Quantitative Imaging in Medicine and Surgery最新文献

{"title":"MRI slow diffusion coefficient (SDC) shows liver pyogenic abscess has faster diffusion than adjacent liver parenchyma.","authors":"Gong-Hao Ling, Yì Xiáng J Wáng","doi":"10.21037/qims-2025-1010","DOIUrl":"10.21037/qims-2025-1010","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6547-6551"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superiority of black-blood computed tomography over conventional computed tomography angiography in the identification of soft plaques: a prospective study.","authors":"Tao Zhou, Ying Li, Nannan Sun, Bing Hua, Min Zhang, Zhuangfei Ma, Min Li, Shouqiang Jia","doi":"10.21037/qims-2024-2989","DOIUrl":"10.21037/qims-2024-2989","url":null,"abstract":"<p><strong>Background: </strong>Carotid computed tomography angiography (CTA) has limited diagnostic value in evaluating the vulnerability of soft plaques. This study compared conventional CTA and black-blood computed tomography (BBCT) in terms of image quality and the ability to diagnose carotid soft plaques.</p><p><strong>Methods: </strong>Patients who underwent carotid CTA and magnetic resonance (MR) vessel wall examination were included in this prospective study. The image quality of plaques was evaluated through objective evaluation [CT values, image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) based on CTA and BBCT] and subjective evaluation. Plaque burden was assessed with the normalized wall index (NWI) in CTA, BBCT, and MR images, as was the remodeling index (RI). The number of soft plaques in CTA, BBCT, and MR images was recorded. The sensitivity, specificity, and accuracy of an NWI higher than 0.56 and an RI higher than 1.0 from CTA and BBCT images in assessing the vulnerability of soft plaques were calculated with MR vessel wall images as a reference standard.</p><p><strong>Results: </strong>A total of 37 patients comprising 53 soft plaques (25 males and 12 females) were analyzed. The average CT values, SNR, and CNR of soft plaques in BBCT were significantly higher compared to those in CTA (BBCT: 65.38±21.34, 16.31±7.69, 6.47±4.97; CTA: 45.58±14.09, 7.16±3.15, 4.45±2.83; all P values <0.05). The image noise in BBCT was significantly lower than that in CTA (BBCT: 10.73±3.75; CTA: 15.52±6.59; P<0.05), while the subjective image score of BBCT (3.04±0.51) was significantly higher than that of CTA (2.32±0.61) (P<0.001). The sensitivity and specificity of an NWI higher than 0.56 with BBCT were 0.98 and 0.86, respectively, which were superior to those with CTA at 0.83 and 0.57, respectively. Meanwhile, the sensitivity and specificity of an RI higher than 1.0 with BBCT were 0.86 and 0.95, respectively, which were superior to those with CTA at 0.71 and 0.85, respectively. The sensitivity and specificity of BBCT in diagnosing vulnerable plaques were 0.90 and 0.93, respectively, while those of CTA were 0.62 and 0.79, respectively. The area under the receiver operating characteristic curve of BBCT for diagnosing vulnerable plaques was 0.91 (95% CI: 0.803-0.973) while that for CTA was 0.70 (95% CI: 0.559-0.819; P<0.001).</p><p><strong>Conclusions: </strong>Compared to conventional CTA, BBCT provides improved image quality and diagnostic performance in assessing carotid soft plaques.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6287-6300"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of magnetic resonance imaging glymphatic function with gray matter volume loss and cognitive impairment in Alzheimer's disease: a diffusion tensor image analysis along the perivascular space (DTI-ALPS) study.","authors":"Qian Zhang, Chao-Gang Wei, Chong Cui, Ting Huang, Shan-Wen Liu, Meng Li, Yu-Qi Zhi, Xiao-Yun Liang, Hua Hu, Zhen Jiang, Jiang-Tao Zhu, Rong Liu","doi":"10.21037/qims-2025-96","DOIUrl":"10.21037/qims-2025-96","url":null,"abstract":"<p><strong>Background: </strong>Diffusion tensor image analysis along the perivascular space (DTI-ALPS) has been used for diagnosing Alzheimer's disease (AD); however, few studies have examined the relationship between the DTI-ALPS index and cortical metrics, and the differentiation between AD severity levels remains unclear. This study aimed to explore the differences in DTI-ALPS index and cortex among AD patients with varying severities and to analyze the interactions between DTI-ALPS index, cortical metrics, and cognitive function.