Revista Romana de Boli Infectioase最新文献

{"title":"Patients with diabetes at risk in COVID-19 pandemic","authors":"R. Tóth, M. Chinceșan, O. Grama, A. Grama","doi":"10.37897/rjid.2020.2.1","DOIUrl":"https://doi.org/10.37897/rjid.2020.2.1","url":null,"abstract":"The new coronavirus infection (COVID-19) spread rapidly from the outbreak in Wuhan, China with a wide range of clinical manifestations, from asymptomatic to fatal. Individuals from the risk factor category, includ-ing those with diabetes mellitus (DM), have a proven higher risk of developing a severe form of the disease, as well as a higher risk of mortality. Through this summary we aim to briefly review the general characteristics of COVID-19 and a special situation, namely that of infection in patients with diabetes. We addressed the potential mechanisms that may increase the susceptibility of diabetic patients to COVID-19, but also the current recommendations in Romania for diabetics in the COVID-19 pandemic. Based on current limited evidence we cannot draw conclusions. Further research on this association between COVID-19 and DM is necessary and justified. © 2020, Amaltea Medical Publishing House. All rights reserved.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48755632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and epidemiological features on re-emergence of measles in Galati County","authors":"M. Arbune, Liliana Baroiu, Gabriela Lupășteanu, Lucreţia Anghel, A. Arbune, C. Dumitru, A. Iancu","doi":"10.37897/rjid.2019.4.2","DOIUrl":"https://doi.org/10.37897/rjid.2019.4.2","url":null,"abstract":"The current re-emergence of measles is a serious worldwide public health problem, favored by the decrease in vaccine coverage. Romania is noted for the highest number of illnesses and deaths in the European Union. The study analyzes the clinical-epidemiological characteristics of measles cases hospitalized in a county in south-eastern Romania, where the vaccine coverage with 2 doses of anti-measles vaccine is of 79.6%. We analyzed a number of 221 hospitalized cases confirmed with measles, according to the case definition, characterized by the predominance in unvaccinated infants, from the urban area, frequently diagnosed after the 4th day of illness, most of them with complicated forms of measles.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49060291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particularităţile clinico-epidemiologice ale reemergenţei rujeolei în judeţul Galaţi","authors":"Manuela Arbune, Liliana Baroiu, Gabriela Lupăşteanu, Lucreţia Anghel, Anca A. Arbune, Caterina Dumitru, Alina-Viorica Iancu","doi":"10.37897/rjid.2019.4.5","DOIUrl":"https://doi.org/10.37897/rjid.2019.4.5","url":null,"abstract":"Prof. dr. manuela arbune1,2, asist. univ. dr. liliana Baroiu1,2, drd. dr. gabriela lupăşteanu1,3, Şef lucr. dr. lucreţia anghel2,4, drd. dr. anca arbune5, Şef lucr. dr. caterina dumitru1,2, Şef lucr. dr. alina-Viorica iancu1,2 1 Spitalul Clinic de Boli Infecţioase, Galaţi, România 2 Facultatea de Medicină şi Farmacie, Universitatea \"Dunărea de Jos\", Galaţi, România 3 Universitatea „Ovidius“, Constanţa, România 4 Spitalul Clinic Judeţean de Urgenţă, Galaţi, România 5 Institutul Clinic Fundeni, Bucureşti, România STUDII CLINICE","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46609480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importanța tabloului clinic în diagnosticul sindromului Guillain-Barré","authors":"Tudorița-Gabriela Părângă, Iași România Spitalul de Boli Infecțioase „Sfânta Parascheva“, Mariana Obreja, Claudia-Elena Pleșca, D. Leca, Larisa Miftode, Oana Stamateanu, Elisabeta Lupu, Egidia Miftode, Iași România Universitatea de Medicină și Farmacie „Gr.T. Popa“, Iaşi România Institutul Regional de Oncologie","doi":"10.37897/rjid.2019.4.6","DOIUrl":"https://doi.org/10.37897/rjid.2019.4.6","url":null,"abstract":"dr. tudorița-gabriela părângă2, asist. univ. dr. maria obreja1, asist. univ. dr. claudia-Elena pleșca1,2, Şef lucr. dr. daniela leca1,2, asist. univ. dr. larisa miftode1,2, asist. univ. dr. oana stamateanu1,2, dr. Elisabeta lupu3, prof. dr. Egidia-gabriela miftode1,2 1 Universitatea de Medicină și Farmacie „Gr.T. Popa“, Iași, România 2 Spitalul de Boli Infecțioase „Sfânta Parascheva“, Iași, România 3 Institutul Regional de Oncologie, Iaşi, România PREZENTĂRI DE CAZ","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47041862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated care services for Romanian HIV/HCV co-infected patients from key populations – lessons learned from HepCare Europe Project experience in Bucharest clinical site","authors":"I. Ianache, Ş. Lazăr, I. Popa, A. Kosa, A. Luca, Ioana Petre, S. Florescu, C. Oprea, B. Pharmacy","doi":"10.37897/rjid.2019.4.1","DOIUrl":"https://doi.org/10.37897/rjid.2019.4.1","url":null,"abstract":"background. HepCare Europe was a project co-funded by the European Commission with the scope to create and implement a model of