Journal of Stroke & Cerebrovascular Diseases最新文献

{"title":"A silent surge: Increasing stroke deaths among older adults with atrial fibrillation in the United States (1999-2020)","authors":"Muhammad Umer Sohail ,&nbsp;Zainab Siddiqua Ibrahim ,&nbsp;Saad Ahmed Waqas ,&nbsp;Muhammad Saad ,&nbsp;Ibrahim Nagmeldin Hassan ,&nbsp;Ishaque Hameed ,&nbsp;Muhammad Ovais Sohail ,&nbsp;Raheel Ahmed ,&nbsp;Vikash Kumar ,&nbsp;Anmol Mohan ,&nbsp;Chadi Alraies","doi":"10.1016/j.jstrokecerebrovasdis.2025.108328","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108328","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) significantly increases stroke risk, particularly among older adults, leading to severe outcomes and elevated mortality. This study investigates trends and disparities in AF-related stroke mortality among U.S. adults aged 65 and older from 1999 to 2020.</div></div><div><h3>Methods</h3><div>Mortality data from the CDC WONDER database were analyzed, identifying stroke as the underlying cause of death (ICD-10 codes I60–I69) with AF as a contributing cause (ICD-10 code I48). Age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated. Annual percentage change (APC) and average annual percentage change (AAPC) were used to assess trends over time using Joinpoint regression.</div></div><div><h3>Results</h3><div>A total of 197,453 deaths were recorded between 1999 and 2020. The AAMR increased from 20.85 in 1999 to 24.09 in 2020, reflecting an AAPC of 0.55 % (95 % CI: 0.19–0.95). Women had a slightly higher overall AAMR (21.69) compared to men (20.38). AAMR for Non-Hispanic (NH) Whites (22.15) was 1.5 times higher than that for Hispanics (14.17). Nonmetropolitan areas reported a higher AAMR (22.68) compared to metropolitan areas (21.03). The West had the highest regional overall AAMR (26.57). States in the top 90th percentile reported nearly double the rates of the lowest 10th percentile states.</div></div><div><h3>Conclusion</h3><div>AF-related stroke mortality in older adults has risen over the past two decades, with disparities across gender, race, and geography. Targeted interventions are essential to address these disparities and reduce the burden of AF-related stroke mortality.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108328"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway","authors":"Lulu Qin ,&nbsp;Lilin Peng ,&nbsp;Yifan Sun ,&nbsp;Guixian Chen ,&nbsp;Chenghao Du ,&nbsp;Ruizhi Xie ,&nbsp;Ying Ling ,&nbsp;Haoyou Xu ,&nbsp;Min Zhao ,&nbsp;Yuanqi Zhao ,&nbsp;Zequan Zheng","doi":"10.1016/j.jstrokecerebrovasdis.2025.108314","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108314","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to explore the effects and mechanisms of Shengjiang Powder (SJP) in alleviating ischemic stroke.</div></div><div><h3>Methods</h3><div>The middle cerebral artery occlusion and reperfusion (MCAO) model was established in rats for both the model and medication groups. Neurological function scores, TTC staining, Hematoxylin-Eosin staining and Nissl staining were employed to evaluate the preventive and therapeutic effects of SJP on MCAO in rats. Real-time quantitative polymerase chain reaction, western blotting, and immunofluorescence double staining were used to detect the expression levels of biological markers related to the NLRP3/Caspase-1 pathway.</div></div><div><h3>Results</h3><div>SJP demonstrated an improvement in brain tissue damage in rats subjected to MCAO. SJP inhibited the activation of the NLRP3/Caspase-1 pathway after MCAO in rats. Caspase-1 was primarily expressed in neurons and microglia 24 h post-MCAO in rats, with minimal expression in astrocytes.</div></div><div><h3>Conclusion</h3><div>SJP ameliorates brain tissue damage by inhibiting the activation of the NLRP3/Caspase-1 pathway, thereby reducing the inflammatory response and cell pyroptosis induced by MCAO in rats.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108314"},"PeriodicalIF":2.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood socio-demographic profile associated with adequate transitions of stroke care: The transitions of care stroke disparities study","authors":"Farya Fakoori MD, MS ,&nbsp;Lili Zhou ,&nbsp;Hannah Gardener ScD ,&nbsp;Carolina Gutierrez PhD ,&nbsp;Negar Asdaghi MD, MSc ,&nbsp;Lauri Bishop PhD, PT, DPT ,&nbsp;Scott C. Brown PhD ,&nbsp;Iszet Campo-Bustillo MD, MPH ,&nbsp;Gillian Gordon Perue MD ,&nbsp;Karlon H. Johnson PhD ,&nbsp;Emir Veledar PhD ,&nbsp;Hao Ying ,&nbsp;Jose G. Romano MD ,&nbsp;Tatjana Rundek MD, PhD, FANA ,&nbsp;Erika Marulanda MD MS ,&nbsp;Transitions of Care Stroke Disparities Study (TCSD-S) Investigators","doi":"10.1016/j.jstrokecerebrovasdis.2025.108330","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108330","url":null,"abstract":"<div><h3>Objective</h3><div>Poor socioeconomic conditions are linked to increased stroke-related mortality and worse clinical outcomes post-stroke. This study examines the association between neighborhood socio-demographic (NSD) profile and adequate transitions of care (ATOC) in acute ischemic stroke patients one month after discharge.