Ana Carolina de Jacomo Claudio, Luana Zava Ribeiro da Silva, Laís Gobbo Fonseca, Caroline Coletti de Camargo, Aryane Flauzino Machado, Jessica Kirsch Micheletti, Berlis Ribeiro dos Santos Menossi
{"title":"Isokinetic testing protocol-based discharge criteria after anterior ligament reconstruction: A systematic review","authors":"Ana Carolina de Jacomo Claudio, Luana Zava Ribeiro da Silva, Laís Gobbo Fonseca, Caroline Coletti de Camargo, Aryane Flauzino Machado, Jessica Kirsch Micheletti, Berlis Ribeiro dos Santos Menossi","doi":"10.3233/ies-220103","DOIUrl":"https://doi.org/10.3233/ies-220103","url":null,"abstract":"BACKGROUND: The return to activities and sports after the anterior cruciate ligament (ACL) reconstruction is a critical decision. OBJECTIVE: To verify the most used elements during the isokinetic evaluation for discharge after ACL reconstruction. METHODS: Systematic review (PROSPERO CRD42021224433). Research in the literature: PubMed, Medline, SciELO, Lilacs, CENTRAL, PEDro, Web of Science and Embase, in February 2022. Studies that performed isokinetic evaluation during the discharge period in male patients aged 18 to 59 years after ACL reconstruction. Descriptive synthesis on the most used parameters during isokinetic evaluation as a discharge criteria after ACL reconstruction. RESULT: Twenty-three studies involving 1,792 participants were included. Medium and high quality evidence identified that most isokinetic evaluations targeted only muscle strength after rehabilitation of the ACL (peak moment). CONCLUSION: The most used elements during the isokinetic evaluation were: angular velocity of 60∘/s, 1 set of 5 repetitions, concentric mode and peak moment.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":"302 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Continuous palm cooling’s effect on heat transfer and physiology","authors":"N.L. Patel, P.M. Quesada, J. Wellwood, B.C. Skutnik, J.P. Daily, J.F. Caruso","doi":"10.3233/ies-230077","DOIUrl":"https://doi.org/10.3233/ies-230077","url":null,"abstract":"BACKGROUND: Excess heat accrual is perhaps the body’s most dangerous exercise-induced stressor. While palm cooling uses conduction to reduce body temperatures, to date the volume of heat transferred by this treatment resulting from exercise is unknown. OBJECTIVE: Asses continuous palm cooling’s impact on heat transfer and physiology. METHODS: Thirty-one subjects did two workouts; one with, and one without, palm cooling. Workouts entailed consecutive stages of submaximal pedaling against prescribed workloads. Gloves were worn at workouts; for palm cooling 10.6∘C gel packs were inserted into gloves at the workout’s start and conclusion. Heart rate, auditory canal and palm skin temperatures, and heat transfer across the palm were collected. Data were obtained pre-exercise, at the end of a warm-up, and at multiple times during the 25 minutes of pedaling and 30 minutes of recovery. RESULTS: Auditory canal temperatures had a significant treatment effect (palm cooling < non-palm cooling). Palm skin temperature had an interaction, with higher non-palm cooling values at multiple times. Conversely, heat transfer also produced an interaction, but palm cooling had significantly higher values at multiple times. Heat transfer was 32% higher for the palm cooling workout. CONCLUSIONS: Continuous palm cooling produced significantly higher heat transfer from submaximal exercise.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of kinesio taping and exercise on functional impairment in patients with different degrees of knee osteoarthritis","authors":"Waleed S. Mahmoud","doi":"10.3233/ies-230028","DOIUrl":"https://doi.org/10.3233/ies-230028","url":null,"abstract":"BACKGROUND: Kinesio Taping (KT) is used for musculoskeletal problems. KT optimizes and reduces mechanical stresses on soft tissues. However, the benefits of KT and traditional exercises for different severities of knee osteoarthritis (OA) remains controversial. OBJECTIVES: This study aimed to investigate the effects of tension KT and traditional physical therapy on different severities of knee OA. METHODS: Fifty-six male patients with knee OA, aged 60–75-y years, were allocated to groups A and B based on grades 1 and 2 and grades 3 and 4 on the Kellgren-Lawrence scale, respectively. Tension KT and traditional physical therapy were administrated to both groups for 6-wks. The extensor peak moment of quadriceps and knee flexion range of motion (ROM) were recorded using an isokinetic dynamometer and universal goniometer, respectively. Visual analog scale (VAS) was used to score pain level. Statistical analysis was performed using the ANCOVA test. RESULTS: ANCOVA revealed an increase in peak extensor moment of quadriceps (Pre: 51.6 ± 2.8 Nm; Post: 63.3 ± 4.3 Nm), knee flexion ROM (Pre: 112.8±∘ 7.2; Post: 122.9±∘ 4.8), and pain improvement (Pre: 5.1 ± 1.07; Post: 2.8 ± 1.6) in group A (p< 0.001). Group B showed insignificant improvements in all outcome measures (p> 0.05). CONCLUSION: KT with traditional physical therapy improved knee pain, quadriceps strength, and knee ROM in older males with knee OA grades 1 and 2. KT and traditional physical therapy were insufficient to produce considerable effects on grades 3 and 4 of knee OA.