Hamostaseologie最新文献_第6页

Ausgewählte Beiträge der BDDH-Veranstaltung im Rahmen der 69. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) am 18.02.2025 in Lausanne. 在第69届BDH会议上选定的贡献。血栓和止血研究学会（GTH）年会于2025年2月18日在洛桑举行。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-04-01 Epub Date: 2025-05-07 DOI: 10.1055/a-2447-6517

Christoph Sucker, Jürgen Koscielny, Günther Kappert

引用次数: 0

Update on Cancer-Associated Venous Thromboembolism in Children. 儿童癌症相关静脉血栓栓塞的最新进展。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-04-01 Epub Date: 2024-12-10 DOI: 10.1055/a-2407-7914

Rahel Kasteler, Manuela Albisetti, Alessandra Bosch

引用次数: 0

Challenging Situations in the Treatment of Cancer-Associated Thrombosis. 癌症相关血栓治疗面临的挑战

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2431-6818

Ekaterina Balaian, Sandra Marten, Jan Beyer-Westendorf, Karolin Trautmann-Grill

引用次数: 0

Platelet Reduction in Rats Exposed to Chronic Hypoxia Is Associated with Interaction of Glycoprotein Ib Alpha von Willebrand Factor. 慢性缺氧大鼠血小板减少与糖蛋白Ib α -血管性血友病因子的相互作用有关

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-03-28 DOI: 10.1055/a-2462-6667

Zhuoya Wang, Drolma Gomchok, Yi Ye, Yi Wen, Tana Wuren

{"title":"Platelet Reduction in Rats Exposed to Chronic Hypoxia Is Associated with Interaction of Glycoprotein Ib Alpha von Willebrand Factor.","authors":"Zhuoya Wang, Drolma Gomchok, Yi Ye, Yi Wen, Tana Wuren","doi":"10.1055/a-2462-6667","DOIUrl":"10.1055/a-2462-6667","url":null,"abstract":"Chronic high-altitude hypoxia is associated with reduced platelet count, but it is unclear whether the decrease in platelet count is due to impaired production or increased clearance. This study examines how hypoxia affects platelet production and apoptosis and elucidates the impact of glycoprotein Ibα-von Willebrand factor interaction on platelets in rats using a hypobaric hypoxia chamber. The results showed that the number of megakaryocytes increased under hypoxia; however, the levels of differentiation and polyploidy decreased, while those of apoptosis increased. Platelet production did not reduce according to the reticulated platelet percentage, while platelet apoptosis enhanced; these results suggest that increased platelet clearance was the main reason behind platelet reduction. Our previous microarray results indicated that glycoprotein Ibα (GPIbα) expression increased under hypoxia, which was a protein involved in platelet clearance; therefore, we examined the interaction of platelet GPIbα with the von Willebrand factor (vWF) both in vivo and in vitro to explore the effect of this process on platelets and whether it is related to platelet apoptosis. Under hypoxia, the stronger interaction between GPIbα and vWF promoted platelet apoptosis; inhibiting this interaction reduced platelet apoptosis and increased platelet counts. Platelet reduction is associated with apoptosis induced by the interaction between GPIbα and vWF.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Platelet-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio and Burden of Thrombus with Disease Severity in Patients with Pulmonary Thromboembolism. 肺血栓栓塞患者血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值及血栓负荷与疾病严重程度的相关性

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-03-28 DOI: 10.1055/a-2506-6705

Ayshan Mammadova, Kübra Taşkaraca, Günel Jeyranova, Aysel Orujlu, Merve Tatlılıoğlu, Serra Duygulu, Zeynep Yalçınkaya, Seriyye Allahverdiyeva, Onur Gündoğdu, Atiye Cenay Karabörk Kılıç, Sevcihan Kesen Özbek, Gonca Erbaş, I Kıvılcım Oğuzülgen

