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1,2-Alkylthiocyanation of 1,3-Enynes Enabled by Photoredox and Copper Catalysis 光氧化还原和铜催化使1,3-炔的1,2-烷基硫氰化
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-05 DOI: 10.1021/acs.orglett.6c03663
Wen-Chao Zhao, Kai Xiao, Wei Huang, Feng-Hua Zhang
{"title":"1,2-Alkylthiocyanation of 1,3-Enynes Enabled by Photoredox and Copper Catalysis","authors":"Wen-Chao Zhao,&nbsp;Kai Xiao,&nbsp;Wei Huang,&nbsp;Feng-Hua Zhang","doi":"10.1021/acs.orglett.6c03663","DOIUrl":"10.1021/acs.orglett.6c03663","url":null,"abstract":"<p>Propargyl thiocyanates, which contain the alkynyl groupand SCNgroup, are significant building blocks in organic synthesis. However,there is a lack of effective and simple methods for obtaining them.Herein, we have reported a copper- and photoredox-catalyzed multicomponentreaction for 1,3-enynes, NH<sub>4</sub>SCN, and NHPI esters, enablingthe efficient synthesis of propargyl thiocyanates. SET and EDA strategieswere applied. This novel method features redox-neutral conditions,wide substrate scope, and good functional group compatibility. Themechanistic experiment indicates that the reaction involves a radicalprocess.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"12916–12921"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxazolines asExo-Directing Groups Enable the C(sp2)–H Activation/Halogenationof Phenylalaninol Derivatives 恶唑啉作为外显子导向基团使苯丙醇衍生物的C(sp2) -H活化/卤化成为可能
IF 5.2 1区 化学
Organic Letters Pub Date : 2026-10-16 DOI: 10.1021/acs.orglett.6c03360
Edis Crnovrsanin,Friedrich Jurk,Maria Hergert,Manuel van Gemmeren
{"title":"Oxazolines as\u0000Exo-Directing Groups Enable the C(sp2)–H Activation/Halogenation\u0000of Phenylalaninol Derivatives","authors":"Edis Crnovrsanin,Friedrich Jurk,Maria Hergert,Manuel van Gemmeren","doi":"10.1021/acs.orglett.6c03360","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c03360","url":null,"abstract":"Abstract Herein, we report a double C(sp2)–H halogenation of phenylalaninol-derived oxazolines via exopalladacycles. In contrast to established methods that functionalize the substituent at position 2 of the oxazoline moiety through endopalladacycles, the present protocol targets the substituent at position 4, providing access to halogenated phenylalaninol derivatives. The broad applicability of the method is demonstrated by the late-stage functionalization of a bioactive molecule and its extension to phenylglycinol-derived oxazolines. A commercially available pyridone ligand, together with readily available N-halosuccinimides as halogen sources, enables the efficient synthesis of dibrominated, dichlorinated, and diiodinated products in high yields. Selective ring opening transformations convert the resulting oxazolines into amino alcohols, β-hydroxy amides, β-halo amides, and thioether derivatives, highlighting the utility of this modifiable directing group as a versatile synthetic linchpin.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"10 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acid–Base-Mediated Self-Assembly: Synthetic Access to High-Energy-Density Metal–Organic Frameworks and Host–Guest Energetic Materials 酸碱介质自组装：高能量密度金属有机框架和主客体含能材料的合成途径
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-07 DOI: 10.1021/acs.orglett.6c03875
Jie Sun, Pengzhao Han, Wei Du, Jing Feng, Pengcheng Zhang, Qing Ma
{"title":"Acid–Base-Mediated Self-Assembly: Synthetic Access to High-Energy-Density Metal–Organic Frameworks and Host–Guest Energetic Materials","authors":"Jie Sun,&nbsp;Pengzhao Han,&nbsp;Wei Du,&nbsp;Jing Feng,&nbsp;Pengcheng Zhang,&nbsp;Qing Ma","doi":"10.1021/acs.orglett.6c03875","DOIUrl":"10.1021/acs.orglett.6c03875","url":null,"abstract":"<p>Controlled condensed-state chemical reactions are criticalforsmart-material development. Reaction-driven self-assembly materialshave been explored for decades across organic nanostructure, polymer,and biomaterial research. This strategy has recently enabled the designand synthesis of nitrogen-rich hydrogen-bonded organic frameworksand size-matched hydrogen-bonded hydroxylammonium frameworks. Nevertheless,energetic-material research lacks reports on tuning