Cardiology Plus最新文献_第8页

Serum N-terminal-pro-B-type natriuretic peptide is dependent on age and sex: a cross-sectional analysis in healthy adults from Northeast China 血清N末端B型钠尿肽依赖于年龄和性别：中国东北地区健康成年人的横断面分析

Cardiology Plus Pub Date : 2022-03-01 DOI: 10.1097/CP9.0000000000000004

B. He, Panyang Xu, Qi Zhou, J. Xu, Lu Cai

{"title":"Serum N-terminal-pro-B-type natriuretic peptide is dependent on age and sex: a cross-sectional analysis in healthy adults from Northeast China","authors":"B. He, Panyang Xu, Qi Zhou, J. Xu, Lu Cai","doi":"10.1097/CP9.0000000000000004","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000004","url":null,"abstract":"Abstract Background: Previous studies suggested higher serum N-terminal-pro-B-type natriuretic peptide (NT-proBNP) level with older age and in women, but the reference intervals (RIs) recommended by assay manufacturers do not fully recognize such pattern. Aims: In this study, we aimed to establish a set of age- and sex-specific RIs for serum NT-proBNP in healthy adults from Northeast China. Methods: Healthy adult subjects (20 to ≤95 years old) were recruited from the physical examination center at a teaching hospital during a period from March 2020 to July 2020. Serum NT-proBNP concentration was measured using the VITROS 5600 Integrated System with a chemiluminescence method. RIs were calculated based on the EP28-A3c guidelines by the Clinical and Laboratory Standards Institute. A generalized linear model was performed to factors that were associated with NT-proBNP level. Results: The final analysis included 2,183 subjects (1,074 men and 1,109 women, mean age 54.2 ± 19.5 years). Serum NT-proBNP level increased with advancing age (20 to <50, 50 to <60, 60 to <75 and ≥75 years), and was significantly higher in women than in men with the exception of the ≥75 age group. Higher NT-proBNP level was associated with the female sex, older age, lower body mass index, higher urea nitrogen, higher creatinine, lower uric acid, and lower triglyceride (P < 0.05 for all). The strongest association was with the female sex, followed by age. Conclusions: Serum NT-proBNP level must be interpreted with consideration of sex and age. Higher NT-proBNP is associated with the female sex and older age.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"48 - 55"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47379031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signaling pathways of inflammation in myocardial ischemia/reperfusion injury 心肌缺血再灌注损伤中炎症信号通路的研究

Cardiology Plus Pub Date : 2022-03-01 DOI: 10.1097/CP9.0000000000000008

Shidi Hu, Ji'e Yang, Feng Zhang

引用次数: 0

Calcific aortic valve stenosis and COVID-19: clinical management, valvular damage, and pathophysiological mechanisms 钙化主动脉瓣狭窄与COVID-19:临床处理、瓣膜损伤和病理生理机制

Cardiology Plus Pub Date : 2022-03-01 DOI: 10.1097/cp9.0000000000000001

Magnus Bäck, M. Hashem, A. Giani, S. Pawelzik, A. Franco-Cereceda

引用次数: 1

Coronary artery fistula: To close or not close, that is the question 冠状动脉瘘：关闭还是不关闭，这是个问题

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334396

W. Pan, Nan-Chao Hong, J. Ge, Da-Xin Zhou

引用次数: 1

COVID-19-induced cardiovascular damage differs from other prevalent viruses covid -19引起的心血管损伤不同于其他流行病毒

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334401

Rachel Parise, S. Ramesh, Manoj Govindarajulu, Amir Ajoolabady, Timothy Moore, M. Dhanasekaran

