Endocrinologia Y Nutricion最新文献

{"title":"Diabetes mellitus tipo 2 y enfermedad de Alzheimer: una relación para no olvidar","authors":"Andreea Ciudin","doi":"10.1016/j.endonu.2015.12.004","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.12.004","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 191-193"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72096838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete pituitary infarction associated with hypothermia and brain death","authors":"Run Yu , Xuemo Fan , Serguei I. Bannykh","doi":"10.1016/j.endonu.2016.01.003","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.01.003","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 250-252"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72096840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment of hyponatraemia in neurosurgical patients","authors":"Martín Cuesta,&nbsp;Mark J. Hannon,&nbsp;Christopher J. Thompson","doi":"10.1016/j.endonu.2015.12.007","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.12.007","url":null,"abstract":"<div><p><span>Hyponatraemia is the most common </span>electrolyte imbalance<span> in neurosurgical patients. Acute hyponatraemia is particularly common in neurosurgical patients after any type of brain insult, including brain tumours and their treatment, pituitary surgery<span>, subarachnoid haemorrhage<span><span> or traumatic brain injury<span>. Acute hyponatraemia is an emergency condition, as it leads to cerebral oedema due to passive osmotic movement of water from the </span></span>hypotonic<span> plasma to the relatively hypertonic brain which ultimately is the cause of the symptoms associated with hyponatraemia. These include decreased level of consciousness, seizures<span>, non-cardiogenic pulmonary oedema or transtentorial brain herniation. Prompt treatment is mandatory to prevent such complications, minimize permanent brain damage and therefore permit rapid recovery after brain insult. The infusion of 3% hypertonic saline is the treatment of choice with different rates of administration based on the severity of symptoms and the rate of drop in plasma sodium concentration.</span></span></span></span></span></p><p><span>The pathophysiology<span> of hyponatraemia in neurotrauma is multifactorial; although the syndrome of inappropriate antidiuresis (SIADH) and central adrenal insufficiency are the commonest causes encountered. Fluid restriction has historically been the classical treatment for SIADH, although it is relatively contraindicated in some neurosurgical patients such as those with subarachnoid haemorrhage. Furthermore, many cases admitted have acute onset hyponatraemia, who require hypertonic saline infusion. The recently developed </span></span>vasopressin receptor 2<span> antagonist class of drug is a promising and effective tool but more evidence is needed in neurosurgical patients. Central adrenal insufficiency may also cause acute hyponatraemia in neurosurgical patients; this responds clinically and biochemically to hydrocortisone. The rare cerebral salt wasting syndrome is treated with large volume normal saline infusion. In this review, we summarize the current evidence based on the clinical presentation, causes and treatment of different types of hyponatraemia in neurosurgical patients.</span></p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 230-238"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.12.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72066104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenocortical carcinoma: Retrospective analysis of the last 22 years","authors":"Daniela Guelho ,&nbsp;Isabel Paiva ,&nbsp;Alexandra Vieira ,&nbsp;Francisco Carrilho","doi":"10.1016/j.endonu.2015.12.009","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.12.009","url":null,"abstract":"<div><h3>Background</h3><p>Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. The clinical experience acquired, even from a small number of cases, has improved understanding of this condition. The purpose of this study is to characterize patients with ACC followed up at a Portuguese reference center over the past 22 years.</p></div><div><h3>Methods</h3><p>Retrospective analysis of clinical records of patients with histopathological diagnosis of ACC followed up from 1992 to 2014.</p></div><div><h3>Results</h3><p>The study sample consisted of 22 patients, 20 of them female. Eleven patients were in stage II, four in stage III, and five in stage IV; 13 patients had functioning lesions. Adrenalectomy was performed in 20 patients, with complete tumor resection in 90% of the cases. During follow-up, eight patients experienced recurrence of local disease, and 12 distant metastases. Fourteen patients received mitotane, 35.7% (<em>n</em> <!-->=<!--> <!-->5) as adjuvant therapy and 64.3% (<em>n</em> <!-->=<!--> <!-->9) after recurrence; therapeutic plasma mitotane levels were achieved in 70% of patients. Stage III patients who received adjuvant therapy had longer survival time (13.5 vs. 2.5 months). Two patients were given chemotherapy associated to mitotane. Median survival was 11 months (0–257 months); it was slightly longer in younger patients or patients with non-functioning tumors. Six patients are still alive, four of them with no evidence of disease.</p></div><div><h3>Conclusion</h3><p>Despite the overall poor prognosis, some patients with ACC may have a long survival time. Although complete tumor removal remains the only potentially curative treatment, diagnosis at a younger age, presence of non-functioning tumors, and mitotane treatment also seemed to be associated to longer survival in our patients.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 212-219"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.12.