New England Journal of Medicine最新文献

{"title":"A Case of Vertical Transmission of Oropouche Virus in Brazil.","authors":"Carlos Garcia Filho, Antônio Silva Lima Neto, Ana Maria Peixoto Cabral Maia, Luiz Osvaldo Rodrigues da Silva, Robson da Costa Cavalcante, Higor da Silva Monteiro, Kamilla Carneiro Alves Marques, Rebeca de Souza Oliveira, Sami de Andrade Cordeiro Gadelha, Deborah Nunes de Melo, Anacelia Gomes de Matos Mota, Shirlene Telmos Silva de Lima, Karene Ferreira Cavalcante, Larissa Maria Façanha Duarte, Ítalo José Mesquita Cavalcante, Leda Maria Simões Mello, Carlos Henrique Alencar, Cintia Damasceno Dos Santos Rodrigues, Carla Santos de Oliveira, Fernanda de Bruycker-Nogueira, Felipe Gomes Naveca, André Ricardo Ribas Freitas, Luciano Pamplona de Góes Cavalcanti","doi":"10.1056/NEJMc2412812","DOIUrl":"10.1056/NEJMc2412812","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"2055-2057"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building Bone while Making Milk.","authors":"Lorenz C Hofbauer","doi":"10.1056/NEJMcibr2409260","DOIUrl":"https://doi.org/10.1056/NEJMcibr2409260","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2052-2054"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degenerative Rotator-Cuff Disorders.","authors":"Nitin B Jain, Michael S Khazzam","doi":"10.1056/NEJMcp1909797","DOIUrl":"https://doi.org/10.1056/NEJMcp1909797","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2027-2034"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing the Cost of Saving Children's Lives.","authors":"Elizabeth Miller","doi":"10.1056/NEJMe2410481","DOIUrl":"https://doi.org/10.1056/NEJMe2410481","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2050-2051"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Sequence.","authors":"Clement Lee, Julie R Barzilay, Emily Ling, Caren G Solomon","doi":"10.1056/NEJMp2414483","DOIUrl":"https://doi.org/10.1056/NEJMp2414483","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"e53"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma. Reply.","authors":"Thomas Powles, Laurence Albiges, Brian Rini","doi":"10.1056/NEJMc2411843","DOIUrl":"https://doi.org/10.1056/NEJMc2411843","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2062-2063"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Cysts. Reply.","authors":"Tamas A Gonda, Djuna L Cahen, James J Farrell","doi":"10.1056/NEJMc2412611","DOIUrl":"https://doi.org/10.1056/NEJMc2412611","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2064"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam.","authors":"Lay-Myint Yoshida, Michiko Toizumi, Hien Anh Thi Nguyen, Billy J Quilty, Le Thuy Lien, Le Huy Hoang, Chihiro Iwasaki, Mizuki Takegata, Noriko Kitamura, Monica L Nation, Jason Hinds, Kevin van Zandvoort, Belinda D Ortika, Eileen M Dunne, Catherine Satzke, Hung Thai Do, Kim Mulholland, Stefan Flasche, Duc-Anh Dang","doi":"10.1056/NEJMoa2400007","DOIUrl":"10.1056/NEJMoa2400007","url":null,"abstract":"<p><strong>Background: </strong>After pneumococcal disease and colonization have been controlled through vaccination campaigns, a reduced pneumococcal conjugate vaccine (PCV) schedule may be sufficient to sustain that control at reduced costs.</p><p><strong>Methods: </strong>We investigated whether a single primary dose and booster dose (1p+1) of the 10-valent PCV (PCV10) would be noninferior to alternative dose schedules in sustaining control of carriage of pneumococcal serotypes included in the vaccine. In Nha Trang, Vietnam, an area in which PCV had not been used previously, a PCV10 catch-up campaign was conducted in which the vaccine was offered to children younger than 3 years of age, after which a cluster-randomized trial was conducted in which children received PCV10 at 2, 3, and 4 months of age (3p+0 group); at 2, 4, and 12 months of age (2p+1 group); at 2 and 12 months of age (1p+1 group); or at 12 months of age (0p+1 group). Annual carriage surveys in infants (4 to 11 months of age) and toddlers (14 to 24 months of age) were conducted from 2016 through 2020. The primary end point was protection against carriage of vaccine serotypes, evaluated in a noninferiority analysis in the 1p+1 group as compared with the 2p+1 and 3p+0 groups, 3.5 years after vaccine introduction (noninferiority margin, 5 percentage points). Noninferiority of the 0p+1 schedule was also evaluated.</p><p><strong>Results: </strong>In 2016, before the introduction of PCV10, vaccine-serotype carriage was found in 160 of 1363 infants (11.7%); in 2020, vaccine-serotype carriage was found in 6 of 333 (1.8%), 5 of 340 (1.5%), and 4 of 313 (1.3%) infants in the 1p+1, 2p+1, and 3p+0 groups, respectively, indicating noninferiority of 1p+1 to 2p+1 (difference, 0.3 percentage points; 95% confidence interval [CI], -1.6 to 2.2) and to 3p+0 (difference, 0.5 percentage points; 95% CI, -1.4 to 2.4). Similarly, 1p+1 was noninferior to 2p+1 and 3p+0 for protection against vaccine-serotype carriage among toddlers. In 2016, carriage of serotype 6A was found in 99 of 1363 infants (7.3%); in 2020, it was found in 12 of 333 (3.6%), 10 of 340 (2.9%), and 3 of 313 (1.0%) infants in the 1p+1, 2p+1, and 3p+0 groups, respectively. The 0p+1 schedule was also noninferior to the other three dose schedules among infants and toddlers, although cross-protection against serotype 6A was less common than with the other vaccination schedules. No PCV10-associated severe adverse effects were observed.</p><p><strong>Conclusions: </strong>A reduced vaccination schedule involving a single primary dose and booster dose of PCV10 was noninferior to alternative schedules in protecting against vaccine-serotype carriage in infants and toddlers. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT02961231.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"1992-2002"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Target Trial Emulation\" for Observational Studies - Potential and Pitfalls.","authors":"Rebecca A Hubbard, Constantine A Gatsonis, Joseph W Hogan, David J Hunter, Sharon-Lise T Normand, Andrea B Troxel","doi":"10.1056/NEJMp2407586","DOIUrl":"10.1056/NEJMp2407586","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1975-1977"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case 37-2024: A 41-Year-Old Man with Seizures and Agitation.","authors":"Sheldon Benjamin, Lara Basovic, Javier M Romero, Alice D Lam, Caitlin Adams","doi":"10.1056/NEJMcpc2402500","DOIUrl":"https://doi.org/10.1056/NEJMcpc2402500","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"391 21","pages":"2036-2046"},"PeriodicalIF":96.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}