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validity of using perceived exertion to assess muscle fatigue during bench press exercise","authors":"Hanye Zhao, Dasom Seo, Junichi Okada","doi":"10.3233/ies-230048","DOIUrl":"https://doi.org/10.3233/ies-230048","url":null,"abstract":"BACKGROUND: Muscle fatigue is nearly unavoidable during resistance exercise, yet evaluating it in such circumstances can be challenging. OBJECTIVE: This study aimed to evaluate the validity of using the rating of perceived exertion (RPE) as a measure of muscle fatigue during non-explosive bench press (BP) exercise. METHODS: Fifteen male collegiate athletes participated in three BP tasks set at 65% of their one-repetition maximum. The RPE, spectral fatigue index (SFI), and velocity loss were measured across different experimental conditions. RESULTS: Significant effects were observed across different experimental conditions for the overall RPE, average velocity loss, and average SFI (all p< 0.001). As the lifting tasks progressed, there were significant increases in the RPE, velocity loss, and SFI (p< 0.001). Additionally, significant differences were observed between the experimental conditions in the RPE (p< 0.001), SFI (p< 0.001), and velocity loss (p< 0.01). A significantly stronger (p< 0.05) correlation was observed between the RPE and SFI (r= 0.68, df= 117, p< 0.001) than between the velocity loss and SFI (r= 0.51, df= 117, p< 0.001). CONCLUSIONS: The corresponding changes observed in the RPE, velocity loss, and SFI suggest that both the RPE and velocity loss can be used as indicators of muscle fatigue during non-explosive BP exercise. However, due to the strong correlation between the RPE and SFI, RPE is more effective for reflecting muscle fatigue in non-explosive resistance exercise settings. Regarding ease of use, the RPE is more suitable than velocity loss for assessing muscle fatigue in training scenarios.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45511036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between muscle quality index and physical function in older adults","authors":"Andreas Stotz, J. Mason, A. Zech","doi":"10.3233/ies-230051","DOIUrl":"https://doi.org/10.3233/ies-230051","url":null,"abstract":"BACKGROUND: The muscle quality index (MQI) has been proposed as a diagnostic tool to detect individuals at risk of limited physical function. OBJECTIVE: Our goal was to examine the relationship of the MQI with physical function and compare its predictive ability with other muscle parameters of strength and mass in an older population. METHODS: Sixty-eight healthy older adults (34 male, 34 female) aged between 69 and 89 years were tested for body composition, MQI, maximum isokinetic concentric KES and physical function including sit-to-stand (STS) time, normal and maximum walking speed (WS), Timed Up and Go (TUG) and static balance. Pearson’s correlation was applied to examine the relationship between muscle parameters. Linear regression analysis including age and sex as additional covariates was performed to assess their predictive ability for physical functions. RESULTS: MQI correlated significantly with relative KES (r= 0.611, p< 0.001), total KES (r= 0.829, p< 0.001) and leg lean tissue mass (r= 0.690, p< 0.001). The MQI was not a significant predictor for any physical function (p> 0.05). STS time was a significant predictor for normal WS and TUG time (p< 0.001). Relative KES was a significant predictor for all physical functions except static balance (p< 0.001). No muscle parameter and only age was a significant predictor for static balance. Models explained 20.4%–57.3% of variances of dependent variables. CONCLUSIONS: The MQI is a useful tool to assess leg lean tissue mass and strength of the knee extensor muscles and outperforms STS time. However, STS time and relative KES are more closely related to physical function than the MQI.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48790808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wollner Materko, Caio Cesar dos Reis Façanha, Gizelly Coelho Guedes, Marcela Fabiani Silva Dias, Alisson Vieira Costa, Dilson Rodrigues Belfort, Demilto Yamaguchi da Pureza, Á. A. Alberto