</p><p><strong>Methods: </strong>A total of 19 individuals with mild cognitive impairment (MCI), 17 individuals exhibiting mild AD, 25 individuals with moderate AD, and 28 healthy controls (HC) who were matched for age, sex, and education level were recruited. All the participants underwent diffusion tensor imaging (DTI) magnetic resonance imaging (MRI), followed by the calculation of the DTI-ALPS index to assess lymphatic system function. FreeSurfer (v7.4.1) was used to calculate thickness, volume, local gyre index, and area. One-way analysis of variance (ANOVA) was performed to compare the differences among HC, MCI, mild AD, and moderate AD groups. Pearson correlation analysis was employed to investigate the connection between the DTI-ALPS index and cognitive function, along with cortical metrics.</p><p><strong>Results: </strong>The HC, MCI, mild AD, and moderate AD groups exhibited significant differences in the DTI-ALPS index of the left hemisphere (P=0.008), whereas 13 cortical metrics revealed a statistical significance between groups (P<0.05). In the left hemisphere, the DTI-ALPS index showed a positive trend with the Montreal Cognitive Assessment (MoCA) score (r=0.397, P<0.001). Higher DTI-ALPS was also associated with an increase in 10 cortical metrics after controlling for age, sex, and education.</p><p><strong>Conclusions: </strong>There is a significant relationship between the DTI-ALPS index, cortical metrics, and cognitive function. This result may suggest that lymphatic dysfunction indicated by the DTI-ALPS index could mirror cortical structural degeneration and cognitive decline within the pathological process of AD. DTI-ALPS can be used as an indicator of structural degeneration and decline in cognitive function in AD.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6160-6174"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of ultrasound-guided percutaneous aspiration-sclerotherapy with anhydrous ethanol for adult simple renal cyst: a multicenter, prospective, randomized controlled trial.","authors":"Shu Luo, Ping Feng, Yongzhong Li, Shuhua Shi, Lichuan Yang, Yanrong Yang, Rongchen Wang, Xuelian Chen, Jiaojiao Zhou","doi":"10.21037/qims-24-2160","DOIUrl":"10.21037/qims-24-2160","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous aspiration-sclerotherapy (PAS) is one of the most common treatments for renal cysts. In this study, we conducted an unequal-group, superior, randomized controlled trial to evaluate the safety and efficacy of ultrasound-guided PAS with anhydrous ethanol involving single-session multiple injections for simple renal cysts (SRCs) in adults by comparing percutaneous aspiration therapy with or without sclerosis agents.</p><p><strong>Methods: </strong>We prospectively collected data from multiple healthcare organizations in China on 149 patients with SRCs from August 2017 to October 2018. The patients enrolled in the study underwent percutaneous aspiration therapy with (treatment group, n=120) or without (control group, n=29) anhydrous ethanol. Treatment success was defined as a reduction in renal cyst volume of 87.5% or more from pre-treatment volume after 24 weeks of treatment. All patients were followed up at weeks 12 and 24. The patient profiles, reduced volume of cysts, treatment success rates, recurrence rates, and complication rates of two groups were compared.</p><p><strong>Results: </strong>In this trial, the analysis of Full Analysis Set (FAS) revealed an average volume reduction of 93.4 mL in the treatment group (PAS with anhydrous ethanol) and 69.8 mL in the control group (percutaneous aspiration treatment) (P<0.01). At the 24-week follow-up, the treatment success rate of the treatment group was significantly higher than that of the control group (90.43% <i>vs</i>. 13.79%; P<0.001).</p><p><strong>Conclusions: </strong>PAS with anhydrous ethanol combined with single-session multiple injections is a safe and effective treatment for SRCs.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry identifier: ChiCTR-TRC-10001114.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6436-6445"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of multiparametric MRI and clinical indicators for renal fibrosis in chronic kidney disease.","authors":"Chaogang Wei, Rong Liu, Xiaojing Li, Chunshan Zhou, Qing Ma, Yilin Xu, Ye Zhu, Junkang Shen, Ying Zeng, Kai Song, Zhen Jiang","doi":"10.21037/qims-2024-2532","DOIUrl":"10.21037/qims-2024-2532","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major global health challenge, while renal fibrosis (RF) is the key pathological process and represents irreversible kidney damage. There is an urgent need for non-invasive techniques for assessment of RF. This study aimed to assess the diagnostic value of integrating native T₁ mapping, readout segmentation of long variable echo-trains-diffusion-weighted imaging (RESOLVE-DWI), and T₂* mapping imaging with clinical indicators in detecting RF caused by CKD.