International Review of Cytology-A Survey of Cell Biology最新文献_第5页

Cell biology and pathophysiology of the diacylglycerol kinase family: morphological aspects in tissues and organs. 二酰基甘油激酶家族的细胞生物学和病理生理学:组织和器官的形态学方面。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)64002-9

Kaoru Goto, Yasukazu Hozumi, Tomoyuki Nakano, Sachiko S Saino, Hisatake Kondo

引用次数: 73

Structure and function of desmosomes. 桥粒的结构和功能。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)64003-0

Bastian Holthöfer, Reinhard Windoffer, Sergey Troyanovsky, Rudolf E Leube

引用次数: 186

Multiple functions of the origin recognition complex. 多重功能的原点识别复合体。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)56003-1

Igor N Chesnokov

{"title":"Multiple functions of the origin recognition complex.","authors":"Igor N Chesnokov","doi":"10.1016/S0074-7696(07)56003-1","DOIUrl":"https://doi.org/10.1016/S0074-7696(07)56003-1","url":null,"abstract":"The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely. In budding yeast the ORC recognizes specific ori elements, however, in higher eukaryotes origin site selection does not appear to depend on the specific DNA sequence. In metazoans, during cell cycle progression, one or more of the ORC subunits can be modified in such a way that ORC activity is inhibited until mitosis is complete and a nuclear membrane is assembled. In addition to its well-documented role in the initiation of DNA replication, the ORC is also involved in other cell functions. Some of these activities directly link cell cycle progression with DNA replication, while other functions seem distinct from replication. The function of ORCs in the establishment of transcriptionally repressed regions is described for many species and may be a conserved feature common for both unicellular eukaryotes and metazoans. ORC subunits were found at centrosomes, at the cell membranes, at the cytokinesis furrows of dividing cells, as well as at the kinetochore. The exact mechanism of these localizations remains to be determined, however, latest results support the idea that ORC proteins participate in multiple aspects of the chromosome inheritance cycle. In this review, we discuss the participation of ORC proteins in various cell functions, in addition to the canonical role of ORC in initiating DNA replication.","PeriodicalId":54930,"journal":{"name":"International Review of Cytology-A Survey of Cell Biology","volume":"256 ","pages":"69-109"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0074-7696(07)56003-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26504691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57

MHC class I antigens and immune surveillance in transformed cells. MHC I类抗原与转化细胞的免疫监视。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)56005-5

Natalia Aptsiauri, Teresa Cabrera, Angel Garcia-Lora, Miguel Angel Lopez-Nevot, Francisco Ruiz-Cabello, Federico Garrido

引用次数: 138

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)57003-8

Yu F Bogdanov, T M Grishaeva, S Ya Dadashev

{"title":"Similarity of the domain structure of proteins as a basis for the conservation of meiosis.","authors":"Yu F Bogdanov, T M Grishaeva, S Ya Dadashev","doi":"10.1016/S0074-7696(07)57003-8","DOIUrl":"https://doi.org/10.1016/S0074-7696(07)57003-8","url":null,"abstract":"Meiosis is conserved in all eucaryotic kingdoms, and homologous rows of variability are revealed for the cytological traits of meiosis. To find the nature of these phenomenons, we reviewed the most-studied meiosis-specific proteins and studied them with the methods of bioinformatics. We found that synaptonemal complex proteins have no homology of amino-acid sequence, but are similar in the domain organization and three-dimensional (3D) structure of functionally important domains in budding yeast, nematode, Drosophila, Arabidopsis, and human. Recombination proteins of Rad51/Dmc1 family are conserved to the extent which permits them to make filamentous single-strand deoxyribonucleic acid (ssDNA)-protein intermediates of meiotic recombination. The same structural principles are valid for conservation of the ultrastructure of kinetochores, cell gap contacts, and nuclear pore complexes, such as in the cases when ultrastructure 3D parameters are important for the function. We suggest that self-assembly of protein molecules plays a significant role in building-up of all biological structures mentioned.","PeriodicalId":54930,"journal":{"name":"International Review of Cytology-A Survey of Cell Biology","volume":"257 ","pages":"83-142"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0074-7696(07)57003-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26536786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Tumor hypoxia and targeted gene therapy. 肿瘤缺氧与靶向基因治疗。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)57005-1

