Cardiology Plus最新文献

{"title":"Trends in percutaneous coronary intervention in China: analysis of China PCI Registry Data from 2010 to 2018","authors":"Zhao-ping Liu, Jianping Li, Yan Zhang, B. Yu, Yitong Ma, G. Ma, Jian'an Wang, Bin Liu, Xin-Yan Su, Bao Li, Zheng-Chang Zhang, Yuguo Chen, Jiyan Chen, Lianglong Chen, Yundai Chen, Zuyi Yuan, S. Jia, Chuanyu Gao, Yida Tang, Xianghua Fu, Yaling Han, Junbo Ge, Xudong Ma, Y. Huo","doi":"10.1097/CP9.0000000000000021","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000021","url":null,"abstract":"Background and purpose: In the past 30 to 40 years, percutaneous coronary intervention (PCI) in China has greatly improved. The State Ministry of Health established a quality control (QC) system in 2009, and all medical centers were required to report their PCI cases. We analyzed the data from the QC system to describe the current status and development of PCI in China. Methods: PCI case data during a period from 2010 to 2018 were extracted from the online QC system. Data quality was audited by QC centers at the provincial level. Statistical analysis was mainly descriptive. Trend analysis was conducted by recoding the year as a continuous variable in linear regression or logistic regression. Results: The number of medical centers reporting PCI cases was 941 in 2010, and increased to 1,788 in 2018. Total number of PCI cases reported online to the QC system was 236,717 in 2010, and increased to 705,970 in 2018. Estimate of the actual case number that included those reported offline only (based on offline audit by provincial QC centers) was 284,936 in 2010, and increased to 915,256 in 2018. The most common indication for PCI was unstable angina (52.9%–59.1%), followed by ST elevation myocardial infarction (STEMI; 25.0%–27.4%). Majority of the PCI procedures were performed via the radial artery (65.4% in 2010 and 90.7% in 2018). Angiography detected a left main lesion in 5%, single-vessel disease in 38.7% to 44.4%, two-vessel disease in 22.3% to 27.5%, and three-vessel disease in 27.0% to 28.7% of the patients. The rate of primary PCI for STEMI in all STEMI cases was 28.0% in 2010, and increased to 45.9% in 2018. The average number of stents implanted per case was 1.63 in 2010, and decreased to 1.46 in 2018. There was a trend for decreasing mortality (0.31% in 2010; 0.26% in 2018). Conclusions: The number of PCI cases in China increased steadily during a period from 2010 to 2018, with stable mortality rate. Transradial access is the dominant PCI route. The rate of primary PCI for STEMI increased substantially, but remained relatively low.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"118 - 124"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45165012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1097/CP9.0000000000000026","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000026","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.4103/2470-7511.312594.][This corrects the article DOI: 10.4103/2470-7511.312596.][This corrects the article DOI: 10.4103/2470-7511.320317.][This corrects the article DOI: 10.4103/2470-7511.320322.][This corrects the article DOI: 10.4103/2470-7511.320318.][This corrects the article DOI: 10.4103/2470-7511.320319.][This corrects the article DOI: 10.4103/2470-7511.327241.][This corrects the article DOI: 10.4103/2470-7511.327240.][This corrects the article DOI: 10.4103/2470-7511.334399.][This corrects the article DOI: 10.1097/CP9.0000000000000009.][This corrects the article DOI: 10.1097/CP9.0000000000000004.][This corrects the article DOI: 10.1097/CP9.0000000000000003.].</p>","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 3","pages":"148-149"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/e7/cp9-7-148.PMC9640275.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40484367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular health status in Chinese Cardiologists: China Cardiologist Heart Survey II","authors":"Shikai Yu, Yi Zhang, W. Peng, Dong Zhao, Hong Shi, Shuning Zhang, Y. Huo, Yawei Xu, J. Ge","doi":"10.1097/CP9.0000000000000022","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000022","url":null,"abstract":"Background and purpose: Cardiologists represent a subset of the population with the highest degree of awareness to cardiovascular diseases (CVD), and thus should have low exposure to modifiable risks and low CVD prevalence. However, the status of cardiovascular health in Chinese cardiologists remains unknown. Methods: China Cardiologist Heart Survey II is a nation-wide cross-sectional survey on licensed cardiologists in Chinese mainland. It was conducted between August 2020 and November 2021. An online questionnaire was used to acquire demographic and lifestyle