Hamostaseologie最新文献_第6页

Thrombosis in Acute Promyelocytic Leukemia: The Current Understanding. 急性早幼粒细胞白血病的血栓形成：目前的认识。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-03-11 DOI: 10.1055/a-2238-4782

Nikica Sabljic, Mirjana Mitrovic, Nikola Pantic, Jecko Thachil

引用次数: 0

Quantifying Residual Rivaroxaban Plasma Concentration after Antagonization with Andexanet Alfa: A Difficult Task in Routine Clinical Practice. 量化安达沙奈α拮抗后残留的利伐沙班血浆浓度：常规临床实践中的一项艰巨任务。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-03-11 DOI: 10.1055/a-2266-8021

Alexander Mair, Gilles Huber, Jan-Dirk Studt, Donat R Spahn, Alexander Kaserer

引用次数: 0

Type 2 Diabetes: Platelets and Long-Term Metabolic Control as Estimated from Glycosylated Haemoglobin (HbA1c). 2 型糖尿病：血小板和根据糖化血红蛋白 (HbA1c) 估算的长期代谢控制。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-03-06 DOI: 10.1055/s-0044-1780535

M Edvardsson, M Oweling, P Järemo

{"title":"Type 2 Diabetes: Platelets and Long-Term Metabolic Control as Estimated from Glycosylated Haemoglobin (HbA1c).","authors":"M Edvardsson, M Oweling, P Järemo","doi":"10.1055/s-0044-1780535","DOIUrl":"https://doi.org/10.1055/s-0044-1780535","url":null,"abstract":"In type 2 diabetes, platelets are likely affected by impaired long-term glycaemic control, but such pathophysiological links are poorly understood. This study thus compares platelet reactivity (i.e. agonist-evoked platelet reactions) in vitro with glycosylated haemoglobin (HbA1c), a measure commonly used for monitoring long-term metabolic control of type 2 diabetes. Elders with type 2 diabetes (n = 35) were divided according to HbA1c into groups (HbA1c-low and high) consisting of 17 and 18 subjects, respectively. For estimating mitochondria disintegration, a flow cytometer determined mitochondrial transmembrane potentials after whole blood agonist stimulation. The activating agents used were α-thrombin (10 μM) and collagen (0.15 μg/mL). The same apparatus analysed the fibrinogen receptor activity, lysosomal exocytosis (surface lysosomal-associated membrane protein 1), and platelet procoagulant characteristics (membrane-attached annexin V) after stimulation. In type 2 diabetes, after in vitro agonist stimulation, platelet mitochondria injury was higher in the HbA1c-high group. The fibrinogen receptor, lysosomal secretion, and the creation of procoagulant platelets proved to be uninfluenced by HbA1c.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period. 评估 COVID 后阶段的因子 VIII 活性和 D-Dimer 水平。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-03-01 DOI: 10.1055/a-2238-4744

Mirjana Kovac, Milena Todorovic Balint, Marija Milenkovic, Dusica Basaric, Branko Tomic, Bela Balint, Vera Ignjatovic

{"title":"Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period.","authors":"Mirjana Kovac, Milena Todorovic Balint, Marija Milenkovic, Dusica Basaric, Branko Tomic, Bela Balint, Vera Ignjatovic","doi":"10.1055/a-2238-4744","DOIUrl":"https://doi.org/10.1055/a-2238-4744","url":null,"abstract":"Changes in the hemostatic system during COVID infection lead to hypercoagulability. Numerous studies have evaluated hemostatic abnormalities in COVID patients during acute infection, in the period of hospitalization. However, the hemostatic status following hospital discharge has not been sufficiently assessed. Considering the importance of FVIII and D-dimer levels as markers for the assessment of thrombosis, our study aimed to evaluate changes in these markers, as well as the influence of patient's age and clinical presentation of COVID infection on those hemostatic markers in the post-COVID phase. This prospective study (July 2020 to December 2022) included 115 COVID patients, 68 (59%) with asymptomatic/mild and 47 (41%) with moderate/severe clinical presentation. Patient follow-up included laboratory evaluation of FVIII and D-dimer levels at 1, 3, and 6 months following the COVID infection. Three months after the COVID infection, elevated FVIII was recorded in 44% of younger versus 65% of older individuals, p = 0.05, respectively, and 30 versus 57% (p = 0.008) 6 months post-COVID infection. With a focus on clinical presentation, a higher number of patients with moderate/severe COVID had elevated FVIII activity, but a statistically significant difference was observed only for the 6 months (32% mild vs. 53% moderate/severe, p = 0.041) post-infection time point. Following a COVID infection, an increase in FVIII activity suggests a continued hypercoagulable state in the post-COVID period and correlates with elevated D-dimer levels. This increase in FVIII is more pronounced in patients with moderate/severe clinical picture and those patients older than 50 years.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Thrombin IgA in a Patient with Multiple Myeloma Leading to In Vitro Interference in Multiple Coagulation Tests and Confounding Diagnosis. [一名多发性骨髓瘤患者体内的抗凝血酶 IgA 导致多种凝血试验的体外干扰并影响诊断]。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-03-01 DOI: 10.1055/a-2211-6841

Christian Irsara, Andrea Griesmacher, Lorin Loacker, Clemens Feistritzer, Cosima Anna Überbacher, Jean Amiral

