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Hyperventilation and the chronic fatigue syndrome. 过度换气和慢性疲劳综合症。
Quarterly Journal of Medicine Pub Date : 1994-06-01
S D Rosen
{"title":"Hyperventilation and the chronic fatigue syndrome.","authors":"S D Rosen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 6","pages":"373-4"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19037457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Graves' disease with the block-replace regimen of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse. 抗甲状腺药物阻断替代方案治疗Graves病:治疗时间和免疫遗传易感性对复发的影响
Quarterly Journal of Medicine Pub Date : 1994-06-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068938
A. Weetman, A. Pickerill, P. Watson, V. Chatterjee, O. M. Edwards
{"title":"Treatment of Graves' disease with the block-replace regimen of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse.","authors":"A. Weetman, A. Pickerill, P. Watson, V. Chatterjee, O. M. Edwards","doi":"10.1093/OXFORDJOURNALS.QJMED.A068938","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A068938","url":null,"abstract":"Antithyroid drugs are commonly used as first-line treatment for Graves' disease, but the optimum regimen for inducing remission remains unclear. We gave the block-replace regimen of carbimazole plus thyroxine to 100 patients for 6 or 12 months, to determine whether prolonged treatment is associated with fewer relapses. The remission rate one year after cessation of treatment was 59% with the 6 month course and 65% with 12 months; this was not significantly different. We also analysed HLA markers identified by restriction fragment length polymorphisms and could not confirm the recently reported associations of outcome with HLA-DR4 or with an HLA-DQA2 allele. These results show that six months treatment with a block-replace regimen of antithyroid drugs is probably sufficient, in the UK, to achieve maximum remission of Graves' disease and that there are no HLA markers which clearly predict outcome.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 6 1","pages":"337-41"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/OXFORDJOURNALS.QJMED.A068938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61293987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
Modern chemotherapy in solid tumours. 实体肿瘤的现代化疗。
Quarterly Journal of Medicine Pub Date : 1994-06-01
S B Kaye
{"title":"Modern chemotherapy in solid tumours.","authors":"S B Kaye","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 6","pages":"319-22"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19035523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of phagocytes by cyclosporin in vitro. 环孢素对体外吞噬细胞的抑制作用。
Quarterly Journal of Medicine Pub Date : 1994-05-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068931
S. Thorat, U. Thatte, N. Pai, S. Dahanukar
{"title":"Inhibition of phagocytes by cyclosporin in vitro.","authors":"S. Thorat, U. Thatte, N. Pai, S. Dahanukar","doi":"10.1093/OXFORDJOURNALS.QJMED.A068931","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A068931","url":null,"abstract":"Cyclosporin is an immunosuppressant that acts by selectively inhibiting the activation of T lymphocytes. Its effects on monocytes and neutrophils are not well explored. We investigated the in vitro effects of cyclosporin on these cells, harvested from venous blood from nine healthy, non-smoking volunteers. In vitro incubation of monocytes with increasing concentrations of cyclosporin (5, 25 and 625 micrograms) depressed their phagocytosis by 22%, 32% and 49%, respectively, compared to the control values. The intracellular killing capacity of monocytes decreased by 26%, 31% and 43% with these doses, and neutrophil phagocytosis was depressed in a similar manner (16%, 30% and 40%). Patients receiving cyclosporin are susceptible to infections, and inhibition of these phagocytic cells by cyclosporin may be partly responsible for this. Neutrophil chemotaxis is reduced in patients with impaired renal function. Treating these patients with cyclosporin may in addition suppress the phagocytic function of these cells.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5 1","pages":"311-4"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/OXFORDJOURNALS.QJMED.A068931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61293359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Glucocorticoids and small babies. 糖皮质激素和小婴儿。
Quarterly Journal of Medicine Pub Date : 1994-05-01
J R Seckl
{"title":"Glucocorticoids and small babies.","authors":"J R Seckl","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5","pages":"259-62"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18938032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Africanized 'killer' bee: biology and public health. 非洲化的“杀手”蜜蜂:生物学和公共卫生。
Quarterly Journal of Medicine Pub Date : 1994-05-01
M L Winston
{"title":"The Africanized 'killer' bee: biology and public health.","authors":"M L Winston","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5","pages":"263-7"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18938033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of anti-neutrophil cytoplasm antibodies detected by a standardized indirect immunofluorescence assay. 标准化间接免疫荧光法检测抗中性粒细胞细胞质抗体的临床意义。
Quarterly Journal of Medicine Pub Date : 1994-05-01
A Davenport, R J Lock, T B Wallington, T G Feest
