Voprosy Detskoi Dietologii最新文献

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Enrichment of gluten-free cereal bars based on expanded grain with functional ingredients of secondary products processed from black currant berries 以膨化谷物为基础,以黑加仑子浆果加工的二次产品为功能成分,强化无谷蛋白谷物棒
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-2-90-94
S. Urubkov, N. V. Myasishcheva
{"title":"Enrichment of gluten-free cereal bars based on expanded grain with functional ingredients of secondary products processed from black currant berries","authors":"S. Urubkov, N. V. Myasishcheva","doi":"10.20953/1727-5784-2023-2-90-94","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-2-90-94","url":null,"abstract":"Objective. To study the influence of functional components of the chemical composition of secondary products processed from black currant berries on the nutritional value of gluten-free cereal bars based on expanded grain and to establish the possibility of satisfying the daily requirements of vitamin C, bioflavonoids, dietary fiber, including pectin, in children when using them. Materials and methods. The objects of the study were expanded grains of millet, rice, buckwheat, amaranth, quinoa, as well as the powder obtained from black currant pomace. When studying the content of substances that determine the nutritional and biological value of black currant pomace powder, standard research methods were used. The nutritional value of gluten-free cereal bars was estimated by the calculation method. Results. The chemical composition of black currant pomace powder was studied. It was found that it contains a large amount of ascorbic acid (139.2 mg/100g) and bioflavonoids: anthocyanins (1381.1 mg/100 g), leuco-anthocyanins (864.9 mg/100 g), and catechins (739.4 mg/100 g). It is characterized by a high ratio of sugars and acids (4), as well as a high content of pectin substances and fiber (11.5 and 10.7%, respectively). The calculation of nutritional value showed that the addition of black currant pomace powder in the recipe of gluten-free cereal bars in an amount of 3.5% or more at the consumption of 100 g of the finished product can cover the daily requirements of children in bioflavonoids and dietary fiber, and an amount from 7.0% of the recipe allows to get a product enriched with vitamin C. Conclusion. The calculations of daily requirements performed in this study indicate the prospects of using black currant pomace powder as an enriching additive in specialized products for children over 3 years of age with gluten intolerance. Key words: gluten-free foods, children, cereal bars, gluten intolerance, expanded grain, black currant powder, biologically active substances","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of basal metabolic rate in adolescent athletes 青少年运动员基础代谢率的评估
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-3-12-16
S. Stolyarova, P. Okorokov, I. V. Zyabkin, E. V. Babaeva, E. P. Isaeva
{"title":"Assessment of basal metabolic rate in adolescent athletes","authors":"S. Stolyarova, P. Okorokov, I. V. Zyabkin, E. V. Babaeva, E. P. Isaeva","doi":"10.20953/1727-5784-2023-3-12-16","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-3-12-16","url":null,"abstract":"Objective. To assess the intensity of basal metabolism in adolescent elite athletes. Patients and methods. This study included 154 adolescent athletes (42 boys, 112 girls) aged 13–18 years (mean age: 15.3 ± 2.5 years). Basal metabolic rate (BMR) was measured in all participants using respiratory indirect calorimetry and the Harris–Benedict equation. Study design: single-center, cross-sectional, randomized, uncontrolled. Results. An increase in BMR was revealed in 79 (51%) participants, normal BMR – in 50 (33%) participants, and a decrease in BMR – in 25 (16%) participants. Increased BMR was statistically significantly more common in boys compared to girls (83% and 39% respectively, p = 0,01), whereas decreased BMR was more characteristic of girls compared to boys (20% and 4%, respectively, p = 0.001). Conclusion. Most adolescent athletes show an increase in BMR, which reflects an adaptation of the organism to high physical exertion. A decrease in BMR may indicate the presence of relative energy deficiency in athletes. The Harris–Benedict equation significantly underestimates the value of BMR in adolescent athletes and is not an alternative to respiratory indirect calorimetry when individual assessment of energy expenditure is necessary as part of biomedical support. Key words: children, high-performance sport, basal metabolic rate, indirect calorimetry","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of the VDR gene with clinical manifestations, complications, and vitamin D status in children with juvenile idiopathic arthritis VDR基因与幼年特发性关节炎儿童临床表现、并发症和维生素D状况的相关性