information, cardiovascular risk factors, CVD status, and medications. Crude prevalence of cardiovascular risk factors, organ damage, and CVD were calculated and compared between sexes and between sub-specialties. Age-weighted prevalence of cardiovascular risk factors were compared to that in the general Chinese population in the literature. Results: The final analysis included a total of 15,827 cardiologists at the age of 25 to 60 years from 31 provinces. The median age was 38 years and 8650 (54.7%) were men. The most common cardiovascular risk factor was family history of premature CVD (20.4%), followed by hypertension (12.4%), hyperlipidemia (10.6%), overweight/obesity (8.3%), smoking (7.3%), and diabetes (2.4%). The most common sub-clinical organ damages included carotid plaque (3.4%) and microalbuminuria (1.2%). The rate of confirmed coronary artery disease was 0.4%. The rate of arrhythmia was 3.1%. The rate of obstructive sleep apnea syndrome was 2.2%. The rate of cardiovascular risk factors and organ damage was higher in men versus in women, and higher in interventional versus non-interventional cardiologists. In comparison to the data reported for the general population in China, cardiologists had lower age-weighted prevalence of hypertension (15.2% vs. 23.2%), diabetes (3.1% vs. 10.9%), hyperlipidemia (12.3% vs. 40.4%), obesity (2.1% vs. 11.9%), and smoking (7.7% vs. 27.7%). Conclusions: In comparison to the general public, cardiologists in Chinese mainland had much lower age-weighted prevalence of cardiovascular risk factors, but there is substantial room for further improvement, particularly in male and interventional cardiologists.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"125 - 131"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45832136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced platelet NLRP3 inflammasome expression in patients with acute coronary syndrome and stable coronary artery disease: A prospective observational study","authors":"Zhiyong Qi, Xin Liu, Gang Zhao, Junbo Ge","doi":"10.1097/CP9.0000000000000018","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000018","url":null,"abstract":"Background and purpose: Nucleotide-binding domain leucine-rich repeat containing protein (NLRP3) inflammasome contributes to the development and progression of atherosclerosis and cardiovascular diseases. Enhanced expression of NLRP3 in monocytes has been reported in patients with coronary artery disease (CAD). However, NLRP3 expression in platelets, an important link between inflammation and atherosclerosis/thrombosis in CAD patients has not been evaluated. The purpose of this study was to explore the expression of NLRP3 in platelets with acute coronary syndrome (ACS) and stable CAD. Methods: This prospective observational study included 60 treatment-naïve patients with newly diagnosed ACS, 60 patients with stable CAD, and 60 age- and sex-matched healthy individuals with normal coronary arteries (NCA). Platelet NLRP3 expression was evaluated by flow cytometry in venous blood samples, and compared among the 3 groups. Multivariate regression analysis was conducted to identify the risk of ACS. Results: Platelet NLRP3 expression was highest in the ACS group, followed by the stable CAD, and lowest in the NCA group (P < 0.001 for ACS vs. stable CAD, 44.7 ± 21.3 vs. 25.9 ± 15.9, as well as for stable CAD, vs. NCA, 25.9 ± 15.9 vs. 12.4 ± 7.2). Higher platelet NLRP3 correlated with higher plasma interleukin-1β and interleukin-18 (r = 0.662 and 0.324, respectively; P < 0.001 for both). In multivariate regression analysis, higher platelet NLRP3 was independently associated with ACS (odds ratio 1.06, 95% CI: 1.02–1.10 vs. stable CAD; odds ratio 1.23, 95% CI: 1.06–1.42 vs. NCA). Conclusion: Platelet NLRP3 expression was highest in the ACS group, followed by the stable CAD group, and lowest in the NCA group. Also, higher platelet NLRP3 expression was independently associated the ACS.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"132 - 137"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49525575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline platelet count independently predicts long-term adverse outcomes in patients undergoing percutaneous coronary intervention: a single-center retrospective cohort study","authors":"Xiangeng Hou, Ying-Ying Zheng, Tingting Wu, You Chen, Yi Yang, Yi-tong Ma, Xiang Xie","doi":"10.1097/CP9.0000000000000023","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000023","url":null,"abstract":"Background and purpose: The association between platelet counts (PC) with clinical outcomes after percutaneous coronary intervention (PCI) in patients with coronary artery disease (CAD) has been reported