pzshkhy blyny bn syn最新文献_第5页

افزایش بیان ژنهای TPT1-AS1 و SAMMSON و کاهش بیان ژن LNC00961 به عنوان نشانگرهای بالقوه تومور در سرطان معده 增加TPT1-AS1和SAMMSON基因的表达，减少LNC00961基因，作为癌症的主要标志

pzshkhy blyny bn syn Pub Date : 2021-03-15 DOI: 10.52547/AJCM.27.4.201

محمد امینی, ایرج خدادادی, حیدر طیبینیا, سید حسن طالبی, بهروز افشار, جمشید صدر کریمی

引用次数: 0

Prevalence of Depression in Patients with Diabetic Retinopathy 糖尿病视网膜病变患者的抑郁症患病率

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.226

N. Bazzazi, Mona Sharafi Zamir, S. Akbarzadeh, Y. Mohammadi, M. Ahmadpanah

{"title":"Prevalence of Depression in Patients with Diabetic Retinopathy","authors":"N. Bazzazi, Mona Sharafi Zamir, S. Akbarzadeh, Y. Mohammadi, M. Ahmadpanah","doi":"10.52547/ajcm.27.4.226","DOIUrl":"https://doi.org/10.52547/ajcm.27.4.226","url":null,"abstract":"Background and Objective: Diabetic retinopathy is one of the most important and debilitating complications of diabetes with an increasing prevalence in most countries. It has a dramatic effect on people's quality of life and increases the symptoms of anxiety and depression in patients with diabetes. Therefore, the present study aimed to determine the prevalence of depression in patients with diabetic retinopathy. Materials and Methods: This descriptive/ cross-sectional study was conducted on 245 patients with retinopathy referred to the ophthalmology clinic of Farshchian Hospital in Hamadan during 20192020. They were selected via available and consecutive sampling method and were evaluated for depression with the 21-item Beck questionnaire. Data were analyzed in SPSS software (version 16) at a 95% confidence level. Results: The mean scores of patients' age and duration of diabetes were reported as 54.47± 8.5 and 8.5 ± 4.15 years, respectively. In terms of gender, the majority of participants (58.7%) were female. The prevalence of depression in patients with diabetic retinopathy was obtained at 49.8% and in proliferative and non-proliferative retinopathy were 68.2% and 43%, respectively (P<0.001). The prevalence rates of depression in men and women were reported as 45.9% and 51.5% (P=0.428). Moreover, in patients treated with insulin and without insulin, the prevalence rates of depression were obtained at 50.4% and 49.2% (P=0.846). The correlation coefficients of depressive disorder with age and duration of diabetes were calculated at 0.123 (P=0.054) and 0.369 (P<0.001), respectively. Conclusion: Depression is one of the most serious problems in patients with diabetic retinopathy. As evidenced by the results of the present study, the prevalence of depression is significantly correlated with the severity of retinopathy and duration of diabetes.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46090667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SyringocystadenomaPapilliferum Arising from Nevus Sebaceous: A Case Report 皮脂痣引起的乳头状注射器囊腺瘤一例报告

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.261

T. Eslammanesh

引用次数: 0

Comparison of the Effectiveness of Schema Therapy and Integrated Cognitive-Speech Approach in Emotional Regulation, and Distress Tolerance of Individuals Suffering from Stuttering 图式疗法和认知言语综合疗法在口吃患者情绪调节和痛苦容忍方面的效果比较

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.239

Kazem Farzinfar, H. Nejat, M. Doustkam, Hassan Tuzandeh Jani

{"title":"Comparison of the Effectiveness of Schema Therapy and Integrated Cognitive-Speech Approach in Emotional Regulation, and Distress Tolerance of Individuals Suffering from Stuttering","authors":"Kazem Farzinfar, H. Nejat, M. Doustkam, Hassan Tuzandeh Jani","doi":"10.52547/ajcm.27.4.239","DOIUrl":"https://doi.org/10.52547/ajcm.27.4.239","url":null,"abstract":"Background and Objective: Numerous approaches, including schema therapy, and an integrated cognitive-speech approach, have been suggested to reduce emotions and increase distress tolerance in people with stuttering. The present study aimed to make a comparison between the effectiveness of schema therapy and integrated cognitive-speech approach in emotional regulation and distress tolerance of individuals suffering from stuttering. Materials and Methods: This quasi-experimental study was conducted based on a pre-test, post-test design, and a follow-up test with a control group. The statistical population included all individuals aged 18-30 who suffered from stuttering in Sabzevar city. The sample consisted of 30 people who were selected via convenience sampling and were randomly assigned to two experimental groups and one control group (n=10 in each group). The experimental schema therapy group underwent treatment in 12 90-minute sessions, the integrated cognitive-speech approach group received 12 60minute sessions of treatment, and the control group received no treatments. The instruments of the research were Gross and John (2003) Emotional Regulation Questionnaire, and Simons and Gaher (2005) Distress Tolerance Questionnaire. These instruments were conducted on three groups in all phases of pre-testing and post-testing and follow-up. The one-way repeated measures ANOVA and Tukey post hoc test were used to analyze the data. Results: As evidenced by the obtained results, the schema therapy and integrated cognitive-speech approach had a significant effect on emotional regulation and distress tolerance of individuals suffering from stuttering","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41674735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Mental Health of Female Students with Early, Late, and Normal Menarche in Isfahan, Iran 伊朗伊斯法罕市初潮、晚潮和初潮正常女生心理健康状况的比较