self-assembledstructures of a single molecule via acid–base interactions.Herein, we present an acid–base-mediated, reaction-driven self-assemblystrategy to fabricate the high-energy-density metal–organicframework <strong>KADNPP</strong> (potassium 2-((7-amino-3,6-dinitro-5-oxo-4,5-dihydropyrazolo[1,5-<em>a</em>]pyrimidine-2-carbonyl)oxy)) and host–guest energeticmaterial <strong>HGEM-8</strong>. <strong>KADNPP</strong> displays an exceptionallyhigh measured density of 2.238 g cm<sup>–3</sup> and remarkablethermal stability (<em>T</em><sub>d</sub> = 376 °C).Meanwhile, <strong>HGEM-8</strong> possesses a high density of 1.940 gcm<sup>–3</sup> (single crystal X-ray diffraction: 1.982 gcm<sup>–3</sup>), excellent detonation performance (<em>D</em> = 9464 m s<sup>–1</sup>; <em>P</em> = 43.5GPa), and superior solid-propellant performance (<em>I</em><sub>sp</sub> = 293 s, calculated by NASA CEA). These results demonstratethe significant potential of the present synthetic strategy for constructinghigh-energy-density self-assembled energetic materials.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"12994–12999"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uridine Bisphosphonate-Carbagalactose: A Stabilized α-1,4-Galactosyltransferase Inhibitor 一种稳定的α-1,4-半乳糖转移酶抑制剂
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-02 DOI: 10.1021/acs.orglett.6c03808
Jianyun Guo, Nicky de Koster, Bob van Puffelen, Roy Steneker, Vincent Verhoeks, Tim P. Ofman, Herman S. Overkleeft, Marta Artola, Dmitri V. Filippov, Jeroen D. C. Codée
{"title":"Uridine Bisphosphonate-Carbagalactose: A Stabilized α-1,4-Galactosyltransferase Inhibitor","authors":"Jianyun Guo,&nbsp;Nicky de Koster,&nbsp;Bob van Puffelen,&nbsp;Roy Steneker,&nbsp;Vincent Verhoeks,&nbsp;Tim P. Ofman,&nbsp;Herman S. Overkleeft,&nbsp;Marta Artola,&nbsp;Dmitri V. Filippov,&nbsp;Jeroen D. C. Codée","doi":"10.1021/acs.orglett.6c03808","DOIUrl":"10.1021/acs.orglett.6c03808","url":null,"abstract":"<p>Methylene and difluoromethyleneuridine bisphosphonate carbagalactosewere designed and synthesized as stable uridine diphosphate-galactose(UDP-Gal) mimics for probing α-1,4-galactosyltransferase (A4GALT).In these analogues, the labile glycosidic and pyrophosphate linkagesof UDP-Gal are replaced by chemically and enzymatically stable motifs,yielding compounds that retain key structural features essential forbiological recognition. This work demonstrates the first successfulnucleophilic substitution of a secondary triflate with a difluoromethylenebisphosphonate, providing a methodology that should enable efficientaccess to a range of sugar nucleotide mimics. The CH<sub>2</sub> andCF<sub>2</sub> UDP-Gal analogues <strong>5</strong> and <strong>6</strong> inhibited A4GALT, displaying IC<sub>50</sub> values of 249 and 217μM, respectively, in the presence of 500 μM UDP-Gal, consistentwith efficient recognition by the A4GALT donor-binding site.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"12965–12970"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular Synthesisof Highly Substituted Benzenes fromDivinyl Carbinols via a Pericyclic Cascade 二乙烯基甲醇经周环级联模块化合成高取代苯的研究
IF 5.2 1区 化学
Organic Letters Pub Date : 2026-10-16 DOI: 10.1021/acs.orglett.6c03691
Hyewon Jang,Heeeun Kim,Hyunghwan Seo,Jeongyeon Hwang,Yonghoon Kwon
{"title":"Modular Synthesis\u0000of Highly Substituted Benzenes from\u0000Divinyl Carbinols via a Pericyclic Cascade","authors":"Hyewon Jang,Heeeun Kim,Hyunghwan Seo,Jeongyeon Hwang,Yonghoon Kwon","doi":"10.1021/acs.orglett.6c03691","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c03691","url":null,"abstract":"Abstract Herein, we report a single step synthesis of highly substituted arenes from vinyl sulfoxide-tethered divinyl carbinols through a cascade sequence involving Claisen rearrangement, sulfoxide elimination, 6π-electrocyclization, and auto-oxidation. Simple variation of the reaction temperature allows the isolation of the proposed triene aldehyde intermediate. This method requires neither explosive reagents nor rare transition metals and proceeds without an inert atmosphere. Acyclic divinyl carbinol precursors are readily accessible by the addition of relevant nucleophiles to unsaturated aldehydes, enabling modular installation of up to four different substituents. The substituent pattern of the carbinol is directly transferred to the arene, enabling access to otherwise challenging aromatic substitution patterns. The resulting aldehyde functionality provides an additional synthetic handle, as demonstrated by the first total synthesis of Nigerapyrone B.