Antibiotiki i Khimioterapiya最新文献_第7页

[Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc]. [寡霉素与锂、锌配合物对肿瘤细胞多重耐药抑制活性的影响]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

M V Bibikova, A N Danilenko, A V Katlinsky, A F Korystova, L N Kublik, M Kh Levitman, V V Shaposhnikova, Yu N Korystov

引用次数: 0

[Antitumor Activity of Polysaccharides from Ganoderma lucidum Mycelium: in vivo Comparative Study]. [灵芝菌丝体多糖抗肿瘤活性的体内比较研究]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

L M Krasnopolskaya, M S Yarina, A V Avtonomova, A I Usov, E B Isakova, V M Bukchman

引用次数: 0

[Optimization of Antibiotic Prophylaxis in Minor Gynecologic Operations]. [妇科小手术抗生素预防优化]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

M S Selikhova, S V Vdovin, M V Mikhailovskaya

引用次数: 0

[Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis]. [荟萃分析方法评价输注含琥珀酸利马索治疗多种病因肝脏病变的临床疗效]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

N K Mazina, P V Mazin

{"title":"[Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis].","authors":"N K Mazina, P V Mazin","doi":"","DOIUrl":"","url":null,"abstract":"Metaanalysis was applied to the published data on the randomized clinical trials of Remaxol in the treatment of various diseases associated with the liver injury: chronic hepatitis B and C, severe ethanol intoxication, drug-induced pathologies due to tuberculosis chemotherapy, leptospirosis, psoriasis, tumor polychemotherapy. The database included information on 2250 patients. The total number of the patients of the control group (n = 1099) were treated according to the routine schemes (active placebo) and that of the main group (n = 1151) were additionally treated with Remaxol. Combination of the frequency characteristics of the positive outcomes (% of elimination of the main clinical symptoms and complications) in the patients of the reference groups allowed to estimate the general clinical efficacy of Remaxol, that was equal to 1.75 by the outcome frequency characteristics. The odds ratio of the positive outcomes equaled 5.3 [1.8; 17.0] and the number of the patients needed to treat (NPNT) equaled 8 [6; 14]. Therefore, the infusion Remaxol hepatoprotector based on succinic acid was shown to have statistically and clinically significant therapeutic efficacy in pharmacologic correction of the liver pathologies of diverse genesis.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":"60 11-12","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34367846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Determination of Microbial Susceptibility to Sulfanilamides by Electrooptic Analysis]. 电光分析法测定微生物对磺胺类药物的敏感性

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

O I Guliy, V D Bunin, O S Larionova, E G Potemkina, O V Ignatov

{"title":"[Determination of Microbial Susceptibility to Sulfanilamides by Electrooptic Analysis].","authors":"O I Guliy, V D Bunin, O S Larionova, E G Potemkina, O V Ignatov","doi":"","DOIUrl":"","url":null,"abstract":"The effect of sulfanilamides (soluble streptocid as an example) on changing of the electrophysical properties (EP) of microbial cells of Escherichia coli XL-1, BL-Ril, Pseudomonasputida C-11 and BA-11 was studied. It was shown that significant changes in the orientation spectra (OS) of the cell suspensions incubated at various concentrations of the sulfanilamide resulted in changing of the electrooptic (EO) signal of the cell suspension at the first five frequencies of the orientation electric field (10-1000 Hz) with the use of soluble streptocid in a concentration of 0.3 mcg/ml. The dynamics of the drug effect on the microbial cells demonstrated a decrease of the EO signal value 5 minutes after the exposure by -59% vs. the control (the cells not exposed to the drug). During the following exposure the EO signal value practically did not change (within 5%). The changes of the OS of the cell suspensions exposed to soluble streptocid significantly differed for the susceptible and resistant strains. Determination of the activity of sulfanilamides by electrooptic analysis of microbial cell suspensions was considered possible. Changing of the microbial suspencion OS under the effect of sulfanilamides can be used as a test on the microbial cell susceptibility to drugs.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":"60 3-4","pages":"14-9"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34043127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Irumamicin Produced by Streptomyces roseoflavus INA-1278]. [玫瑰黄链霉菌INA-1278产Irumamicin]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

O A Lapchinskaya, G S Katrukha, L P Terekhova, E G Gladkikh, V V Kulyaeva, V V Pogozheva, G I Orlova, A S Trenin, G B Fedorova

引用次数: 0

[Discovery of Genetic Markers of Resistance to β-Lactams in Gramnegative Microorganisms by PCR Diagnosis]. PCR诊断革兰氏阴性微生物β-内酰胺耐药遗传标记的发现

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

E S Lisitsina, T V Chernenkaya, E N Ilyina, I V Lazareva, V A Ageevets, S V Sidorenko

