Quantitative Imaging in Medicine and Surgery最新文献

{"title":"Diagnostic performance of shear wave elastography and contrast-enhanced ultrasound in evaluating the pathological response of breast cancer patients to neoadjuvant chemotherapy: a meta-analysis.","authors":"Yan Liu, Wenxiao Li, Sirui Wang, Jinli Wang, Xiaowu Yuan, Yaqian Deng, Zelin Xu, Jixue Hou, Jun Li, Tao Song","doi":"10.21037/qims-2024-2730","DOIUrl":"10.21037/qims-2024-2730","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemotherapy (NAC) is administered to specific subgroups of breast cancer patients to improve clinical outcomes. Achieving a pathological complete response (pCR) is strongly associated with improved survival. This meta-analysis systematically evaluated the diagnostic performance of shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) in predicting the pathological response of breast cancer patients to NAC.</p><p><strong>Methods: </strong>Relevant studies were searched in the databases of PubMed, Web of Science, and Embase until July 14, 2024. The articles were screened and relevant data were extracted, and study quality was assessed using Review Manager 5.4. The area under the curve (AUC) was calculated, and publication bias was evaluated by funnel plots generated using Stata 18.0. These analyses aimed to assess the diagnostic performance of SWE and CEUS in predicting the pathological response of breast cancer patients to NAC in terms of sensitivity (Sen) and specificity (Spe).</p><p><strong>Results: </strong>A total of 22 studies comprising 1,725 breast cancer patients were included in the meta-analysis. The composite combined AUC, Sen, and Spe of CEUS in monitoring the pathological response of breast cancer patients to NAC were 0.86 [95% confidence interval (CI), 0.83-0.89], 0.88 (95% CI, 0.80-0.93), and 0.80 (95% CI, 0.74-0.84), respectively, and those of SWE were 0.88 (95% CI, 0.84-0.90), 0.82 (95% CI, 0.77-0.85), and 0.81 (95% CI, 0.74-0.86), respectively.</p><p><strong>Conclusions: </strong>This meta-analysis confirmed that CEUS and SWE had comparable Spe in predicting the pathological response of breast cancer patients to NAC (CEUS: 0.80 <i>vs.</i> SWE: 0.81), but CEUS had superior Sen (0.88 <i>vs.</i> 0.82). Both modalities have clinically relevant diagnostic value (AUC >0.80), supporting their utility in the non-invasive monitoring of NAC efficacy.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8333-8347"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of fetal laryngotracheal atresia combined with tracheoesophageal fistula via prenatal ultrasound: a case description.","authors":"Xuelu Feng, Pujuan Jia, Xiaxia Cheng, Bin Ma","doi":"10.21037/qims-2025-394","DOIUrl":"10.21037/qims-2025-394","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8751-8754"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoring system combining CatLet score and clinical variables as a predictor of long-term prognosis in patients with chronic coronary syndrome after percutaneous coronary intervention.","authors":"Juan Wang, Rongbo Yu, Mingchao Zhang, Jiayan Zhou, Dasheng Lu, Lingfei Yang","doi":"10.21037/qims-2025-171","DOIUrl":"10.21037/qims-2025-171","url":null,"abstract":"<p><strong>Background: </strong>The Coronary Artery Tree Description and Lesion Evaluation (CatLet) angiographic scoring system is a newly developed vascular scoring for assessing the degree of coronary artery stenosis. It has unique advantages in reflecting coronary artery variability as compared to Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score. Preliminary studies support its superiority over SYNTAX in predicting clinical outcomes after percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). This study aimed to determine whether the CatLet score incorporating three clinical variables (CVs)-age, ejection fraction, and creatinine-is a better predictor of clinical outcomes in patients treated with PCI for CCS as compared to the CatLet score.</p><p><strong>Methods: </strong>A total of 222 patients who were diagnosed with CCS, underwent coronary drug-eluting stent (DES) implantation, and had a calculable CatLet score were retrospectively selected from the Second Affiliated Hospital of Wannan Medical College in China between April 2019 and June 2020. The primary endpoint was major adverse cardiac events (MACEs), including myocardial infarction, recurrent angina, cardiac death, heart failure, and ischemia-driven revascularization, and was stratified according to CatLet score tertiles as follows: >0 and ≤23= CatLet low (n=72), 24-43= CatLet mid (n=76), and ≥44= CatLet top (n=74).