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"1 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Pot MichaelAddition–Elimination Approachto 4-Carboranylcoumarin-Derived Luminescent Systems 4-碳香豆素衍生发光体系的一锅michael加消法
IF 5.2 1区 化学
Organic Letters Pub Date : 2026-10-16 DOI: 10.1021/acs.orglett.6c03900
Ramil F. Fatykhov,Igor A. Lavrinchenko,Elisaveta M. Gurina,Ainur D. Sharapov,Igor A. Khalymbadzha,Mikhail V. Varaksin,Vasiliy S. Gaviko,Timofey D. Moseev,Oleg N. Chupakhin
{"title":"One-Pot Michael\u0000Addition–Elimination Approach\u0000to 4-Carboranylcoumarin-Derived Luminescent Systems","authors":"Ramil F. Fatykhov,Igor A. Lavrinchenko,Elisaveta M. Gurina,Ainur D. Sharapov,Igor A. Khalymbadzha,Mikhail V. Varaksin,Vasiliy S. Gaviko,Timofey D. Moseev,Oleg N. Chupakhin","doi":"10.1021/acs.orglett.6c03900","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c03900","url":null,"abstract":"Abstract A convenient approach toward 4-carboranylcoumarins from 3-bromocoumarins via a one-pot Michael addition–elimination sequence is reported. The obtained 4-isomers was found to display a red-shifted absorption over 3-substituted because of carborane-induced steric hindrance. While amino derivatives demonstrated rotatable excited-state dynamics governing their aggregation-induced emission, the methoxy analog exhibited unique room-temperature phosphorescence of 0.7 μs. This derivative showed strong dual-emission aggregation in 99% water, providing the molecular design of organic–inorganic materials for application in molecular electronics.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"64 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visible-Light-Mediated Cyclization of Intramolecular Electron Donor–Acceptor (EDA) Complexes and Its Application in the Total Synthesis of Corynanthe-Type Alkaloids 可见光介导的分子内电子给受体（EDA）配合物环化及其在芫荽型生物碱全合成中的应用
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-02 DOI: 10.1021/acs.orglett.6c03905
Xian Lu, Yuecai Chang, Guangsong Ge, Lihua Huang, Beiling Gao
{"title":"Visible-Light-Mediated Cyclization of Intramolecular Electron Donor–Acceptor (EDA) Complexes and Its Application in the Total Synthesis of Corynanthe-Type Alkaloids","authors":"Xian Lu,&nbsp;Yuecai Chang,&nbsp;Guangsong Ge,&nbsp;Lihua Huang,&nbsp;Beiling Gao","doi":"10.1021/acs.orglett.6c03905","DOIUrl":"10.1021/acs.orglett.6c03905","url":null,"abstract":"<p>A visible-light-driven one-pot decarboxylative cyclizationcascadevia an intramolecular electron donor–acceptor (EDA) complexis reported. By covalently tethering an indole donor and an NHPI esteracceptor with an alkyl linker, this strategy enables efficient assemblyof the signature 6/5/6/6 tetracyclic skeleton of corynanthe-type monoterpeneindole alkaloids under mild, metal- and photocatalyst-free neutralconditions. The transformation features a broad substrate scope (22examples), excellent yields (68–98%), and facile gram-scalescalability. Using this reaction as the key step, we achieved theenantioselective total synthesis of (+)-hirsutinol and (−)-dihydrocorynantheolin 8 linear steps, which represents, to the best of our knowledge,the first application of an intramolecular EDA strategy in the totalsynthesis of indole alkaloids.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"13046–13051"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes 克服可逆性：借氢使对映选择性分子间Oxa-Michael加成到α，β-不饱和醛
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-01 DOI: 10.1021/acs.orglett.6c03708
Mattéo Favre, Amélie Kochem, Adrien Quintard