{"title":"COVID-19-induced cardiovascular damage differs from other prevalent viruses","authors":"Rachel Parise, S. Ramesh, Manoj Govindarajulu, Amir Ajoolabady, Timothy Moore, M. Dhanasekaran","doi":"10.4103/2470-7511.334401","DOIUrl":"https://doi.org/10.4103/2470-7511.334401","url":null,"abstract":"Viral infections persist globally, among all ages, gender, and ethnicity. Of particular importance is COVID-19, associated with asymptomatic to severe symptoms, including complications/mortality. Cardiovascular disease (CVD) involves heart and blood vessel disorders including coronary heart disease, cerebrovascular disease, peripheral artery disease, thrombosis, and more. CVD associated with severe COVID-19 includes heart failure, coronary artery disease, cardiomyopathy, hypertension, and cerebrovascular disease/stroke. Data were acquired from PubMed, Google Scholar, Centers for Disease Prevention and Control, and Lexi-Comp using the search terms “COVID-19 and cardiovascular pathology;” “COVID-19 induced CVD;” “Viral infection induced CVD;” and “Viral infection induced heart damage.” COVID-19-induced CVD mechanisms include direct viral entry, inflammation, cytokine storm, hypoxia, interferon-mediated immune response, plaque destabilization, stress, and drug-induced causes. Other viral pathologies causing CVD include atherosclerosis, inflammation, cytokine storm, and plaque destabilization. Individual parameters, such as old age, males, and higher body mass index (BMI), are more likely to experience viral-associated complications, possibly explained by patient risk factors or comorbidities. Populations at higher risk include older males with an elevated BMI. Viral mechanisms associated with CVD are similar but differ in disease severity, potentially explained by diverse cytokine profiles where COVID-19 activates different types at higher quantities.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"231 - 245"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42766914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cardiac protective effects of proinflammatory cytokines during ischemia-reperfusion 缺血再灌注过程中促炎细胞因子对心脏的保护作用

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334402

Li-Sha Li, Hong Wu, Shu-Xia Wang, Sui-xin Liu, Le-Qing Lin, Da-Ke Qi

引用次数: 3

Quality of Care for Patients with Acute Coronary Syndrome 急性冠状动脉综合征患者的护理质量

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334403

Donghui Zhao, Sidney Smith Jr

引用次数: 2

Re-visit the concept of M1 versus M2 phenotypes of BV2 microglia and test their effects on stroke outcome in mice 重新考察BV2小胶质细胞M1与M2表型的概念，并测试它们对小鼠中风结果的影响

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334399

D. Yan, Yongming Zhang, Yu-hua Ji, Tao Wang, Xiao-Xing Xiong, Heng Zhao

{"title":"Re-visit the concept of M1 versus M2 phenotypes of BV2 microglia and test their effects on stroke outcome in mice","authors":"D. Yan, Yongming Zhang, Yu-hua Ji, Tao Wang, Xiao-Xing Xiong, Heng Zhao","doi":"10.4103/2470-7511.334399","DOIUrl":"https://doi.org/10.4103/2470-7511.334399","url":null,"abstract":"Backgrounds: Whether there are distinctive macrophage functional phenotypes of M1 versus M2 has been debated. We re-examined them by studying M1/M2 gene and protein expressions in cultured BV2 microglial cells and their effects on stroke outcomes in vivo. Methods: BV2 microglia cells were cultured and polarized with lipopolysaccharide (LPS) and interleukin-4 (IL-4) to produce M (LPS) and M (IL-4) phenotypes, which were originally defined as M1 and M2 phenotypes, respectively. Typical M1 and M2 gene or protein expression patterns were analyzed in M (LPS) and M (IL-4) phenotypes and their distinctive effects on stroke outcomes were compared. Results: M (LPS) and M (IL-4) had distinctive morphologies. M (IL-4) had significantly higher gene expressions of the typical M2 markers and other anti-inflammatory genes, while M (LPS) had higher gene expression of typical M1 markers and other pro-inflammatory genes. Nevertheless, M2 gene expressions were also enhanced in M (LPS), and M1 gene expressions were increased in M (IL-4), although with relatively lower levels. Adoptive transfer of M (IL-4) reduced infarction and improved neurological scores, while M (LPS) macrophages generated the opposite effect. Fluorescence activated cell sorting (FACS) and confocal studies suggest that M (IL-4) inhibited, while M (LPS) promoted the infiltration of monocyte-derived macrophages and iNOS-positive cells. Conclusions: M (LPS) and M (IL-4) from cultured BV2 cells indeed are distinctive functional phenotypes, but it is inaccurate to simply classify them into M1 and M2 phenotypes based on a few typical gene and protein markers.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"264 - 273"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47752503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Challenges in management of ST elevation myocardial infarction during COVID-19 pandemic 新冠肺炎大流行期间ST段抬高型心肌梗死的管理挑战

Cardiology Plus Pub Date : 2021-10-01 DOI: 10.4103/2470-7511.334400

C. Tam, C. Siu, H. Tse

引用次数: 3

Cardiovascular medicine in the era of COVID-19 pandemics. COVID-19大流行时代的心血管医学

Cardiology Plus Pub Date : 2021-10-01 Epub Date: 2021-12-30 DOI: 10.4103/2470-7511.334404

Jun Ren

引用次数: 0