International Journal of Women''s Dermatology最新文献

{"title":"Exploring the historical stigma of spironolactone use in breast cancer survivors with alopecia.","authors":"Michael G Buontempo, Lina Alhanshali, Jerry Shapiro, Kristen Lo Sicco","doi":"10.1097/JW9.0000000000000083","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000083","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 2","pages":"e083"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain management and emergency care in adolescent patients with hidradenitis suppurativa: a cross-sectional hospital-based study.","authors":"Helen H Park, Carrie L Vuong, Katy Phan, Kumudra Nyun, Elana Kleinman, Romeo C Ignacio, George K Hightower","doi":"10.1097/JW9.0000000000000086","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000086","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 2","pages":"e086"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/5e/jw9-9-e086.PMC10155899.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired vulvar lymphangioma: risk factors, disease associations, and management considerations: a systematic review.","authors":"Amber Duong,&nbsp;Alex Balfour,&nbsp;Christina N Kraus","doi":"10.1097/JW9.0000000000000087","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000087","url":null,"abstract":"<p><p>Acquired vulvar lymphangioma (AVL) is not well-characterized. Diagnosis is delayed and the condition is often refractory to therapy.</p><p><strong>Objective: </strong>The objective of this study was to provide a systematic review of AVL including risk factors, disease associations, and management options.</p><p><strong>Methods: </strong>A primary literature search was conducted using 3 databases: PubMed, CINAHL, and OVID, from all years to 2022.</p><p><strong>Results: </strong>In total, 78 publications with 133 patients (48 ± 17 years) were included. Most studies were case reports/series. The most common disease association was prior malignancy (70 patients, 53% of cases) and inflammatory bowel disease (6 patients, 5% of cases). The most common malignancy was cervical cancer (57 patients, 43% of cases). Most patients had prior radiation or surgery, with 36% (n = 48) treated with radiation, 30% (n = 40) with lymph node dissection, and 27% (n = 36) with surgical resection. Common presenting symptoms included discharge/oozing, pain, and pruritus. Most patients underwent surgical treatment for AVL with 39% treated with excision, 12% with laser therapy (the majority used CO₂), and 11% with medical therapies. Most patients had failed prior therapies and there was a diagnostic delay.</p><p><strong>Limitations: </strong>Retrospective nature. Most studies were limited to case reports and case series, with interstudy variability and result heterogeneity.</p><p><strong>Conclusion: </strong>AVL is an underrecognized entity and should be considered in patients with a history of malignancy or radiation to the urogenital area. Treatment should include multidisciplinary care and address underlying lymphatic changes, manage any existing inflammatory conditions, and utilize skin-directed therapies and barrier agents while addressing symptoms of pruritus and pain. Prospective studies are needed to further characterize AVL and develop treatment guidelines.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 2","pages":"e087"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/5a/jw9-9-e087.PMC10208695.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphedema and painless papules of the vulva.","authors":"Brandon J Calley,&nbsp;Karolyn A Wanat,&nbsp;Olushola L Akinshemoyin Vaughn","doi":"10.1097/JW9.0000000000000081","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000081","url":null,"abstract":"An 86-year-old woman with a history of urothelial bladder cancer currently on enfortumab and pembrolizumab presented with several months of painless papules on the bilateral labia majora, with the extension of induration to the lower abdomen. Computed tomography (CT) scan 2 months prior showed bladder wall thickening secondary to urothelial bladder cancer and subcutaneous edema in the anterior lower pelvis without enlarged lymph nodes or adnexal masses suggestive of metastatic disease. She had no history of transplant, abdominal surgery, or radiation. She wore incontinence garments for bouts of diarrhea. Physical examination revealed confluent firm and nontender pink plaques involving the bilateral labia majora, mons pubis, and lower abdomen (Fig. 1). There were 1–2 mm vesicles at the medial free margins of the clitoral hood. Punch biopsies of both the lower abdomen and right labium majus were performed with histopathologic features shown (Fig. 2).","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 2","pages":"e081"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/db/jw9-9-e081.PMC10072308.