</p><p><strong>Results: </strong>The CatLet score predicted long-term prognosis, with a 4.5-year-follow-up and a median of 3.4 years. Of the 222 patients analyzed, the rates of MACEs, cardiac death, and reangina were 27.03%, 3.60%, and 18.02%, respectively. In the Kaplan-Meier analysis, as the tertiles of the CatLet score increased, so did the cumulative incidence event rates for all endpoints (log-rank test for trend P<0.05). The area under the curve (AUC) of the CatLet score was 0.73, 0.76, and 0.73 for MACEs, cardiac death, and reangina, respectively, while the AUCs for CV-adjusted CatLet score models were 0.78, 0.88, and 0.74, respectively. Alone or after adjustments for risk factors, the multivariable-adjusted hazard ratio/unit higher score was 6.22 [95% confidence interval (CI): 2.40-16.13] for MACEs, 4.84 (95% CI: 2.52-9.32) for cardiac death, and 8.59 (95% CI: 2.53-29.10) for heart failure.</p><p><strong>Conclusions: </strong>As compared with CatLet score alone, the model incorporating the CatLet score and three CVs can provide superior prediction ability.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8112-8124"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted neurovascular coupling in patients with lung cancer after chemotherapy.","authors":"Lanyue Hu, Shaohua Ding, Jun Yao, Yujie Zhang, Jia You, Huiyou Chen, Qian Li, Yu-Chen Chen, Xindao Yin","doi":"10.21037/qims-24-1321","DOIUrl":"10.21037/qims-24-1321","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy-related cognitive impairments (CRCIs) are frequently reported by patients with non-small cell lung cancer (NSCLC) following chemotherapy treatment. Studies have revealed that cognitive impairment may be linked to abnormal spontaneous neuronal activity and changes in cerebral blood flow (CBF). However, the specific impact of neurovascular coupling (NVC) alterations on patients who have undergone chemotherapy has not been clarified. The aim of this study was to examine the variations in NVC in patients with lung cancer postchemotherapy and to determine potential correlations between these NVC alterations and neurocognitive dysfunction.</p><p><strong>Methods: </strong>A sample of 43 patients with NSCLC was recruited, including 20 patients treated with chemotherapy [CT(+)] and 23 chemotherapy-naïve [CT(-)] individuals who underwent pseudocontinuous arterial spin labeling (pCASL) scans and resting-state functional magnetic resonance imaging (rs-fMRI), along with neurocognitive evaluations. Global and regional NVC indices were assessed according to correlation coefficients and the ratios between CBF and neuronal activity-derived metrics, including the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo). Statistical analyses were conducted to calculate the difference between groups and characterize relationships between alterations in global and regional NVC and cognitive performance.</p><p><strong>Results: </strong>In comparison to the CT(-) group, the CT(+) group exhibited significantly lower coupling strength for global CBF-ALFF and CBF-ReHo correlations (P<0.05). Regionally, the CT(+) group demonstrated a decreased CBF:ALFF ratio in the right middle temporal gyrus (MTG) and left middle frontal gyrus (MFG), as well as an increased CBF:ALFF ratio in the left thalamus and left parahippocampal region. Furthermore, the CT(+) group had higher CBF:ReHo ratios in the left precuneus, right central operculum, right inferior parietal lobule, and right superior occipital gyrus but lower CBF:ReHo ratios in the left inferior frontal gyrus and right MFG (false-discovery rate-corrected P value <0.05). Notably, there was a negative correlation observed between Montreal Cognitive Assessment scores and memory scores and the CBF:ALFF ratios in the right MFG and left parahippocampal region.</p><p><strong>Conclusions: </strong>This research offers comprehensive insights into the neurological foundations of CRCI. The application of multimodal neuroimaging analyses combining rs-fMRI and pCASL may uncover the induction of neurovascular decoupling in lung cancer patients undergoing chemotherapy.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"7820-7832"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension.","authors":"Junqing Ma, Wenting Li, Sunan Xu, Ruichen Ren, Xiaopei Cui, Yongze Zheng, Yan Deng, Yongfeng Liang, Yang Zhang","doi":"10.21037/qims-24-2152","DOIUrl":"10.21037/qims-24-2152","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary vascular resistance (PVR) is essential in managing pulmonary hypertension (PH) and has prompted the search for noninvasive assessment techniques. This study investigates the integration of morphological parameters from computed tomography pulmonary angiography (CTPA) and functional parameters from transthoracic echocardiography (TTE) to develop a noninvasive method for evaluating PVR in patients with PH.