</div></div><div><h3>Methods</h3><div>The Transitions of Care Stroke Disparities Study (TCSD-S) is an observational prospective cohort investigating disparities in stroke care transitions. Data from 1132 acute ischemic stroke (AIS) patients was obtained from three sources: 1) publicly available NSD data using participants’ ZIP codes, 2) Structured telephone interviews at 30 days post-discharge to ascertain participants’ behavior in six categories, and 3) covariates obtained from Get with the Guidelines-Stroke® (GWTG-S). Logistic regression models examined the relationship between NSDs and achieving ATOC, defined as adherence to at least 75 % of the six behavioral modifications for ATOC, adjusting for patient demographics, social determinants of health, and stroke severity.</div></div><div><h3>Results</h3><div>The sample included 56 % males, 51.5 % non-Hispanic White, 22.6 % non-Hispanic Black, and 21.8 % Hispanic individuals, with a median age of 64 (IQR = 55-74 years). ATOC was achieved in 994 (88 %) participants. While NSDs did not independently predict the overall ATOC success, we observed a direct association of NSD profile (education level and median income) with patients’ adherence to rehabilitation follow-up (<em>p</em> = 0.03), toxic habit cessation (<em>p</em> = 0.04), and medical appointment attendance (<em>p</em> = 0.04), independent of the effects of individual socioeconomic status.</div></div><div><h3>Conclusions</h3><div>Neighborhood socioeconomic status directly impacts protective behaviors. This finding can inform future community-level interventions aimed at improving patients' adherence to behavioral modifications.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108330"},"PeriodicalIF":2.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rate and predictors of white matter disease volume progression across different age groups","authors":"Sai Krishna Vallamchetla MBBS ,&nbsp;Mutlu Demirer PhD ,&nbsp;Erik H. Middlebrooks MD ,&nbsp;Michelle P. Lin MD MPH","doi":"10.1016/j.jstrokecerebrovasdis.2025.108329","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108329","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>White matter disease (WMD) is common among aging populations and is associated with adverse neurological outcomes. While age is a known risk factor for WMD burden, the precise relationship between age and the rate of WMD volume progression remains unclear. The purpose of this study is to investigate the age-dependent acceleration of WMD volume progression across different age groups and its potential clinical implications.</div></div><div><h3>Methods</h3><div>This retrospective study included 2356 patients aged 40 years or older who underwent longitudinal MRI brain scans between 2011 and 2019 at Mayo Clinic. Baseline demographic and clinical characteristics, including vascular risk factors, were collected. The primary outcome was the annual rate of WMD volume progression, which was analyzed across the five age groups (40-49, 50-59, 60-69, 70-79, and 80-99 years). Analysis of Covariance (ANCOVA) assessed the effect of different age groups on WMD progression, while linear ridge regression was used to identify predictors of WMD progression.</div></div><div><h3>Results</h3><div>The mean age of the cohort was 67.6 ± 11.5 years, with 52.7 % female and 95.1 % White. The baseline WMD volume averaged 13.05 ± 14.49 cm³, increasing to 18.30 ± 17.10 cm³ after a median follow-up of 4.8 years, corresponding to an annual progression rate of 1.19 ± 3.01 cm³/year. The annualized rate of WMD volume progression increased significantly with age, from 0.39 cc/year in the 40-49 age group to 1.63 cc/year in the 80-99 age group (<em>p</em> &lt; 0.001). Additionally, the linear ridge regression model identified age, female sex, ever-smoker, diabetes, and baseline WMD volume as significant predictors of faster WMD progression (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our study revealed a significant age-dependent acceleration in WMD volume progression. Age, female sex, ever smoker, diabetes, and baseline WMD volume emerged as significant predictors of the rate of WMD volume progression.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108329"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early neurological deterioration in minor stroke caused by small artery occlusion: Incidence, risk factors and treatment impact","authors":"Dung Tien Nguyen MD ,&nbsp;Duy Ton Mai MD, PhD (Ass Prof) ,&nbsp;Hung Tran Ha MD, PhD (Ass Prof) ,&nbsp;Phuong Viet Dao MD, PhD ,&nbsp;Minh Cong Tran PhD ,&nbsp;Huan Xuan Nguyen (Professor)","doi":"10.1016/j.jstrokecerebrovasdis.2025.108331","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108331","url":null,"abstract":"<div><h3>Introduction</h3><div>Early neurological deterioration (END) is a forecast factor in poor outcomes in minor strokes. END's prevalence and forecast factors in minor strokes caused by small artery occlusion (SAO) are still unclear.