Journal of Investigative Dermatology Symposium Proceedings最新文献_第6页

Tofacitinib for the Treatment of Severe Alopecia Areata in Adults and Adolescents 托法替尼治疗成人和青少年重度斑秃

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.003

Lucy Yichu Liu , Brett Andrew King

引用次数: 27

Quantifying Alopecia Areata via Texture Analysis to Automate the SALT Score Computation 通过纹理分析量化斑秃，实现SALT评分自动计算

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.010

Elena Bernardis , Leslie Castelo-Soccio

{"title":"Quantifying Alopecia Areata via Texture Analysis to Automate the SALT Score Computation","authors":"Elena Bernardis , Leslie Castelo-Soccio","doi":"10.1016/j.jisp.2017.10.010","DOIUrl":"10.1016/j.jisp.2017.10.010","url":null,"abstract":"<div><p>Quantifying alopecia areata in real time has been a challenge for clinicians and investigators. Although several scoring systems exist, they can be cumbersome. Because there are more clinical trials in alopecia areata, there is an urgent need for a quantitative system that is reproducible, standardized, and simple. In this article, a computer imaging algorithm to recreate the Severity of Alopecia Tool scoring system in an automated way is presented. A pediatric alopecia areata image set of four view-standardized photographs was created, and texture analysis was used to distinguish between normal hair and bald scalp. By exploiting local image statistics and the similarity of hair appearance variations across the pediatric alopecia examples, we then used a reference set of hair textures, derived from intensity distributions over very small image patches, to provide global context and improve partitioning of each individual image into areas of different hair densities. This algorithm can mimic a Severity of Alopecia Tool (score) and may also provide more information about the continuum of changes in density of hair seen in alopecia areata.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 1","pages":"Pages S34-S40"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2017.10.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35683640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Building and Crossing the Translational Bridge: 2016 Alopecia Areata Research Summit Highlights 搭建和跨越桥梁:2016年斑秃研究峰会亮点

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.004

Dory Kranz , Abby Ellison , Natasha A. Mesinkovska , Angela M. Christiano , Maria K. Hordinsky , John E. Harris

引用次数: 0

Large-Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata 大规模表位筛选及其在斑秃研究中的潜在应用

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.001

Cecilia S. Lindestam Arlehamn , Sinu Paul , Eddy Hsi Chun Wang , Annemieke de Jong , Angela M. Christiano , Alessandro Sette

引用次数: 2

Big Data Reveal Insights into Alopecia Areata Comorbidities 大数据揭示斑秃合并症

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.006

Chean Ping Lim , Rachel K. Severin , Lynn Petukhova

引用次数: 12

The Utility and Validity of the Alopecia Areata Symptom Impact Scale in Measuring Disease-Related Symptoms and their Effect on Functioning 斑秃症状影响量表在测量疾病相关症状及其对功能影响中的效用和有效性

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/j.jisp.2017.10.009

Tito R. Mendoza , Joyce Osei , Madeleine Duvic

{"title":"The Utility and Validity of the Alopecia Areata Symptom Impact Scale in Measuring Disease-Related Symptoms and their Effect on Functioning","authors":"Tito R. Mendoza , Joyce Osei , Madeleine Duvic","doi":"10.1016/j.jisp.2017.10.009","DOIUrl":"10.1016/j.jisp.2017.10.009","url":null,"abstract":"<div><p>Alopecia areata (AA) is an autoimmune disease that causes hair loss. Although persons with the disease can be physically described as having varying degrees of hair loss, the condition has significant ramifications on an individual’s well-being. We previously reported the preliminary psychometric properties of the Alopecia Areata Symptom Impact Scale (AASIS), a disease-specific measure that asks participants about their AA symptoms and how these symptoms interfere with their daily functioning. The goals of this article are to provide a detailed description of the development of the AASIS items and to offer a psychometric update for the measure. Preliminary items for the AASIS were developed on the basis of responses from 1,649 participants to 125 health-related quality-of-life questions/items from the National Alopecia Areata Registry. Clinicians affiliated with the registry were asked to rate the relevance of these items for content validity. Cluster analysis and clinician ratings were used to reduce the number of items. The resulting 13-item AASIS was administered to 452 participants, who were also cognitively debriefed. Results showed that the AASIS is a valid and reliable measure of AA symptoms and their impact on functioning.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 1","pages":"Pages S41-S46"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2017.10.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35683641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Title Page/Disclaimer Statement 标题页/免责声明

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/S1087-0024(17)30053-9

引用次数: 0

Subscription Information 订阅信息

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI: 10.1016/S1087-0024(17)30052-7

引用次数: 0

Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus 不只是皮肤深层:皮肤病狼疮患者的全身性疾病

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.09.001

Jack C. O’Brien , Benjamin F. Chong

{"title":"Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus","authors":"Jack C. O’Brien , Benjamin F. Chong","doi":"10.1016/j.jisp.2016.09.001","DOIUrl":"10.1016/j.jisp.2016.09.001","url":null,"abstract":"<div><p>Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus. If they progress to systemic disease, patients often develop mild systemic disease with primarily mucocutaneous and musculoskeletal manifestations. Patients with cutaneous lupus should be followed up closely to monitor for systemic disease involvement. The University of Texas Southwestern Cutaneous Lupus Erythematosus Registry, of which almost two thirds of participants are those with skin of color, is a part of an ongoing effort to better understand the pathophysiologic mechanisms of CLE and to identify prognostic indicators of risk of progression to systemic lupus.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S69-S74"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

016 Anesthetics Prior to Keloid Injections: A Painless Approach 016注射瘢痕疙瘩前的麻醉剂：一种无痛的方法

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.018

Lauren Henderson, Bryan T. Carroll

引用次数: 0