</p><p><strong>Methods: </strong>A prospective analysis was conducted on 117 patients with a clinical diagnosis of CKD who were scheduled for renal biopsy and underwent multiparametric magnetic resonance imaging (MRI) (native T₁ mapping, RESOLVE-DWI, and T₂* mapping) examinations from September 2021 to December 2023. Patients were divided into RF 1 (no fibrosis; n=23), RF 2 (mild RF, ≤25% fibrosis; n=54), and RF 3 (moderate to severe RF, >25% fibrosis; n=40). Univariate and multivariate logistic regression analyses were used to identify independent predictors for the presence of RF (RF 1 <i>vs</i>. RF 2 + RF 3) and the severity of RF (RF 2 <i>vs</i>. RF 3). Then, combined models were constructed. Receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic performance of the models. Areas under the curves (AUCs) were compared using DeLong's test.</p><p><strong>Results: </strong>The independent predictors for the presence of RF were the estimated glomerular filtration rate (eGFR), mean corticomedullary T₁ ratio (T₁%), and mean corticomedullary apparent diffusion coefficient (ADC) ratio (ADC%). The independent predictors for the severity of RF were the eGFR and mean corticomedullary T₁ difference (ΔT₁). The AUC of the combined model-1 (eGFR + T₁% + ADC%) was 0.919, which was significantly greater than that of the eGFR (AUC =0.828, P=0.008) and ADC% (AUC =0.801, P=0.009), but not significantly different from that of T₁% (AUC =0.879, P=0.087). The diagnostic sensitivity of the combined model-1 for identifying RF increased to 90.4% and the specificity was 87.0%. The AUC of the combined model-2 (eGFR + ΔT₁) was 0.887, which was significantly greater compared with the eGFR (AUC =0.808, P=0.019) and ΔT₁ (AUC =0.834, P=0.032) models. When the eGFR was combined with ΔT₁, the sensitivity of the combined model-2 to discriminate mild RF from moderate to severe RF increased to 92.5%, with a specificity of 77.8%.</p><p><strong>Conclusions: </strong>Native T₁ mapping and RESOLVE-DWI in combination with the eGFR can improve the diagnostic sensitivity of CKD-related RF, thus contributing to the early detection of RF and clinical decision-making.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6200-6216"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Larger nail-shaft gap as a potential risk factor of femoral head varus in patients treated with proximal femoral nail antirotation fixation: a retrospective, observational, single-center study with corresponding numerical simulation.","authors":"Xiang Zhang, Guoqing Tang, Ji Chen, Xinghua Jiang, Jingchi Li","doi":"10.21037/qims-2024-2988","DOIUrl":"10.21037/qims-2024-2988","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Deterioration of postoperative local biomechanical environment is a primary contributor to varus deformity of the femoral head in patients with intertrochanteric fractures treated with proximal femoral nail antirotation (PFNA) fixation. Theoretically, increasing the number of threaded anchors can optimize the local biomechanical environment and enhance the fixation stability. According to this principle, a larger gap between the intramedullary nail and the surrounding femoral shaft at the distal locking screw may compromise fixation stability by reducing the number of thread anchorages. However, whether this issue can lead to a higher incidence of biomechanical varus deformity of the femoral head remains to be determined. The main objective of this study was to investigate the clinical and biomechanical effect of nail-shaft gap on the incidence of femoral head varus in PFNA-treated patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study conducted a comprehensive investigation that included both a retrospective clinical analysis and numerical biomechanical simulations. In the retrospective component, data from patients with PFNA-fixed intertrochanteric fracture were collected. The nail-shaft gap was measured in the distal locking screw location. The varus alignment of the femoral head was evaluated based on measurements of the neck-trunk angle, which were obtained from anterior-posterior radiographs taken immediately postoperatively and at 6 months postoperatively. Additionally, patient demographics-including age, sex, body mass index, bone density (represented by T-score), and fracture types (stable or unstable)-were recorded. Regression analysis was performed to identify the effect of changes in gap size on femoral head varus. Furthermore, biomechanical alterations resulting from variations in nail-shaft gap size were investigated to elucidate the mechanisms underlying clinically observed phenomena.