Delta Medical College Journal最新文献

{"title":"Evaluation of the Patient Profile and Current Pattern of Care with Docetaxel Based Adjuvant Regimen in Operable Breast Cancer","authors":"M. Hai, P. Akhter, Q. Chowdhury, P. Banu, M. Hossain, K. Pervin","doi":"10.3329/DMCJ.V7I1.40614","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40614","url":null,"abstract":"Background: Early stage breast cancer can often be cured with surgery alone though there are chances of recurrent disease and decrease in survival. Adjuvant poly-chemotherapy with docetaxel-based regimens can improve both disease-free and overall survival in patients with operable breast cancer. \u0000Objective: This study was designed to evaluate the patient profile and current pattern of care with docetaxel based adjuvant regimen in operable breast cancer patients including the treatment outcome from clinical practice. \u0000Materials and method: This prospective, observational, non-comparative study planned to enroll newly diagnosed operable breast cancer patients with high risk of recurrence after surgery. Selection of docetaxel-based treatment strategy and dosage of therapy was at the discretion of individual oncologists as per routine clinical practice. Patient data were recorded during inclusion, each cycle of therapy, and follow-up at 1 year (+/- 1 month) after inclusion. \u0000Results: Between August 2008 and July 2011 a total of 85 patients with median age of 53 years (23-73 years) were enrolled and 53 (62.4%) patients were postmenopausal. Ductal carcinoma, the most common cancer type,was found in 73 (85.9%) patients. Receptor status was positive for estrogen, progesterone or Her2/neu/erbB2 in 65.9%, 47.1% and 5.8% patients, respectively. Mastectomy either partial or total was performed in 76 (89.4%) patients for the current disease. An average of 8 (range: 2-15) lymph nodes (LN) mostly in axilla were excised in 56 patients and average of 4 (range: 1-11) LN nodes were positive. Sentinel LNs were negative, excised in 4 patients. The mean tumor size was 5.5 cm and most (82.4%) patients were diagnosed at Stage II disease including some at Stage I and III (7.1%, 10.6%). Docetaxel (Taxotere®) was combined with cyclophosphamide alone or in addition with doxorubicin, epirubicin, 5 FU and trastuzumab either in combination or sequential regimen. Taxotere in combination with adriamycin and cyclophosphamide was planned for 63.5% patients. Trastuzumab as sequential therapy could be afforded by 1 patient only. Data regarding radiotherapy or hormone therapy was not recorded. At the end of four cycles, 83.5% of patients were found disease free and 5.9% had loco regional relapse. At 1 year 71 (93.4%) patients were alive, 63 (88.7%) were relapse-free and 8 (11.2%) had loco regional relapse. Nausea, vomiting, diarrhea, alopecia, anemia and neutropenia were most commonly reported adverse events classified as Grade 1 or Grade 2. Grade 3 neutropenia was reported in 5 patients and 2 patients reported grade 4 neutropenia. Grade 3 diarrhea was reported in 1 patient. \u0000Conclusion: Docetaxel as adjuvant chemotherapy offered one year survival in 93.4% (71/76) of the patients and 88.7% (63/71 patients) were disease-free. The safety profile of docetaxel based regimens was expected and manageable. \u0000Delta Med Col J. Jan 2019 7(1): 4-10","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46574971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vitamin E on Serum Urea Level on Gentamicin Induced Nephrotoxicity in Long Evans Rats","authors":"Shameem Ahmed, Mohammad Ashraf Ahmed, Rezwanur Rahman, Ashrafuzzaman, M. Jahan, A. Matin, Aysha Yasmin, M. Khatun, F. Afroz, Kuazi Dil Afroz","doi":"10.3329/DMCJ.V7I1.40613","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40613","url":null,"abstract":"Background: The kidneys have an important role in eliminating the final products of metabolic activities, excreting the drugs and chemicals. A variety of frequently used drugs have been demonstrated to produce nephrotoxic effects. \u0000Objective: This study was carried out to observe the effect of vitamin E on gentamicin-induced nephrotoxicity by assessing serum urea level in Long Evans rats. \u0000Materials and method: The experimental study was carried out on 40 healthy Long Evans rats of both sex with the weight ranges from 172-255 gm and the age ranges from 7 to 10 weeks. The rats were divided into four groups - Group A (normal control) received normal saline, group B, C and D received gentamicin for 6 days, rats of group C received vitamin E capsule for total 9 days with gentamicin whereas group D received vitamin E capsule for total 10 days with gentamicin. Serum urea level was measured at the end of the experiment. \u0000Results: The (mean±SD) serum urea levels in group A, B, C and D were 4.79±0.32, 12.41±1.22, 7.56±1.11 and 7.15±1.09 mmol/L respectively. The differences between groups were highly significant (p<0.001) for group A & B, A & C, A & D, B & C, B & D whereas the difference between C & D (p>0.01) was not significant. Serum urea level of the normal saline control group (group A) was within the normal limit (4.79 mmol/L). Serum urea level in gentamicin treated rats (group B) was more in comparison to gentamicin and vitamin E treated rats (group C & D) and pretreatment with longer duration group (group D) showed lower serum urea value than shorter one (group C) though the groups showed no significant difference. \u0000Conclusion: Vitamin E treatment showed some protective effect against gentamicin-induced nephrotoxicity. The results also indicated that effectiveness of vitamin E depends