Nepalese Medical Journal最新文献_第8页

Prevalence of High-Risk Groups for Gastric Carcinoma – A Biopsy Finding 胃癌高危人群的患病率-活检发现

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21600

K. Geetika, S. Kc, Purnima Gyawali

{"title":"Prevalence of High-Risk Groups for Gastric Carcinoma – A Biopsy Finding","authors":"K. Geetika, S. Kc, Purnima Gyawali","doi":"10.3126/NMJ.V1I2.21600","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21600","url":null,"abstract":"Introduction: Gastric carcinoma is leading cause of death world wide including Nepal. The 5 years survival rate of gastric carcinoma (25%) has drastically decreased compared to early gastric cancers (90-90%) hence implying the need for early detection. Atrophic gastritis and intestinal metaplasia are considered as major high-risk factors and is a precancerous lesion along with Helicobacter pylori. This study tries to look at the distribution of atrophy and intestinal metaplasia across age and gender and their occurrence in Helicobacter pylori positive cases.Materials and methods: It is Cross-sectional study of a retrospectively collected data at KIST medical college and GRP poly clinic private limited from April 2008 till March 2018. Total of 10,683 cases were included. The slides were stained with Hematoxilin and Eosin stain and Giemsa stain and evaluated by two pathologists. Statistical analysis was done using SPSS vs 21.Results: Total numbers of cases studied were 10,683 with male to female ratio of 1.04:1. The most common age group of the study was 18-40 years (n=6206; 58.8%). Atrophy was seen in 81 (0.8 %) cases, Intestinal metaplasia in 298 (2.8 %) cases and Helicobacter Pylori was positive in 4459 (42.2%) cases. The incidence of atrophic gastritis was more in H. pylori positive group 54 (0.5%) group where as intestinal metaplasia was more in H. pylori negative 190(1.8%) group.Conclusion: Atrophic gastritis and intestinal metaplasia, high-risk factors for gastric carcinoma, were not the common findings. Atrophic gastritis was seen in 0.8% and intestinal metaplasia was seen in 2.8% of the total study population.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84138630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histopathological Evaluation of Skin Neoplasms 皮肤肿瘤的组织病理学评价

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21591

P. Sherpa, S. Kc

{"title":"Histopathological Evaluation of Skin Neoplasms","authors":"P. Sherpa, S. Kc","doi":"10.3126/NMJ.V1I2.21591","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21591","url":null,"abstract":"Introduction: Skin tumor incidence has increased over the last several decades. A wide range of tumors are encountered in clinical practice. Accurate identification of skin lesions is vital in ensuring malignancies are not missed and that they are treated early to avoid morbidity and mortality.Materials and Methods: A retrospective cross sectional hospital based study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0.Results: During the study period, 410 skin biopsies were received, of which 214 (52.2%) were skin neoplasms. Among them, 175 (81.8%) were benign and 39 (18.2%) were malignant neoplasms. Incidence of keratinocytic tumors was highest followed by soft tissue tumors and melanocytic tumors. Intradermal nevus was the most common benign neoplasm. Among the malignant neoplasms, squamous cell carcinoma was most prevalent (46.1%) followed by basal cell carcinoma (15.3%). Skin neoplasms were present in all age groups with maximum number of benign neoplasms prevalent in 21-30 years and malignant in 51-60 years age group. Mean age was 38 years and 58 years for benign and malignant neoplasms respectively.Conclusions: Histopathological evaluation of skin biopsy is an important tool in diagnosis of skin neoplasms. Intradermal nevus and squamous cell carcinoma was the most common benign and malignant neoplasm respectively. Malignant neoplasms were more common in older patients.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84445268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Advertisement in Medical Journal – To Be or Not To Be! 医学杂志上的广告——生存还是毁灭!

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21745

N. Basnet

{"title":"Advertisement in Medical Journal – To Be or Not To Be!","authors":"N. Basnet","doi":"10.3126/NMJ.V1I2.21745","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21745","url":null,"abstract":"Medical journals are unbiased and reliable sources of information. They disseminate knowledge to educate medical practitioners and scientists of new development in different fields of medical science. The state of research and publication in developing countries is primitive, and those that are done fail to compete to be published in reputed international journals. The regional open access journals provide an opportunity to such researchers indisseminating their work. Their work is then recorded and available for other researchers and practitioners for reference.Open access journals are good platform, but it is a tremendous task for journals to survive with the little or no resource. Common sources of revenue are sales of print version and article publication charges which are often inadequate. Survival is hard and journals have to look for other sources such as individual donations and fund from institutions or medical societies. One of such journal is PloS Medicine, which has a reputable presence. These alternative sources of income may not be available for all journals and have to turn to advertisements as a majorsource of revenue. Even some of the reputed traditional, subscription-based journals put advertisements as their reliable source of income.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88827186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endovenous Ablation of Varicose Veins Experience at Tertiary Neurological Center 第三神经中心静脉内消融治疗静脉曲张的经验

