Ru（II）催化2-氨基酚醇的多米诺烷基化/环化/氧化法制备3-羟基吲哚-2-酮

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-24 DOI:10.1021/acs.orglett.5c01063

Chuanhu Wang, Jingwen Huang, Bo Deng, Wei Sun, Tongyu Xu, Fanlong Zeng

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引用次数: 0

摘要

采用Ru（II）催化的多米诺骨牌反应，通过烷基化、环化和苯甲醇氧化合成了3-羟基吲哚-2-酮。该转化具有优异的合成效率，在相同条件下一步可选择性形成4个或3个σ键、1个π键和1个季碳中心。此外，它还为具有不同取代基的3-羟基吲哚-2- 1框架提供了一种通用的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Construction of 3-Hydroxyindolin-2-ones via Ru(II)-Catalyzed Domino Alkylation/Cyclization/Oxidation of 2-Aminophenethanols

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Construction of 3-Hydroxyindolin-2-ones via Ru(II)-Catalyzed Domino Alkylation/Cyclization/Oxidation of 2-Aminophenethanols

A novel Ru(II)-catalyzed domino reaction, comprising alkylation, cyclization, and oxidation of 2-aminophenethanols with benzyl alcohols, has been developed for the synthesis of 3-hydroxyindolin-2-ones. This transformation exhibits excellent synthetic efficiency, enabling the selective formation of four or three σ bonds, one π bond, and one quaternary carbon center in one step under identical conditions. Furthermore, it provides a versatile approach to 3-hydroxyindolin-2-one frameworks with distinct substituents at the 1- and 3-positions.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.