{"title":"Temporal cross-correlation between Polar® heart rate monitor interface board and ECG to measure RR interval at rest","authors":"Wollner Materko, Caio Cesar dos Reis Façanha, Gizelly Coelho Guedes, Marcela Fabiani Silva Dias, Alisson Vieira Costa, Dilson Rodrigues Belfort, Demilto Yamaguchi da Pureza, Á. A. Alberto","doi":"10.3233/ies-230061","DOIUrl":"https://doi.org/10.3233/ies-230061","url":null,"abstract":"BACKGROUND: A Polar heart rate monitor is a device that measures RR intervals, but has not been correlated to accurately measure the series of RR interval signals between the ECG and the Polar® Heart Rate Monitor Interface (HRMI) Board at rest. OBJECTIVE: The aim of the study was to evaluate the temporal cross-correlations between the Polar® HRMI Board and an ECG to measure the series of RR intervals at rest. METHODS: The sample consisted of eighteen healthy male subjects and they were instructed to lie in the supine position at rest while breathing normally and a time window of the last 2 min was recorded to analyse RR intervals were obtained for each subject with a Polar® HRMI Board and an ECG. Cross-correlation analysis of RR interval signals between methods and reliability was expressed by Bland and Altman analysis. RESULTS: The cross-correlation was excellent, resulting in a mean of 0.98 ± 0.01 and no lag or delay between the signals. The bias was 0.03 ± 0.08 s or 8.0% for MeanRRi from Polar® HRMI Board and ECG, no significant difference. CONCLUSIONS: The Polar® HRMI Board is acceptable for assessment of serial RR intervals. The results support the reliability of the Mean RR interval compared to a resting ECG.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43937315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Sekine, Haruna Hayashi, R. Hirabayashi, H. Yokota, Kazusa Saisu, T. Takabayashi, M. Edama
{"title":"Trunk muscle activity while lifting objects of expected and unexpected weight in normal subjects and patients with low back pain","authors":"C. Sekine, Haruna Hayashi, R. Hirabayashi, H. Yokota, Kazusa Saisu, T. Takabayashi, M. Edama","doi":"10.3233/ies-230044","DOIUrl":"https://doi.org/10.3233/ies-230044","url":null,"abstract":"BACKGROUND: Lifting heavy objects can induce postural stress and low back pain. OBJECTIVE: This study aimed to examine the effect of object weight expectations on trunk muscle activity and assess trunk muscle activity in people with chronic low back pain. METHODS: Twenty-two male college students (11 healthy and 11 participants with chronic low back pain) were recruited. The procedure was performed in three settings: lifting an expected 5-kg object, lifting an unexpected 10-kg object, and lifting an expected 10-kg object. Lifting was divided into five phases, and the muscle activity in each phase was compared between groups (chronic low back pain/control), object weight predictions, and phases. RESULTS: Compared to the control group, the chronic low back pain group had higher erector spinae muscle activity, regardless of weight or prediction, and significantly higher rectus femoris muscle activity in the early lifting phase of the expected 10 kg object (p= 0.043). Compared to when lifting the expected 10 kg object, erector spinae muscle activity was higher in the early lifting phase of the control group when lifting the unexpected 10-kg object (p= 0.016). CONCLUSIONS: Healthy individuals and individuals with chronic low back pain had different recruitment strategies for lifting objects heavier than predicted.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43925453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santos de Holanda Laís Regina, Gabriel de Amorim Batista, Oliveira Felipe, A. Pitangui, R. D. de Araújo
{"title":"Electromyographic activity of periscapular muscles in symptomatic people: Does scapular dyskinesis have an impact on it?","authors":"Santos de Holanda Laís Regina, Gabriel de Amorim Batista, Oliveira Felipe, A. Pitangui, R. D. de Araújo","doi":"10.3233/ies-230040","DOIUrl":"https://doi.org/10.3233/ies-230040","url":null,"abstract":"BACKGROUND: Scapular dyskinesis (SD) is a modification of the positioning and movement of the scapula and is associated with shoulder pain. Exercises to strengthen the shoulder and scapular muscles have been proposed as a therapeutic strategy to reduce pain and improve function. OBJECTIVE: We aimed to investigate the electromyographic activity of the periscapular and trunk muscles in individuals with shoulder pain and SD in different multi-joint exercises. METHODS: Thirty-two subjects with subacromial pain, of both sexes, with the presence or absence of SD, participated in this study. Volunteers performed five repetitions in five exercises (Closed Row; Pronated Row; Push-up; Scapular Push-up; T-push-up). The activity of the upper trapezius, middle trapezius, lower trapezius, serratus anterior, external oblique, and rectus abdominis muscles was recorded using electromyography. RESULTS: Our results showed a decrease in the electromyographic activity of the serratus anterior and external oblique during the T-push-up exercise in individuals with shoulder pain and SD. No differences were observed between groups for the trapezius and the rectus abdominis. CONCLUSIONS: Rehabilitation programs may initially prioritize rowing and push-up exercises to strengthen periscapular muscles. More complex exercises with greater mechanical demand on the kinetic chain, such as the T-push-up, may have to be implemented in later phases.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45574016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma Kızılay, Muhammed Emin Kafkas, M. Çağatay Taşkapan, Ali Haydar Demirel, Z. Radák