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/nmj.v1i2.21580

S. Pandey, G. Katwal, S. Gajuryal

{"title":"Endovenous Ablation of Varicose Veins Experience at Tertiary Neurological Center","authors":"S. Pandey, G. Katwal, S. Gajuryal","doi":"10.3126/nmj.v1i2.21580","DOIUrl":"https://doi.org/10.3126/nmj.v1i2.21580","url":null,"abstract":"Introduction: Endovascular ablation of varicose vein either by radiofrequency ablationor laser delivers sufficient thermal energy to incompetent vein segments to produce irreversible occlusion, fibrosis and ultimately disappearance of the vein.Materials and Methods: Three hundred patients with varicosities due to primary or recurrent sapheno-femoral or sapheno-popliteal junction and great or small saphenous veinreflux underwent out-patient and in-patient endovenous thermal ablation between January 2015 to December 2017.The great saphenous vein was ablated from 2-2.5 cm below sapheno-femoral junction to knee and the small saphenous vein was ablated from mid-calf to the sapheno-popliteal junction.Results: Patient returning time to normal activity was 0–1 days returning to normal daily activity were immediately after 4 hours. Duplex ultrasound follow-up (median 3-months) confirmed abolition of sapheno-femoral junction/great saphenous vein and sapheno-popliteal junction/small saphenous vein reflux in all limbs. There were no instances of skin burns or deep vein thrombosis, but, 7 patients developed transient cutaneous numbness involving sural nerve and 1 developed endovenous heat induced thrombosis 3.Conclusions: This is likely to be more effective than conventional surgery, although long-term follow up is required. Despite being expensive in comparison to open surgery, endovenous thermal ablation is superior in terms of: minimizing pain, avoiding incision, early mobilisation and discharge. Changing the treatment distance from 2 cm to 2.5 cm peripheral to the Deep veins junction may result in a diminished incidence of endovenous heat induced thrombosis 3.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80693995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Melanoma of Testis- A Case Report 睾丸原发性黑色素瘤1例报告

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21594

S. Pudasaini, B. Joshi, N. Subedi, R. Pathak, Kricha Pande, Shradha Koirala, N. Kafle, K. K. Bhomi, A. Shahi

引用次数: 0

Antimicrobial Resistance Patterns in Clinical Isolates of Enterobacteriaceae from a Tertiary Care Hospital, Kathmandu, Nepal 尼泊尔加德满都一家三级医院肠杆菌科临床分离株的抗微生物药物耐药性模式

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21578

R. Adhikari, S. Shrestha, Junu Richhinbung Rai, R. Amatya

{"title":"Antimicrobial Resistance Patterns in Clinical Isolates of Enterobacteriaceae from a Tertiary Care Hospital, Kathmandu, Nepal","authors":"R. Adhikari, S. Shrestha, Junu Richhinbung Rai, R. Amatya","doi":"10.3126/NMJ.V1I2.21578","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21578","url":null,"abstract":"Introduction: Multidrug resistance among Enterobacteriaceae is in increasing trend these days. The objective of this study was to determine the antibiogram of clinical isolates of Enterobacteriaceae with special reference to multidrug resistance and extended spectrum beta-lactamases production.Materials and Methods: A descriptive cross sectional study was conducted over a period of six months (February -July, 2017) in the microbiology laboratory of Nepal Medical College Teaching Hospital, Kathmandu, Nepal. A total of 936 bacterial isolates of Enterobacteriaceae from clinical specimens were processed for antimicrobial susceptibility testing and screened for multidrug resistance. ESBL production was detected among potential isolates by combination disk diffusion test.Results: The rate of multidrug resistance and extended spectrum beta-lactamases production was 54.2% and 23.8% respectively. Of the total ESBL producers 92.4% were multidrug resistance. The rate of multidrug resistance and extended spectrum beta-lactamases production were higher in organisms isolated from clinical samples collected from inpatients. High rate of multidrug resistance and extended spectrum beta-lactamases production was seen in E. coli (54.4% & 27.7%), Klebsiella spp. (67.1% & 28.2%) and Citrobacter spp. (70.3% & 10.9%). The antimicrobial resistance rate was highest against ampicillin (76.7%) followed by cefixime (54. 0%), ceftazidime (51.5%), ceftriaxone (51.0%), cotrimoxazole (48.7%), ciprofloxacin (43.9%) and ofloxacin (41.1%).Conclusions: Multidrug resistance is common among Enterobacteriaceae. These bacteria have high rate of resistance against commonly used groups of antibiotics like cephalosporins and quinolones. Continuous monitoring, surveillance of antimicrobial resistance, proper infection control and practices are important to combat with these issues.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87084335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Adult Colonic Intussusception due to a Lipoma Mimicking Carcinoma 成人结肠肠套叠致脂肪瘤样癌