on duration of pretreatment that means the pretreatment duration must be increased to a suitable period for better protection against gentamicin-induced nephrotoxicity. \u0000Delta Med Col J. Jan 2019 7(1): 11-15","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44599946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situation of Working Slum Children in Dhaka City","authors":"S. Farah, M. Karim, S. Afrin","doi":"10.3329/DMCJ.V7I1.40617","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40617","url":null,"abstract":"Background: Rapid urbanisation in the 20th century has been accompanied by the development of slums. Nearly one-third of the world’s population and more than 60% of urban population in the least developed countries live in slums, including hundreds of millions of children. Slums are areas of broad social and health disadvantage to children and their families due to extreme poverty, overcrowding, poor water and sanitation, substandard housing, limited access to basic health and education services. \u0000Objective: To assess the demographic and nutritional situation of working slum children in Dhaka city. \u0000Materials and method: This descriptive cross sectional study was conducted at Moghbazar slum situated in Dhaka city from July to December, 2015. \u0000Results: Out of 200 slum children, 57 (28.5%) were in the age group of 12-14 years, among them 110 (55.0%) were male. Regarding educational background, more than fifty percent never attended any kind of school. Forty five percent respondents lived with their parents. About 26% of the slum children were engaged in beggary, 23% were van/rickshaw puller, 22% were tokai, and 10% were cooli. Near about 75% respondents did medium type of work and 80% did 5-8 hour work per day and most of their income was 500-800 Tk. per month. One third respondents were severe under nourished, 50 (25%) were normal and 30 (15%) respondents were obese. \u0000Conclusion: Increasing numbers of slums constitute a major challenge to development. Therefore, health related programmes should focus to improve the overall wellbeing of the working slum children. \u0000Delta Med Col J. Jan 2019 7(1): 26-30","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46096445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Medicine - Current","authors":"Rezwanur Rahman","doi":"10.3329/DMCJ.V7I1.40612","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40612","url":null,"abstract":"Abstract not available \u0000Delta Med Col J. Jan 2019 7(1): 1-3","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44971262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Foreign Body in Nose in Adult for a Long Time: A Rare Case","authors":"K. Haq, R. Tabassum, Shoriful Islam, A. I. Siddiqui, M. A. Basunia, R. Lodi, Mithun Paul, Amirul Islam","doi":"10.3329/DMCJ.V7I1.40620","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40620","url":null,"abstract":"Otolaryngologists frequently encounter nasal foreign bodies, particularly among children and mentally retarded patients. Many unusual foreign bodies in the nose have been reported like nuts, plastic toy parts, beads and even button batteries. Several symptoms may be present in the case of a nasal foreign body which includes nasal discharge, epistaxis, infection, halitosis, foul breath or body odour and chronic sinusitis. We present a case of 19 years old girl with left sided nasal blockage, foul smell from left nostril and mouth with occasional nasal bleeding for last 13 years. She was treated conservatively but was not improved. On anterior rhinoscopy some blackish material covered with exudates was revealed which was very foul smelling and bleeds on touch. After nasoendoscopy we suspected that it would be an old foreign body which had already formed rhinolith. The large foreign body was fixed with floor, lateral and medial wall (nasal septum) and was removed by 0˚nasoendoscope and also through oral cavity under general anaesthesia. \u0000Delta Med Col J. Jan 2019 7(1): 49-52","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41678234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Peripheral Neuropathy: Epidemiology, Physiopathology, Diagnosis and Treatment","authors":"N. Akter","doi":"10.3329/DMCJ.V7I1.40619","DOIUrl":"https://doi.org/10.3329/DMCJ.V7I1.40619","url":null,"abstract":"Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and type 2 diabetes. It affects over 90% of the diabetic patients. It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication, but several other hypotheses have been postulated. It is typically characterized by significant deficits in tactile sensitivity, vibration sense, lower-limb proprioception, and kinesthesia. Painful DPN has been shown to be associated with significant reductions in overall quality of life, increased levels of anxiety and depression, sleep impairment, and greater gait variability. DPN is often misdiagnosed and inadequately treated. Clinical recognition of DPN is imperative for allowing timely symptom management to reduce the morbidity associated with this condition. The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy, improving glycemic control as a prophylactic therapy and using medications to alleviate pain. First line drugs for pain relief include anticonvulsants, such as pregabalin and gabapentin and antidepressants, especially those that act to inhibit the reuptake of serotonin and noradrenaline. In addition, there is experimental and clinical evidence that opioids can be helpful in pain control, mainly if associated with first line drugs. Other agents, including for topical