</div></div><div><h3>Patients and Method</h3><div>We retrospectively analyzed 451 patients with minor stroke (NIHSS ≤ 5) caused by SAO hospitalized within an initial 24 h at BachMai Hospital's stroke center. END was defined as conditions with an elevated two or more NIHSS points within an initial 72 h. The primary outcome included the determination of the END incidence. The secondary outcome identified forecast factors for END through multivariate logistic regression analyses, and therapeutic impacts of antiplatelet and thrombolytic treatments.</div></div><div><h3>Results</h3><div>END occurred in 9.5 % (43/451) of patients (62.7 % male, mean age 63.8 ± 11.8 years). Independent forecast included admission SBP ≥ 150 mmHg (OR = 1.99; 95 % CI: 1.01 - 3.94; <em>p</em> = 0.048), diabetes history (OR = 0.58; 95 % CI: 1.05 - 4.33; <em>p</em> = 0.036), admission blood glucose ≥ 14mmol/L (OR = 2.99; 95 % CI: 1.05 - 8.54; <em>p</em> = 0.04), and internal capsule infarction (OR = 2.23; 95 % CI: 1.01 - 4.92; <em>p</em> = 0.048). The patients group admitted within 4.5 h, DAPT has significantly lower END risk compared to SAPT (OR = 0.079; 95 % CI: 0.007 - 0.939; <em>p</em> = 0.04) and altepase (OR = 0.013; 95 % CI: 0.01 - 0.12; <em>p</em> &lt; 0.01). END risk was similar between SAPT and altepase (<em>p</em> = 0.074).</div></div><div><h3>Discussion and Conclusion</h3><div>END is a 9.5 % incidence in minor acute ischemic stroke due to SAO. Independent forecasts are admission SBP and blood glucose, diabetes history, and internal capsule infarction. The DAPT group has significantly lower END risk than the SAPT and alteplase groups.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108331"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Grade 3 Carotid Dissections: A 7-Year Retrospective Analysis of Stroke, Stenosis, and Pseudoaneurysm Progression","authors":"Barnabas Obeng-Gyasi ,&nbsp;Kailah Young ,&nbsp;Danielle Wilmes,&nbsp;Matthew P. Blackwell,&nbsp;Matthew K. Tobin,&nbsp;Bradley N. Bohnstedt","doi":"10.1016/j.jstrokecerebrovasdis.2025.108307","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108307","url":null,"abstract":"<div><h3>Background</h3><div>Grade 3 blunt cerebrovascular injuries (BCVIs), also known as pseudoaneurysms, are characterized by arterial wall injury forming a sac-like structure, which can sometimes be associated with stenosis and poses a substantial risk of ischemic stroke. This study evaluates the outcomes of traumatic Grade 3 internal carotid artery injuries treated at a single institution.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted on 33 patients with Grade 3 carotid dissections treated between 2015 and 2022. Primary outcomes included stenosis progression, pseudoaneurysm status, and stroke occurrence.</div></div><div><h3>Results</h3><div>At final imaging, 90.9 % of stenoses had resolved or improved, while 9.1 % remained unchanged or worsened. For pseudoaneurysms, 61 % had resolved or improved, while 39 % remained stable or worsened. Two patients (6.1 %) experienced strokes despite antiplatelet therapy, with one occurring early and one delayed. The majority (84.8 %) received conservative medical management, with only 9.1 % undergoing endovascular treatment.</div></div><div><h3>Conclusion</h3><div>Grade 3 carotid dissections have variable outcomes, with most improving or resolving. However, the persistent risk of stroke and pseudoaneurysm progression emphasizes the need for vigilant long-term monitoring and reconsideration of optimal management strategies, particularly regarding the role of antiplatelet therapy and endovascular intervention.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108307"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of post-stroke cognitive impairment in patients with periodontal disease","authors":"Karly Pikel BS ,&nbsp;Lawson Logue BS ,&nbsp;Haley Verkuilen BS ,&nbsp;Stefanie Wood BS ,&nbsp;Arianne Fritts BS, MS ,&nbsp;Jacobo Mintzer MD, MBA ,&nbsp;Leonardo Bonilha MD, PhD ,&nbsp;Pramod Sethi MD ,&nbsp;Anne Beckwith BS ,&nbsp;David Huang MD PhD ,&nbsp;Souvik Sen MD, MS, MPH","doi":"10.1016/j.jstrokecerebrovasdis.2025.108327","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108327","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontal disease (PD) is a risk factor for stroke and cardiovascular disease. The effect of PD on post-stroke cognitive impairment (PSCI) remains underexplored.