HCV management (screening, linkage to care, treatment) for patients from key populations, through outreaching the community and to offer integrated primary and secondary care services. The aim of this sequential research inside the project was to evaluate the socio-demographic and clinical characteristics of HIV/HCV co-infected patients enrolled in HepCare Europe Project at Bucharest clinical site and to compare them to HCV-mono-infected patients. Methods. Prospective study on patients who tested positive for HCV antibodies (using rapid oral tests), part of them being linked to care at “Dr. Victor Babes” Clinical Hospital Bucharest, Romania (SVB), between April 2016 and April 2019. Socio-demographic and clinical characteristics of patients linked to care were compared according to their HIV status. Statistical analysis was performed using SPSS vs. 20.0. results. A total of 525 patients were screened for HCV antibodies using rapid oral tests, out of which 230 (43.8%) tested positive. Almost all of them were young males (85.2%) and injecting drug users (IDUs) (92.2%). 168 patients (73.0%) were linked to care, with 41.6% being coinfected with HIV. Liver fibrosis assessment was performed in 82.1% patients, almost a third of them having advanced liver fibrosis (27.5%). Plasma HCV-RNA was performed for half of the patients linked to care and 80.9% were detectable. Directing acting antivirals (DAA) treatment was initiated in 24 patients out of which 22 achieved SVR (sustained virological response) and 2 were non-responders (IDUs with genotype 3 treated with non-pan genotypic regimens). HIV-infection was associated with homelessness (p<0.0001), injecting drug use (p=0.001), NPS (new psychoactive substances) use in combination with opioids (p<0.0001), needle sharing (p<0.0001) and alcohol abuse (p<0.0001). The median CD4 cell count (/μl) and median plasma HIV-RNA (log10copies/ml) were 483 (IQR 290, 646) and 2.74 (IQR 1.27, 4.67), respectively. HCV-RNA was significantly higher in HIV/ HCV co-infected patients (p=0.047). conclusions. HIV/HCV co-infection was high among patients from key populations. HIV infection was associated with multiple risk factors and higher HCV-RNA. Socio-economic barriers and the lack of pan genotypic DAAs limited the treatment and outcomes in this group. This is the first pilot study on managing patients with HCV from key population in Romania.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45001765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium difficile infection in patients with chronic hepatic disease","authors":"Liliana Baroiu, M. Arbune, A. Iancu, C. Dumitru, Gabriela Lupășteanu, M. Draganescu, M. Debita, S. Rugina, Dunărea de Jos","doi":"10.37897/rjid.2019.3.1","DOIUrl":"https://doi.org/10.37897/rjid.2019.3.1","url":null,"abstract":"Clostridium difficile infection (CDI) associates in the spectrum of comorbidities, more and more often, chronic toxic metabolic or viral hepatic diseases. Patients with chronic hepatic diseases have more severe episodes of CDI with poorer prognosis than episodes of CDI that have occurred in patients with other comorbidities. The measures of prophylaxis and treatment of CDI in these patients require particularizations according to the risk factors and the clinical-evolutionary specificity of these patients. The present study aims to identify the main risk factors of these patients for CDI, as well as to evaluate the severity of the episodes of CDI, the rate of recurrence and death in these patients, compared to those without liver disease.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48044878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consideraţii clinice şi opţiuni de tratament în infecţiile piciorului cu Staphylococcus aureus","authors":"Cătălin Bejinariu, C. Giuglea, Silviu Marinescu","doi":"10.37897/rjid.2019.3.5","DOIUrl":"https://doi.org/10.37897/rjid.2019.3.5","url":null,"abstract":"Revista Română de Boli infecţioase – Volumul XXII, Nr. 3, An 2019 Autor de corespondenţă: Dr. Cătălin Bejinariu, Secţia de Chirurgie Plastică şi Microchirurgie Reconstructivă, Spitalul Clinic de Urgenţă „Bagdasar-Arseni“, Şoseaua Berceni nr. 12, cod 041915, Bucureşti, România E-mail: drbejinariu@gmail.com Consideraţii CliniCe şi opţiuni de tratament în infeCţiile piCiorului Cu StaphylococcuS aureuS","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46938825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infecţia cu Clostridium difficile la pacienţii cu afectare cronică hepatică","authors":"Liliana Baroiu, Manuela Arbune, Alina-Viorica Iancu, Caterina Dumitru, Gabriela Lupăşteanu, Miruna Drăgănescu, Mihaela Debita, Sorin Rugină, România Spitalul Clinic de Boli Infecţioase Galaţi, Constanţa România Universitatea „Ovidius“, Academia de Ştiinţe Medicale din România, România Academia de Ştiinţe Medicale","doi":"10.37897/rjid.2019.3.4","DOIUrl":"https://doi.org/10.37897/rjid.2019.3.4","url":null,"abstract":"","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48060472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical considerations and treatment options in Staphylococcus aureus foot infections","authors":"Catalin Bejinariu, C. Giuglea, S. Marinescu","doi":"10.37897/rjid.2019.3.2","DOIUrl":"https://doi.org/10.37897/rjid.2019.3.2","url":null,"abstract":"Objectives. Foot cellulitis caused by Staphylococcus aureus raises multiple problems regarding early diagnosis and choice of the optimal treatment, especially in diabetic patients. The research aims to research clinical and prognostic features related to patients diagnosed with foot cellulitis. Material and methods. The study presents the clinical and prognostic features of 41 patients who received treatment at the \"Bagdasar-Arseni\" Emergency Clinical Hospital. Outcomes. The results of the analysis show that cellulitis caused by Staphylococcus aureus is associated with a favorable prognosis in the case of the rapid establishment of specific antibiotic treatment in combination with serial excisional debridement. conclusions. It is well known that the late establishment of therapeutic measures can have devastating consequences, culminating in the death of the patient. However, it should not be neglected that the combination of the surgical treatment with the specific antibiotic therapy can most often be the salvage solution for these difficult cases.","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43727211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and evolutive aspects of Coxiella burnetii infection","authors":"M. Hoara, S. Florescu, S. Pișcu, G. Țârdei, P. Calistru, “Dr. Victor Babes” Infectious, B. Pharmacy","doi":"10.37897/rjid.2019.2.2","DOIUrl":"https://doi.org/10.37897/rjid.2019.2.2","url":null,"abstract":"Introduction. Coxiella burnetii is the etiological agent of Q fever, a zoonosis that is still subject of „Query”. Formerly classified as a Rickettsia, C. burnetii is a highly infectious obligate intracellular bacteria, whose main animal reservoirs are cattle, sheep and goats. Commonly following transmission through inhalation of aerosols containing the pathogen spread during animal parturition, Q fever may present as a self-limited febrile illness, pneumonia or acute hepatitis. Nevertheless, the possibility of evolving towards a chronic form exists under certain circumstances, mainly involving previously affected heart valves or blood vessels. Diagnosis is usually serologically based and Doxycycline represents the most frequent choice of antibiotherapy. Objectives. The aim of this study is to analyse the clinical and laboratory settings that led to diagnosis of acute or chronic Q fever, the treatment regimens applied and consecutive outcome within the group of patients defined below. Materials and methods. The present paper represents an observational descriptive study performed on a group composed of 24 patients admitted in our hospital along 2018 and diagnosed with confirmed or probable acute or chronic Q fever. Both male and female subjects regardless of their age were included, under the condition of meeting the CDC case definition, by integrating the serological results into the clinical context. results and conclusions. A suggestive epidemiological frame was rarely proven. Out of the 24 subjects with ages between 34 and 80 years old, of which only 2 were women, 22 had acute Q fever, manifested mostly as a combination of atypical pneumonia and hepatitis (9 cases, representing 41. Only 2 of the acute Q fever cases had a confirmed diagnosis. Frequent complaints were fever (all cases), chills, headaches and vomiting. Only 28% of the radiologically confirmed pneumonias were accompanied by dry cough, whilst only 21% of the hepatitis cases associated jaundice. Biologically, although leukocytosis was more weakly cor-related with acute disease activity, all patients exhibited a moderate to high inflammatory response (through C reactive protein). Considering the latency of specific antibodies’ dosage results, the decision of initiating treatment was based on a clinical support. Antibiotherapy consisted of Doxycyclin, alone or in combinations meant to cover a larger spectrum, given the usually nonspecific symptoms and the initially low clinical suspicion for Q fever. Clinical evolution was favorable in all cases. Regarding the two patients with chronic Q fever, manifested as blood culture-negative endocarditis, of which only one was confirmed according to the CDC definition, both had presented valvular lesions before developing IE and had no history of acute infection with C. burnetii. In the first case, under empirical infective endocarditis agents (Ceftriaxone and Vancomycin), acute heart failure and necessity of surgical replacement of the affected","PeriodicalId":53394,"journal":{"name":"Revista Romana de Boli Infectioase","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42817190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}