Quarterly Journal of Medicine最新文献_第5页

The Africanized 'killer' bee: biology and public health. 非洲化的“杀手”蜜蜂:生物学和公共卫生。

Quarterly Journal of Medicine Pub Date : 1994-05-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068926

M. Winston

引用次数: 26

Expression of the costimulatory molecule B7/BB1 in autoimmune thyroid disease. 自身免疫性甲状腺疾病中共刺激分子B7/BB1的表达

Quarterly Journal of Medicine Pub Date : 1994-04-01

N Tandon, R A Metcalfe, D Barnett, A P Weetman

引用次数: 0

Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus. 90kda热休克蛋白在系统性红斑狼疮特定亚群中的升高。

Quarterly Journal of Medicine Pub Date : 1994-04-01

V B Dhillon, S McCallum, D S Latchman, D A Isenberg

引用次数: 0

Analysis of HLA-class-II-encoded antigen-processing genes TAP1 and TAP2 in primary biliary cirrhosis. 原发性胆汁性肝硬化中hlaⅱ类编码抗原加工基因TAP1和TAP2的分析。

Quarterly Journal of Medicine Pub Date : 1994-04-01

W L Gregory, A K Daly, A N Dunn, G Cavanagh, J R Idle, O F James, M F Bassendine

{"title":"Analysis of HLA-class-II-encoded antigen-processing genes TAP1 and TAP2 in primary biliary cirrhosis.","authors":"W L Gregory, A K Daly, A N Dunn, G Cavanagh, J R Idle, O F James, M F Bassendine","doi":"","DOIUrl":"","url":null,"abstract":"The search for genes involved in the aetiology of primary biliary cirrhosis (PBC) has centred on the major histocompatibility complex (MHC) on chromosome 6. Genotyping studies have confirmed an association with HLA class II allele DR8. We investigated polymorphisms in two newly identified genes (TAP1 and TAP2) situated close to the DR locus and thought to encode membrane transporter molecules involved in endogenous antigen processing. Genomic DNA extracted from PBC patients was compared with local healthy controls. TAP1 was analysed by amplification refractory mutation system (ARMS) PCR, and two alleles (A and B) were identified. In 126 PBC patients and 116 controls, allele frequencies were (A:B) 81:19% and 79:21%, respectively (NS). TAP2 analysis was by PCR followed by Bfal restriction digest, and again two alleles (A and B) were identified. Their frequencies in 109 PBC patients and 96 controls were (A:B) 76:24% and 73:27%, respectively (NS). No TAP1-TAP2 haplotype was associated with PBC. TAP allele frequencies were estimated within the DR8 subgroups (22 PBC, 14 controls). B allele frequency for TAP1 was increased in both DR8-positive PBC patients and controls compared with DR8-negative patients and controls (41% vs. 14% in PBC; 43% vs. 18% in controls), but no disease association was found. However, the increased frequency of TAP1B in DR8-positive subjects (42% DR8-positive vs. 16% DR8-negative, p < 0.001) indicates linkage disequilibrium between these two loci.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 4","pages":"237-44"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-DNA interactions: new discoveries and possibilities for cancer treatment. 药物- dna相互作用:癌症治疗的新发现和可能性。

Quarterly Journal of Medicine Pub Date : 1994-04-01

R L Souhami

引用次数: 0

Osteoporosis: recent advances in pathogenesis and treatment. 骨质疏松症:发病机制和治疗的最新进展。

Quarterly Journal of Medicine Pub Date : 1994-04-01

C Cooper, A Aihie

引用次数: 0

Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. 冠心病死亡患者血管紧张素转换酶基因多态性研究

Quarterly Journal of Medicine Pub Date : 1994-04-01

A E Evans, O Poirier, F Kee, L Lecerf, E McCrum, T Falconer, J Crane, D F O'Rourke, F Cambien

引用次数: 0

Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure. 强的松龙和氯霉素治疗特发性膜性肾病伴进行性肾功能衰竭。

Quarterly Journal of Medicine Pub Date : 1994-04-01

G L Warwick, C G Geddes, J M Boulton-Jones

{"title":"Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure.","authors":"G L Warwick, C G Geddes, J M Boulton-Jones","doi":"","DOIUrl":"","url":null,"abstract":"Twenty-one patients with membranous nephropathy, heavy proteinuria and progressive renal failure were treated with alternating monthly cycles of corticosteroids and chlorambucil for six months. Four patients received repeat courses. After a median period of follow-up of 39 months, three patients had died, six were receiving renal replacement therapy or had serum creatinine > 500 mumol/l, and one had progressive renal failure. Eleven patients had either stable or improved renal function, as judged by serum creatinine concentration. Of these eleven, four patients were in partial remission (daily protein excretion 0.2-2.0 g), and two were in complete remission. There was a tendency for those who received intravenous methylprednisolone to have a more favourable outcome. There was a high incidence of side-effects, with significant complications related to drug therapy observed in > 50% of subjects. Although individual patients appeared to respond well, sometimes dramatically, these results are less encouraging than other reports. We would urge caution in the use of this form of therapy, particularly in older patients who may have occult neoplasms, impaired glucose intolerance or pre-existing cardiac disease.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 4","pages":"223-9"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DDD vs. VVI pacing in patients aged over 75 years with complete heart block: a double-blind crossover comparison. 75岁以上完全性心脏传导阻滞患者的DDD与VVI起搏:双盲交叉比较

Quarterly Journal of Medicine Pub Date : 1994-04-01

K M Channon, M R Hargreaves, T R Cripps, M Gardner, O J Ormerod

{"title":"DDD vs. VVI pacing in patients aged over 75 years with complete heart block: a double-blind crossover comparison.","authors":"K M Channon, M R Hargreaves, T R Cripps, M Gardner, O J Ormerod","doi":"","DOIUrl":"","url":null,"abstract":"We studied 16 patients aged 77-88 years to determine whether elderly patients gain significant benefit from dual-chamber (DDD) compared with single-chamber ventricular demand (VVI) pacing. The study was designed as a double-blind randomized two-period crossover study--each pacing mode was maintained for 7 days. End points included: (i) overall symptoms scores; (ii) exercise tests related to daily activities; and (iii) perceived level of difficulty (Borg score). The mean symptom score in DDD mode was 7.07 (6.38) vs. 12.27 (7.29) in VVI mode (p < 0.006). Dizziness, breathlessness and fatigue were the most noticed symptoms during VVI pacing. One patient dropped out from follow-up and three patients requested early reprogramming, all from VVI mode. Overall, no patient preferred VVI mode, 11 preferred DDD mode and four expressed no preference. There were significant improvements in all objective test performances in DDD mode. Mean (SD) total Borg scores in DDD mode and VVI mode were 36.57 (5.85) and 41.93 (6.49), respectively (p < 0.002). Ventricular demand pacing in elderly patients with complete heart block is associated with higher symptom scores, reduced exercise ability and greater perceived exercise difficulty compared with dual-chamber pacing.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 4","pages":"245-51"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of aggressive idiopathic membranous glomerulonephritis. 侵袭性特发性膜性肾小球肾炎的治疗。

Quarterly Journal of Medicine Pub Date : 1994-04-01

C G Winearls, F Sanderson

引用次数: 0