New England Journal of Medicine最新文献

{"title":"Erythrocytosis and Variants of <i>EPO</i>.","authors":"Mary Frances McMullin","doi":"10.1056/NEJMe2501849","DOIUrl":"https://doi.org/10.1056/NEJMe2501849","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1742-1745"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Physiology of Hunger.","authors":"Jens Lund, Thorkild I A Sørensen, Mark I Friedman","doi":"10.1056/NEJMc2502445","DOIUrl":"https://doi.org/10.1056/NEJMc2502445","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1767-1768"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Physiology of Hunger.","authors":"Hakim Rahmoune, Nada Boutrid","doi":"10.1056/NEJMc2502445","DOIUrl":"https://doi.org/10.1056/NEJMc2502445","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1766-1767"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Alcohol Use.","authors":"Alex H Krist, Katharine A Bradley","doi":"10.1056/NEJMcp2402121","DOIUrl":"https://doi.org/10.1056/NEJMcp2402121","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1721-1731"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype.","authors":"Frank C Sciurba,Gerard J Criner,Stephanie A Christenson,Fernando J Martinez,Alberto Papi,Nicolas Roche,Jean Bourbeau,Stephanie Korn,Mona Bafadhel,MeiLan K Han,Stefanie Kolterer,Karen Miller,Dalal Mouneimne,Joanne Fletcher,Bhabita Mayer,Jeff Min,Ian D Pavord,","doi":"10.1056/nejmoa2413181","DOIUrl":"https://doi.org/10.1056/nejmoa2413181","url":null,"abstract":"BACKGROUNDMepolizumab is a humanized monoclonal antibody that targets interleukin-5, a cytokine that plays a central role in eosinophilic inflammation, which is present in 20 to 40% of patients with chronic obstructive pulmonary disease (COPD).METHODSIn a phase 3, double-blind, randomized, placebo-controlled trial, patients with COPD, a history of exacerbations, and a blood eosinophil count of at least 300 cells per microliter who were receiving triple inhaled therapy were assigned, in a 1:1 ratio, to receive mepolizumab (at a dose of 100 mg) or placebo subcutaneously every 4 weeks for 52 to 104 weeks. The primary end point was the annualized rate of moderate or severe exacerbations. Secondary end points, tested hierarchically to control for multiplicity, were moderate or severe exacerbation as assessed in a time-to-first-event analysis, measures of health-related quality of life and symptoms, and the annualized rate of exacerbations leading to an emergency department visit, hospitalization, or both.RESULTSOf the 804 patients who underwent randomization, 403 were assigned to receive mepolizumab and 401 to receive placebo. The annualized rate of moderate or severe exacerbations was significantly lower with mepolizumab than with placebo (0.80 vs. 1.01 events per year; rate ratio, 0.79; 95% confidence interval [CI], 0.66 to 0.94; P = 0.01). The time to the first moderate or severe exacerbation was longer with mepolizumab than with placebo (Kaplan-Meier median time to the first moderate or severe exacerbation, 419 vs. 321 days; hazard ratio, 0.77; 95% CI, 0.64 to 0.93; P = 0.009). Between-group differences in measures of health-related quality of life and symptoms were not significant; thus, no statistical inferences regarding subsequent secondary end points in the statistical testing hierarchy were made. The incidence of adverse events was similar in the mepolizumab and placebo groups.CONCLUSIONSTreatment with mepolizumab led to a lower annualized rate of moderate or severe exacerbations when added to background triple inhaled therapy among patients with COPD and an eosinophilic phenotype. (Funded by GSK; MATINEE ClinicalTrials.gov number, NCT04133909.).","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"56 1","pages":"1710-1720"},"PeriodicalIF":158.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Lipoprotein(a) - the Next Frontier in Cardiovascular Disease.","authors":"Daniel J Rader","doi":"10.1056/nejme2503824","DOIUrl":"https://doi.org/10.1056/nejme2503824","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"18 1","pages":"1740-1742"},"PeriodicalIF":158.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The View from a Milestone in Gene Therapy.","authors":"Alessandro Aiuti","doi":"10.1056/nejme2502803","DOIUrl":"https://doi.org/10.1056/nejme2502803","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"1 1","pages":"1745-1746"},"PeriodicalIF":158.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death and Taxes - Is Alcohol the Solution?","authors":"Arthur Robin Williams","doi":"10.1056/NEJMp2500793","DOIUrl":"https://doi.org/10.1056/NEJMp2500793","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1665-1667"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gazing into a Crystal Ball.","authors":"Sanjna L Surya, Joseph Y Cheung, Sujal I Shah, Yee-Ping Sun, Bruce Levy","doi":"10.1056/NEJMcps2403489","DOIUrl":"https://doi.org/10.1056/NEJMcps2403489","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 17","pages":"1733-1738"},"PeriodicalIF":96.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption.","authors":"Susan M Gapstur,Daniela Mariosa,Luciana Neamtiu,Suzanne T Nethan,Jürgen Rehm,Taisia Huckle,David H Jernigan,Elizabeth A O'Connor,Mindaugas Štelemėkas,Peter Allebeck,Sawitri Assanangkornchai,Nicholas Carah,Surasak Chaiyasong,Samantha Cukier,The Son Dao,Rijo M John,Richard Matzopoulos,Petra S Meier,Paula O'Brien,Guillermo Paraje,Robin Room,Claire Wilkinson,Norman D Maldonado,Tim Stockwell,Maria Neufeld,Dag Rekve,Béatrice Lauby-Secretan","doi":"10.1056/nejmsr2413289","DOIUrl":"https://doi.org/10.1056/nejmsr2413289","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"276 1","pages":"1752-1759"},"PeriodicalIF":158.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}