Korean Journal of Physiology & Pharmacology最新文献_第6页

3,3',4,4'-tetrachlorobiphenyl (PCB77) enhances human Kv1.3 channel currents and alters cytokine production. 3,3',4,4'-四氯联苯（PCB77）可增强人类 Kv1.3 通道电流并改变细胞因子的产生。

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.323

Jong-Hui Kim, Soobeen Hwang, Seo-In Park, Hyo-Ji Lee, Yu-Jin Jung, Su-Hyun Jo

{"title":"3,3',4,4'-tetrachlorobiphenyl (PCB77) enhances human Kv1.3 channel currents and alters cytokine production.","authors":"Jong-Hui Kim, Soobeen Hwang, Seo-In Park, Hyo-Ji Lee, Yu-Jin Jung, Su-Hyun Jo","doi":"10.4196/kjpp.2024.28.4.323","DOIUrl":"10.4196/kjpp.2024.28.4.323","url":null,"abstract":"Polychlorinated biphenyls (PCBs) were once used throughout various industries; however, because of their persistence in the environment, exposure remains a global threat to the environment and human health. The Kv1.3 and Kv1.5 channels have been implicated in the immunotoxicity and cardiotoxicity of PCBs, respectively. We determined whether 3,3',4,4'-tetrachlorobiphenyl (PCB77), a dioxin-like PCB, alters human Kv1.3 and Kv1.5 currents using the Xenopus oocyte expression system. Exposure to 10 nM PCB77 for 15 min enhanced the Kv1.3 current by approximately 30.6%, whereas PCB77 did not affect the Kv1.5 current at concentrations up to 10 nM. This increase in the Kv1.3 current was associated with slower activation and inactivation kinetics as well as right-shifting of the steady-state activation curve. Pretreatment with PCB77 significantly suppressed tumor necrosis factor-α and interleukin-10 production in lipopolysaccharide-stimulated Raw264.7 macrophages. Overall, these data suggest that acute exposure to trace concentrations of PCB77 impairs immune function, possibly by enhancing Kv1.3 currents.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 4","pages":"323-333"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart. 更正：通过线粒体移植保护心脏，支持缺血再灌注损伤大鼠心脏的脂肪酸代谢。

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.391

Jehee Jang, Ki-Woon Kang, Young-Won Kim, Seohyun Jeong, Jaeyoon Park, Jihoon Park, Jisung Moon, Junghyun Jang, Seohyeon Kim, Sunghun Kim, Sungjoo Cho, Yurim Lee, Hyoung Kyu Kim, Jin Han, Eun-A Ko, Sung-Cherl Jung, Jung-Ha Kim, Jae-Hong Ko

引用次数: 0

Corrigendum to: Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe. 更正：开发和评估联合给药罗伐他汀和依折麦布的纳米给药系统。

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.389

Mohamed Ali Metwally, El-Yamani Ibrahim El-Zawahry, Maher Amer Ali, Diaa Farrag Ibrahim, Shereen Ahmed Sabry, Omnia Mohamed Sarhan