by some but not all previous studies. The present study aims to investigate the association of PC with the outcomes of CAD patients who underwent PCI. Methods: We conducted a retrospective cohort study to examine the potential impact of baseline PC with long-term outcomes in patients receiving at least one stent. The final analysis included a total of 6,046 patients. The median follow-up was 32 (1–120) months Results: All-cause mortality did not differ significantly among the four groups based on baseline PC (lowest 25%, Quartile 1 [Q1], PC < 173, n = 1,473; 25%–50%, Quartile 2 [Q2], 173 ≤ PC < 208, n = 1,529; 50%–75%, Quartile 3 [Q3], 208 ≤ PC < 250, n = 1,507; and 75%–100%, Quartile 4 [Q4], PC ≥ 250, n = 1,537). The rate of major adverse cardiovascular and cerebrovascular events was 12.8% (188/1,473) in the Q1 group, 12.8% (196/1,529) in the Q2 group, 15.1% (228/1,507) in the Q3 group, and 16.3% (150/1,537) in the Q4 group (P = 0.010). The rate of major adverse cardiovascular events was 11.3% (167/1,473) in the Q1 group, 11.6% (177/1,529) in the Q2 group, 13.9% (210/1,507) in the Q3 group, and 15.0% (231/1,537) in the Q4 group (P = 0.004). Using Q1 as reference, the adjusted hazard ratio (aHR) for major adverse cardiovascular and cerebrovascular events in multivariate Cox regression was 1.212 (95% confidence interval [CI]: 1.004–1.455, P < 0.001) in Q2, 1.455 (95% CI: 1.200–1.766, P < 0.001) in Q3, and 1.754 (95% CI: 1.426–2.118, P < 0.001) in Q4. Using Q1 as reference, the aHR for major adverse cardiovascular events was 1.201(95% CI: 0.968–1.492, P = 0.096) in Q2, 1.489 (95% CI: 1.206–1.837, P < 0.001) in Q3, and 1.847 (95% CI: 1.500–2.275, P < 0.001) in Q4. Conclusion: A higher baseline PC was independently associated with an increased risk of major adverse cardiovascular and cerebrovascular events and major adverse cardiovascular events, but not all-cause-mortality in CAD patients after PCI.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"138 - 143"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61654755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality trend of heart diseases in China, 2013–2020","authors":"Z. Long, Yangyang Xu, Wei Liu, Lijun Wang, Maigeng Zhou, P. Yin, Y. Huo","doi":"10.1097/CP9.0000000000000019","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000019","url":null,"abstract":"Background and purpose: Heart diseases are the leading cause of death in China. Understanding of the secular trend of different subcategories of heart disease is important for policy making. The purpose of this study is to analyze the mortality trend of heart diseases in China from 2013 to 2020. Methods: A population-based longitudinal analysis was conducted using the China National Mortality Surveillance System to examine heart disease mortality change during a period from 2013 to 2020. The causes of death were coded using the International Classification of Diseases-10th Revision. The number of deaths and mortality rate were calculated based on sex, subcategories of heart disease, urban versus rural setting, and across different geographic locations. Data from the sixth census in China in 2010 was used as the standard population, and the mortality rates were adjusted based on the under-reporting rate. Results: Ischemic heart disease (IHD), hypertensive heart disease (HHD), and rheumatic heart disease (RHD) are the three leading causes of heart disease deaths during 2013–2020. There was a trend for increased age-standardized mortality rate (ASMR) of cardiac arrest, aortic aneurysm (AA), and nonrheumatic valvular heart diseases (NRVHDs) during the study period. In comparison to men, women had higher ASMR of RHD, and lower ASMR of IHD, HHD, cardiac arrest, AA, and NRVHDs. In comparison to rural areas, urban areas had lower ASMR of IHD, HHD, and RHD, and higher ASMR of cardiac arrest, AA, and NRVHDs. The spectrum of heart diseases differed significantly across age groups. In 2020, the percentages of IHD and HHD in the ≥65-year age group were higher than in other age groups. Significant differences in ASMR were noted across different geographic locations, with the highest in Xinjiang (198.14/100,000) and the lowest in Shanghai (62.19/100,000) in 2020. Conclusions: The mortality rate decreased for IHD, HHD, and RHD during the study period, but remained the leading causes of heart disease death in China. There was a trend for increasing mortality of cardiac arrest, AA, and NRVHDs, and significant difference across different geographic locations.