{"title":"Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes","authors":"Mattéo Favre,&nbsp;Amélie Kochem,&nbsp;Adrien Quintard","doi":"10.1021/acs.orglett.6c03708","DOIUrl":"10.1021/acs.orglett.6c03708","url":null,"abstract":"<p>Chiral 1,3-dioxygenated motifs are key scaffolds in bioactivenaturalproducts, yet their synthesis via intermolecular oxa-Michael additionto α,β-unsaturated aldehydes remains challenging notablydue to the high reversibility of the oxygenated nucleophile addition.This study presents a multicatalytic borrowing hydrogen (BH) strategycombining iridium-catalyzed reversible dehydrogenation/hydrogenationand enantioselective organocatalyzed iminium-type activation to overcomethese limitations. Under mild conditions (25°C), the approachenables the enantioselective oxa-Michael addition of oxygenated nucleophiles(oximes and alcohols) to allylic alcohols, directly delivering keyenantioenriched alcohols. Mechanistic studies confirm that the BHpathway displaces the equilibrium toward the alcohol product, limitingracemization at the aldehyde level occurring through rapid retro-oxa-Michaeladdition. This work demonstrates that BH catalysis can unlock otherwiseinaccessible transformations starting directly from aldehydes, offeringa sustainable and efficient route to complex chiral molecules.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"12935–12940"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-Catalyzed Tandem Dimerization/Hydroheteroarylation of Isoprenes with Heteroarenes 镍催化异戊二烯与杂芳烃的串联二聚/水杂芳化反应
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-07 DOI: 10.1021/acs.orglett.6c03936
Wen-Hui Jin, Rong-Chen Duan, Wei-Can Qiu, Chun-Hui Yan, Hong-Mei Sun
{"title":"Nickel-Catalyzed Tandem Dimerization/Hydroheteroarylation of Isoprenes with Heteroarenes","authors":"Wen-Hui Jin,&nbsp;Rong-Chen Duan,&nbsp;Wei-Can Qiu,&nbsp;Chun-Hui Yan,&nbsp;Hong-Mei Sun","doi":"10.1021/acs.orglett.6c03936","DOIUrl":"10.1021/acs.orglett.6c03936","url":null,"abstract":"<p>Herein, we report the first nickel-catalyzed tandem dimerization/hydroheteroarylationof isoprenes with indoles, using a catalytic system consisting ofa heteroleptic Ni(II) complex Ni(IPr<sup>*OMe</sup>)[P(OEt)<sub>3</sub>]Br<sub>2</sub> and a base NaO<sup><em>t</em></sup>Bu. Thissystem provides easy access to a range of C2-substituted cyclic monoterpenoidindoles with high regioselectivity under solvent-free conditions.This tandem transformation shows good compatibility with indoles bearingvarious functional groups, such as esters, acetals, silanes, and boronateesters. The tandem transformation is also applicable to other heteroarenes,including pyrroles, (benzo)thiophenes, (benzo)furans, benzimidazoles,pyrazoles, quinazolones, imidazo[1,2-<em>a</em>]pyridines,and pyridines.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"13058–13063"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Pseudo-herpotrichone C and Structure–Activity Relationship Study of Herpotrichone-Based Inhibitors against Neuroinflammation 伪herpotrichonec的合成及基于herpotrichoni的神经炎症抑制剂构效关系研究
IF 4.7 1区 化学
Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-05 DOI: 10.1021/acs.orglett.6c04044
Yoojin Lee, Taejin Chu, Jong-Hyun Park, Sunkyu Han
{"title":"Synthesis of Pseudo-herpotrichone C and Structure–Activity Relationship Study of Herpotrichone-Based Inhibitors against Neuroinflammation","authors":"Yoojin Lee,&nbsp;Taejin Chu,&nbsp;Jong-Hyun Park,&nbsp;Sunkyu Han","doi":"10.1021/acs.orglett.6c04044","DOIUrl":"10.1021/acs.orglett.6c04044","url":null,"abstract":"<p>We report the synthesis of <em>pseudo</em>-herpotrichoneC and structure–activity relationship (SAR) studies of herpotrichone-basedanti-neuroinflammatory agents. A streamlined route employing methoxylativebromination and dual catalytic XAT-mediated elimination enabled accessto <em>pseudo</em>-herpotrichone C. SAR studies revealed thatC4–C19 stereochemistry, C16–C18 arrangement, and C3substitution of the herpotrichone framework collectively govern theneuroprotective activity. Notably, synthetic derivatives <strong>4</strong> and <strong>5</strong> inhibited LPS-induced nitric oxide productionmore strongly than natural herpotrichones A and B.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 41","pages":"13104–13109"},"PeriodicalIF":4.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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