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-3-42-52
E. Loshkova, E. Kondratyeva, L. Klimov, N. S. Podchernyaeva, N. Ilyenkova, S. Chebysheva, E. Shitkovskaya, S. Dolbnya, V. A. Kuryaninova, E. Zhekayte, M. I. Tikhaya, Yuliia V. Kotova, Y. Melyanovskaya, M. I. Erokhina, A. Khavkin
{"title":"Association of the VDR gene with clinical manifestations, complications, and vitamin D status in children with juvenile idiopathic arthritis","authors":"E. Loshkova, E. Kondratyeva, L. Klimov, N. S. Podchernyaeva, N. Ilyenkova, S. Chebysheva, E. Shitkovskaya, S. Dolbnya, V. A. Kuryaninova, E. Zhekayte, M. I. Tikhaya, Yuliia V. Kotova, Y. Melyanovskaya, M. I. Erokhina, A. Khavkin","doi":"10.20953/1727-5784-2023-3-42-52","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-3-42-52","url":null,"abstract":"Objective. To conduct an association search between genetic variants (c.1206T>C, c.152T>C, c.1174+283G>A) of the VDR gene and clinical manifestations of juvenile idiopathic arthritis (JIA), need for genetically engineered biological drugs (GEBDs) and vitamin D status in children. Patients and methods. This study included 150 children (mean age: 9.11 ± 2.21 years) with JIA and 333 healthy controls. The determination of serum calcidiol concentrations was performed in all patients. Polymorphic variants of the VDR gene (c.1206T>C, c.1175-9G>T, c.152T>C, c.1174+283G>A) were tested by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique. Results. Carriers of the minor TT genotype of the genetic variant c.1206T>C(A>G) TaqI are 4 time more likely to develop systemic JIA, 5 time more likely to have high disease activity and uveitis, as well as 9.9 times more often require prescription of GEBDs. Carriers of the minor genotype TT of the genetic variant c.152T>C FokI are 7.7 times more likely to develop systemic JIA and 4.3 times – polyarticular JIA, 6.2 times more likely to have high disease activity and 5.6 times – uveitis, 8 times more often have a severe calcidiol deficiency and 4 times more often require prescription of GEBDs. Carrying the minor AA genotype of the BsmlI polymorphism (c.1174+283G>A) increases the risk of systemic-onset JIA by 17 times, high disease activity and uveitis – by 18 times, and need for GEBDs – by 15 times; carrying the AA and GA genotypes increases the risk of calcidiol deficiency by 5 times and severe calcidiol deficiency by 9 times. Conclusion. All studied genetic variants of the VDR gene verifiably affect the development of clinical manifestations, complications, calcidiol levels and response to therapy in JIA. Key words: VDR gene, juvenile idiopathic arthritis, children, vitamin D, autoimmune disease","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical case of hereditary pancreatitis in four siblings due to mutations in the PRSS1 gene 由于PRSS1基因突变导致的四兄弟姐妹遗传性胰腺炎的临床病例
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-3-72-81
M. G. Ipatova, V. V. Kholostova, S.M. Chekh, E. Sergeeva, P. Shumilov, A. Razumovskiy
{"title":"Clinical case of hereditary pancreatitis in four siblings due to mutations in the PRSS1 gene","authors":"M. G. Ipatova, V. V. Kholostova, S.M. Chekh, E. Sergeeva, P. Shumilov, A. Razumovskiy","doi":"10.20953/1727-5784-2023-3-72-81","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-3-72-81","url":null,"abstract":"Hereditary pancreatitis in children remains a challenging problem in clinical genetics, gastroenterology, and surgery. Genetic causes account for more than 50% of all cases of acute recurrent pancreatitis and 75% of chronic pancreatitis in children. The development of chronic pancreatitis is commonly caused by mutations in the CFTR, PRSS1, SPINK1, CTRC, and CPA1 genes. This article presents a clinical case of hereditary pancreatitis with an autosomal dominant inheritance in 4 siblings, in whom a pathogenic variant in the PRSS1 gene was detected during molecular genetic testing. Key words: hereditary pancreatitis, pathogenic variant, PRSS1 gene, children, siblings","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factors for outcomes in patients with cystic fibrosis who are observed at the Federal Clinical Center 在联邦临床中心观察到的囊性纤维化患者预后因素
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-2-5-12
O. Zonenko, P. Suter, P. Shumilov, S. Krasovsky
