South African Journal of Oncology最新文献

{"title":"Succinate dehydrogenase-deficient renal cell carcinoma: A retrospective study, 1999–2018","authors":"Ella Morrison, J. Goedhals, S. Pretorius, G. Joubert, A. Gill, G. van der Westhuizen","doi":"10.4102/sajo.v7i0.252","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.252","url":null,"abstract":"","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42105684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictors of adverse outcomes of in paediatric febrile neutropenia","authors":"Motunrayo O. Adekunle, Alan Davidson, Marc Hendricks","doi":"10.4102/sajo.v7i0.232","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.232","url":null,"abstract":"Background: Febrile neutropenia (FN) is the commonest acute complication of cancer treatment in children. The identification of patients at risk for FN as well as adverse outcomes has been described.Aim: To evaluate the prevalence and potential risk factors for FN and describe adverse outcomes in a cohort of children treated for cancer.Setting: The study was carried out in a paediatric oncology unit in a children’s hospital, Cape Town, South Africa.Methods: A retrospective study from 01 January 2017 to 31 December 2019 on children with cancer at Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.Results: Two hundred and sixty-seven episodes of FN occurred in 179 patients. Independent predictors of FN were acute myeloid leukaemia (AML) (p = 0.039), acute lymphocytic leukaemia (ALL) (p = 0.020) and intensive chemotherapy (p ≤ 0.001). Mucositis (p = 0.001), central venous access device (CVAD) placement (p = 0.004), haematologic malignancies (p = 0.040), blood transfusion during FN episode (p 0.001) and severe neutropenia (white cell counts 0.3 × 109 cells/L) (p ≤ 0.001) were risk factors for adverse outcomes. The mortality rate from FN was 3.57%. Independent predictors of adverse outcomes in those with FN were AML (p = 0.001), CVAD placement (p = 0.019) and severe neutropenia (p = 0.005).Conclusion: Treatment related adverse outcomes following chemotherapy-induced FN are likely in children with AML, severe neutropenia and with CVAD placement.Contribution: Adverse outcomes from paediatric febrile neutropenia is high. There is need for clinical decision making aimed at prevention and early identification of individuals at risk.","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135837901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between clinical and laboratory characteristics on the short-term outcome of acute promyelocytic leukaemia patients at a central South African tertiary hospital","authors":"Wriothesley Naicker, J. Kloppers, F. C. Van Rooyen, Anne-Cecilia van Marle, C. Barrett","doi":"10.4102/sajo.v7i0.245","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.245","url":null,"abstract":"Background: Targeted therapies combined with anthracycline chemotherapy have improved the survival of patients with acute promyelocytic leukaemia (APL). High short-term mortality has been demonstrated in low- and upper-middle-income countries, with limited local data.Aim: This study aimed to describe the demographic variables, clinical characteristics and laboratory features associated with the short-term mortality of patients with APL.Setting: The Division of Clinical Haematology, Universitas Academic Hospital (UAH), Bloemfontein, South Africa.Methods: Demographic and clinical data were obtained from the patients’ files and the MEDITECH electronic filing system. Laboratory data were retrieved from TrakCare, the National Health Laboratory Service (NHLS) electronic database. Data were analysed to report the demographic variables, clinical characteristics and laboratory features, and the short-term mortality of all newly diagnosed patients treated for APL during the 5-year period, 2015–2019.Results: Twenty-seven patients were included in this study. The 7-day mortality rate was 18.5%, and the 30-day mortality rate was 33.3%. Sanz and modified Sanz scores were significantly associated with 7-day mortality but not 30-day mortality. Creatinine ≥ 105 µmol/L was significantly associated with both 7- and 30-day mortalities. Patients who died within the first 30 days of admission had significantly higher median white cell counts and partial thromboplastin times. Hypogranular APL was identified in 55.6% of patients.Conclusion: The short-term mortality of APL at UAH is in keeping with findings at other treatment centres in middle-income countries. Despite being considered rare, hypogranular APL was the predominant type in this cohort.Contribution: This study highlights the need for practices pertaining to peripheral