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"111 - 117"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47043933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: C-reactive protein and cardiovascular events in obstructive and nonobstructive coronary artery disease","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.1097/cp9.0000000000000010","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000010","url":null,"abstract":"","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49489727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: C-reactive protein and cardiovascular events in obstructive and nonobstructive coronary artery disease","authors":"Jian‐Jun Li","doi":"10.1097/cp9.0000000000000014","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000014","url":null,"abstract":"","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44436834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALDH2 mutation results in excessive basal nitric oxide production and a delayed response to nitroglycerin","authors":"Hongming Zhu, Jingjing Hu, Z. Dong, Yang Liu, Xiaolei Sun, A. Sun","doi":"10.1097/CP9.0000000000000011","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000011","url":null,"abstract":"Abstract Background and purpose: Nitroglycerin tolerance is a common phenomenon in patients with coronary artery disease (CAD). Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that metabolizes nitroglycerin to its active form nitric oxide (NO). Previous studies showed altered nitroglycerin in subjects with ALDH2 mutation, but the functional impact on endothelial cells is not fully understood. Methods: In the first step of in vitro experiments, we examined functional properties of induced pluripotent stem cell-derived CD144+ endothelial cells (iPSC-ECs) that expressed wildtype (WT) vs ALDH2+/− variant. In the second step of human studies, diameter of the left anterior descending (LAD) coronary artery was determined using angiography in 151 adult volunteers (111 with WT ALDH2, 32 with ALDH2+/− and 8 with ALDH2−/− genotype) prior to as well as after intracoronary injection of 200-μg nitroglycerin. Results: Briefly, the ALDH2+/− iPSC-ECs demonstrated impaired low-density lipoprotein (LDL) uptake, proliferation, migration, tube formation, oxidative stress resistance, and viability. In comparison to the WT control, the ALDH2+/− iPSC-ECs had elevated NO production under baseline conditions, but exhibited a delayed NO release after nitroglycerin treatment. Exposure to 10-μg/mL nitroglycerin for 2 h increased NO production in WT iPSC-ECs but 4-h exposure was required to stimulate NO production in the ALDH2+/− iPSC-ECs. In comparison to the WT control, the subjects carrying the ALDH2+/− variants had seemingly larger LAD coronary artery diameter (3.5 and 3.8 mm vs 3.4 mm in the WT control), but attenuated vasodilatory response to nitroglycerin (ALDH2MUT group vs the WT control, 7.1 ± 0.6% vs 10.1 ± 0.8%, P = 0.024). Conclusion: These findings indicated elevated NO production by endothelia cells under basal conditions but attenuated response to nitroglycerin upon ALDH2 mutation.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"85 - 91"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47000085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duchenne muscular dystrophy and dilated cardiomyopathy with deletion of exon 45 and 49","authors":"X. Zhuang, S. Luo, Huizhi Fan, Jin-Jin Zhang, Hua Chen, Ping-ping Yan, Liwen Bao","doi":"10.1097/CP9.0000000000000006","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000006","url":null,"abstract":"Abstract A 26-year-old young man presented with paroxysmal chest pain and systemic edema that started 2 years earlier and worsened during the past 2 months. Echocardiogram indicated total heart enlargement as well as severe left and right ventricular systolic dysfunction. MRI revealed atrophy of most muscles in the thigh and calf on both sides. EMG suggested myogenic damage to myoelectrical changes and early recruitment changes. A diagnosis of Duchenne muscular dystrophy (DMD) was established on biopsy and genetic testing showing deletion of exons 45 and 49 of the dystrophin gene. He had no family history of major cardiovascular diseases. The patient disclosed later that muscle weakening started at 7 years of age. Symptoms improved after treatment with a variety of agents to manage heart failure and complications, and was discharged. He survived for 2 years, during which the general condition and heart failure deteriorated progressively. In summary, skeletal muscle weakness is typically the first sign of DMD, but heart involvement is commonly seen later. With the current treatment options, prognosis is poor. Gene therapy might be warranted.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"7 1","pages":"97 - 101"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43784092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}