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/nmj.v1i2.21599

D. V. Karkee

引用次数: 0

Fractional Ablative Carbondioxide Laser Resurfacing for Acne Scars - A Single Centered Study 分数烧蚀二氧化碳激光置换痤疮疤痕-一项单中心研究

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21582

R. Shrestha, A. Karki

{"title":"Fractional Ablative Carbondioxide Laser Resurfacing for Acne Scars - A Single Centered Study","authors":"R. Shrestha, A. Karki","doi":"10.3126/NMJ.V1I2.21582","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21582","url":null,"abstract":"Introduction: Pulsed carbon dioxide laser devices are considered highly effective treatment options for skin resurfacing. The aim of this study was to evaluate the efficacy and safety of an ablative 10,600-nm carbon dioxide fractional laser system on moderate to severe acne scarsMaterials and Methods: Forty participants (Fitzpatrick skin types III–IV) ranging from the age group of 25-45 who had moderate to severe acne scars were included in the study.CO2 Fractional laser was used, Unit: eCO2 Lutronic Korea; FDA approved, in 3 sessions at one month interval and 4th and 5th sessions at the interval of 2 months. Comparison was done on a monthly basis for the improvement of scars at one monthly interval and any other symptoms like pain, recovery time for wound healing and complications of laser like hyperpigmentation were noted by asking the patient to fill up a questionaire.Results: All the patients completed the treatment.At the end of the session participants experienced a reduction in the size of the scars. At the first laser session, they presented 10-25%, at the second session 20-45% and at the third session 30-60%. All participants felt an ascending improvement rate during and after the course of treatment. An average improvement of 71% was observed. Twelve of sixteen patients showed mild erythema which was transient and recovered at its own.Conclusions: Fractional Co2 laser ablation provides a safe and effective treatment of moderate to severe facial acne.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87285754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology 血清前列腺特异性抗原与多种前列腺病理的相关性研究

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21579

N. Mainali, N. Nepal, P. Chaudhary, Jit Shrestha

{"title":"Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology","authors":"N. Mainali, N. Nepal, P. Chaudhary, Jit Shrestha","doi":"10.3126/NMJ.V1I2.21579","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21579","url":null,"abstract":"Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82599722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Flexible Nasopharyngolaryngoscopy for the Assessment of Upper Airway Disorders 柔性鼻咽喉镜对上呼吸道疾病的评估

Nepalese Medical Journal Pub Date : 2018-12-02 DOI: 10.3126/NMJ.V1I2.21590

Sangita Regmi Chalise, S. Khadka

{"title":"Flexible Nasopharyngolaryngoscopy for the Assessment of Upper Airway Disorders","authors":"Sangita Regmi Chalise, S. Khadka","doi":"10.3126/NMJ.V1I2.21590","DOIUrl":"https://doi.org/10.3126/NMJ.V1I2.21590","url":null,"abstract":"Introduction: Upper airway problems are frequently encountered in ENT practice. It is difficult to diagnose upper airway pathology by conventional methods. So use of fibreoptic flexible nasopharyngoscopy (NPL) is very helpful in both diagnosis and treatment of upper airway disorders. The aim of this study is to observe the usefulness of flexible NPL in patients with upper airway problems as an outpatient procedure. Materials and Methods: A cross sectional descriptive study was conducted in the department of ENT at KIST medical college teaching hospital during the period of 2years. A total of 138 patients who had persistent upper airway symptoms and underwent NPL were included in the study Detail history, clinical examination and required investigations were done. Data were recorded and analysed.Results: Total 138 patients suffering from upper airway disorders underwent NPL. Among them 65(47.1%) were males and 73(52.9%) were females. Age range was from 16 to 82 years. Most common problem observed was laryngopharyngeal reflux disease accounting for 41 percent of cases followed by vocal cord nodule and polyp.Conclusions: Flexible fiberoptic nasopharyngolaryngoscopy (NPL) is safe and noninvasive outpatient department procedure for the assessment of upper airway disorders.","PeriodicalId":52856,"journal":{"name":"Nepalese Medical Journal","volume":"350 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79763972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0