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating co-existent genitourinary syndrome of menopause in patients with lichen sclerosus improves symptoms.","authors":"Shivani Desai,&nbsp;Sarah B Corley","doi":"10.1097/JW9.0000000000000071","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000071","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e071"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/ac/jw9-9-e071.PMC9833441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulvar squamous cell carcinoma guidelines do not include tissue-sparing techniques as a treatment option.","authors":"Cesar A Virgen,&nbsp;Isabella I Sanchez,&nbsp;Ashley N Elsensohn,&nbsp;Christina N Kraus","doi":"10.1097/JW9.0000000000000078","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000078","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e078"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/6f/jw9-9-e078.PMC9995084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orange palpebral spots: a rare entity of unknown clinical significance.","authors":"Gloria Munayco Maldonado,&nbsp;Zelma Chiesa Fuxench","doi":"10.1097/JW9.0000000000000072","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000072","url":null,"abstract":"Orange palpebral spots (OPS) is a rarely described entity of unknown etiology first reported in 2008 by Assouly et al.1 OPS most commonly presents on females as flat, nonpalpable lesions on the superior eyelids. The coloration of OPS tends to vary between yellow-orange and light orange. Due to this, it has been previously suggested that the nomenclature be expanded to “yellow-orange palpebral spots.” Herein, we present the case of a 53-year-old woman with a 2-year history of asymptomatic, yellow-orange patches on the upper eyelids (Fig. 1). Medical history was unremarkable except for gastroesophageal reflux disease and depression treated with omeprazole and escitalopram, respectively. Our patient did not recall any triggers and denied the use of makeup, protective eyewear (ie, goggles), or contact lens solution. Skin examination was remarkable for the presence of well-defined, yellow-to-orange patches on the medial upper eyelids. Lipid panel was within normal limits. No other testing was performed. Given the patient’s clinical presentation, a diagnosis of OPS was favored. The differential diagnosis of OPS includes xanthoma or xanthelasma. OPS, unlike xanthelasma or xanthoma, do not have an elevated appearance with coloration that varies between yellow-orange to light orange.1,2 Skin biopsies of OPS have shown increased adipose tissue and pigment-laden macrophages in the superficial dermis without the characteristic lipid-laden macrophages of xanthelasma.1,2 In our case, because a diagnosis of OPS was favored at the outset and because of the sensitive location of these lesions, a biopsy was not performed. While xanthelasma tends to correlate with hyperlipidemia, patients with OPS present with normal lipid levels and lipid screens are often uncecessary.1 In our case, the patient’s primary care physician had ordered a lipid panel as routine lab work. Evolution of these 2 distinct conditions has not found them to be interlinked as patients that have been followed for xanthelasma have never shown clinical features of OPS and vice versa.1 The differential diagnoses of OPS also include use of fluorescein solutions in ophthalmology and necrobiotic xanthogranuloma. However, staining due to fluorescein solution typically affects the lower eyelids.1,3 Necrobiotic xanthogranuloma involves the periorbital area in addition to the eyelids and is often seen in patients with monoclonal gammopathy and clinically present with red-tobrown, violaceous, or yellowish papules and nodules.1,3 The etiology of OPS remains to be fully elucidated. Assouly et al.1 proposed a correlation between OPS and high levels of vitamin E, total carotenoids, or β-cryptoxanthin secondary to high citrus consumption.1,4 Our patient maintained a low-citrus diet due to her history of gastroesophageal reflux disease indicating that exposure to high levels of the previously mentioned compounds was unlikely. Belliveau et al.2 also described melanin incontinence in the histopathologic analysis of","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e072"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/c7/jw9-9-e072.PMC9886507.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10650696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study on the association of keloids with underlying health conditions in African-American Women.","authors":"Pooja Marella,&nbsp;Donald A Glass","doi":"10.1097/JW9.0000000000000074","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000074","url":null,"abstract":"<p><p>Keloids are disfiguring benign scars that develop due to an exaggerated response to cutaneous wound healing, growing beyond the boundaries of the cutaneous insult into normal, previously uninvolved skin. The association of keloids with other underlying health conditions has been postulated, but not well characterized.</p><p><strong>Objective: </strong>This study aims to identify whether there is any association of keloids with underlying health conditions in African-American women.</p><p><strong>Methods: </strong>This study was done via the use of the National Inpatient Sample, a subset of the Healthcare Cost and Utilization Project. African-American women with keloids who had undergone cesarean sections were compared with a control group of African-American women with no history of keloids who had undergone cesarean sections.