smear utility and interpretation to be reviewed outside of tertiary centres. ","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48425564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit","authors":"Sumaya Ismail, Francois Malherbe, Eugenio Panieri, Lydia Cairncross, Gaseeda Boltman, Florence E. Davidson","doi":"10.4102/sajo.v7i0.233","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.233","url":null,"abstract":"Background: The radioguided occult lesion localisation (ROLL) technique was introduced at Groote Schuur Hospital in 2003 replacing the wire-guided localisation (WGL) technique. In the case of preoperative histologically proven impalpable breast cancers, a sentinel lymph node (SLN) biopsy was done simultaneously (sentinel node [SN] with occult lesion localisation or SNOLL).Aim: To assess the efficacy of the ROLL and SNOLL techniques for diagnostic and therapeutic excisions.Setting: A retrospective record analysis of 190 patients who underwent a ROLL procedure for diagnostic or therapeutic excision of occult breast lesions was performed at a large tertiary hospital in the Western Cape.Methods: Data were collected on patient and tumour characteristics, successful localisation rates, the volume of tissue removed, complete tumour resection rates, the number of re-operations performed and the proportion of SLN detection. The Pearson’s chi-squared test was used to test for significance between variables at α = 0.05.Results: Correct radiopharmaceutical placement was achieved in 177/190 (93.2%) lesions. Histologic examination of excised specimens confirmed 115/190 (61.0%) malignant and 75/190 (39.0%) benign lesions. Involved margins were found in 37/115 (32.2%). Complete excision with adequate margins occurred in 50/70 (71.4%) of cases of invasive cancer and in 11/45 (24.4%) of ductal carcinoma in situ (DCIS). The SN was successfully identified in 30/37 (81.1%) of SNOLL cases.Conclusion: Radioguided occult lesion localisation is an effective tool in the preoperative localisation of occult lesions for surgical biopsy as well as the removal of impalpable breast cancers. A single intratumoural injection with 99mTc nanocolloid combined with lymphoscintigraphy is a reliable method of localising the SN.","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136335960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent tuberculous pericarditis and lung adenocarcinoma presenting with cardiac tamponade","authors":"K. Naicker, Sameera Dalvie, Q. Said-Hartley, M. Ntsekhe","doi":"10.4102/sajo.v7i0.255","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.255","url":null,"abstract":"","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43183590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[123I]-metaiodobenzylguanidine imaging findings and outcome in patients with metastatic neuroblastoma","authors":"Y. Amoako, A. Van Eyssen, A. Brink","doi":"10.4102/sajo.v7i0.250","DOIUrl":"https://doi.org/10.4102/sajo.v7i0.250","url":null,"abstract":"","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44965891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Table of Contents Vol 6 (2022)","authors":"Editorial Office","doi":"10.4102/sajo.v6i0.264","DOIUrl":"https://doi.org/10.4102/sajo.v6i0.264","url":null,"abstract":"No abstract available.","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47177559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroblastoma survival in South African children is more influenced by biological than socioeconomic factors","authors":"R. Charlton, Thandeka Ngcana, J. Geel","doi":"10.4102/sajo.v6i0.244","DOIUrl":"https://doi.org/10.4102/sajo.v6i0.244","url":null,"abstract":"Background: Optimal management of neuroblastoma depends on accurate risk stratification at diagnosis. Many low- and middle-income countries lack access to specific genetic tests used globally for this purpose.Aim: To determine whether socioeconomic factors predict prognosis in neuroblastoma and could therefore provide alternative measures for risk stratification in resource-constrained settings.Setting: The three main paediatric oncology units in Johannesburg, South Africa: Charlotte Maxeke Johannesburg Academic Hospital, Chris Hani Baragwanath Academic Hospital and Wits Donald Gordon Medical Centre.Methods: This retrospective record review included 145 patients presenting with biopsy-proven neuroblastoma between 01 January 2000 and 31 December 2018. Kaplan–Meier survival analysis was performed in relation to biological and socioeconomic factors, the latter including parental employment status, nationality, and distance of residence from treating facility. Cox proportional hazards regression