{"title":"[Discovery of Genetic Markers of Resistance to β-Lactams in Gramnegative Microorganisms by PCR Diagnosis].","authors":"E S Lisitsina, T V Chernenkaya, E N Ilyina, I V Lazareva, V A Ageevets, S V Sidorenko","doi":"","DOIUrl":"","url":null,"abstract":"Fifteen specimens of the hemoculture and 89 specimens of the broncho-alveolar lavage were used in the study. Monocultures of gramnegative bacteria resistant to cefotaxime, cefepime, imipenem and meropenem were isolated from the specimens. The PCR method with detection of the results in the real time regimen (PCR test-system Litekh) provided detection of the beta-lactamase genes: bla(CTX-M-like) (72/104, 69.2%), bla(NDM) (6/104, 5.8%), bla(VIM) (49/104, 47.1%) and bla(OXA48-like) (59/104, 56.7%). There was identified correlation between the phenotype of resistance of Acinetobacter spp., Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli to cefotaxime and carbopenems and detection of the bla(CTX-M-like) and bla(NDM) genes. At the same time, up to 70% of the K. pneumoniae isolates from the biological specimes positive with respect to the presence of the carbapenase bla(VIM) and bla(OXA48-like) genes demonstrated their phenotypic susceptibility to carbopenems. The results of the study confirmed the prognostic value of the genetic diagnosis for improvement of the routine bacteriological investigations.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":"60 9-10","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34451741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Antimicrobial Activity of Substances Produced by Trichoderma citrinoviride Strain VKPM F-1228: Optimization of Cultivation and Assessment of Spectrum of Individual Peptaibols]. [柠檬酸木霉VKPM F-1228菌株的抑菌活性:培养优化及单个肽谱评价]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

V S Sadykova, A V Kurakov, V A Korshun, E A Rogozhin, T I Gromovykh, A E Kuvarina, A A Baranova

引用次数: 0

[Antibiotic Resistance of MRSA in the Russian Federation]. [MRSA在俄罗斯联邦的抗生素耐药性]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

V V Gostev, O S Kalinogorskaya, L N Popenko, T V Chernenkaya, Z S Naumenko, T M Voroshilova, Yu A Zakharova, O E Khokhlova, A N Kruglov, M G Ershova, I V Molchanova, S V Sidorenko

{"title":"[Antibiotic Resistance of MRSA in the Russian Federation].","authors":"V V Gostev, O S Kalinogorskaya, L N Popenko, T V Chernenkaya, Z S Naumenko, T M Voroshilova, Yu A Zakharova, O E Khokhlova, A N Kruglov, M G Ershova, I V Molchanova, S V Sidorenko","doi":"","DOIUrl":"","url":null,"abstract":"The results of the multicentre trial on estimation of MRSA antibiotic susceptibility to 17 antibiotics are presented. 474 nonrepeting isolates of MRSA (mecA+), collected in 2011-2014 in 10 cities of the Russian Federation were used in the trial. The antibiotic susceptibility was determined by the method of serial microdilutions in broth with estimation of the MICs in accordance with the international standards CLSI 2014 and EUCAST 2014. The highest levels of the MRSA resistance were stated against ciprofloxacin--92%(MIC50 32 mcg/ml), gentamicin--85% (MIC50 128 mcg/ml), erythromycin--54% (MIC50 32-mcg/ml) and clindainycin - 45% (MIC50 0.03 mcg/ml), as well as against rifampicin--38% (MIC50 0.06 mcg/ml). The frequency of MRSA isolated at the vancomycin dose of 2 mcg/ml equaled 26%. No correlation of the decrease in susceptibility to vancomycin and rifampicin was observed. In 5% of MRSA isolated from infected surgical wounds in patients with bone infection or sepsis, there was observed a decrease in the susceptibility to ceftarolin (MIC 2-4 mcg/ml). Co-trimoxasole, fusidic acid (MIC50 0.06 mcg/ml) and mupirocin (MIC50 0.5 mcg/ml) showed high antibacterial activity, 93-98% of the isolates being susceptible to the drugs. No resistance to linezolid and tigecycline was detected. By the associate resistance spectrum, most of the MRSA isolates were characterized by resistance to drugs of 3-7 groups (56%). The phenotypes with simultaneous resistance to drugs of 8-10 groups amounted to 6%. As a whole, 70 variants of associate resistance combinations were detected.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":"60 1-2","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34283242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data]. [PK/PD模型作为预测细菌对抗生素耐药性的工具:实验数据的替代分析]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

M V Golikova, E N Strukova, Y A Portnoy, A A Firsov

引用次数: 0