</p><p><strong>Results: </strong>A total of 301 African-American inpatient encounters with patients with keloids were compared with 37,144 encounters in the control group. The keloid patients had an increased association with peritoneal adhesions compared with the control group.</p><p><strong>Limitations: </strong>results are limited to one race and restricted age range; also, unable to differentiate keloids from hypetrophic scarring with ICD-10 codes.</p><p><strong>Conclusion: </strong>These findings suggest that keloids and peritoneal adhesions may have similar inflammatory processes.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e074"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/cc/jw9-9-e074.PMC9949828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10794232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccination among patients with cicatricial alopecia: patient concerns, experiences, and treatment modifications.","authors":"Kelly E Flanagan,&nbsp;James T Pathoulas,&nbsp;Maryanne M Senna,&nbsp;Chloe J Walker,&nbsp;Isabel Pupo Wiss,&nbsp;Maya Collins,&nbsp;Shaheir Ali,&nbsp;Rita Wanser,&nbsp;Jean Pickford,&nbsp;Wilma Bergfeld","doi":"10.1097/JW9.0000000000000036","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000036","url":null,"abstract":"","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e036"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/19/jw9-9-e036.PMC9973349.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10824275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing trends in treatment of acne vulgaris in pregnancy: a retrospective study.","authors":"Swati P Garg,&nbsp;Saira Alvi,&nbsp;Roopal V Kundu","doi":"10.1097/JW9.0000000000000076","DOIUrl":"https://doi.org/10.1097/JW9.0000000000000076","url":null,"abstract":"Acne vulgaris is an inflammatory disease of the skin common in pregnancy.1 Many first-line acne treatments are teratogenic, complicating management of this condition (Table 1).2 Although recommendations from the American Board of Family Medicine (ABFM) exist for treatment of acne in pregnancy,3 no studies have analyzed real-life data of acne management in pregnant patients. A retrospective study utilizing patient data from the Northwestern Medicine Enterprise Data Warehouse was approved by the Northwestern University Institutional Review Board (STU00037913). Data from over 40 clinic locations and 100 providers across the Chicago metropolitan area resulted in 4,050 analyzed patient encounters with a diagnosis of acne vulgaris. One hundred fifteen of these visits occurred in pregnancy-related encounters. Within our 115 patients, 57.4% (66) of patients were trying to get pregnant within the next year, 32.2% (37) were pregnant, and 10.4% (12) were breastfeeding (Table 2). Patients in this cohort were exclusively prescribed pregnancy category B and C medications.2 Azelaic acid 15% gel and clindamycin 1% gel, solution, or lotion were the most commonly prescribed treatments with 83.3% (55/66) and 69.7% (46/66) of patients trying to get pregnant and 75.7% (28/37) and 56.8% (21/37) of pregnant patients prescribed these medications, respectively. Only 13.5% (5/37) of currently pregnant patients were prescribed category C prescriptions, suggesting safe treatment of acne in pregnancy. In nonpregnancy-related encounters, prescription rates of azelaic acid (4.5%, 178/3,935) and clindamycin (54.0%, 2,124/3,935) were lower and recommendation rates of other pregnancy C medications including retinoids (59.8%, 2,355/3,935), spironolactone (10.2%, 401/3,935), and dapsone (9.1%, 358/3,935) were higher compared to pregnancy-related encounters. These findings suggest substantial adjustment of acne treatment regimens for safety in pregnancy and peri-pregnancy and recognition of the teratogenic effects of acne medications by providers. ABFM guidelines recommend avoidance of antibiotic monotherapy and encourage use of benzoyl peroxide as first-line treatment of acne in pregnancy to avoid antibiotic resistance.3,4 Of 37 pregnant patients, 6 (16.2%) were prescribed antibiotic monotherapy which was higher than the rate of 6.9% (270/3,935) in the nonpregnant population. Benzoyl peroxide 2.5–10% in the form of a face wash, cream, or gel was recommended at lower rates in the pregnant group (13.5%, 5/37) compared to those not pregnant (46.4%, 1,825/3,935). The higher rates of antibiotic monotherapy and lower rates of benzoyl peroxide prescribed in pregnant patients may reflect the limitations for ideal acne treatment and highlight a potential area for improvement. One limitation of this study is the relatively small sample size. Although prescription trends and generalizations can be inferred from the data, the sample size is not large enough to determine statistical significanc","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"9 1","pages":"e076"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/1b/jw9-9-e076.PMC9997801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}