{"title":"Anti-Thrombin IgA in a Patient with Multiple Myeloma Leading to In Vitro Interference in Multiple Coagulation Tests and Confounding Diagnosis.","authors":"Christian Irsara, Andrea Griesmacher, Lorin Loacker, Clemens Feistritzer, Cosima Anna Überbacher, Jean Amiral","doi":"10.1055/a-2211-6841","DOIUrl":"10.1055/a-2211-6841","url":null,"abstract":"Background: We report the case of a 59-year-old multiple myeloma patient in whom an anti-human thrombin IgA antibody led to prolonged in vitro coagulation times, suggesting inhibitors to all intrinsic coagulation factors in the absence of spontaneous bleeding.Methods: Routine and extensive special coagulation tests, in vivo bleeding time, and specific antibody testing were performed.Results: Although the patient did not suffer from spontaneous bleeding and had a normal in vivo bleeding time, the anti-human thrombin IgA autoantibody affected all coagulation assays involving human thrombin in vitro, mimicking inhibitors to intrinsic coagulation factors. As the IgA paraprotein and the IgA antibody virtually disappeared after autologous stem cell transplantation, the coagulation tests also largely normalized.Conclusion: Antibodies to human thrombin may interfere with all coagulation assays involving thrombin, imitating a severe coagulopathy. However, in vivo they do not necessarily lead to strongly increased bleeding tendency. Complex and ambiguous coagulation abnormalities should be evaluated and treated in an interdisciplinary setting, including a highly specialized coagulation laboratory, from the beginning.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria. 一名阵发性夜间血红蛋白尿患者的多处血栓形成。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-02-09 DOI: 10.1055/a-2231-5277

Lennart Beckmann, Tobias D Faizy, Fabian Flottmann, Jens Fiehler, Carsten Bokemeyer, Lennart Well, Antonia Beitzen-Heineke, Florian Langer

引用次数: 0

Oral Anticoagulation and Mortality in Cases with Intracranial Bleeding: Analysis of Nationwide Prescription and Hospitalization Data. 口服抗凝药与颅内出血病例的死亡率：全国处方和住院数据分析》。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-02-05 DOI: 10.1055/a-2229-8047

Knut Kröger, Fabian Heldt, Ludger Feyen, Kathrin Feller, Bernd Kowall, Andreas Stang

{"title":"Oral Anticoagulation and Mortality in Cases with Intracranial Bleeding: Analysis of Nationwide Prescription and Hospitalization Data.","authors":"Knut Kröger, Fabian Heldt, Ludger Feyen, Kathrin Feller, Bernd Kowall, Andreas Stang","doi":"10.1055/a-2229-8047","DOIUrl":"https://doi.org/10.1055/a-2229-8047","url":null,"abstract":"Objectives: To demonstrate the safety of direct oral anticoagulants in relation to intracranial bleeding (ICB), we compared the number of patients taking anticoagulants in all cases of hospitalization and cases of hospitalization for ICB over time in Germany. We analyzed the intrahospital mortality of ICB cases in relation to long-term use of anticoagulants (LUAs).We performed a retrospective registry analysis of nationwide German hospitalizations including all hospital admissions and admission for ICB in patients aged ≥60 years in the period from 2006 to 2020 and separated for LUAs.Results: In 2006, the age-standardized rate of hospitalized male patients with LUAs was 7.3% and that of female patients was 5.6%. In 2020, the rates increased to 22.0 and 17.7% for male and female patients, respectively. Among patients hospitalized for ICB in 2006, 7.0 and 5.6% were male and female patients with LUAs, respectively. In 2020, the rate increased to 13.7% for males and 10.8% for females.In 2006, age-standardized mortality rates of male and female patients with ICB without LUAs were 24.1 and 23.9%, respectively. In 2020, the rate slightly decreased to 22.7% in males, but it remained almost unchanged in females at 23.8%. In the cases with LUA, the mortality rate decreased from 30.1 to 24.3% in males and from 28.4 to 24.2% in females in the same period.Conclusion: LUA seems to be safe because there is a slower increase of the rate of LUAs in ICB cases than in generally hospitalized cases in the period from 2006 to 2020. In addition, mortality in ICB cases with LUA tends to decrease compared to cases without LUA.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Petition "Vergütung für medizinische Leistungen - Verbesserung der Rahmenbedingungen für die ambulante Versorgung", ATMP-QS-Richtlinie Hämophilie und aktueller Stand zur Digitalisierung im Gesundheitswesen: E-Rezept. 请愿书 "医疗服务报酬--改善门诊护理的框架条件"、ATMP-QS 血友病指南和医疗保健行业的数字化现状：电子处方。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.1055/a-2177-9429

Jürgen Koscielny, Günther Kappert, Christoph Sucker

引用次数: 0

Thrombozytopenie: Sind Thrombozytentransfusionen vor Legen eines ZVK verzichtbar? 血小板减少症：置入 CVC 前是否可以不输血小板？

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.1055/s-0044-1782594

引用次数: 0

Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management. 重塑抗凝：血栓管理中的因子 XI 抑制。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1055/a-2202-8620

Andreas Verstraete, Matthias M Engelen, Charlotte Van Edom, Thomas Vanassche, Peter Verhamme

引用次数: 0