application, such as capsaicin cream and lidocaine patches, have also been proposed to be useful as adjuvant in the control of diabetic neuropathic pain, but the clinical evidence is insufficient to support their use. The purpose of this review is to examine proposed mechanisms of DPN, summarize current treatment regimen. A better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies. \u0000Delta Med Col J. Jan 2019 7(1): 35-48","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V7I1.40619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44496903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Notice for \"Preconception Care through Religious Leaders in Bangladesh - A Novel Approach\"","authors":"Rezwanur Rahman","doi":"10.3329/DMCJ.V6I2.40608","DOIUrl":"https://doi.org/10.3329/DMCJ.V6I2.40608","url":null,"abstract":"On 18th March 2019 the Editorial Board of Delta Medical College Journal agreed to retract the Editorial 'Preconception Care through Religious Leaders in Bangladesh – A Novel Approach’ published in Delta Medical College Journal, Vol.6(2) pages 59-61 (DOI: https://doi.org/10.3329/dmcj.v6i2.38212) as the authors had already committed it for publication elsewhere. This error is regretted, and we apologise for any inconvenience.","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45670206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Stress among Nurses in a Public Medical College Hospital","authors":"S. Das, C. Biswas, S. Afrin","doi":"10.3329/dmcj.v6i2.38218","DOIUrl":"https://doi.org/10.3329/dmcj.v6i2.38218","url":null,"abstract":"Background: Now a days, there is increased demand and progress in the nursing profession. Along with these stress among the nurses has also increased.Objective: Purpose of the study was to assess the extent of perceived occupational stress and its association with work-related and non-work related causes among nurses.Materials and method: This Cross-sectional study was carried out among 197 nurses of Shaheed Suhrawardy Medical College hospital (ShSMCH), Dhaka, Bangladesh, from the period of 1st July 2015 to 30th June 2016. Sampling method was simple random sampling. Data was collected by face to face interview with the help of semi-structured questionnaire and finally all data were analyzed using SPSS software version 21.Results: It was found that 69% nurses were between the age of 21 to 39 years, 94.9% were female, 68% were married, 79.2% were Muslim, 84.3% had diploma, family income of 91.4% were equal to more than 40,000 Tk. and 95.5% used to do clinical work. Only 5.1% found to experience high stress. Statistically significant difference was found between sex, occupational stress and religion, educational status, and type of work (p < 0.05). Few nurses suffered from high stress but high level of stress were more in male, non Muslim, post graduate nurse and those who were engaged in administrative work.Conclusion: Nurse Managers should take appropriate actions to decrease stress helping their nurses to work efficiently and effectively.Delta Med Col J. Jan 2018 6(2): 86-89","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/dmcj.v6i2.38218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44124445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Preconception Care through Religious Leaders in Bangladesh – A Novel Approach","authors":"S. Jahan, S. Shermin","doi":"10.3329/dmcj.v6i2.38212","DOIUrl":"https://doi.org/10.3329/dmcj.v6i2.38212","url":null,"abstract":"The following retraction notice for this article appears in Vol.6(2) 2018 https://doi.org/10.3329/dmcj.v6i2.40608. \u0000On 18th March 2019 the Editorial Board of Delta Medical College Journal agreed to retract the Editorial 'Preconception Care through Religious Leaders in Bangladesh – A Novel Approach’ published in Delta Medical College Journal, Vol.6(2) pages 59-61 (DOI: https://doi.org/10.3329/dmcj.v6i2.38212) as the authors had already committed it for publication elsewhere. This error is regretted, and we apologise for any inconvenience.","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/dmcj.v6i2.38212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48305080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross Sectional Study of Burn - Experience in 158 Cases","authors":"F. Shahid, T. M. Chowdhury, A. Begum, Haibuzzaman Chowdhury, N. Khan, S. Akhter, Mohammad Jubaidul Kabir, Palash Bose, Omma Hafsa Any","doi":"10.3329/DMCJ.V6I2.38217","DOIUrl":"https://doi.org/10.3329/DMCJ.V6I2.38217","url":null,"abstract":"Background: Burns are a global public health problem.Objectives: To find out the status of burn victims along with the causes and consequences of fatal burn injuries.Material and method: The data is collected from the autopsy reports of Dhaka Medical College in 2012. The purpose of this study was to record and evaluate the causes and magnitude of the fatal burn injuries.Results: In 2012, among total 2527 deaths reported at Dhaka Medical College, 158 (6.25%) cases were due to burn. The victims within 21 to 40 years were more vulnerable in comparison to other age groups. Female were more vulnerable than male (55.69% vs. 44.31%). Accidental burn was the commonest cause (55%).Conclusion: Thermal burns and related injuries are major cause of death and disability all over the world as well as Bangladesh. Detail study regarding flame burn is required to be carried out in this country.Delta Med Col J. Jan 2018 6(2): 82-85","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/DMCJ.V6I2.38217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47210530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}