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.253

Elham Irannezhad, M. Soltanizadeh

{"title":"Comparison of Mental Health of Female Students with Early, Late, and Normal Menarche in Isfahan, Iran","authors":"Elham Irannezhad, M. Soltanizadeh","doi":"10.52547/ajcm.27.4.253","DOIUrl":"https://doi.org/10.52547/ajcm.27.4.253","url":null,"abstract":"Background and Objective: The changes that occur in the female body with the onset of menstruation affect the psychological components, including mental health. This study aimed to compare the mental health of adolescent females with early, late, and normal menarche. Materials and Methods: This descriptive study was conducted based on a causal-comparative design. The statistical population included 9to 17-yearold female students in Isfahan, Iran, who were selected through multistage random cluster sampling. The sample size was determined at 56, 37, and 43 cases in the group of students with normal, early, and late menarche, respectively. The data were collected using the Pediatric Symptom Checklist for school-aged children (age range: 3-18 years) (Jelink, Murphy, and Burns, 1986). Following that, the collected data were analyzed using SPSS software (version 25) through a covariance test. Results: According to the results, no significant difference was observed between the two groups of female students with normal and early menarche regarding mental health and its subscales. However, the adolescent females with late menarche had better mental health, compared to those with early and normal menarche (P<0.01). Conclusion: Based on the results, it seems that the timing of the onset of menstruation affects mental health. The late menarche is associated with fewer mental health problems.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43432455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Specific Schroth Exercises on Cobb Angle, Flexibility, and Functional Capacity of Adolescents with Idiopathic Scoliosis 特定Schroth运动对青少年特发性脊柱侧凸的Cobb角、柔韧性和功能能力的影响

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.217

F. Saki, H. Gholami, A. Yalfani, Marziyeh Zia

{"title":"Effects of Specific Schroth Exercises on Cobb Angle, Flexibility, and Functional Capacity of Adolescents with Idiopathic Scoliosis","authors":"F. Saki, H. Gholami, A. Yalfani, Marziyeh Zia","doi":"10.52547/ajcm.27.4.217","DOIUrl":"https://doi.org/10.52547/ajcm.27.4.217","url":null,"abstract":"Background and Objective: Adolescent idiopathic scoliosis is one of the complex and common deformities of the spine. It is a condition that can cause a lot of pain and discomfort for individuals and has consequences and complications. There are different exercises and approaches for correction of this deformity, such as Schroth exercise. In this regard, the purpose of this study was to investigate the effect of corrective exercises on Cobb angle, flexibility, functional capacity, and quality of life of adolescents with idiopathic scoliosis. Materials and Methods: This controlled clinical trial with pre-test and posttest design was performed on 24 adolescents with idiopathic scoliosis who were randomly divided into control and experimental groups. Cobb angle, flexibility, and functional capacity were measured by X-ray imaging, flexibility box, and six-minute walk test, respectively. The collected data were statistically analyzed in SPSS software (version 23) using a mixeddesign analysis of variance with repeated measures. It must be noted that a p-value of 0.05 was considered statistically significant. Results: Based on the results, after 10 weeks of Schroth exercises, there was a significant difference in the exercise group regarding the reduction of Cobb angle as well as the increase of flexibility and functional capacity. However, no significant difference was observed in the control group from pre-test to","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45333476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antibiotic Resistance to Colistin in Nosocomial Infections with Multidrug-Resistant Acinetobacter 耐多药不动杆菌医院感染对粘菌素的耐药性评价