analysis assessed the significance and effect of these prognostic factors.Results: Factors with significant effect on survival were age below 18 months (p  0.0001), extra-abdominal primary tumour site (p = 0.02), lower stage (p  0.001), serum ferritin level 0.0001) and favourable International Neuroblastoma Pathological Committee histology (p  0.0001), race (p = 0.005), nationality (p = 0.05) and paternal employment (p = 0.02). The association between distance from treating facility and stage at diagnosis was not significant (Tb = 0.108, p = 0.06).Conclusion: Biological factors exert a great influence on neuroblastoma survival than the socioeconomic factors analysed. This suggests that tumour biology exerts an overriding influence on prognosis in neuroblastoma. ","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45120064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-myelocytomatosis tag antibody detects myelocytomatosis oncogene expression in Burkitt lymphoma","authors":"Nokuphila B. Shezi, N. Ntshwanti, P. Magangane","doi":"10.4102/sajo.v6i0.239","DOIUrl":"https://doi.org/10.4102/sajo.v6i0.239","url":null,"abstract":"Background: The immunohistochemical (IHC) detection of myelocytomatosis oncogene (MYC) is a crucial step in the diagnosis and prognosis of Burkitt lymphoma (BL). Sections of the MYC protein are routinely used as tags in protein precipitation experiments to assist with the isolation of proteins without antibodies. However, it is unknown if the tag antibodies can also be used for BL diagnosis.Aim: This project aimed to determine whether the MYC tag 9E10 antibody can be used to detect MYC overexpression because of MYC translocation in BL cases.Setting: Charlotte Maxeke Johannesburg Academic Hospital, South Africa.Methods: Immunohistochemical staining for 9E10 was optimised and used to stain 10 BL with known MYC translocation status to calculate sensitivity, specificity and predictive values.Results: Staining of the BL cases generally produced a ‘very weak’ (70%) and weak-moderate (18.2%) staining patterns with a staining extent of 1+ (36%) and 3+ (27%). Of the 10 samples, 6 (60%) showed a positive MYC protein expression by IHC. In comparison, 7 (70%) samples indicated MYC gene rearrangements. There were 5 (50%) cases with both MYC IHC expression and gene translocations and 2 (20%) cases that were negative for both MYC IHC and gene rearrangements.Conclusion: The authors demonstrate that the 9E10 MYC tagged antibody may be used to detect MYC gene expression with a sensitivity of 71% and a specificity of 67%. In addition, the positive predictive value (PPV) and negative predictive value (NPV) varied according to IHC staining cut-offs. Immunohistochemical expression does not perfectly correlate with translocation status because of inconsistencies with IHC interpretation.Contribution: MYC gene rearrangements are present in nearly all BL cases. Finding more affordable and convenient ways to predict the presence of MYC gene rearrangements is of utmost importance, given the lack of financial resources in our continent. This study shows that the 9E10 antibody, commonly used in protein tagging experiments, may also be used to predict MYC gene rearrangements in BL.","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":"249 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41315553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute promyelocytic leukaemia: A central South African experience","authors":"Wriothesley Naicker, J. Kloppers, F. C. Van Rooyen, Anne-Cecilia van Marle, C. Barrett","doi":"10.4102/sajo.v6i0.245","DOIUrl":"https://doi.org/10.4102/sajo.v6i0.245","url":null,"abstract":"mortality rate was 18.5 % , and the 30-day mortality rate was 33.3 % . Sanz and modified Sanz scores were significantly associated with 7-day mortality but not 30-day mortality. Creatinine ≥ 105 µmol/L was significantly associated with both 7-and 30-day mortalities. Patients who died within the first 30 days of admission had significantly higher median white cell counts and partial thromboplastin times. Hypogranular APL was identified in 55.6 % of patients. Conclusion: The short-term mortality of APL at UAH is in keeping with findings at other treatment centres in middle-income countries. Despite being considered rare, hypogranular APL was the predominant type in this cohort. Contribution: This study highlights the need for practices pertaining to peripheral smear utility and interpretation to be reviewed outside of tertiary centres.","PeriodicalId":52950,"journal":{"name":"South African Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49403059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}