity to the phenotypic plasticity of more integrated organismal traits thus provides useful information about which genes influence the development and expression of which traits, even in the absence of genetic variation. We here appraise the prospects and limits of such an environment-for-gene substitution for investigating the genotype-phenotype map. We review models of gene regulatory networks, and discuss the different ways in which they can incorporate the environment to mechanistically model phenotypic plasticity and its evolution. We suggest that substantial progress can be made in deciphering this genotype-environment-phenotype map, by connecting theory on gene regulatory network to empirical patterns of gene co-expression, and by more explicitly relating gene expression to the expression and development of phenotypes, both theoretically and empirically.","PeriodicalId":55121,"journal":{"name":"Genetica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39492513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Correction to: What is a phenotype? History and new developments of the concept. 更正:什么是表现型?历史和新发展的概念。

IF 1.5 4区生物学

Genetica Pub Date : 2022-08-01 DOI: 10.1007/s10709-021-00144-4

Dominique de Vienne

引用次数: 0

Chromosomal distribution of major rDNA and genome size variation in Belostoma angustum Lauck, B. nessimiani Ribeiro & Alecrim, and B. sanctulum Montandon (Insecta, Heteroptera, Belostomatidae) Belostoma angustum Lauck、B. nessimiani Ribeiro & Alecrim和B. sanctulum Montandon主要rDNA的染色体分布及基因组大小差异(昆虫科，异翅目，Belostomatidae)

IF 1.5 4区生物学

Genetica Pub Date : 2022-05-11 DOI: 10.1007/s10709-022-00156-8

Cassiane Furlan Lopes, Alice Lemos Costa, J. F. Dionísio, Andres Delgado Cañedo, R. da Rosa, Analía Del Valle Garnero, José Ricardo Inacio Ribeiro, R. J. Gunski

引用次数: 1

Identification of a 5-gene-risk score model for predicting luminal A-invasive lobular breast cancer survival 预测腔a浸润性小叶乳腺癌症生存率的5基因风险评分模型的确定

IF 1.5 4区生物学

Genetica Pub Date : 2022-05-10 DOI: 10.1007/s10709-022-00157-7

Yi-Huan Chen, Taofeng Zhang, Yiyuan Liu, Jiehua Zheng, Weixun Lin, Yaokun Chen, Jiehui Cai, Juan Zou, Zhiyang Li

引用次数: 2

The species of Oxytropis DC. of section Gloeocephala Bunge (Fabaceae) from Northeast Asia: genetic diversity and relationships based on sequencing of the intergenic spacers of cpDNA and ITS nrDNA. 棘豆属植物。基于cpDNA和ITS - nrDNA基因间间隔序列的遗传多样性和亲缘关系。

IF 1.5 4区生物学

Genetica Pub Date : 2022-04-01 Epub Date: 2022-02-25 DOI: 10.1007/s10709-022-00152-y

Alla Kholina, Marina Kozyrenko, Elena Artyukova, Valentin Yakubov, Mariya Khoreva, Elena Andrianova, Olga Mochalova, Denis Sandanov

{"title":"The species of Oxytropis DC. of section Gloeocephala Bunge (Fabaceae) from Northeast Asia: genetic diversity and relationships based on sequencing of the intergenic spacers of cpDNA and ITS nrDNA.","authors":"Alla Kholina, Marina Kozyrenko, Elena Artyukova, Valentin Yakubov, Mariya Khoreva, Elena Andrianova, Olga Mochalova, Denis Sandanov","doi":"10.1007/s10709-022-00152-y","DOIUrl":"https://doi.org/10.1007/s10709-022-00152-y","url":null,"abstract":"Phylogenetic relationships within Oxytropis DC. sect. Gloeocephala Bunge from Northeast Asia were studied using plastid intergenic spacers (psbA-trnH + trnL-trnF + trnS-trnG) and ITS nrDNA. Populations of O. anadyrensis Vass., O. borealis DC., O. middendorffii Trautv., O. trautvetteri Meinsh., and O. vasskovskyi Jurtz. were monomorphic or characterised by a low level of chloroplast genetic diversity (h varied from 0.143 to 0.692, and π from 0.0001 to 0.0005). Presumably, the low genetic diversity was a result of the severe bottlenecks during Pleistocene glaciation-interglacial cycles. Twenty chlorotypes were identified; species studied had no shared chlorotypes. Chlorotypes of O. anadyrensis, O. borealis, and O. middendorffii formed two lineages each, while the chlorotypes of O. trautvetteri and O. vasskovskyi formed one separate lineage each in the phylogenetic network. There were specific diagnostic markers of cpDNA in each lineage, excluding O. vasskovskyi. The presence of a species-specific diagnostic marker in O. trautvetteri and specific markers in two lineages of O. anadyrensis support circumscribing these taxa as independent species. Regarding ITS nrDNA polymorphism, five ribotypes were detected. The differences revealed in plastid and nuclear genomes of Oxytropis sect. Gloeocephala confirmed that the Asian sector of Megaberingia was the main centre of diversification of arctic legumes.","PeriodicalId":55121,"journal":{"name":"Genetica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Human genes with codon usage bias similar to that of the nonstructural protein 1 gene of influenza A viruses are conjointly involved in the infectious pathogenesis of influenza A viruses 人类密码子使用偏向性基因与甲型流感病毒非结构蛋白1基因相似，共同参与甲型流感病毒的感染发病过程

IF 1.5 4区生物学

Genetica Pub Date : 2022-04-01 DOI: 10.1007/s10709-022-00155-9

Komi Nambou, Manawa Anakpa, Yin Tong

引用次数: 1