Olga Greco, Simon Scott

{"title":"Tumor hypoxia and targeted gene therapy.","authors":"Olga Greco, Simon Scott","doi":"10.1016/S0074-7696(07)57005-1","DOIUrl":"https://doi.org/10.1016/S0074-7696(07)57005-1","url":null,"abstract":"Hypoxia is an integral characteristic of the tumor microenvironment, primarily due to the microvascular defects that accompany the accelerated neoplastic growth. The presence of tumor hypoxic areas correlates with negative outcome after radiotherapy, chemotherapy, and surgery, as hypoxia not only provides an environment directly facilitating chemo- and radio-resistance, but also encourages the evolution of phenotypic changes inducing permanent resistance to treatment and metastatic spread. Therefore, successful treatment of hypoxic cells has the potential to not only improve local control but also impact overall patient survival. Specific and selective targeting of hypoxic tumor areas can be achieved at all three steps of a gene therapy treatment: delivery of the therapeutic gene to the tumor, regulation of gene expression, and therapeutic efficacy. In this review the latest developments and innovations in hypoxia-targeted gene therapy are discussed. In particular, approaches such as hypoxia-conditionally replicating viruses, cellular vehicles, and gene therapy means to disrupt the hypoxia-inducible factor (HIF) signaling are outlined.","PeriodicalId":54930,"journal":{"name":"International Review of Cytology-A Survey of Cell Biology","volume":"257 ","pages":"181-212"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0074-7696(07)57005-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26536788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Oxytocin and the human prostate in health and disease. 催产素与人类前列腺健康和疾病的关系。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)63006-X

Helen D Nicholson, Kate Whittington

引用次数: 16

Cellular basis of chronic obstructive pulmonary disease in horses. 马慢性阻塞性肺疾病的细胞基础。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)57006-3

Darko Marinkovic, Sanja Aleksic-Kovacevic, Pavle Plamenac

{"title":"Cellular basis of chronic obstructive pulmonary disease in horses.","authors":"Darko Marinkovic, Sanja Aleksic-Kovacevic, Pavle Plamenac","doi":"10.1016/S0074-7696(07)57006-3","DOIUrl":"https://doi.org/10.1016/S0074-7696(07)57006-3","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is an inflammatory obstructive disease of the airways characterized with hypersensitivity of the airway tissues to various allergens, most commonly the fungi contained in the poor-quality hay and straw bedding-Saccharopolyspora rectivirgula, Aspergillus fumigatus, and Thermoactinomyces vulgaris. It is manifested clinically in middle-aged horses with recurrent episodes of dyspnea, chronic cough, and their reduced athletic and working capacity. Pulmonary emphysema and lack of pulmonary collapse are the most common gross lesion. Pathohistological findings in horses with COPD are chronic bronchitis/bronchiolitis, with characteristic changes in lumen, mucosa, submucosa, and smooth muscle layer and alveolar emphysema, both distensive and destructive form. Increased immunoreactivity in lungs and tracheobronchial lymph nodes is also noted. Most common lesions seen on cytology imprint smears from tracheal bifurcation is thick, viscous, PAS-positive mucus that forms Curschmann's spirals. Dominant cell population consists of desquamated airway epithelial cells, as well as eosinophils, neutrophils, mast cells, erythrocytes, and alveolar macrophages. Primary pulmonary pathogens as well as potential contaminants and secondary infection agents were isolated bacteriologically from lung samples. All of the aforementioned findings correlate pointing to the fact that chronic bronchitis/bronchiolitis represents a basic substrate of COPD, which have combined inflammatory and immunological etiology, and emphysema is secondary to airway obstruction.","PeriodicalId":54930,"journal":{"name":"International Review of Cytology-A Survey of Cell Biology","volume":"257 ","pages":"213-47"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0074-7696(07)57006-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26536789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

New insights into membrane trafficking and protein sorting. 膜运输和蛋白质分类的新见解。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)61002-X

Merran C Derby, Paul A Gleeson

{"title":"New insights into membrane trafficking and protein sorting.","authors":"Merran C Derby, Paul A Gleeson","doi":"10.1016/S0074-7696(07)61002-X","DOIUrl":"https://doi.org/10.1016/S0074-7696(07)61002-X","url":null,"abstract":"Protein transport in the secretory and endocytic pathways is a multistep process involving the generation of transport carriers loaded with defined sets of cargo, the shipment of the cargo-loaded transport carriers between compartments, and the specific fusion of these transport carriers with a target membrane. The regulation of these membrane-mediated processes involves a complex array of protein and lipid interactions. As the machinery and regulatory processes of membrane trafficking have been defined, it is increasingly apparent that membrane transport is intimately connected with a number of other cellular processes, such as quality control in the endoplasmic reticulum (ER), cytoskeletal dynamics, receptor signaling, and mitosis. The fidelity of membrane trafficking relies on the correct assembly of components on organelles. Recruitment of peripheral proteins plays a critical role in defining organelle identity and the establishment of membrane subdomains, essential for the regulation of vesicle transport. The molecular mechanisms for the biogenesis of membrane subdomains are also central to understanding how cargo is sorted and segregated and how different populations of transport carriers are generated. In this review we will focus on the emerging themes of organelle identity, membrane subdomains, regulation of Golgi trafficking, and advances in dissecting pathways in physiological systems.","PeriodicalId":54930,"journal":{"name":"International Review of Cytology-A Survey of Cell Biology","volume":"261 ","pages":"47-116"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0074-7696(07)61002-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26768805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 110

Cell responses to biomimetic protein scaffolds used in tissue repair and engineering. 组织修复与工程中仿生蛋白支架的细胞反应。

International Review of Cytology-A Survey of Cell Biology Pub Date : 2007-01-01 DOI: 10.1016/S0074-7696(07)62002-6

Robert A Brown, James B Phillips

引用次数: 140