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A larger nail-shaft gap was not significantly correlated with the progression of femoral head varus (correlation coefficient =0.169; P=0.145), nor was it identified as an independent risk factor for this complication (P=0.145). In contrast, a lower T-score (correlation coefficient =-0.269; P=0.019) and unstable fracture type (correlation coefficient =0.26; P=0.023) were significantly correlated with femoral head varus. Moreover, the results of the multivariable regression analysis indicated that a lower T-score (P=0.005) and unstable fracture (P=0.034) were determined to be independent risk factors for this complication. Furthermore, while displacement values of the femoral head increased under both physiological and compressive loads with larger gap sizes, stress values in both the femoral head and antirotation blade remained comparable across different models.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;A larger nail-shaft gap does not lead to more severe varus deformity of the femoral head from ","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6032-6043"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of the multiparameter combination diagnostic model based on 2-[¹⁸F]FDG PET/CT metabolic parameters and clinical variables in distinguishing non-metastatic cholangiocarcinoma from cholangitis.","authors":"Jingfeng Zhang, Jianbo Cui, Yun Han, Can Li, Yue Pan, Jiajin Liu, Xiaodan Xu, Yabing Sun, Guanyun Wang, Baixuan Xu","doi":"10.21037/qims-24-1626","DOIUrl":"10.21037/qims-24-1626","url":null,"abstract":"<p><strong>Background: </strong>The clinical value of 2-[¹⁸F]fluoro-D-glucose {2-[¹⁸F]FDG} positron emission tomography (PET)/computed tomography (CT) has been demonstrated in the staging, evaluation of treatment response, and prediction of prognosis across various anatomical subtypes of cholangiocarcinoma (CCA). However, the same uptake of FDG in inflammatory diseases of the biliary tract may lead to misdiagnosis and unnecessary treatment. This study explored the 2-[¹⁸F]FDG PET/CT metabolic parameters in the differential diagnosis of different anatomical subtypes of non-metastatic CCA [including intrahepatic CAA (iCAA) and extrahepatic CCA (eCCA)] with those of the corresponding pathological location cholangitis.</p><p><strong>Methods: </strong>A total of 181 patients [137 patients with non-metastatic CCA (iCCA n=48, eCCA n=89) and 44 patients with cholangitis (intrahepatic n=15, extrahepatic n=29)] who underwent 2-[¹⁸F]FDG PET/CT were included. The baseline characteristics, clinical variables, and 2-[¹⁸F]FDG PET/CT metabolic parameters were collected. The discriminatory performance of both single biomarkers and the multi-parameter composite model was evaluated through receiver operating characteristic (ROC) curve analysis. The incremental diagnostic value achieved by combining multiple parameters was quantitatively measured using two established metrics: integrated discrimination improvement (IDI) and net reclassification improvement (NRI).</p><p><strong>Results: </strong>The ROC curve analysis demonstrated that peak standardized uptake value (SUVpeak) [area under the ROC curve (AUC) =0.740, sensitivity =0.625, specificity =0.867] and metabolic tumor volume (MTV =0.669, sensitivity =0.655, specificity =0.663) had the highest differential diagnostic ability among 2-[¹⁸F]FDG PET/CT metabolic parameters in non-metastatic iCCA and intrahepatic cholangitis and non-metastatic eCCA and extrahepatic cholangitis, respectively. For the combined diagnostics model (intrahepatic) of cholecystolithiasis, carbohydrate antigen 19-9 (CA19-9) >37 ng/mL and SUVpeak showed an AUC of 0.853 (sensitivity =0.833, specificity =0.800); for the combined diagnostics model (extrahepatic) of cholecystolithiasis, fever, CA19-9 >37 ng/mL and MTV showed AUC of 0.863 (sensitivity =0.884, specificity =0.724). Through IDI and NRI, the diagnostic efficiency of the model was shown to be significantly improved compared to individual 2-[¹⁸F]FDG PET/CT metabolic parameters.