{"title":"Management challenges in primary and secondary postpartum haemorrhage","authors":"Naomi Taylor, Nicholas Brazel","doi":"10.1016/j.ogrm.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.06.001","url":null,"abstract":"<div><p>In this review article we will cover the management of both primary and secondary postpartum haemorrhage<span><span>. Detailed national guidance on the management of primary PPH has been in place since 1998. Despite this, multiple MBRRACE-UK reports have consistently found significant scope for improvement in the care delivered to women. The recurrent nature of the themes highlighted in the reports is equally sobering, which suggests a failure to learn from these tragic cases. The first part of this paper will provide practical steps that can be taken to embed the learning from successive MBRRACE-UK reports into our day-to-day clinical practice. The second part of this paper will provide an overview of the literature on secondary postpartum haemorrhage. Secondary PPH is associated with significant maternal morbidity. Despite this, there is a lack of </span>randomised controlled trials to inform the management of these women, and the long-term sequalae associated with both the condition and its management is unknown.</span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Organoid cultures as model systems to study disorders of the human endometrium and placenta","authors":"Ashley Moffett","doi":"10.1016/j.ogrm.2023.06.004","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.06.004","url":null,"abstract":"<div><p><span>Studying the underlying pathogenesis of disorders of the endometrium<span><span> and of human pregnancy is challenging due to the lack of good in vivo and animal models. The development of organoid cultures has provided new opportunities to perform experiments in humans that recapitulate the in vivo situation. Endometrial organoids can be derived from tissues or menstrual fluid and respond robustly to ovarian hormones. Placental trophoblast organoids can only be generated from </span>placentas<span> under 9 weeks gestation. These assemble to form the structure of a placental villus. Modification of the culture conditions drives them to differentiate to the invading trophoblast that functions to transform the uterine </span></span></span>spiral arteries<span>. This process is critical for pregnancy success. These model systems will be transformative in understanding the biology of the female reproductive tract in health and disease.</span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The management of acquired bleeding disorders in pregnancy","authors":"Jahnavi Daru, Bethan Myers","doi":"10.1016/j.ogrm.2023.06.003","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.06.003","url":null,"abstract":"<div><p>This article will highlight how to identify, diagnose and manage acquired bleeding disorders in pregnancy. Postpartum haemorrhage<span> is the leading acquired bleeding disorder, but is extensively covered in multiple guidelines and within the MRCOG curriculum, so we will instead focus on platelet disorders<span>. This is an important area to understand the investigation of and how platelet disorders can range from pre-existing conditions to those acquired only in pregnancy and related to placental dysfunction.</span></span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine Lattey, Andrew Demetri, Timothy Draycott, Emily Hotton
{"title":"Assisted vaginal birth: what is best practice?","authors":"Katherine Lattey, Andrew Demetri, Timothy Draycott, Emily Hotton","doi":"10.1016/j.ogrm.2023.06.002","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.06.002","url":null,"abstract":"<div><p><span><span>Assisted vaginal birth<span> (AVB) is the vaginal birth of a baby performed with the help of a medical device<span>. In the United Kingdom, 10–15% of birthing people will have an AVB for maternal and/or fetal indications. Devices for AVB most commonly include forceps and vacuum, with differing risks and benefits. However, complications can include maternal and fetal morbidity. The decision-making in AVB is complex and multi-factorial to ensure a safe AVB is achieved. Technical and non-technical skills including: communication, situational awareness and human factors, are crucial for </span></span></span>holistic care<span>. Safety considerations comprised of a thorough assessment, intrapartum care and postnatal aspects of management. Training needs to cover all aspects of a competent AVB, including understanding the different devices and evaluating which to use in varied clinical settings. With rising rates of second-stage caesarean AVB continues to be an essential skill in </span></span>obstetric care.</p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary dysmenorrhoea: a review of the current evidence","authors":"Sophie Walter, Y. Jeve","doi":"10.1016/j.ogrm.2023.08.003","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.08.003","url":null,"abstract":"","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72614808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of malposition and malpresentation in labour","authors":"A. Richmond, J. R. Ashworth","doi":"10.1016/j.ogrm.2023.08.004","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.08.004","url":null,"abstract":"","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79994011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antenatal assessment of fetal well-being","authors":"Sumana Narain, Alec McEwan","doi":"10.1016/j.ogrm.2023.05.002","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.05.002","url":null,"abstract":"<div><p>Assessment of fetal well-being is one of the key aims of obstetric care<span>. This article reviews various tools and interventions that are currently available to assess fetal well-being, including the ongoing assessment of risk factors (leading to the triaging of women into appropriate pathways of care) through to the assessment of fetal well-being with the computerised CTG<span>. Included is a brief overview of screening, symphysis fundal height<span> measurements, growth and Doppler scanning, and perception of fetal movements. A good history, clinical assessment, and appropriate use and interpretation of investigations form a holistic approach for assessment of fetal well-being.</span></span></span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Borna Poljak, Delima Khairudin, Nia Wyn Jones, Andrea Kaelin Agten
{"title":"Placenta accreta spectrum: diagnosis and management","authors":"Borna Poljak, Delima Khairudin, Nia Wyn Jones, Andrea Kaelin Agten","doi":"10.1016/j.ogrm.2023.05.004","DOIUrl":"https://doi.org/10.1016/j.ogrm.2023.05.004","url":null,"abstract":"<div><p><span><span>Placenta accreta spectrum (PAS) is caused by abnormal placental attachment to the uterine wall that can involve invasion into the </span>myometrium<span>, uterine serosa<span> or even surrounding organs. Women with suspected PAS should be referred to centres with appropriate expertise as they are associated with increased maternal morbidity and mortality. Women with PAS are at significant risk of haemorrhage and other </span></span></span>surgical complications<span>. Suspicion is raised in the presence of risk factors and the patient assessed with ultrasound scan. Once PAS is suspected skilled surgeons, anaesthetists and interventional radiologists should be involved in patient care and delivery planning. Unfortunately, not all cases are detected antenatally and when the condition is recognized only at the time of delivery the morbidity and mortality rates are higher. Urgent assistance of experienced surgeons should be sought in these cases to optimize the outcome for the patient.</span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50191556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}