Journal of the Hong Kong College of Cardiology最新文献_第5页

ICSM 3rd Annual Scientific Meeting Plenary Lectures ICSM第三届年度科学会议全体演讲

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-28 DOI: 10.55503/2790-6744.1472

PLenAry LeCTureS, W. F. Graier

{"title":"ICSM 3rd Annual Scientific Meeting Plenary Lectures","authors":"PLenAry LeCTureS, W. F. Graier","doi":"10.55503/2790-6744.1472","DOIUrl":"https://doi.org/10.55503/2790-6744.1472","url":null,"abstract":"Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes mellitus. However, little is known on changes in smooth muscle contractility and the intracellular mechanisms contributing to such altered responsiveness in blood vessels from diabetic patients. Thus, smooth muscle reactivity to increased K + , norepinephrine (NE) and phenylephrine (PE) and acetylcholine-induced endothelium-dependent relaxation were assessed in uterine arteries from control individuals (CI) and diabetic patients (DM). Smooth muscle sensitivity to K + , NE and PE was enhanced by 1.4, 2.3-and 9.7-fold and relaxation was reduced by 64% in vessels from DM. In addition, in freshly isolated smooth muscle cells from DM an increased perinuclear Ca 2+ signaling to K + (30 mmol/l: +73%; 30 mmol/l: +68%) and NE (300 nmol/l +86%; 10  mol/l +67%) was found, which promotes smooth muscle contraction. In contrast, subplasmalemmal Ca 2+ response, which favors smooth muscle relaxation due to activation of Ca 2+ -activated K + channels, was reduced by 38% in DM, indicating a significant change in the subcellular Ca 2+ distribution in vascular smooth muscle cells during diabetes. In contrast to the altered Ca 2+ signaling found in freshly isolated cells from DM, in cultured smooth muscle cells isolated from CI and DM no further difference in the Ca 2+ signaling to stimulation with either K + or NE was found. Hence, production of superoxide anions (ïO 2) in intact and endothelium-denuded arteries from DM was increased by 150 and 136%, respectively. Incubation of freshly isolated smooth muscle cells from CI with","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41964750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Use of 18-lead Electrocardiogram in Diagnosing Right Ventricular and Posterior Wall Involvement in Patients with Acute Inferior Myocardial Infarction 18导联心电图在诊断急性下壁心肌梗死患者右室及后壁受累中的应用

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1464

C. Yue, Wai‐Kwong Chan

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ECG QUIZ 心电图测试

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1467

N. Mok, P. Tsui, Chee-Wo Wu

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3rd Annual Scientific Meeting Abstracts for Poster Presentation 第三届科学年会海报摘要

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1471

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Update on Antiarrhythmic Therapy: Dofetilide 抗心律失常治疗的最新进展:多非利特

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1466

Q. Wang, H. Tse, C. Lau

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Cardiovascular Disease Prevention: What Makes an InterventionWorthwhile? 心血管疾病预防:干预有何价值?

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1463

Cyrus R. Kumana, B. M. Cheung

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Electrophysiologic Mechanism of Conversion of Atrial Fibrillation to Sinus Rhythm 心房颤动向窦性心律转换的电生理机制

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1385

K. Moroe, Tadayuki Hiroki, K. Miyoshi, T. Wakiyama

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3rd Annual Scientific Meeting Abstracts for Oral Presentation 第三届科学年会口头报告摘要

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1470

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Role of Angiotensin II Subtype 1 Receptor in Smooth Muscle Cells Apoptosis after Balloon Injury to Vessel 血管紧张素II亚型1受体在血管球囊损伤后平滑肌细胞凋亡中的作用

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1465

Geng M. Wang, G. He, Xiao-hui Xu, GUO-CHAO Wang

{"title":"Role of Angiotensin II Subtype 1 Receptor in Smooth Muscle Cells Apoptosis after Balloon Injury to Vessel","authors":"Geng M. Wang, G. He, Xiao-hui Xu, GUO-CHAO Wang","doi":"10.55503/2790-6744.1465","DOIUrl":"https://doi.org/10.55503/2790-6744.1465","url":null,"abstract":"ET AL.: Role of Angiotensin II Subtype 1 Receptor in Smooth Muscle Cells Apoptosis after Balloon Injury to Vessel. In order to investigate the mechanism of smooth muscle cells apoptosis after balloon injury to vessel, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and immunohistochemistry were adopted to measure the percentage of vascular smooth muscle cell (VSMC) apoptosis and the expression of angiotensin II subtype 1 receptor (AT 1 R). Compared with sham's, the expression of AT 1 R protein in vascular media was significantly increased at 3 days after balloon injury (P<0.05), and then did not change significantly . At 7 days, it was approximately twice in intima as that in media. At 28 days it reached its peak. VSMCs apoptosis occurred in vascular media at 3 days after balloon injury and reached a peak in media and intima where apoptosis was mainly present at 7 days, then decreased. At 28 days after balloon injury, only a few apoptotic cells were in intima. AT 1 R antagonist (irbesartan) significantly increased VSMCs apoptosis. We thus conclude that AT 1 R is upregulated after balloon injury and angiotensin II inhibits VSMC apoptosis by binding to AT 1 R. (J HK Coll Cardiol 2000;8:49-57) Angiotensin II, receptor, vascular smooth muscle, apoptosis","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49560844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Drainage of Pericardial Effusions: Percutaneous or Surgical? 心包积液引流:经皮还是手术?

Journal of the Hong Kong College of Cardiology Pub Date : 2022-07-27 DOI: 10.55503/2790-6744.1389

Albert Wai-Suen Leung, N. Chan, L. Ho, WAI-CHO Yu

{"title":"Drainage of Pericardial Effusions: Percutaneous or Surgical?","authors":"Albert Wai-Suen Leung, N. Chan, L. Ho, WAI-CHO Yu","doi":"10.55503/2790-6744.1389","DOIUrl":"https://doi.org/10.55503/2790-6744.1389","url":null,"abstract":"LEUNG, ET AL : Drainage of Pericardial Effusions: Percutaneous or Surgical? Background: There are 2 modes of drainage of pericardial effusions: percutaneous pericardiocentesis (PP) and surgical pericardiotomy (SP). Certain features, which are indicative of cardiac tamponade, should guide us to the choice of drainage of pericardial effusions. It is unclear if this is followed in clinical practice. Objective: To review patients with pericardial drainage done for a period of 36 months, and to correlate the features with the choice of drainage mode. Results: 39 patients and 47 procedures (20 PP and 27 SP) were reviewed. Several clinical features were correlated with the use of PP: dyspnoea on exertion, dyspnoea at rest, orthopnoea, tachycardia, elevated jugular venous pressure and hypotension. Pulsus paradoxus was not adequately checked. Electrocardiographic and radiographic findings were similar between the 2 modes. 91% of the patients had large effusions by echocardiography. Right atrial collapse and right ventricular collapse occurred more frequently in the group of PP. Conclusion: Some features were more relied by us to indicate the presence of cardiac tamponade. Their presence should lead us more to the use of percutaneous drainage and they should be checked thoroughly. The decision to drain and the selection should be assessed after an integration of all these features. (J HK Coll Cardiol 1999;7:104-108)","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45928055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0