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72066173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin-related myotoxicity","authors":"Vera Fernandes ,&nbsp;Maria Joana Santos ,&nbsp;Antonio Pérez","doi":"10.1016/j.endonu.2016.01.001","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.01.001","url":null,"abstract":"<div><p>Statin therapy has a very important role in decreasing cardiovascular risk, and treatment non-compliance may therefore be a concern in high cardiovascular risk patients. Myotoxicity is a frequent side effect of statin therapy and one of the main causes of statin discontinuation, which limits effective treatment of patients at risk of or with cardiovascular disease. Because of the high proportion of patients on statin treatment and the frequency of statin-related myotoxicity, this is a subject of concern in clinical practice. However, statin-related myotoxicity is probably underestimated because there is not a gold standard definition, and its diagnosis is challenging. Moreover, information about pathophysiology and optimal therapeutic options is scarce. Therefore, this paper reviews the knowledge about the definition, pathophysiology and predisposing conditions, diagnosis and management of statin-related myotoxicity, and provides a practical scheme for its management in clinical practice.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 239-249"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72066105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estado hiperglucémico hiperosmolar: una forma poco frecuente de inicio de la diabetes mellitus tipo 1 en la infancia","authors":"Ana Hernández Moreno ,&nbsp;María Sanz Fernández ,&nbsp;María D. Ballesteros Pomar ,&nbsp;Amparo Rodríguez Sánchez","doi":"10.1016/j.endonu.2016.02.001","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.02.001","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 252-253"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72096839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asociación entre las fuentes de información y el nivel de conocimientos sobre diabetes en pacientes diabéticos tipo 2","authors":"Katherine Cántaro ,&nbsp;Jimena A. Jara ,&nbsp;Marco Taboada ,&nbsp;Percy Mayta-Tristán","doi":"10.1016/j.endonu.2016.01.005","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.01.005","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the association between the type of information source and the level of knowledge about diabetes mellitus in patients with type 2 diabetes.</p></div><div><h3>Methodology</h3><p>A cross-sectional study was conducted at a reference diabetes and hypertension center in Lima, Peru, during 2014. Level of knowledge was measured using the Diabetes Knowledge Questionnaire-24 and 12 information sources. Patients with 75% correct answers were considered to have a good knowledge. Adjusted odds ratios were calculated.</p></div><div><h3>Results</h3><p>Of the total 464 patients enrolled, 52.2% were females, and 20.3% used the Internet as information source. Mean knowledge was 12.9<!--> <!-->±<!--> <!-->4.8, and only 17.0% had a good knowledge, which was associated with information on diabetes obtained from the Internet (OR<!--> <!-->=<!--> <!-->2.03, 95% <span>CI</span> 1.32 to 3.14), and also from other patients (OR<!--> <!-->=<!--> <!-->1.99, 95% CI 1.20 to 3.31). Good knowledge was also associated with postgraduate education (OR<!--> <!-->=<!--> <!-->3.66, 95% CI 1.21 to 11.09), disease duration longer than 12 years (OR<!--> <!-->=<!--> <!-->1.91, 95% CI 1,22 to 3.01), and age older than 70 years (OR<!--> <!-->=<!--> <!-->0.39, 95% CI 0.21-0.72).</p></div><div><h3>Conclusion</h3><p>Search for information in the Internet was positively associated to a good level of knowledge. It is suggested to teach patients with diabetes to seek information on the Internet and, on the other hand, to develop virtual spaces for interaction of patients with diabetes.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 202-211"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72066175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rendimiento físico y fuerza muscular en pacientes adultos mayores con diabetes y sin diabetes de un hospital público de Lima (Perú)","authors":"Milenka Palacios-Chávez ,&nbsp;Christine Dejo-Seminario ,&nbsp;Percy Mayta-Tristán","doi":"10.1016/j.endonu.2015.12.008","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.12.008","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the relationship between physical performance (PP) and muscle strength (MS) in elderly subjects with and without diabetes in a public hospital of Lima, Peru.</p></div><div><h3>Subjects and method</h3><p>A cross-sectional analysis of subjects aged 60 years or older with and without diabetes. MS was measured with a handheld dynamometer, and PP with the «timed get-up-and-go» test. Nutritional status was determined using body mass index, body fat percentage measured with a handheld fat loss monitor and protein intake based on the 24-hour recall. Age, sex, and history of hospitalization and supplementation were also recorded. The association was assessed using adjusted prevalence ratios.</p></div><div><h3>Results</h3><p>Overall, 139 patients with diabetes (26.6% with low PP and 13.7% with decreased MS) and 382 subjects without diabetes (36.6% with low PP and 23.0% with decreased MS) were evaluated. No association was found between T2DM and MS (aPR: 0.99; 95% CI: 0.67-1.57) or PP (aPR: 1.13; 95% CI: 0.84-1.52). Protein and supplement consumption was also unrelated (<em>P</em>&gt;.05); however, history of hospitalization, age, sex, nutritional status, and body fat percentage were related (<em>P</em>&gt;.05).