Hamostaseologie最新文献_第10页

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IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/s-0043-1774286

引用次数: 0

Treatment of Inherited Platelet Disorders: Current Status and Future Options. 遗传性血小板疾病的治疗:现状和未来选择。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/a-2080-6602

Caroline Bargehr, Ralf Knöfler, Werner Streif

引用次数: 1

Expression and Release of Tumor Cell Tissue Factor Triggers Recurrent Thromboembolism in a Patient with Endometrial Cancer. 肿瘤细胞组织因子的表达和释放引发子宫内膜癌患者复发性血栓栓塞。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/a-2010-6484

Lennart Beckmann, Maximilian Lennartz, Annika Poch, Katharina Holstein, Carsten Bokemeyer, Florian Langer

{"title":"Expression and Release of Tumor Cell Tissue Factor Triggers Recurrent Thromboembolism in a Patient with Endometrial Cancer.","authors":"Lennart Beckmann, Maximilian Lennartz, Annika Poch, Katharina Holstein, Carsten Bokemeyer, Florian Langer","doi":"10.1055/a-2010-6484","DOIUrl":"https://doi.org/10.1055/a-2010-6484","url":null,"abstract":"Although cancer-associated thrombosis (CAT) is a frequent complication in patients with malignancies, its treatment remains a challenge in daily practice. Here, we report the clinical course of a 51-year-old woman presenting with a highly thrombogenic paraneoplastic coagulopathy. Despite therapeutic anticoagulation with various agents, including rivaroxaban, fondaparinux, and low-molecular-weight heparin, the patient suffered from recurrent venous and arterial thromboembolism. Locally advanced endometrial cancer was identified. Tumor cells showed strong expression of tissue factor (TF), and significant concentrations of TF-bearing microvesicles were detected in patient plasma. Coagulopathy was controlled only by continuous intravenous anticoagulation with the direct thrombin inhibitor, argatroban. Multimodal antineoplastic treatment, including neoadjuvant chemotherapy followed by surgery and postoperative radiotherapy, resulted in clinical cancer remission, which was paralleled by normalization of tumor markers, CA125 and CA19-9, D-dimer levels, and TF-bearing microvesicles. In summary, continuous anticoagulation with argatroban and multimodal anticancer treatment may be necessary to control TF-driven coagulation activation with recurrent CAT in endometrial cancer.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10479002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erhöhte Faktor-VIII-Aktivität – gesteigertes Risiko für Pfortaderthrombosen. 降低因素四活跃度，降低门静脉血栓的风险

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/s-0043-1774284

引用次数: 0

Postthrombotisches Syndrom: SOX-PTS-Score und Méan-Modell zeigen beste Prädiktion. Postthrombotisches综合征:SOX-PTS-Score和Méan-Modell展示最佳Prädiktion .

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/s-0043-1774285

引用次数: 0

Comparison of Performances among Four Bleeding-Prediction Scores in Elderly Cancer Patients with Venous Thromboembolism. 老年肿瘤静脉血栓栓塞患者四种出血预测评分的比较

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-08-01 DOI: 10.1055/a-1984-7210

Shaozhi Xi, Chaoyang Liu, Shuihua Yu, Jingxuan Qiu, Shuibo He, Zhong Yi

{"title":"Comparison of Performances among Four Bleeding-Prediction Scores in Elderly Cancer Patients with Venous Thromboembolism.","authors":"Shaozhi Xi, Chaoyang Liu, Shuihua Yu, Jingxuan Qiu, Shuibo He, Zhong Yi","doi":"10.1055/a-1984-7210","DOIUrl":"https://doi.org/10.1055/a-1984-7210","url":null,"abstract":"The performances of RIETE, VTE-BLEED, SWITCO65 + , and Hokusai-VTE scores for predicting major bleeding events in hospitalized elderly cancer patients with venous thromboembolism (VTE) have not been evaluated. This study validated the performances of these scoring systems in a cohort of elderly cancer patients with VTE. Between June 2015 and March 2021, a total of 408 cancer patients (aged ≥ 65 years) with acute VTE were consecutively enrolled. The overall rates of in-hospital major bleeding and clinically relevant bleeding (CRB) were 8.3% (34/408) and 11.8% (48/408), respectively. RIETE score could categorize patients with increasing rate of major bleeding and CRB into low-/intermediate- and high-risk categories (7.1 vs. 14.1%, p = 0.05 and 10.1 vs. 19.7%, p = 0.02, respectively). The discriminative power of the four scores for predicting major bleeding was poor to moderate, indicated by areas under the receiver operating characteristic curves (0.45 [95% confidence interval, CI: 0.35-0.55] for Hokusai-VTE, 0.54 [95% CI: 0.43-0.64] for SWITCO65 + , 0.58 [95% CI: 0.49-0.68] for VTE-BLEED, and 0.61 [95% CI: 0.51-0.71] for RIETE). RIETE score might be used to predict major bleeding in hospitalized elderly cancer patients with acute VTE.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/ca/10-1055-a-1984-7210.PMC10446890.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nachtrag zur kritischen Diskussion über das Deutsche Hämophilieregister (DHR) anlässlich der GTH-Jahrestagung in Frankfurt 2023, aktuelle Informationen zur Gefährdung der Versorgung mit Blutplasmaprodukten und Aus für Siemens Atellica in Deutschland. 2023 年法兰克福全球血友病协会（GTH）年会关于德国血友病登记册（DHR）的重要讨论增编、血浆产品供应面临威胁的最新信息以及西门子 Atellica 在德国的终结。