</p><p><strong>Methods: </strong>Data from PH patients who underwent CTPA, TTE, and right heart catheterization (RHC) were analyzed retrospectively. The Cobb angle, defined as the angle between the spine and interventricular septum, was calculated by CTPA. It is assumed that thorax geometry, pericardial morphology, and body surface area (BSA) are factors influencing the Cobb angle measurement, and these factors were adjusted for in the analysis. Multiple linear regression was performed to evaluate the multivariate ability to predict PVR. Multivariate Cox regression analysis assessed the prognostic value of parameters in predicting hospitalization for heart failure.</p><p><strong>Results: </strong>In total, 78 patients meeting the criteria were enrolled. Among the TTE parameters, the right ventricular outflow tract acceleration time (RVOT-AT) demonstrated the best goodness-of-fit to PVR (R²=0.433, P<0.001). Correcting the Cobb angle by BSA significantly improved its fit to PVR (R²=0.510, P<0.001), compared to the uncorrected angle (R²=0.450, P<0.001). The model combining Cobb angle/BSA and RVOT-AT strongly predicted PVR (r=0.815, R²=0.634, P<0.001) and was effective across different demographics. After multivariable adjustment, the Cobb angle [hazard ratio (HR): 1.057; P<0.001], Cobb angle/BSA (HR: 1.087; P<0.001), tricuspid annular plane systolic excursion (TAPSE) (HR: 0.878; P=0.014), RVOT-AT (HR: 0.968; P=0.030), and right ventricular myocardial performance index (RVMPI) (HR: 5.324; P<0.001) remained significant independent predictors of heart failure.</p><p><strong>Conclusions: </strong>The integration of BSA-adjusted morphological markers from CTPA with hemodynamic parameters derived from TTE provides a promising noninvasive method for predicting PVR and demonstrates significant prognostic value in evaluating heart failure in PH patients.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8567-8578"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of skeletal muscle microcirculation via magnetic resonance intravoxel incoherent motion perfusion imaging in an acute ischemia rabbit model.","authors":"Guoping Song, Xinyu Song, Jienan Wang, Xiance Zhao, Junkang Shen","doi":"10.21037/qims-2025-711","DOIUrl":"10.21037/qims-2025-711","url":null,"abstract":"<p><strong>Background: </strong>Acute limb ischemia (ALI) necessitates prompt intervention to prevent severe complications such as amputation. Current clinical assessments lack reliable quantitative methods for gauging skeletal muscle ischemia severity. Intravoxel incoherent motion (IVIM) perfusion imaging is a noninvasive approach for quantifying microvascular perfusion. We aimed to assess microcirculation alterations in rabbit vastus lateralis muscle following acute ischemia using IVIM.</p><p><strong>Methods: </strong>Acute ischemia models were established in 25 New Zealand white rabbits through arterial ligation of their right hind legs. Magnetic resonance imaging (MRI) examinations of the vastus lateralis muscle were conducted hourly postsurgery for a duration of 7 hours. The scan sequences included IVIM, adenosine triphosphate (APT), T1-weighted imaging (T1WI), T2-weighted imaging with fat suppression (T2WI-FS), T2 mapping, and diffusion-weighted imaging (DWI). The correlations between MRI results, ischemic time, and pathological changes were analyzed.</p><p><strong>Results: </strong>The perfusion fraction (f) of ischemic muscle significantly decreased from 6.19%±1.13% at 1 hour to 2.50%±0.64% at 7 hours (control: 7.19%±1.03%), representing a strong negative correlation with ischemic duration (r=-0.790). The true diffusion coefficient (D) remained relatively stable [(1.41-1.46)×10^-3 mm²/s] but was slightly elevated compared to controls. The pseudo-diffusion coefficient (D*) showed a sharp increase at 5 hours [(74.01±5.79)×10^-3 mm²/s]; control: [(61.28±9.31)×10^-3 mm²/s], followed by a drop at 6 hours [(59.44±15.77)×10^-3 mm²/s], suggesting sudden structural changes, which were confirmed by histopathology. T2WI-FS and DWI showed increased signal intensity in ischemic muscle, with the T2 relaxation times being significantly elevated (P<0.001) and positively correlated with ischemic duration (r=0.807). Apparent diffusion coefficient (ADC) values also increased with time (r=0.623). The amide proton transfer effect was enhanced in ischemic skeletal muscle throughout the 2-7-hour post-ischemic period (ischemic: 2.26%±0.39% at the 7th hour <i>vs</i>. control: 1.77%±0.33%; P<0.05).