</p></div><div><h3>Conclusions</h3><p>No association was found between T2DM, MS, and PP. However, low PP was associated to female sex and overweight/obesity, and decreased MS was associated to high body fat percentage and underweight. Moreover, MS and PP were related to older age and history of hospitalization.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 5","pages":"Pages 220-229"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.12.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72066176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish consensus for the management of patients with advanced radioactive iodine refractory differentiated thyroid cancer","authors":"Garcilaso Riesco-Eizaguirre ,&nbsp;Juan Carlos Galofré ,&nbsp;Enrique Grande ,&nbsp;Carles Zafón Llopis ,&nbsp;Teresa Ramón y Cajal Asensio ,&nbsp;Elena Navarro González ,&nbsp;Paula Jiménez-Fonseca ,&nbsp;Javier Santamaría Sandi ,&nbsp;José Manuel Gómez Sáez ,&nbsp;Jaume Capdevila","doi":"10.1016/j.endonu.2015.08.007","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.08.007","url":null,"abstract":"<div><h3>Background</h3><p>Approximately one third of the patients with differentiated thyroid cancer (DTC) who develop structurally-evident metastatic disease are refractory to radioactive iodine (RAI). Most deaths from thyroid cancer occur in these patients. The main objective of this consensus is to address the most controversial aspects of management of these patients.</p></div><div><h3>Methods</h3><p>On behalf of the Spanish Society of Endocrinology &amp; Nutrition (SEEN) and the Spanish Group for Orphan and Infrequent Tumors (GETHI), the Spanish Task Force for Thyroid Cancer, consisting of endocrinologists and oncologists, reviewed the relevant literature and prepared a series of clinically relevant questions related to management of advanced RAI-refractory DTC.</p></div><div><h3>Results</h3><p>Ten clinically relevant questions were identified by the task force. In answering to these 10 questions, the task force included recommendations regarding the best definition of refractoriness; the best therapeutic options including watchful waiting, local therapies, and systemic therapy (e.g. kinase inhibitors), when sodium iodide symporter (NIS) restoration may be expected; and how recent advances in molecular biology have increased our understanding of the disease.</p></div><div><h3>Conclusions</h3><p>In response to our appointment as a task force by the SEEN and GHETI, we developed a consensus to help in clinical management of patients with advanced RAI-refractory DTC. We think that this consensus will provide helpful and current recommendations that will help patients with this disorder to get optimal medical care.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 4","pages":"Pages e17-e24"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.08.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72043886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveles de ALT y respuesta hipoglucemiante al tratamiento con agonistas del receptor de GLP-1","authors":"Jose A. Gimeno-Orna ,&nbsp;Guayente Verdes-Sanz ,&nbsp;Laura Borau-Maorad ,&nbsp;Julia Campos-Fernández ,&nbsp;Beatriz Lardiés-Sánchez ,&nbsp;Marta Monreal-Villanueva ,&nbsp;en representación de la Sociedad Aragonesa de Endocrinología y Nutrición (SADEN)","doi":"10.1016/j.endonu.2015.11.009","DOIUrl":"https://doi.org/10.1016/j.endonu.2015.11.009","url":null,"abstract":"<div><h3>Background and objectives</h3><p>This study aimed to assess if ALT levels, as a marker of non-alcoholic fatty liver disease, may predict HbA1c response to treatment with GLP-1 receptor agonists (GLP-1 RAs).</p></div><div><h3>Patients and methods</h3><p>A retrospective, longitudinal, analytical study was conducted including patients with type<!--> <!-->2 diabetes mellitus continuously treated with GLP-1 agonists (85% with liraglutide) for one year. Patients were divided into two groups according to baseline ALT levels, with 24<!--> <!-->U/L (the median of the distribution) as the cut-off point. The dependent variable was HbA1c change (one-year follow-up minus baseline).</p><p>The predictive value of ALT levels above 24 U/L and ALT change was analyzed using multivariate linear regression adjusted to age, gender, diabetes duration, type and dose of GLP-1 RA, baseline HbA1c, baseline body mass index (BMI), and change in BMI.</p></div><div><h3>Results</h3><p>A total of 117 patients (48% females) aged 58.6 (SD 9.6) years were enrolled into the study. Treatment was associated with a change in ALT of −4.3<!--> <!-->U/L (p<!--> <!-->=<!--> <!-->0.041) and a change in HbA1c of −1.1% (p<!--> <!-->&lt;<!--> <!-->0.0001). Decreases in HbA1c (−1.41% vs −0.76%; p<!--> <!-->=<!--> <!-->0.045) and ALT (−9.25 vs 0.46<!--> <!-->U/L; p<!--> <!-->=<!--> <!-->0.002) were significantly higher in patients with ALT levels above the median. In the multivariate analysis, both ALT<!--> <!-->&gt;<!--> <!-->24<!--> <!-->U/L (b<!--> <!-->=<!--> <!-->−0.74; 95%<!--> <!-->CI: −1.31 to −0.18; p<!--> <!-->=<!--> <!-->0.011) and ALT change (b<!--> <!-->=<!--> <!-->0.028; 95%<!--> <!-->CI: 0.010 to 0.046; p<!--> <!-->=<!--> <!-->0.003), were significant response predictors.</p></div><div><h3>Conclusions</h3><p>Elevated baseline transaminase values and decreased transaminase levels during follow-up are associated to a favorable glycemic response to GLP-1 RAs.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 4","pages":"Pages 164-170"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2015.11.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72043885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}