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis of the Periodontal tReatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) study participants was conducted. Baseline cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) within 90 days of the index event. MoCA score ≤21 indicated severe PSCI. White matter hyperintensity, indicating cerebral small vessel disease (cSVD), was evaluated using the Fazekas scale on MRI. Due to non-normal MoCA distribution, two analytical approaches were employed: 1) logistic regression using dichotomized MoCA scores based on clinically relevant cutoffs and 2) generalized linear mixed modeling after bootstrap normalization that examined MoCA scores continuously.</div></div><div><h3>Results</h3><div>Among 280 participants with PD, 48% exhibited severe PSCI. Both analytical approaches demonstrated that severe PD, African American (AA) race, and greater stroke severity significantly and independently predicted severe PSCI, while advanced education was protective. Fazekas' scale showed no significant associations with PSCI.</div></div><div><h3>Conclusions</h3><div>This study identifies PD severity as a novel and independent contributor to early PSCI. Traditional predictors like AA race, educational attainment, and stroke severity remained significant.</div></div><div><h3>Clinical Trial Registration Information</h3><div><span><span>https://www.clinicaltrials.gov</span><svg><path></path></svg></span>; Unique identifier: NCT 02541032</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108327"},"PeriodicalIF":2.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual assessment of cylinder rearing behavior is more sensitive than automated gait evaluations in young, male mice post-stroke of the forepaw somatosensory cortex","authors":"Cynthia X. Li ,&nbsp;Esha Kapoor ,&nbsp;Wei Chen ,&nbsp;Lance M. Ward ,&nbsp;David D. Lee ,&nbsp;Amanda Titus ,&nbsp;Kate M. Reardon ,&nbsp;Jin-Moo Lee ,&nbsp;Carla M. Yuede ,&nbsp;Eric C. Landsness","doi":"10.1016/j.jstrokecerebrovasdis.2025.108325","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108325","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is a leading cause of long-term adult disability. Behavioral testing with animal stroke models, which offers a way to evaluate the effectiveness of new interventions, currently relies on methods that are time- and labor-intensive. Automated behavioral assessments of locomotion and gait have been proposed as an alternative, but it is currently unknown whether they are sensitive enough to assess behavioral deficits following stroke of the forepaw somatosensory cortex. The purpose of this study was to compare a validated, manually assessed behavioral test, cylinder rearing (a measure of forepaw asymmetry during exploration), with automated behavior tests of locomotion in a rodent photothrombotic stroke model.</div></div><div><h3>Methods</h3><div>We induced a focal photothrombotic stroke in young (12-16 week old) male mice over the left forepaw somatosensory cortex, conducted behavioral testing at acute (48 h) and sub-acute (4 weeks) time points post-stroke, and then correlated behavior deficits to histological measures.</div></div><div><h3>Results</h3><div>Three automated behavioral tests were used in comparison to cylinder rearing: CatWalk (spontaneous gait), DigiGait (forced treadmill locomotion), and open field (a measure of general locomotor activity). Cylinder rearing testing showed significant forepaw asymmetry between stroke and sham groups acutely and sub-acutely after stroke. Catwalk, DigiGait, and open field tests showed no significant differences between groups. When correlating behavior to histological measures of stroke, the presence of secondary thalamic injury (STI) was associated with forepaw asymmetry on cylinder rearing.</div></div><div><h3>Conclusions</h3><div>These findings illustrate the need to find alternative automated behavioral measures for mouse photothrombotic stroke of the forepaw somatosensory cortex.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 7","pages":"Article 108325"},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “exploring the bidirectional relationships between alzheimer's disease and cerebral small vessel disease: Insights from mendelian randomization”","authors":"Jianming Ke MD,&nbsp;Jin Li MD,&nbsp;Min Yu MD","doi":"10.1016/j.jstrokecerebrovasdis.2025.108326","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108326","url":null,"abstract":"","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 6","pages":"Article 108326"},"PeriodicalIF":2.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Serum uric acid levels and intracerebral hemorrhage: A two-sample Mendelian randomization study”","authors":"Huan Song MD","doi":"10.1016/j.jstrokecerebrovasdis.2025.108305","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108305","url":null,"abstract":"","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 6","pages":"Article 108305"},"PeriodicalIF":2.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}