{"title":"Impact of differing eccentric-concentric phase durations on muscle damage and anabolic hormones","authors":"Fatma Kızılay, Muhammed Emin Kafkas, M. Çağatay Taşkapan, Ali Haydar Demirel, Z. Radák","doi":"10.3233/ies-220078","DOIUrl":"https://doi.org/10.3233/ies-220078","url":null,"abstract":"BACKGROUND: Resistance exercises are widely used to enhance muscle hypertrophy. Hypertrophy occurs with effect of mechanical loading, metabolic stress, and muscle damage. The time under tension in eccentric, isometric, and concentric phases of resistance exercises can alter muscle damage and anabolic hormone responses. OBJECTIVES: The aim of the study was to reveal the effect of the time spent in the concentric and eccentric phases of the movement on muscle damage and anabolic hormone response during resistance exercise. METHODS: Ten male subjects participated in the study. A, B, C tempo protocols were created by changing the time under tension to be 1 or 2 seconds in the eccentric and concentric phases of bench press and squat movements. In all protocols, isometric phases were 0 sec. The metronome was used to apply tempos. Blood samples were taken before each protocol, after administration, and in the 24th, 48th and 72nd hours after exercise; and serum insulin, testosterone, Insuline-like Growth Factor-1 (IGF-1), Creatine Kinase (CK) and Lactate Dehydrogenase (LDH) levels were evaluated. RESULTS: Time-wise changes in CK were statistically different for all protocols (p< 0.05). CK levels in the 24th hour of the protocol C and the 48th hour of the protocol B were significantly higher than those in the other protocols (p< 0.05). IGF-1 and testosterone levels were significantly higher in the protocol B in the post-test, compared to the other protocols (p< 0.05). Insulin levels in the 24th hour were significantly higher in the protocol B compared to those in others (p< 0.05). Time-wise changes in LDH parameters were not statistically significant in any hours (p> 0.05). CONCLUSIONS: Extending time under tension in the eccentric phase of a bout of resistance exercise appears to affect the anabolic hormone response and muscle damage. In this way, increased metabolic response and mechanical stress can induce muscle mass gain.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44487705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniele Detanicoa, Rodrigo Ghedini Gheller, Marina Saldanha da Silva Athayde, Rafael Lima Kons
{"title":"Shoulder rotator strength in judo athletes: A cross-sectional study with different experience levels","authors":"Daniele Detanicoa, Rodrigo Ghedini Gheller, Marina Saldanha da Silva Athayde, Rafael Lima Kons","doi":"10.3233/ies-230027","DOIUrl":"https://doi.org/10.3233/ies-230027","url":null,"abstract":"BACKGROUND: Judo practice requires high effort from athletes, mainly focused on the upper limbs, involving the shoulder complex. OBJECTIVE: To compare the shoulder internal (IR) and external (ER) rotation peak torque and conventional ratio (ER: IR) between judo athletes from different experience levels (novice vs. advanced) and to verify the distribution of athletes according to the ER: IR ratio classification. METHODS: Thirty-nine male judo athletes were divided into two groups (advanced: 20.5 ± 2.8 years and novice: 22.1 ± 5.5 years). The athletes performed a shoulder isokinetic protocol to measure IR and ER strength and the ER: IR ratio in novice and advanced groups. Chi-square tests were used to investigate the distribution of athletes according to the different groups of ER: IR ratio classification, and t-tests were used to compare the IR and ER peak torque and the ER: IR ratio between novice and advanced groups, with the level of significance set at 5%. RESULTS: The main results showed higher values of IR peak torque (77.3 ± 15.7 N⋅m in advanced vs. 48.2 ± 8.4 N⋅m in novices; p= 0.013), and a lower ER: IR conventional ratio in advanced athletes compared to novices (0.63 ± 0.1 advanced vs. 0.73± 0.2 in novice; p= 0.01). When individual values were analyzed, advanced athletes presented higher imbalance (< 0.66 ER: IR ratio) than novices (p= 0.023). CONCLUSION: Advanced athletes presented higher shoulder IR peak torque, but higher imbalance in the ER: IR ratio than novices, probably because the long-term training induced an increase in IR strength without concomitant development in ER strength. Coaches and strength and conditioning trainers should monitor shoulder rotator strength in judo athletes to avoid muscle imbalances in this region, which is frequently employed in judo training routines.","PeriodicalId":54915,"journal":{"name":"Isokinetics and Exercise Science","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49013094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}