</p><p><strong>Conclusions: </strong>MRI effectively visualizes and detects skeletal muscle ischemia, with IVIM-derived f values providing a quantitative measure of microcirculatory impairment. D* potentially serves as a biomarker for identifying irreversible muscle fiber damage and may be a valuable tool for the quantitative assessment of ischemic injury to skeletal muscle.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8064-8078"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular volume fraction based on dual-layer spectral computed tomography in assessment of gastric cancer: feasibility analysis of low-dose equilibrium phase scanning.","authors":"Zhen Zhang, Xiaoping Zhao, Xuelian Chen, Hongyan Wang, Xiaohui Zhang, Yonggang Li, Mengzhe Zuo","doi":"10.21037/qims-24-2013","DOIUrl":"10.21037/qims-24-2013","url":null,"abstract":"<p><strong>Background: </strong>The extracellular volume fraction (fECV) based on equilibrium phase iodine density images (IDIs) of dual-layer spectral detector computed tomography (DLCT) can be used in the assessment of gastric cancer (GC). However, obtaining the equilibrium phase images requires a higher radiation dose. The purpose of our study was to evaluate the feasibility of low-dose equilibrium phase scans on DLCT for fECV acquisition in histological grading assessment of GC.</p><p><strong>Methods: </strong>A total of 86 gastric adenocarcinoma patients confirmed by surgical pathology were divided into two groups that underwent contrast-enhanced DLCT with routine-dose (120 kV/129 refmAs) and low-dose (120 kV/90 refmAs) equilibrium phases, respectively. The fECV values of GC lesions were measured from IDIs in the equilibrium phase. The radiation dose, image quality of the equilibrium phase images, and fECV values were compared between the low- and routine-dose groups. Then, the performance of the fECV in the two groups to distinguish histological grades of GC lesions was evaluated using a receiver operating characteristic (ROC) curve and the DeLong test. The fECV maps were reconstructed from the IDIs of the equilibrium phase.</p><p><strong>Results: </strong>The radiation dose of the equilibrium phase and the accumulated dose in the low-dose group decreased by 54% and 34%, respectively, compared to the routine-dose group (both P<0.001). The image noise of equilibrium phase images was higher in the low-dose group than that in the routine-dose group (P<0.001) and the noise scores of the low-dose group were lower than those of the routine-dose group (P=0.003), whereas no significant differences were detected in the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), detail score, and fECV values between the two groups (P=0.243, 0.607, 0.861, and 0.301, respectively). The fECV values of high-grade GC lesions were higher than those of the low-grade lesions in the two groups (52.98%±8.06% <i>vs.</i> 38.31%±5.24%, P<0.001, and 51.94%±9.11% <i>vs.</i> 36.91%±5.26%, P=0.002). The fECV obtained in the low-dose group had a similar performance compared to the routine-dose group in histological grading assessment of GC [area under the curve (AUC): 0.871 <i>vs.</i> 0.879, <i>Z</i>=-0.148, P=0.882].</p><p><strong>Conclusions: </strong>Contrast-enhanced DLCT with low-dose equilibrium phase scans in GC reduced the radiation dose while providing comparable image quality and performance of fECV in histological grading assessment to those of routine-dose scans.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8529-8540"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-parametric magnetic resonance imaging evaluation of a novel <i>ex ovo</i> chick chorioallantoic membrane model for cancer research.","authors":"Guodong Feng, Weili Peng, Zhenfeng Ma, Houhui Shi, Jiaqi Zhang, Bin Song, Jun Chen, Yi-Jun Liang","doi":"10.21037/qims-2024-2612","DOIUrl":"10.21037/qims-2024-2612","url":null,"abstract":"<p><strong>Background: </strong>The chick chorioallantoic membrane (CAM) tumor model has garnered significant interest due to its robust applications in research. However, there is a lack of understanding regarding the characteristics of nodules at different developmental stages and their corresponding imaging features. This study aimed to establish correlations between nodule attributes and magnetic resonance imaging (MRI) features via an <i>ex ovo</i> pancreatic cancer CAM model. Furthermore, this study explored the potential of functional MRI techniques in quantitatively discriminating pathological characteristics.