Minerva Biotecnologica最新文献_第4页

Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test 幽门螺杆菌感染的诊断:尿素呼气试验分子方面的探讨

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Minerva Biotecnologica Pub Date : 2019-07-01 DOI: 10.23736/s1120-4826.19.02555-2

C. Marinoni, D. Ribaldone, C. Rosso, M. Astegiano, G. P. Caviglia

{"title":"Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test","authors":"C. Marinoni, D. Ribaldone, C. Rosso, M. Astegiano, G. P. Caviglia","doi":"10.23736/s1120-4826.19.02555-2","DOIUrl":"https://doi.org/10.23736/s1120-4826.19.02555-2","url":null,"abstract":"Helicobacter pylori ( H. pylori ) is a bacterium that selectively colonizes gastric epithelium in more than 50% people over the world. The infection is usually acquired in early childhood and rarely resolved spontaneously; transmission is mostly person to person, and occurs by fecal-oral or oral-oral modality. Diagnosis and antibiotic treatment may lead to eradication of H. pylori , improving the prevention and the outcome of gastric and extragastric diseases. Many tests are currently available for the diagnosis of H. pylori infection and the choice depends on several clinical aspects including symptoms, age, indications for testing, concomitant medications and comorbidities. Invasive tests (i.e. endoscopy with histologic assessment) are considered the gold standard, but they are expensive and should be performed only in an appropriate context. The most common non-invasive tests are urea breath test (UBT), stool antigens test and serology. UBT is non-invasive, quick, safe, accurate and cheap. This test is performed mainly with 13 C and is based on the presence of H. pylori urease, an enzyme that converts urea (labelled with an isotope) into CO 2 . Labelled CO 2 is then exhaled and measured by dedicated spectrophotometers. This review analyses with special emphasis UBT, focusing on its molecular aspects.","PeriodicalId":54738,"journal":{"name":"Minerva Biotecnologica","volume":"77 2 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89715100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Evaluation of a new diagnostic method for quantification of EBV and HHV-6 viral load in bronchoalveolar lavage 支气管肺泡灌洗液中EBV和HHV-6病毒载量定量诊断新方法的评价

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Minerva Biotecnologica Pub Date : 2019-07-01 DOI: 10.23736/S1120-4826.19.02557-6

Jessica Montemezzo, F. Patrucco, F. Gavelli, L. Ferrari, Giulia Faolotto, M. G. Crobu, L. Castello, Matteo Daverio, P. Balbo, P. Ravanini

引用次数: 7

Glypican-1 in serum-derived exosomes as a potential biomarker in liquid biopsy of non-small cell lung cancer 血清来源外泌体中的Glypican-1作为非小细胞肺癌液体活检的潜在生物标志物

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Minerva Biotecnologica Pub Date : 2019-05-01 DOI: 10.23736/S1120-4826.19.02542-4

Xuan Zhou, Hongmei Zhang, H. Feng, Xiangkuan Meng, Shi-Yang Li, Yingnan Cui, Ya-Nan Zhao, Yu-bing Chen, T. Tong

引用次数: 1

Roles of polyphenols as dietary epigenetic modulators 多酚作为膳食表观遗传调节剂的作用

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Minerva Biotecnologica Pub Date : 2019-05-01 DOI: 10.23736/S1120-4826.19.02522-9

T. Hyun

引用次数: 4

Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats 益生菌对大鼠单碘乙酸诱导骨关节炎时血清细胞因子和基质金属蛋白酶谱的影响

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Minerva Biotecnologica Pub Date : 2019-05-01 DOI: 10.23736/S1120-4826.19.02548-5

O. Korotkyi, A. Vovk, Tetiana Galenova, T. Vovk, Kateryna Dvorschenko, F. Luzza, L. Abenavoli, N. Kobyliak, T. Falalyeyeva, L. Ostapchenko