{"title":"Correlation between Platelet-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio and Burden of Thrombus with Disease Severity in Patients with Pulmonary Thromboembolism.","authors":"Ayshan Mammadova, Kübra Taşkaraca, Günel Jeyranova, Aysel Orujlu, Merve Tatlılıoğlu, Serra Duygulu, Zeynep Yalçınkaya, Seriyye Allahverdiyeva, Onur Gündoğdu, Atiye Cenay Karabörk Kılıç, Sevcihan Kesen Özbek, Gonca Erbaş, I Kıvılcım Oğuzülgen","doi":"10.1055/a-2506-6705","DOIUrl":"10.1055/a-2506-6705","url":null,"abstract":"High neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of subclinical inflammation and have been associated with prognosis and mortality in many diseases. In this study, we evaluated the comparative value of NLR and PLR in identifying high mortality risk in patients hospitalized with acute pulmonary thromboembolism (PTE), and their relationship with the anatomical burden of thrombus.Patients who were followed up due to PTE were evaluated retrospectively. NLR and PLR were calculated from complete blood counts. The thrombus burden was assessed by the Qanadli score; based on the patients' archival computed tomography angiography images. Mortality prediction was based on an algorithm using the Pulmonary Embolism Severity Index, echocardiographic findings, and troponin levels.Three hundred-two PTE patients were included in the study. Median NLR, PLR, and Qanadli score values were higher in nonsurvivors, with NLR (8.4 [2.2-18.9]) vs. (3.1 [0.4-13.1]), PLR (317 [87.6-525.3]) vs. (124.4 [30-476.3]), and Qanadli scores (21 [3-26]) vs. (9 [1-28]), respectively (p < 0.001). We showed that setting a threshold value of >4.45 for NLR and >151.59 for PLR significantly predicts the high mortality-risk group. In the receiver operating characteristic analysis, when the threshold value for the Qanadli score distinguishing between low-risk and high-risk disease was set at 15.5, the sensitivity was calculated as 98.8% and the specificity was 94.9% (p = 0.001).This study showed that NLR, PLR, and Qanadli scores can provide essential contributions to the clinician's determination of the anatomical burden of thrombus and disease severity in PTE patients.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Congenital Fibrinogen Deficiencies: Not So Rare. 先天性纤维蛋白原缺乏：并不罕见。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-03-13 DOI: 10.1055/s-0045-1806916

Alexander Couzens, Marguerite Neerman-Arbez

引用次数: 0

Changes in Hemophilia Treatment in the Eastern Part of Germany between 2015 and 2021-Data from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO). 2015年至2021年德国东部血友病治疗的变化-来自Kompetenznetz Hämorrhagische Diathese Ost （KHDO）的数据。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-02-18 DOI: 10.1055/a-2499-2912

Christian Pfrepper, Annika Siecke, Robert Klamroth, Caspar Kühnöl, Karim Kentouche, Susanne Holzhauer, Lars Fischer, Volker Aumann, Karolin Trautmann-Grill, Ute Scholz, Ines Halm-Heinrich, Beate Krammer-Steiner, Kristina Schilling, Ralf Knöfler, Nikola Hagedorn