{"title":"Prognostic factors for outcomes in patients with cystic fibrosis who are observed at the Federal Clinical Center","authors":"O. Zonenko, P. Suter, P. Shumilov, S. Krasovsky","doi":"10.20953/1727-5784-2023-2-5-12","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-2-5-12","url":null,"abstract":"Objective. To identify the factors significantly affecting clinical outcomes in patients with cystic fibrosis who are observed at the Federal Clinical Center based on a multivariate analysis of the disease course. Patients and methods. A total of 657 medical records of patients with cystic fibrosis were examined. The survival rate was analyzed depending on the type of genetic mutation and sex of patients. The dynamic model for predicting 2-year survival outcomes based on 36 parameters from the National Registry was developed. Results. The multivariate Cox proportional hazard model applied to dynamic data by a landmarking method revealed a statistically significant association between mortality over a 2-year lifetime with the values of the following factors: FEV1 (relative risk (RR): 0.95; 95% confidence interval (CI): 0.94–0.97); cystic fibrosis-related diabetes (RR: 2.36; CI: 1.47–3.80); Burkholderia cepacia complex infection (RR: 3.22; CI: 2.12–4.91); need for oxygen therapy (RR: 1.9; CI: 1.15–3.12); previous pneumothorax (RR: 2.72; CI: 1.19-6.20); vitamin therapy (RR: 2.72; CI: 1.09–6.81); pancreatic enzyme intake (RR: 0.38; CI: 0.17–0.86). Conclusion. The awareness of prognostic survival factors will allow to optimize treatment and rehabilitation programs for patients with cystic fibrosis, which will lead to an increase in patients’ life expectancy. Key words: cystic fibrosis, children, survival rate","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical features of 22q11.2 deletion syndrome in early childhood 儿童早期22q11.2缺失综合征的临床特征
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-2-77-89
V. Antonyan, A. Shakirova, A.A. Vyalykh, P. Shumilov, H. Sarkisyan, I. Moreno, Yulia Petrova, A. Poghosyan
{"title":"Clinical features of 22q11.2 deletion syndrome in early childhood","authors":"V. Antonyan, A. Shakirova, A.A. Vyalykh, P. Shumilov, H. Sarkisyan, I. Moreno, Yulia Petrova, A. Poghosyan","doi":"10.20953/1727-5784-2023-2-77-89","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-2-77-89","url":null,"abstract":"DiGeorge syndrome is characterized by conotruncal heart defects, an immunodeficiency state, and underdeveloped parathyroid glands. Contemporary medicine describes more than 180 clinical forms of this disease, which are usually classified under the heading “chromosome 22q11.2 deletion syndrome” (D 82.1). Along with the above abnormalities, there are other malformations and pathological conditions in 22q11.2DS that not only complicate diagnosis, neonatal nursing, and further management, but also lead to an increased frequency of surgical interventions. This article presents 8 clinical cases of 22q11.2DS with multiple congenital disorders. The children under observation had malformations of the central nervous, maxillofacial, genitourinary, musculoskeletal systems, anorectal region, as well as diaphragmatic and inguinal hernias. Key words: multiple congenital disorders, 22q11.2 deletion syndrome, DiGeorge syndrome, conotruncal congenital heart defects, cleft lip and palate, anorectal malformations, hypoparathyroidism, delayed speech and psychomotor development, primary immunodeficiency","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and awareness of celiac disease among Russian healthcare professionals 俄罗斯医疗保健专业人员对乳糜泻的认识和认识
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-2-95-96
V. Novikova, N. Shapovalova, A. Kamalova, I. Bavykina, A. A. Zvyagin, D. S. Fugol, I. E. Romanovskaya, A. Khavkin
{"title":"Knowledge and awareness of celiac disease among Russian healthcare professionals","authors":"V. Novikova, N. Shapovalova, A. Kamalova, I. Bavykina, A. A. Zvyagin, D. S. Fugol, I. E. Romanovskaya, A. Khavkin","doi":"10.20953/1727-5784-2023-2-95-96","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-2-95-96","url":null,"abstract":"","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of a clinical study of a specialized food product for dietary therapeutic nutrition “Bifinilan” for children over seven years of age with phenylketonuria 一项针对7岁以上苯丙酮尿症儿童的特殊食品“比非尼兰”的临床研究结果
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-3-22-27
T. P. Zhukova, S. Ratnikova, N. A. Irinina, E.S. Zaytseva, N.B. Sedova