IF 2.7 4区医学

Hamostaseologie Pub Date : 2023-08-01 Epub Date: 2023-08-31 DOI: 10.1055/a-2031-7804

Jürgen Koscielny, Günther Kappert, Christoph Sucker

引用次数: 0

Veranstaltung des BDDH im Rahmen der 67. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung in Frankfurt. BDDH事件，作为67的一部分。在法兰克福举行的血栓和止血研究学会年会。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-06-01 Epub Date: 2023-06-20 DOI: 10.1055/a-2017-8694

Christoph Sucker, Jürgen Koscielny

引用次数: 0

Laboratory Findings, Medical Imaging, and Clinical Outcome in Children with Cerebral Sinus Venous Thrombosis. 脑静脉窦血栓形成儿童的实验室发现、医学影像和临床结果。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-06-01 DOI: 10.1055/a-1848-3649

Hannah Glonnegger, Nicole Glatthaar, Matthias Eckenweiler, Michael Barth, Markus Uhl, Martin Büchsel, Barbara Zieger

{"title":"Laboratory Findings, Medical Imaging, and Clinical Outcome in Children with Cerebral Sinus Venous Thrombosis.","authors":"Hannah Glonnegger, Nicole Glatthaar, Matthias Eckenweiler, Michael Barth, Markus Uhl, Martin Büchsel, Barbara Zieger","doi":"10.1055/a-1848-3649","DOIUrl":"https://doi.org/10.1055/a-1848-3649","url":null,"abstract":"Introduction: Cerebral sinus venous thrombosis (CSVT) is a rare disease, especially in children. Therefore, thrombophilia markers, risk factors, treatment strategy, and MRI, as well as clinical outcome need further investigation to support future diagnostic and therapeutic guidelines for children.Methods: We retrospectively identified all children with CSVT treated in our center between January 1, 2000, and December 31, 2015. Risk factors and laboratory findings were investigated. Furthermore, outcome and treatment satisfaction were evaluated using magnetic resonance imaging (MRI) analyses and a modified questionnaire.Results: All 43 patients, who agreed to participate, were treated with therapeutic levels of heparin; 86% of children had an increased risk for thromboembolic events upon onset of CSVT (acute disease: 58.1%, perinatal risk factors: 9.3%, medical intervention/immobility: 14%, chronic disease: 16.3%). Thrombophilia markers showed positive results (e.g., reduced values for protein C/S, factor-V-Leiden mutation) in 58% of children at the time of CSVT diagnosis but dropping to 20.9% over the course of the disease. Forty-two of 43 patients received MRI follow-ups and the outcome showed complete recanalization in 69% of the patients and partial recanalization in 31%. At the onset of CSVT, 88% of patients reported restrictions in everyday life due to CSVT; at follow-up this percentage declined to 18%. Satisfaction with the outcome among parents/patients according to the questionnaire was high with 1.7 (German school grades from 1 to 6).Conclusions: All 42 children with MRI follow-up demonstrated complete or partial recanalization under anticoagulation. This positive result underlines the need for future studies on anticoagulation to optimize therapy regimens of pediatric CSVT.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10025947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectus Sheath Hematoma in a Patient with Dual-Antiplatelet Therapy Including Ticagrelor: A Case Report. 包括替格瑞洛在内的双重抗血小板治疗患者的直肌鞘血肿1例报告。

IF 3.2 4区医学

Hamostaseologie Pub Date : 2023-06-01 DOI: 10.1055/a-2020-4643

Sinan Genç, Ahmet Sefa Yeter, Ahmet Burak Oğuz, Ayça Koca, Onur Polat, Müge Günalp Eneyli

{"title":"Rectus Sheath Hematoma in a Patient with Dual-Antiplatelet Therapy Including Ticagrelor: A Case Report.","authors":"Sinan Genç, Ahmet Sefa Yeter, Ahmet Burak Oğuz, Ayça Koca, Onur Polat, Müge Günalp Eneyli","doi":"10.1055/a-2020-4643","DOIUrl":"https://doi.org/10.1055/a-2020-4643","url":null,"abstract":"Rectus sheath hematoma (RSH) is an uncommon cause of abdominal pain associated with several risk factors including trauma, asthma, chronic obstructive pulmonary disease, pregnancy, and anticoagulation as it can be iatrogenic. Dual-antiplatelet therapy (DAPT), combined usage of a P2Y12 receptor inhibitor and aspirin, is a cornerstone treatment for patients with acute coronary syndromes. Ticagrelor is a P2Y12 receptor inhibitor with several adverse hemorrhagic complications. An 86-year-old male patient was admitted to the emergency department with abdominal pain and a palpable abdominal mass at the left upper quadrant of the abdomen. His medical history revealed coronary artery disease with medications including acetylsalicylic acid and ticagrelor. Contrast-enhanced abdominal computed tomography revealed RSH. The patient was treated conservatively with bed rest and analgesia. DAPT is an essential component of the management of acute coronary syndromes to prevent recurrent cardiac thrombotic events. However, hemorrhagic complications such as RSH may be encountered with DAPT. Emergency medicine physicians and cardiologists should keep in mind RSH in patients presenting with abdominal pain and using DAPT with ticagrelor.","PeriodicalId":55074,"journal":{"name":"Hamostaseologie","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9671248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1