{"title":"Changes in Hemophilia Treatment in the Eastern Part of Germany between 2015 and 2021-Data from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO).","authors":"Christian Pfrepper, Annika Siecke, Robert Klamroth, Caspar Kühnöl, Karim Kentouche, Susanne Holzhauer, Lars Fischer, Volker Aumann, Karolin Trautmann-Grill, Ute Scholz, Ines Halm-Heinrich, Beate Krammer-Steiner, Kristina Schilling, Ralf Knöfler, Nikola Hagedorn","doi":"10.1055/a-2499-2912","DOIUrl":"10.1055/a-2499-2912","url":null,"abstract":"Introduction: Treatment options for patients with hemophilia (PWH) have changed substantially in the last years. This study aimed to compare hemophilia treatment in the eastern part of Germany in 2021 with data from 2015.Methods: Substitution diaries and patient records of PWH from 2021 were collected in 13 hemophilia centers from the \"Kompetenznetz Hämorrhagische Diathese Ost\" (KHDO) and compared with 2015.Results: A total of 130 children and 357 adults, 411 hemophilia A (HA) and 76 hemophilia B (HB), were included in 2021, and 359 were already analyzed in 2015. In 2021, 97.8% of children and 95.7% of adults with severe hemophilia had prophylaxis compared with 98.8 and 80.2% in 2015. Plasma-derived concentrates were used in 25.6%, recombinant in 30.2%, extended half-life (EHL) factor concentrates in 24.4%, and emicizumab in 19.8% of the children with severe HA (sHA). In adults with sHA, plasma-derived, recombinant concentrates, EHL, and emicizumab were used in 21.0, 33.2, 31.2, and 14.2%, respectively. All children and 93.3% of the adults with severe HB (sHB) were on EHL. Median annual factor consumption per body weight increased in adults with sHA, remained stable in children with sHA and adults with sHB, and decreased in children with sHB between 2015 and 2021. Annualized bleeding rate (ABR) decreased in children with sHB and sHA.Conclusion: The use of EHL and emicizumab has changed hemophilia treatment. About 50% of the sHA patients switched to EHL or emicizumab and almost all sHB patients to EHL. More adults with sHA received prophylaxis and ABR decreased in children.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Prevalence of Acquired Platelet Secretion Defects in Multiple Myeloma. 获得性血小板分泌缺陷在多发性骨髓瘤中的高发性。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-02-11 DOI: 10.1055/a-2418-5664

Frauke Swieringa, Yaqiu Sang, Jasper A Remijn, Rob Fijnheer, Suzanne J A Korporaal, Rolf T Urbanus, Dana Huskens, Joke Konings, Li Li, Bas de Laat, Mark Roest

{"title":"High Prevalence of Acquired Platelet Secretion Defects in Multiple Myeloma.","authors":"Frauke Swieringa, Yaqiu Sang, Jasper A Remijn, Rob Fijnheer, Suzanne J A Korporaal, Rolf T Urbanus, Dana Huskens, Joke Konings, Li Li, Bas de Laat, Mark Roest","doi":"10.1055/a-2418-5664","DOIUrl":"10.1055/a-2418-5664","url":null,"abstract":"Thrombocytopenia at admission predicts mortality in multiple myeloma (MM) and might link to disease progression. Although thrombocytopenia is known to be associated with MM, a possible thrombopathy is clinically less known. We conducted a case-control study comparing platelet responses of MM patients to controls via flow cytometry, integrin αIIbβ3 activation and P-selectin exposure, and a bioluminescent assay, ATP release. No difference was found at baseline, but upon platelet stimulation, MM patients had decreased αIIbβ3 activation, partly impaired P-selectin exposure, and reduced δ-granule (ATP) secretion. Aspirin treatment in patients did not account for these diminished platelet responses. In total, 29% of patients had thrombocytopenia, while 60% had decreased αIIbβ3 activation and 67% had reduced platelet secretion capacity. Importantly, as secretion capacity was corrected for platelet count, granule release per platelet was reduced in patients versus controls. Of 6 patients with thrombocytopenia 4 displayed a thrombopathy, while for 15 patients with normal count, 64% had reduced αIIbβ3 activation and 73% had reduced platelet secretion capacity. Of all patients, 10% had thrombocytopenia combined with reduced αIIbβ3 activation plus low secretion capacity (one patient showed no qualitative or quantitative platelet defect). Our data suggest that beyond the known thrombocytopenia, MM patients also have reduced platelet function, which could reflect impaired platelet vitality. Combined measurement of platelet count and function, especially secretion capacity, gives a more comprehensive view of platelet phenotype than count alone. Large prospective follow-up studies are needed to confirm the importance of the acquired platelet secretion defect on the prognosis of MM patients.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GTH 2025 ARTE: The Art in Science - Curiosity and Creativity. GTH 2025 ARTE：科学中的艺术-好奇心和创造力。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI: 10.1055/a-2343-6618

Manuela Albisetti, Lorenzo Alberio

引用次数: 0

Combining Diagnostics and Research in an Academic Laboratory. 在学术实验室中结合诊断和研究。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI: 10.1055/a-2491-3668

Grit Waitz, Stefan Handtke, Carlo Zaninetti, Linda Schönborn, Thomas Thiele

引用次数: 0