Practical Radiation Oncology最新文献

{"title":"Association of Patient Comorbidities with Treatment Regret Among Patients with Localized Prostate Cancer - Results from a Population-Based Cohort.","authors":"Rahul D Mali, Ying Cao, Aaron J Katz, Katelyn Kane, Yahui Xie, Deborah S Usinger, Xinglei Shen, Ronald C Chen","doi":"10.1016/j.prro.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.prro.2025.07.007","url":null,"abstract":"<p><strong>Objectives: </strong>Decision regret is a well-established, negative outcome in prostate cancer. We hypothesized that baseline comorbidities, which impact treatment tolerability, are associated with regret.</p><p><strong>Materials and methods: </strong>In a prospective, population-based cohort of prostate cancer patients, patient-reported regret was assessed at 12 months after treatment using a validated measure. Comorbidities were assessed using medical record abstraction and scored using the validated NCI Comorbidity Index. Multivariable logistic regression assessed the association between comorbidity score with regret, accounting for treatment-related symptoms, treatment received, and sociodemographic measures.</p><p><strong>Results: </strong>This is a diverse cohort with 25.3% Black and 24.2% living in rural areas. A total of 108 out of 981 patients (11%) reported regret. On multivariable analysis, comorbidity burden (OR 1.58, p<.05), not married (OR 1.72, p=.04), worsening of bowel symptoms (OR 2.12, p<.01) and worsening of urinary obstruction/irritation (OR 1.60, p=.05) were associated with decision regret. In addition, radiation therapy was associated with less regret compared to radical prostatectomy (OR 0.48, p=.015).</p><p><strong>Conclusion: </strong>Among men with localized prostate cancer, baseline comorbidity burden is associated with increased decision regret. These results illustrate the importance of assessing baseline comorbidities and incorporation of its consideration in the treatment decision-making process, to ensure that patients have realistic expectations and make an informed decision.</p>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Malouff et al.","authors":"Dimitri Alex Dimitroyannis PhD, MBA","doi":"10.1016/j.prro.2025.01.018","DOIUrl":"10.1016/j.prro.2025.01.018","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Page 520"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Dimitroyannis","authors":"Timothy D. Malouff MD ,&nbsp;Mark Newpower PhD ,&nbsp;Aaron Bush MD ,&nbsp;Danushka Seneviratne MD, PhD ,&nbsp;Daniel K. Ebner MD, MPH","doi":"10.1016/j.prro.2025.03.003","DOIUrl":"10.1016/j.prro.2025.03.003","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 521-522"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Recall Dermatitis Following Capivasertib Administration","authors":"Yuhao Shi MD, PhD ,&nbsp;Ian W. Tattersall MD, PhD ,&nbsp;Boris Kobrinsky MD ,&nbsp;Alexandra Flamm MD ,&nbsp;Benjamin T. Cooper MD","doi":"10.1016/j.prro.2025.04.004","DOIUrl":"10.1016/j.prro.2025.04.004","url":null,"abstract":"<div><div>Radiation recall dermatitis is a known but rare adverse effect that is characterized by the development of dermatitis in the region of prior irradiated tissue triggered by exposure to a systemic agent. Capivasertib is a small-molecule inhibitor targeting the phosphatidylinositol 3-kinase/protein kinase B pathway recently approved in locally advanced and metastatic breast cancer; however, the safety of its use in the setting of palliative radiation is currently unclear. Here, we report a case of radiation recall dermatitis in a patient with metastatic breast cancer on capivasertib with history of radiation to the right lower extremity managed with corticosteroids, antibiotics, and switching to alpelisib.