{"title":"Results of a clinical study of a specialized food product for dietary therapeutic nutrition “Bifinilan” for children over seven years of age with phenylketonuria","authors":"T. P. Zhukova, S. Ratnikova, N. A. Irinina, E.S. Zaytseva, N.B. Sedova","doi":"10.20953/1727-5784-2023-3-22-27","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-3-22-27","url":null,"abstract":"Objective. To evaluate the efficacy, safety, and tolerability of a specialized food product for dietary therapeutic nutrition “Bifinilan” in children over 7 years of age with phenylketonuria. Patients and methods. An open-label prospective study was conducted in outpatient clinical settings. It included 17 children with phenylketonuria aged between 8 and 15 years (12 girls and 5 boys), who received a specialized product “Bifinilan” for 30 ± 2 days. Clinical and anamnestic characteristics, blood phenylalanine levels determined by the fluorescent method were assessed at the beginning and at the end of the study. Results. During the study, blood phenylalanine levels decreased significantly and were within the reference range (median before the study was 9.11 mg/dL, at the end of the study – 6.17 mg/dL, p < 0.05). At the same time, in children with initially elevated phenylalanine level, it decreased to an acceptable range, and in children with a normal phenylalanine level, it remained within the same range. Patients, their parents, and physicians were completely satisfied with the use of the product, which was well tolerated and the transition to which was not followed by an adaptation period. Conclusion. The efficacy, safety, and good tolerability of a specialized food product for dietary therapeutic nutrition “Bifinilan” in children over 7 years of age with phenylketonuria was demonstrated. Key words: children, specialized food product for dietary therapeutic nutrition, phenylalanine, phenylketonuria","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DGAT1-associated protein-losing enteropathy: the first clinical case report in Russia dgat1相关蛋白丢失性肠病:俄罗斯首例临床病例报告
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-1-83-92
E. Kostomarova, I. V. Zhuravleva, O.V. Pravoslavnaya, P. Shumilov, T.G. Demyanova, A. Chubarova, E. Tumanova, Y. Dmitrieva, A. Yudina, E. I. Epifanova, N. S. Korchagina
{"title":"DGAT1-associated protein-losing enteropathy: the first clinical case report in Russia","authors":"E. Kostomarova, I. V. Zhuravleva, O.V. Pravoslavnaya, P. Shumilov, T.G. Demyanova, A. Chubarova, E. Tumanova, Y. Dmitrieva, A. Yudina, E. I. Epifanova, N. S. Korchagina","doi":"10.20953/1727-5784-2023-1-83-92","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-1-83-92","url":null,"abstract":"DGAT1-associated protein-losing enteropathy is a rare autosomal recessive disorder related to congenital diarrhea and associated with a mutation in the DGAT1 gene that encodes the enzyme DGAT1, which is responsible for the final step of triglyceride resynthesis in enterocytes. With insufficient activity of DGAT1 enzyme, fatty acids and diacylglycerols accumulate in the enterocyte, having a cytotoxic effect and causing enterocyte apoptosis. As a result, atrophic enteropathy develops, which is manifested as protein-losing diarrhea from the first months of life, iron deficiency anemia, and vitamin D deficiency. The currently known treatment methods for DGAT1-associated enteropathy are a low-fat diet and parenteral nutrition. This article presents the first genetically confirmed clinical case of DGAT1-associated protein-losing enteropathy in the Russian Federation. Key words: DGAT1, enteropathy, congenital diarrhea, protein-losing diarrhea, children","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67718060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic esophagitis: clinical presentation, current aspects of diagnosis and treatment 嗜酸性粒细胞性食管炎的临床表现、诊断和治疗现状
Voprosy Detskoi Dietologii Pub Date : 2023-01-01 DOI: 10.20953/1727-5784-2023-1-52-65
A. Paraskevova, A. Trukhmanov, T. Lapina, S. S. Pirogov, A. Tertychny, O. Storonova, A. A. Makushina, V. Ivashkin
{"title":"Eosinophilic esophagitis: clinical presentation, current aspects of diagnosis and treatment","authors":"A. Paraskevova, A. Trukhmanov, T. Lapina, S. S. Pirogov, A. Tertychny, O. Storonova, A. A. Makushina, V. Ivashkin","doi":"10.20953/1727-5784-2023-1-52-65","DOIUrl":"https://doi.org/10.20953/1727-5784-2023-1-52-65","url":null,"abstract":"Eosinophilic esophagitis (EoE) is an immune-mediated disease characterized by complaints of dysphagia and eosinophilic infiltration of the esophageal epithelium with at least 15 cells per high power field (×400). Currently, there has been an increase in the incidence of EoE worldwide. Patients with EoE include both adults and children. The diagnosis of EoE requires morphological confirmation. Triggers for EoE can be aeroallergens and food allergens. EoE is often accompanied by other atopic diseases. The treatment of EoE is based on proton pump inhibitors (PPIs), topical glucocorticosteroids (GCs), and elemental or elimination diets. This review presents a detailed analysis of literature and proposes the therapeutic algorithm for patients with EoE. Key words: atopic diseases, dysphagia, eosinophilic infiltration, eosinophilic esophagitis","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67717401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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