{"title":"Clinical significance of anti-neutrophil cytoplasm antibodies detected by a standardized indirect immunofluorescence assay.","authors":"A Davenport,&nbsp;R J Lock,&nbsp;T B Wallington,&nbsp;T G Feest","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We assessed the use of a standardized antineutrophil cytoplasm antibody (ANCA) test in diagnosing Wegener's granulomatosis (WG), microscopic polyarteritis (mPA) and systemic vasculitis (SV). All samples (n = 779) tested for ANCA at our laboratory were identified, and clinical information was obtained for 783/779 patients by questionnaire, and by visits where necessary. The combined prevalence of WG/mPA/SV was 123/738 (17%). The ANCA test was positive in 48/68 WG patients (71%; 38 cANCA, 10 pANCA), 22/43 mPA patients (51%; 12 cANCA, 10 pANCA) and 3/12 SV patients (25%). WG and mPA patients in remission had similar frequencies of positive ANCA to those with active disease. The sensitivity and specificity for WG (71% and 80%) and mPA (51% and 80%) were lower than previously reported. In this high-prevalence population, the overall (WG/mPA/SV) positive predictive value was only 40%, and the sensitivity 59%. Only 29% of positive tests were from patients with active disease. Overall, 78% of test results gave a 'true' prediction. On this basis, a diagnosis of necrotizing vasculitis (WG/mPA/SV) can be neither made nor refuted by ANCA test alone.</p>","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5","pages":"291-9"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18938036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of phagocytes by cyclosporin in vitro. 环孢素对体外吞噬细胞的抑制作用。
Quarterly Journal of Medicine Pub Date : 1994-05-01
S P Thorat, U M Thatte, N Pai, S A Dahanukar
{"title":"Inhibition of phagocytes by cyclosporin in vitro.","authors":"S P Thorat,&nbsp;U M Thatte,&nbsp;N Pai,&nbsp;S A Dahanukar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cyclosporin is an immunosuppressant that acts by selectively inhibiting the activation of T lymphocytes. Its effects on monocytes and neutrophils are not well explored. We investigated the in vitro effects of cyclosporin on these cells, harvested from venous blood from nine healthy, non-smoking volunteers. In vitro incubation of monocytes with increasing concentrations of cyclosporin (5, 25 and 625 micrograms) depressed their phagocytosis by 22%, 32% and 49%, respectively, compared to the control values. The intracellular killing capacity of monocytes decreased by 26%, 31% and 43% with these doses, and neutrophil phagocytosis was depressed in a similar manner (16%, 30% and 40%). Patients receiving cyclosporin are susceptible to infections, and inhibition of these phagocytic cells by cyclosporin may be partly responsible for this. Neutrophil chemotaxis is reduced in patients with impaired renal function. Treating these patients with cyclosporin may in addition suppress the phagocytic function of these cells.</p>","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5","pages":"311-4"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18938038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual manifestations of salmonellosis--a surgical problem. 沙门氏菌病的异常表现，手术问题。
Quarterly Journal of Medicine Pub Date : 1994-05-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A068930
M. Lalitha, R. John
{"title":"Unusual manifestations of salmonellosis--a surgical problem.","authors":"M. Lalitha, R. John","doi":"10.1093/OXFORDJOURNALS.QJMED.A068930","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A068930","url":null,"abstract":"From January 1981 to December 1992, of 6250 cases of salmonellosis treated at the Christian Medical College and Hospital, Vellore, India, 100 patients with focal pyogenic infection caused by salmonellae required surgical intervention in addition to medical therapy. Thirty-one had involvement of the hepatobiliary system, and 10 more had other intra-abdominal infections. Involvement of bone and joint as well as soft tissue constituted 15% each. The site of infection in patients with soft tissue abscesses included skin (7), parotid (2), thyroid (2), breast (1) inguinal node (1), branchial sinus (1) and injection site (1). Three patients had arterial infections. Noteworthy among the cases of genital infections was one case of salmonella infection in a pre-existing hydrocele, and one case of epididymo-orchitis with a loculated salmonella infection. Salmonella infection in a pre-existing ovarian cyst was seen in a patient with endometriosis. The salmonella serotypes most frequently encountered were S. typhi (36) and S. typhimurium (36), followed by S. paratyphi A (15). The importance of recognition of these protean manifestations of salmonellosis in an endemic setting is discussed. The microbiological evaluation of properly obtained specimens is mandatory in such unusual pyogenic infections.","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5 1","pages":"301-9"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/OXFORDJOURNALS.QJMED.A068930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61293304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
Unusual manifestations of salmonellosis--a surgical problem. 沙门氏菌病的异常表现，手术问题。
Quarterly Journal of Medicine Pub Date : 1994-05-01
M K Lalitha, R John
{"title":"Unusual manifestations of salmonellosis--a surgical problem.","authors":"M K Lalitha,&nbsp;R John","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From January 1981 to December 1992, of 6250 cases of salmonellosis treated at the Christian Medical College and Hospital, Vellore, India, 100 patients with focal pyogenic infection caused by salmonellae required surgical intervention in addition to medical therapy. Thirty-one had involvement of the hepatobiliary system, and 10 more had other intra-abdominal infections. Involvement of bone and joint as well as soft tissue constituted 15% each. The site of infection in patients with soft tissue abscesses included skin (7), parotid (2), thyroid (2), breast (1) inguinal node (1), branchial sinus (1) and injection site (1). Three patients had arterial infections. Noteworthy among the cases of genital infections was one case of salmonella infection in a pre-existing hydrocele, and one case of epididymo-orchitis with a loculated salmonella infection. Salmonella infection in a pre-existing ovarian cyst was seen in a patient with endometriosis. The salmonella serotypes most frequently encountered were S. typhi (36) and S. typhimurium (36), followed by S. paratyphi A (15). The importance of recognition of these protean manifestations of salmonellosis in an endemic setting is discussed. The microbiological evaluation of properly obtained specimens is mandatory in such unusual pyogenic infections.</p>","PeriodicalId":54520,"journal":{"name":"Quarterly Journal of Medicine","volume":"87 5","pages":"301-9"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18938037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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