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages e397-e403"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Patient Priorities for Religious and Spiritual Needs During Radiation Therapy for Gynecological Malignancies","authors":"Lauren M. Jacobs MD ,&nbsp;Jason Gurewitz DO ,&nbsp;Joshua Hurwitz MD ,&nbsp;Aishwarya Shah MD ,&nbsp;Karyn A. Goodman MD, MS ,&nbsp;Stella Lymberis MD","doi":"10.1016/j.prro.2025.03.012","DOIUrl":"10.1016/j.prro.2025.03.012","url":null,"abstract":"<div><h3>Purpose</h3><div>Addressing religion and spirituality (R/S) in the patient care setting has shown associations with health care outcomes and quality of life. Patients with gynecologic malignancies demonstrate increased distress and fear following treatment. The <em>F</em>aith or belief, <em>I</em>mportance and <em>I</em>nfluence of spirituality, spiritual <em>C</em>ommunity; and interventions to <em>A</em>ddress spiritual needs (<em>FICA</em>) Spiritual History Tool outlines 4 domains of assessment. Using the FICA Spiritual History Tool, we sought to evaluate the importance of R/S for patients with gynecologic cancer who had undergone external beam radiation therapy or brachytherapy and assess the most meaningful questions from the FICA Spiritual History Tool that best facilitate conversation.</div></div><div><h3>Methods and Materials</h3><div>Eleven patients with gynecologic malignancy treated with external beam radiation therapy and/or brachytherapy were interviewed with the FICA Spiritual History Tool to assess each question as helpful or unhelpful, and to select 1 or 2 questions they perceived to best open the conversation with providers.</div></div><div><h3>Results</h3><div>Average age was 59 years old (range, 37-74). Religious identities included Christian denominations, Buddhist, Jewish, Muslim, and Hindu. Nine of 11 patients (82%) rated the importance of their faith as 5/5. On average, 9.5 of 11 questions (range, 7-11) were thought to be helpful if asked. All patients reported the same 6 questions as helpful, ranging across all domains. The two most common questions identified to best facilitate conversation were related to alleviating stress: “<em>Do you have spiritual beliefs that help you cope with stress?</em>” and “<em>Have your beliefs influenced you in how you handle stress</em>?”</div></div><div><h3>Conclusions</h3><div>Among gynecological cancer patients who underwent radiation therapy, conversations regarding R/S are highly coveted across a spectrum of demographics and ethnic identities. How R/S helps patients cope with stress was identified as the most meaningful question to open this conversation with providers. Furthermore, engaging patients on their R/S invites further conversation and understanding regarding stress, coping, and anxiety surrounding treatment, findings that should be explored in larger cohorts.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 509-519"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROshot: Stereotactic Body Radiation Therapy for Painful Bone Metastases, Hypofractionated Sarcoma Radiation, Breast Cancer Brain Metastases, and Elective Nodal Irradiation for Prostate Cancer Nodal Recurrences","authors":"Caleb Dulaney MD ,&nbsp;Laura Dover MD, MSPH","doi":"10.1016/j.prro.2025.06.002","DOIUrl":"10.1016/j.prro.2025.06.002","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 416-419"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Radiation Oncology Match in 2025: A New Steady-State?","authors":"James E. Bates MD ,&nbsp;Robert J. Amdur MD ,&nbsp;W. Robert Lee MD, MS, MEd","doi":"10.1016/j.prro.2025.04.005","DOIUrl":"10.1016/j.prro.2025.04.005","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 425-427"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masthead/Sub page","authors":"","doi":"10.1016/S1879-8500(25)00177-8","DOIUrl":"10.1016/S1879-8500(25)00177-8","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Page A1"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“All Men Are Mortal”—A Lesson in Living","authors":"Michael Oertel MD ,&nbsp;Hans Theodor Eich MD ,&nbsp;Oliver Micke MD","doi":"10.1016/j.prro.2025.01.019","DOIUrl":"10.1016/j.prro.2025.01.019","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 423-424"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Radiation Therapy Challenges in Breast Cancer: A Rare Case of Hepatodiaphragmatic Intestinal Interposition","authors":"Richard L. Huang MD ,&nbsp;Biral S. Amin MD ,&nbsp;Aaron D. Bleznak MD, MBA ,&nbsp;Angela M. DeRidder MD, MPH ,&nbsp;E. Ronald Hale MD, MPH ,&nbsp;Benjamin J. Pettus MD, PhD ,&nbsp;Leonid B. Reshko MD","doi":"10.1016/j.prro.2025.03.016","DOIUrl":"10.1016/j.prro.2025.03.016","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 5","pages":"Pages 413-415"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}