引用次数: 0

Barefoot walking improves cognitive ability in adolescents. 赤足行走提高青少年的认知能力

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.295

Taehun Kim, Dae Yun Seo, Jun Hyun Bae, Jin Han

{"title":"Barefoot walking improves cognitive ability in adolescents.","authors":"Taehun Kim, Dae Yun Seo, Jun Hyun Bae, Jin Han","doi":"10.4196/kjpp.2024.28.4.295","DOIUrl":"10.4196/kjpp.2024.28.4.295","url":null,"abstract":"Walking can have a positive impact on cognitive function in adolescents. This study aimed to compare the effects of walking with sneakers and barefoot on cognitive ability in adolescents. Fifty-nine adolescent male students were included in the study and assigned to the control (n = 20), sneaker (n = 19), and barefoot (n = 20) groups. The barefoot and sneakers group performed a 40-min walking exercise four times a week for 12 weeks during the morning physical activity time, while the control group performed self-study. Electroencephalogram (EEG) and brain activity variables were measured before and after the exercise program. The results showed that after 12 weeks, the barefoot group had a significant decrease in Gamma and H-beta waves and a significant increase in sensorimotor rhythm (SMR) and Alpha waves. Conversely, the control group showed a significant decrease in SMR waves and increase in Theta waves. The sneaker group showed a significant decrease in SMR waves alone. In an eyes-open resting state, the barefoot group showed a significant increase in H-beta, M-beta, SMR, and Alpha waves. The barefoot group also had a significant increase in cognitive speed and concentration and a significant decrease in brain stress. Taken together, barefoot walking can effectively enhance cognitive ability in adolescents, as demonstrated by the significant variation in EEG activity. This research highlights the potential benefits of barefoot walking as a simple and effective form of exercise for enhancing cognitive function in adolescents.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 4","pages":"295-302"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells. TGF-β1/SMADs 信号通路在白藜芦醇诱导的地塞米松处理人小梁网细胞细胞外基质沉积减少中的作用。

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.345

Amy Suzana Abu Bakar, Norhafiza Razali, Renu Agarwal, Igor Iezhitsa, Maxim A Perfilev, Pavel M Vassiliev

{"title":"Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells.","authors":"Amy Suzana Abu Bakar, Norhafiza Razali, Renu Agarwal, Igor Iezhitsa, Maxim A Perfilev, Pavel M Vassiliev","doi":"10.4196/kjpp.2024.28.4.345","DOIUrl":"10.4196/kjpp.2024.28.4.345","url":null,"abstract":"Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-induced increase in IOP and increase the TM expression of ECM proteolytic enzymes; however, its effects on the deposition of ECM components by TM and its associated pathways, such as TGF-β-SMAD signalling remain uncertain. This study, therefore, explored the effects of trans-resveratrol on the expression of ECM components, SMAD signalling molecules, plasminogen activator inhibitor-1 and tissue plasminogen activator in dexamethasone-treated human TM cells (HTMCs). We also studied the nature of molecular interaction of trans -resveratrol with SMAD4 domains using ensemble docking. Treatment of HTMCs with 12.5 µM trans-resveratrol downregulated the dexamethasone-induced increase in collagen, fibronectin and α-smooth muscle actin at gene and protein levels through downregulation of TGF-β1, SMAD4, and upregulation of SMAD7. Downregulation of TGF-β1 signalling by trans-resveratrol could be attributed to its effect on the transcriptional activity due to high affinity for the MH2 domain of SMAD4. These effects may contribute to resveratrol's IOP-lowering properties by reducing ECM deposition and enhancing aqueous humour outflow in the TM.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 4","pages":"345-359"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics. 基于转录组学和蛋白质组学的纤维乌头碱缓解阿尔茨海默病的机制分析

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.361

Lu Han, Weijia Chen, Ying Zong, Yan Zhao, Jianming Li, Zhongmei He, Rui Du

{"title":"Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics.","authors":"Lu Han, Weijia Chen, Ying Zong, Yan Zhao, Jianming Li, Zhongmei He, Rui Du","doi":"10.4196/kjpp.2024.28.4.361","DOIUrl":"10.4196/kjpp.2024.28.4.361","url":null,"abstract":"The dried rattan stem of the Fibraurea Recisa Pierre plant contains the active ingredient known as fibrauretine (FN). Although it greatly affects Alzheimer's disease (AD), the mechanism of their effects still remains unclear. Proteomics and transcriptomics analysis methods were used in this study to determine the mechanism of FN in the treatment of AD. AD model is used through bilateral hippocampal injection of Aβ1-40. After successful modeling, FN was given for 30 days. The results showed that FN could improve the cognitive dysfunction of AD model rats, reduce the expression of Aβ and P-Tau, increase the content of acetylcholine and reduce the activity of acetylcholinesterase. The Kyoto Encyclopedia of Genes and Genomes enriched differentially expressed genes and proteins are involved in signaling pathways including metabolic pathway, AD, pathway in cancer, PI3K-AKT signaling pathway, and cAMP signaling pathway. Transcriptomics and proteomics sequencing resulted in 19 differentially expressed genes and proteins. Finally, in contrast to the model group, after FN treatment, the protein expressions and genes associated with the PI3K-AKT pathway were significantly improved in RT-qPCR and Western blot and assays. This is consistent with the findings of transcriptomic and proteomic analyses. Our study found that, FN may improve some symptoms of AD model rats through PI3K-AKT signaling pathway.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 4","pages":"361-377"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The NADPH oxidase inhibitor diphenyleneiodonium suppresses Ca²⁺ signaling and contraction in rat cardiac myocytes. NADPH 氧化酶抑制剂二苯基碘抑制大鼠心肌细胞的 Ca2+ 信号传导和收缩。