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.52547/ajcm.27.4.211

F. Keramat, Hamid Reza Ghasemi Basir, A. Taher, A. Moradi, A. Saadatmand, Pooria Owji Nejad

引用次数: 0

Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus 恩帕列嗪治疗对2型糖尿病患者T辅助细胞22相关因子影响的评价

pzshkhy blyny bn syn Pub Date : 2021-03-01 DOI: 10.29252/AJCM.27.4.193

Hamideh Moghimi, S. Borzouei, A. Zamani, Mahdi Behzad

{"title":"Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus","authors":"Hamideh Moghimi, S. Borzouei, A. Zamani, Mahdi Behzad","doi":"10.29252/AJCM.27.4.193","DOIUrl":"https://doi.org/10.29252/AJCM.27.4.193","url":null,"abstract":"Background and Objective: The increased response of T helper (Th) 22 cells might be involved in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). The present study aimed to investigate the transcription factor of Th22 cells (aryl hydrocarbon receptor [AHR]) and interleukin 22 (IL-22) in CD4 T cells as well as the impact of oral empagliflozin treatment. The correlation between the aforementioned factors and clinical parameters was also determined among the patients. Materials and Methods: In this case-control study, 50 patients under the treatment of metformin and gliclazide were divided into two equal groups, including the patients receiving empagliflozin (EMPA) and not receiving empagliflozin (EMPA, as the control group). The peripheral blood CD4 T cells were isolated on the initiation day of the study and after 6 months of therapy, and the gene expression levels of AHR and IL-22 were evaluated by real-time polymerase chain reaction. In addition, the production of IL-22 after activation was measured using enzyme-linked immunosorbent assay. Results: The levels of fasting plasma glucose and hemoglobin A1c diminished in the EMPA group after empagliflozin therapy, compared to those reported at the baseline (initiation day; P<0.001 and P=0.04). The gene expression level of IL-22 and production of IL-22 significantly reduced after 6 months of empagliflozin therapy (P=0.011 and P=0.001). A significant positive correlation between IL-22 production and its gene expression with AHR as well as between fasting plasma glucose and hemoglobin A1c was observed in the EMPA patients after therapy (P˂0.05). Conclusion: In addition to antidiabetic effects, empagliflozin has antiinflammatory impacts on the immune system, especially on Th22 cell-","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41574422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Efficacy Analysis of lncRNA NEAT1 Gene Knockout and Apoptosis Induction in Prostate Cancer Cell Line Using CRISPR/Cas9 利用CRISPR/Cas9基因敲除lncRNA NEAT1基因诱导前列腺癌细胞凋亡的疗效分析

pzshkhy blyny bn syn Pub Date : 2021-01-01 DOI: 10.52547/ajcm.28.1.49

Nastaran Haghighi, A. Doosti, J. Kiani

{"title":"Therapeutic Efficacy Analysis of lncRNA NEAT1 Gene Knockout and Apoptosis Induction in Prostate Cancer Cell Line Using CRISPR/Cas9","authors":"Nastaran Haghighi, A. Doosti, J. Kiani","doi":"10.52547/ajcm.28.1.49","DOIUrl":"https://doi.org/10.52547/ajcm.28.1.49","url":null,"abstract":"Background and Objective: Long non-coding ribonucleic acid (lncRNA) has been identified as an important gene regulator and prognostic marker in various cancers. The present study aimed to investigate the effects of Nuclear Paraspeckle Assembly Transcript1 (NEAT1) gene knockout using Clustered Regularly Interspaced Short Palindromic Repeats-associated Protein 9 (CRISPR/Cas9) in PC-3 cell line. Materials and Methods: In this experimental study, recombinant plasmids carrying single guide RNA in the CRISPR system were designed and constructed. The prostate cancer PC3 cell lines were transfected by recombinant vectors, and apoptotic gene expression was evaluated using the quantitative polymerase chain reaction technique. Furthermore, annexin, MTT, and wound healing assays were applied for apoptosis, cell proliferation, and cell migration activities respectively. Results: Knockout of NEAT1 gene using CRISPR/Cas9 technique caused significant changes in the expression of apoptosis-related genes in a way that the expression of P21, BCL2, and BIRC5 genes decreased, while the expression of P53 and BAX increased. In addition, in the treatment group, the rate of cell proliferation and migration was reduced compared to those in the control group. Moreover, an increase was observed in the apoptosis rate in genetically modified cells compared to the control group. Conclusion: As an oncogene, NEAT1 plays an important role in tumorigenesis and its knockout reduces cell survival and migration and increases the apoptosis of cancer cells.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Patients Suffering from Relapsing-Remitting Multiple Sclerosis with Healthy Individuals regarding Serum Selenium and Zinc Levels 复发性缓解性多发性硬化患者和健康人血清硒锌水平的比较

pzshkhy blyny bn syn Pub Date : 2020-12-01 DOI: 10.29252/AJCM.27.3.157

A. Vahidinia, M. Mazdeh, Salahadin Adman, Z. Cheraghi

引用次数: 0