{"title":"Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats","authors":"O. Korotkyi, A. Vovk, Tetiana Galenova, T. Vovk, Kateryna Dvorschenko, F. Luzza, L. Abenavoli, N. Kobyliak, T. Falalyeyeva, L. Ostapchenko","doi":"10.23736/S1120-4826.19.02548-5","DOIUrl":"https://doi.org/10.23736/S1120-4826.19.02548-5","url":null,"abstract":"BACKGROUND: Cytokines (CKs) and matrix metalloproteinases (MMPs) play a major role in the pathogenesis of osteoarthritis (OA). The recent studies showed the effect of probiotics (PBs) on inflammatory processes during OA, but available results are limited and conflicted. In this study, we investigated the effect of alive probiotic on the levels of CKs (interleukins [ILs] IL-1β, IL-4, IL-10, IL-12 p40, tumor necrosis factor [TNF]-α, interferon [IFN]-γ) and MMPs (MMP-1, MMP-2, MMP-3, MMP-8) in rats with monoiodoacetate-induced OA. METHODS: We used a single injection of monoiodoacetate through the infrapatellar ligament of nonlinear male rats to start OA model (1st day of the experiment). Therapeutic groups got an intragastric feeding of PB composition (“Symbiter” O.D. Prolisok, Kyiv, Ukraine) from 8th to 21st. Sampling (serum, knee joint) was provided on the 30th day. The pathophysiological aspects of OA was described by histology assessment of knee cartilage. The levels of CKs and MMPs were measured in serum by enzyme-linked immunosorbent assay. RESULTS: OA model caused a significant increasing the levels of pro-inflammatory CKs (IL-1β, TNF-α, IFN-γ), and all studied MMPs, while IL-4 and IL-10 were decreased, comparing to group without OA (except IL12 p40, no significance changes in all groups). An application of the PB had positive effect on the levels of cKs and MMPs. CONCLUSIONS: The use of the PBs has anti-inflammatory effect during experimental OA. Thus, action of PB is promising and further investigations are waited with interest. (Cite this article as: Korotkyi o, vovk a, galenova t, vovk t, Dvorschenko K, luzza F, et al. effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats. Minerva Biotec 2019;31:68-73. DOI: 10.23736/S1120-4826.19.02548-5)","PeriodicalId":54738,"journal":{"name":"Minerva Biotecnologica","volume":"180 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74592719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Human endogenous retroviruses expressional level is influenced by gender 人内源性逆转录病毒的表达水平受性别的影响

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Minerva Biotecnologica Pub Date : 2019-05-01 DOI: 10.23736/S1120-4826.19.02517-5

C. Alliaudi, I. Galliano, P. Montanari, Marzia Pavan, Cristina Calvi, V. Daprá, M. Bergallo

引用次数: 1

Prevalence of human Rhinovirus in stool samples of children with acute gastroenteritis in Italy 意大利急性胃肠炎患儿粪便样本中人鼻病毒的流行情况

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Minerva Biotecnologica Pub Date : 2019-01-01 DOI: 10.23736/S1120-4826.18.02462-X

M. Bergallo, V. Daprá, M. Rassu, Cristina Calvi, I. Galliano, P. Montanari

引用次数: 2

Non-invasive biomarkers for the detection of hepatocellular carcinoma 检测肝细胞癌的非侵入性生物标志物

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Minerva Biotecnologica Pub Date : 2019-01-01 DOI: 10.23736/S1120-4826.18.02488-6

D. Campion, A. Tucci, P. Ponzo, G. P. Caviglia

引用次数: 13

Detection of gastrointestinal cancer: the role of cancer biomarkers 胃肠道肿瘤的检测:肿瘤生物标志物的作用

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Minerva Biotecnologica Pub Date : 2019-01-01 DOI: 10.23736/S1120-4826.18.02494-1

G. P. Caviglia

引用次数: 3

Non-invasive markers to detect colorectal cancer in asymptomatic population 无创标志物在无症状人群中检测结直肠癌

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Minerva Biotecnologica Pub Date : 2019-01-01 DOI: 10.23736/S1120-4826.18.02493-X

C. Rosso, L. Cabianca, F. Gili

引用次数: 6