IF 1.6 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-07-01 DOI: 10.4196/kjpp.2024.28.4.335

Qui Anh Le, Tran Nguyet Trinh, Phuong Kim Luong, Vu Thi Van Anh, Ha Nam Tran, Joon-Chul Kim, Sun-Hee Woo

{"title":"The NADPH oxidase inhibitor diphenyleneiodonium suppresses Ca2+ signaling and contraction in rat cardiac myocytes.","authors":"Qui Anh Le, Tran Nguyet Trinh, Phuong Kim Luong, Vu Thi Van Anh, Ha Nam Tran, Joon-Chul Kim, Sun-Hee Woo","doi":"10.4196/kjpp.2024.28.4.335","DOIUrl":"10.4196/kjpp.2024.28.4.335","url":null,"abstract":"Diphenyleneiodonium (DPI) has been widely used as an inhibitor of NADPH oxidase (Nox) to discover its function in cardiac myocytes under various stimuli. However, the effects of DPI itself on Ca2+ signaling and contraction in cardiac myocytes under control conditions have not been understood. We investigated the effects of DPI on contraction and Ca2+ signaling and their underlying mechanisms using video edge detection, confocal imaging, and whole-cell patch clamp technique in isolated rat cardiac myocytes. Application of DPI suppressed cell shortenings in a concentration-dependent manner (IC50 of ≅0.17 µM) with a maximal inhibition of ~70% at ~100 µM. DPI decreased the magnitude of Ca2+ transient and sarcoplasmic reticulum Ca2+ content by 20%-30% at 3 µM that is usually used to remove the Nox activity, with no effect on fractional release. There was no significant change in the half-decay time of Ca2+ transients by DPI. The L-type Ca2+ current (ICa) was decreased concentration-dependently by DPI (IC50 of ≅40.3 µM) with ≅13.1%-inhibition at 3 µM. The frequency of Ca2+ sparks was reduced by 3 µM DPI (by ~25%), which was resistant to a brief removal of external Ca2+ and Na+. Mitochondrial superoxide level was reduced by DPI at 3-100 µM. Our data suggest that DPI may suppress L-type Ca2+ channel and RyR, thereby attenuating Ca2+-induced Ca2+ release and contractility in cardiac myocytes, and that such DPI effects may be related to mitochondrial metabolic suppression.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 4","pages":"335-344"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway. 新型青蒿琥酯-二甲双胍共轭物可抑制与 Clusterin/SREBP1/FASN 信号通路相关的膀胱癌细胞生长。

IF 2 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-05-01 DOI: 10.4196/kjpp.2024.28.3.219

Peiyu Lin, Xiyue Yang, Linghui Wang, Xin Zou, Lingli Mu, Cangcang Xu, Xiaoping Yang