</p><p><strong>Methods: </strong>A total of 50 chicken embryos were cultured <i>in ovo</i> through embryonic day (ED) 3, then transferred to a customized chamber for <i>ex ovo</i> culture and subsequent experiments. On ED7, cancer cell mixtures [pancreatic cancer cells mixed with Matrigel and Dulbecco's modified Eagle medium (DMEM)] were implanted on the CAM to establish the cancer model. At each observation time point (ED10, ED12, and ED14), eight models were randomly selected for multi-parametric MRI (mpMRI) via a 3.0 Tesla (T) magnetic resonance (MR) scanner and pathological examination. The remaining models were observed on ED16. Quantitative assessments including tumor nodule volume, apparent diffusion coefficient (ADC), and T1 values were further correlated with histopathological findings.</p><p><strong>Results: </strong>Among 50 embryos, 90% (45/50) underwent tumor implantation, with 68% (34/50) models completing mpMRI scanning and pathological examination (n=8 at each of the first three time points; n=10 at the last time point). MRI could clearly observe differences in tumor signals, except for the T1 mapping sequence. Nodule volumes were 60.40±12.18 mm³ on ED12, 87.44±17.45 mm³ on ED14, and 108.13±5.45 mm³ on ED16, showing significant progression (P<0.001 for all intergroup comparations). ADC values were (1.47±0.48)×10⁻³ mm²/s on ED12, (1.32±0.13)×10⁻³ mm²/s on ED14 (P=0.29 <i>vs.</i> ED12), and (0.96±0.07)×10⁻³ mm²/s on ED16 (P<0.05 <i>vs.</i> both earlier time points). T1 relaxation times were measured (1.64±0.31)×10³ ms on ED12, (1.73±0.16)×10³ ms on ED14, and (1.74±0.29)×10³ ms on ED16, with no significant variations (P=0.69 for all intergroup comparisons). Pathological examination confirmed viable tumor cells in all specimens, demonstrating ring-like tumor tissue by ED12 that progressively replaced the Matrigel over subsequent time points.</p><p><strong>Conclusions: </strong>The <i>ex ovo</i> CAM serves as a reliable and reproducible experimental platform. Conventional 3.0 T MRI provides high-resolution morphological assessment of tumor dynamics, whereas functional imaging techniques offer promising capabilities for quantifying inter-nodular heterogeneity.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"7977-7988"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of left atrial reservoir strain on right ventricular dysfunction in left-sided heart failure.","authors":"Guangyuan Li, Yonghuai Wang, Chunyan Ma","doi":"10.21037/qims-2024-2832","DOIUrl":"10.21037/qims-2024-2832","url":null,"abstract":"<p><p>This study examined the potential of left atrial (LA) reservoir strain to be an independent determinant of right ventricular (RV) dysfunction (RVD) in the context of left-sided heart failure (HF). We recruited 301 patients with HF (age 61.1±10.7 years; 71.1% male) from The First Hospital of China Medical University between 2021 and 2023, comprising a representative sample of both reduced (47.8%) and preserved ejection fraction (EF) (52.2%) phenotypes. Each participant underwent comprehensive transthoracic echocardiography. Conventional echocardiography measured left ventricular (LV) EF and pulmonary artery systolic pressure (PASP), and two-dimensional speckle tracking echocardiography was applied to quantify LV global longitudinal strain (LVGLS), LA reservoir strain, and RV free wall strain. The cohort demonstrated a 48.5% prevalence of RVD (defined as RV free wall strain < |20%|). RVD was associated with higher body surface area [odds ratio (OR) 12.01] and PASP (OR 1.02), lower LVEF (OR 0.92), LVGLS (OR 1.35), and LA reservoir strain (OR 0.82) (all P values <0.05). Critically, LA reservoir strain (OR 0.83; P<0.001) remained independently associated with RVD even after adjustments were made for age, sex, body surface area, atrial fibrillation, diabetes, hypertension, coronary artery disease, LVEF, LVGLS, and PASP. Thus, in left-sided HF, LA reservoir strain independently predicts RVD irrespective of LVEF or PASP, highlighting the critical role of LA function in RVD.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8641-8647"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of giant diverticulum at the apex of the left ventricle.","authors":"Zhourui Liu, Dandan Song, Jun Yang, Lina Zhao, Sha Li","doi":"10.21037/qims-2024-2550","DOIUrl":"10.21037/qims-2024-2550","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 9","pages":"8663-8667"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}