</p><p><strong>Conclusions: </strong>The 2-[¹⁸F]FDG PET/CT metabolic parameters and combined diagnostics models can help to distinguish between non-metastatic iCCA and intrahepatic cholangitis, and non-metastatic eCCA and extrahepatic cholangitis, respectively.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6147-6159"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transarterial chemoembolization for inoperable primary cardiac angiosarcoma: a description of two cases and literature analysis.","authors":"Qiaoqi Li, Juan Wu, Hanjun Mo, Cheng Yi, Xiaoqiang Tang, Biao Yang","doi":"10.21037/qims-24-2458","DOIUrl":"10.21037/qims-24-2458","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6578-6583"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided percutaneous transhepatic duct drainage for decompression in management of afferent loop obstruction caused by anastomotic ulcer following pancreaticoduodenectomy: a case description.","authors":"Yi Mao, Li Chen, Zhi-Xing Liu","doi":"10.21037/qims-24-2381","DOIUrl":"10.21037/qims-24-2381","url":null,"abstract":"","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6552-6558"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered coupling of cerebral blood perfusion and neuronal activity in children with MRI-negative drug refractory epilepsy.","authors":"Haifeng Ran, Kexin Huang, Yuxin Xie, Yulun He, Guiqin Chen, Qiane Yu, Xuhong Li, Jie Hu, Tijiang Zhang","doi":"10.21037/qims-2024-2756","DOIUrl":"10.21037/qims-2024-2756","url":null,"abstract":"<p><strong>Background: </strong>Drug refractory focal epilepsy (DRFE) often gives rise to structural and functional damage in the brain accompanied by neuronal activity and cerebral vascular hemodynamics changes, which may result in neurovascular decoupling. However, neuroimaging evidence on neurovascular decoupling remains scarce. This study aimed to assess the manifestation of neurovascular coupling (NVC) in childhood DRFE using resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labeling imaging (ASL).</p><p><strong>Methods: </strong>The rs-fMRI and ASL imaging data were obtained from 24 children with DRFE and 35 healthy controls (HC). Based on the collected data, degree centrality (DC) and cerebral blood flow (CBF) were calculated respectively. Across voxel CBF-DC correlations were calculated to evaluate the NVC within whole gray matter (GM), and NVC of brain region was assessed by the CBF/DC ratio, the whole-brain GM across voxel CBF-DC correlations and CBF/DC ratio of the 2 groups were compared. We further analyzed the relationships between the changed CBF, DC and CBF/DC ratio values and cognitive performance, clinical variables. Finally, we explored the value of machine learning methods for classifying DRFE and HC.</p><p><strong>Results: </strong>Compared with the HC group, the DRFE children showed higher across voxel CBF-DC correlations. Increased CBF/DC ratio located in the orbital part of the superior frontal gyrus, superior parietal lobule, and lower in the left inferior temporal gyrus and precuneus in the DRFE group. The brain regions of abnormal CBF, DC, and CBF/DC ratio were predominantly in regions in the default mode network, and the executive control network, and the abnormally CBF, DC values in some brain regions were significantly correlated to cognitive function. The classification model using CBF/DC ratio as features achieved the 72.8% accuracy, 0.764 area under the curve (AUC), 68.5% sensitivity and 87.5% specificity. The classification accuracy was higher than the model with other feature type (CBF: 67.8% accuracy; DC: 66.1% accuracy).</p><p><strong>Conclusions: </strong>The study reveals the cerebral blood perfusion, neuronal activity, global and regional NVC alteration in children with magnetic resonance imaging (MRI)-negative DRFE non-invasively, associated with lower cognitive performance. These findings indicate that NVC-based study can better integrate information of neuronal activity and cerebral hemodynamics, offering a new insight into the neuropathological mechanisms of DRFE and providing potential imaging biomarkers, and neurovascular decoupling may help clinical classification for childhood DRFE.</p>","PeriodicalId":54267,"journal":{"name":"Quantitative Imaging in Medicine and Surgery","volume":"15 7","pages":"6501-6516"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}