Quarterly Journal of Medicine最新文献_第10页

Treatment of aggressive idiopathic membranous glomerulonephritis. 侵袭性特发性膜性肾小球肾炎的治疗。

Quarterly Journal of Medicine Pub Date : 1994-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068916

C. Winearls, F. Sanderson

引用次数: 2

Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus. 90kda热休克蛋白在系统性红斑狼疮特定亚群中的升高。

Quarterly Journal of Medicine Pub Date : 1994-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068919

V. Dhillon, S. McCALLUM, D. Latchman, D. Isenberg

引用次数: 16

Chest pain with normal coronary arteries. 胸痛，冠状动脉正常。

Quarterly Journal of Medicine Pub Date : 1994-01-01

J W Paulley

引用次数: 0

Drug-DNA interactions: new discoveries and possibilities for cancer treatment. 药物- dna相互作用:癌症治疗的新发现和可能性。

Quarterly Journal of Medicine Pub Date : 1994-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068915

R. Souhami

引用次数: 0

Chest pain with normal coronary arteries. 胸痛，冠状动脉正常。

Quarterly Journal of Medicine Pub Date : 1994-01-01

P B Fowler

引用次数: 0

Bronchiolitis obliterans--current concepts. 闭塞性细支气管炎——当前概念。

Quarterly Journal of Medicine Pub Date : 1994-01-01

T Ezri, S Kunichezky, A Eliraz, D Soroker, D Halperin, A Schattner

{"title":"Bronchiolitis obliterans--current concepts.","authors":"T Ezri, S Kunichezky, A Eliraz, D Soroker, D Halperin, A Schattner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We review current concepts about the clinical manifestations, diagnosis and treatment of patients with bronchiolitis obliterans (BO) with emphasis on clinical/pathological correlations and recent developments. BO is a relatively rare disease, but its incidence is probably higher than generally believed and is continuously rising, partly because of better recognition, but also because of increased exposure to industrial fumes, and its occurrence in lung transplantation. BO is characterized histologically by varying degrees of obliteration of the lumen of the respiratory bronchioles by organizing connective tissue often extending into the alveoli ('proliferative' BO with organizing pneumonia--BOOP) or by more extensive fibrosis and scarring of the more proximal, conductive bronchioles ('constrictive' BO). Diverse clinical conditions have been associated with the development of BO, notably viral and mycoplasma infection, toxic fume exposure and immune reactions in the setting of a collagen vascular disease, drug reaction or organ transplantation. The clinical course and features of BO may vary considerably according to the aetiology, histological pattern and stage of the disease. The most common presentation is that of a progressive dry cough and dyspnea, associated with diffuse patchy interstitial lung infiltrates on chest X-ray. In the more advanced cases, lung function tests show either restrictive or obstructive defects, depending on the extent of alveolar involvement, and hypoxemia without CO2 retention. The diagnosis is often possible on clinical grounds, however, in a seriously ill patient uncertainty should be resolved by tissue diagnosis, preferably by open lung biopsy. Treatment is based on symptomatic therapy. The use of corticosteroids is controversial, but common. Patients with BOOP are exceptional, in that there may be no underlying condition ('idiopathic' BOOP or cryptogenic organizing pneumonia--COP), a restrictive ventilatory defect is usual and the response to corticosteroids often remarkable.</p>","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108655/pdf/87-1-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19132124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure. 强的松龙和氯霉素治疗特发性膜性肾病伴进行性肾功能衰竭。

Quarterly Journal of Medicine Pub Date : 1994-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068920

G. Warwick, C. G. Geddes, J. Boulton-Jones

{"title":"Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure.","authors":"G. Warwick, C. G. Geddes, J. Boulton-Jones","doi":"10.1093/OXFORDJOURNALS.QJMED.A068920","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A068920","url":null,"abstract":"Twenty-one patients with membranous nephropathy, heavy proteinuria and progressive renal failure were treated with alternating monthly cycles of corticosteroids and chlorambucil for six months. Four patients received repeat courses. After a median period of follow-up of 39 months, three patients had died, six were receiving renal replacement therapy or had serum creatinine > 500 mumol/l, and one had progressive renal failure. Eleven patients had either stable or improved renal function, as judged by serum creatinine concentration. Of these eleven, four patients were in partial remission (daily protein excretion 0.2-2.0 g), and two were in complete remission. There was a tendency for those who received intravenous methylprednisolone to have a more favourable outcome. There was a high incidence of side-effects, with significant complications related to drug therapy observed in > 50% of subjects. Although individual patients appeared to respond well, sometimes dramatically, these results are less encouraging than other reports. We would urge caution in the use of this form of therapy, particularly in older patients who may have occult neoplasms, impaired glucose intolerance or pre-existing cardiac disease.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 4 1","pages":"223-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/OXFORDJOURNALS.QJMED.A068920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61292709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Chest pain with normal coronary arteries. 胸痛，冠状动脉正常。

Quarterly Journal of Medicine Pub Date : 1994-01-01

I H Mills

引用次数: 0

The role of serotonin 5HT2 receptor antagonism in the control of coronary artery disease. 5 -羟色胺5HT2受体拮抗剂在冠心病控制中的作用

Quarterly Journal of Medicine Pub Date : 1994-01-01

M I Noble, A J Drake-Holland

引用次数: 0

Expression of the costimulatory molecule B7/BB1 in autoimmune thyroid disease. 自身免疫性甲状腺疾病中共刺激分子B7/BB1的表达

Quarterly Journal of Medicine Pub Date : 1994-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068921

N. Tandon, R. Metcalfe, D. Barnett, A. Weetman

引用次数: 49