{"title":"Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway.","authors":"Peiyu Lin, Xiyue Yang, Linghui Wang, Xin Zou, Lingli Mu, Cangcang Xu, Xiaoping Yang","doi":"10.4196/kjpp.2024.28.3.219","DOIUrl":"https://doi.org/10.4196/kjpp.2024.28.3.219","url":null,"abstract":"Bladder cancer remains the 10th most common cancer worldwide. In recent years, metformin has been found to have potential anti-bladder cancer activity while high concentration of IC50 at millimolar level is needed, which could not be reached by regular oral administration route. Thus, higher efficient agent is urgently demanded for clinically treating bladder cancer. Here, by conjugating artesunate to metformin, a novel artesunate-metformin dimer triazine derivative AM2 was designed and synthesized. The inhibitory effect of AM2 on bladder cancer cell line T24 and the mechanism underlying was determined. Anti-tumor activity of AM2 was assessed by MTT, cloning formation and wound healing assays. Decreasing effect of AM2 on lipogenesis was determined by oil red O staining. The protein expressions of Clusterin, SREBP1 and FASN in T24 cells were evaluated by Western blotting. The results show that AM2 significantly inhibited cell proliferation and migration at micromolar level, much higher than parental metformin. AM2 reduced lipogenesis and down-regulated the expressions of Clusterin, SREBP1 and FASN. These results suggest that AM2 inhibits the growth of bladder cancer cells T24 by inhibiting cellular lipogenesis associated with the Clusterin/SREBP1/FASN signaling pathway.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 3","pages":"219-227"},"PeriodicalIF":2.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe. 开发和评估联合给药罗伐他汀和依折麦布的纳米给药系统。

IF 2 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-05-01 DOI: 10.4196/kjpp.2024.28.3.275

Mohamed Ali Metwally, El-Yamani Ibrahim El-Zawahry, Maher Amer Ali, Diaa Farrag Ibrahim, Shereen Ahmed Sabry, Omnia Mohamed Sarhan

{"title":"Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe.","authors":"Mohamed Ali Metwally, El-Yamani Ibrahim El-Zawahry, Maher Amer Ali, Diaa Farrag Ibrahim, Shereen Ahmed Sabry, Omnia Mohamed Sarhan","doi":"10.4196/kjpp.2024.28.3.275","DOIUrl":"https://doi.org/10.4196/kjpp.2024.28.3.275","url":null,"abstract":"Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181-0.72) and (-13.4 to -6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 3","pages":"275-284"},"PeriodicalIF":2.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma. Tivozanib诱导激活线粒体凋亡途径并抑制口腔鳞状细胞癌的上皮细胞向间质转化。

IF 2 4区医学

Korean Journal of Physiology & Pharmacology Pub Date : 2024-05-01 DOI: 10.4196/kjpp.2024.28.3.197

Nak-Eun Choi, Si-Chan Park, In-Ryoung Kim

{"title":"Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma.","authors":"Nak-Eun Choi, Si-Chan Park, In-Ryoung Kim","doi":"10.4196/kjpp.2024.28.3.197","DOIUrl":"https://doi.org/10.4196/kjpp.2024.28.3.197","url":null,"abstract":"The potential of tivozanib as a treatment for oral squamous cell carcinoma (OSCC) was explored in this study. We investigated the effects of tivozanib on OSCC using the Ca9-22 and CAL27 cell lines. OSCC is a highly prevalent cancer type with a significant risk of lymphatic metastasis and recurrence, which necessitates the development of innovative treatment approaches. Tivozanib, a vascular endothelial growth factor receptor inhibitor, has shown efficacy in inhibiting neovascularization in various cancer types but has not been thoroughly studied in OSCC. Our comprehensive assessment revealed that tivozanib effectively inhibited OSCC cells. This was accompanied by the suppression of Bcl-2, a reduction in matrix metalloproteinase levels, and the induction of intrinsic pathway-mediated apoptosis. Furthermore, tivozanib contributed to epithelial-to-mesenchymal transition (EMT) inhibition by increasing E-cadherin levels while decreasing N-cadherin levels. These findings highlight the substantial anticancer potential of tivozanib in OSCC and thus its promise as a therapeutic option. Beyond reducing cell viability and inducing apoptosis, the capacity of tivozanib to inhibit EMT and modulate key proteins presents the possibility of a paradigm shift in OSCC treatment.","PeriodicalId":54746,"journal":{"name":"Korean Journal of Physiology & Pharmacology","volume":"28 3","pages":"197-207"},"PeriodicalIF":2.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0