Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology最新文献_第2页

Study the Hypersensitivity Type 1 in Patients Suffering from Drug and Asthma Allergy 药物及哮喘过敏患者1型超敏反应的研究

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-25 DOI: 10.21608/eajbsc.2023.322409

Asmaa Mahmood, Hajar Rasheed

引用次数: 0

Assessment of the Annexin A2 as a Predictive Biomarker for the Severity of Disseminated Intravascular Coagulation in Acute Leukemia Patients 评估膜联蛋白A2作为急性白血病患者弥散性血管内凝血严重程度的预测性生物标志物

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-25 DOI: 10.21608/eajbsc.2023.322408

Dhuha Aljuboory, Intisar Sharba

引用次数: 0

Studying the Effect of AgNPs Silver Nanoparticles on The Spike Glycoprotein of SARS-CoV-2 Virus AgNPs银纳米颗粒对SARS-CoV-2病毒刺突糖蛋白影响的研究

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-22 DOI: 10.21608/eajbsc.2023.322407

Faesal Hassen, Amidah Atiyah

引用次数: 0

Altered Insulin, IRS/PI3K/AKT/mTOR Signaling, ACE2 and Angiotensin II, Correlating with Vitamin K Status and Severity in Metabolically Disordered COVID-19 Egyptian patients 代谢紊乱的COVID-19患者胰岛素、IRS/PI3K/AKT/mTOR信号、ACE2和血管紧张素II的改变与维生素K水平和严重程度相关

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-21 DOI: 10.21608/eajbsc.2023.321787

Huda Ismail Abo-Elfadl, Gehan Morsy

{"title":"Altered Insulin, IRS/PI3K/AKT/mTOR Signaling, ACE2 and Angiotensin II, Correlating with Vitamin K Status and Severity in Metabolically Disordered COVID-19 Egyptian patients","authors":"Huda Ismail Abo-Elfadl, Gehan Morsy","doi":"10.21608/eajbsc.2023.321787","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.321787","url":null,"abstract":"Aims: Metabolic disorders are essential risks of adverse outcomes in coronavirus disease 2019 (COVID-19). Vitamin K status might play an important role in metabolic regulation and influence the severity of COVID-19. This research shed light on vitamin K status in association with some metabolic pathways; pancreatic beta-cell function, insulin resistance, PI3K/AKT/mTOR signaling, and the angiotensin-converting enzyme 2 (ACE2)/angiotensin II in the context of COVID-19 and its metabolic effects in metabolically disordered patients. Main methods: This study included hospital-confirmed COVID-19 patients with or without obesity and/or diabetes mellitus (DM) and control subjects. The effect of viral infection on PERK double-stranded RNA-dependent protein kinase (PKR) and ACE2 was regressed against insulin resistance and blood pressure, respectively. Demographic and clinical characteristics, blood, and, clinical indices, were collected. Key findings: A total of 90 hospital-confirmed COVID-19-positive patients were eligible for our study. COVID-19 patients with obesity and DM showed poor vitamin K status which is correlated with severely compromised insulin signaling and inflammatory and immune states. It is also adversely associated with the existence of hypertension comorbidities. PKR levels significantly (P<0.05) and negatively predicted IRS (R 2 = 0.598) explaining 59.8% of the variance in IRS. Also, ACE2 is significantly (P<0.05) and negatively predicted systolic blood pressure and explained 45.6% of the variance in SBP (R 2 =0.456). Significance: Our study indicated that poor vitamin K status might be an important risk factor for severe adverse outcomes in COVID-19 patients with pre-existing obesity and type 2 diabetes. Also, metabolically disordered patients are highly susceptible to COVID-19 infection and its related adverse metabolic effects.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"13 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochar and Biochar Magnetite of Spirulina platensis to Remove Cadmium Ions from Aqueous Solutions 生物炭和生物炭磁铁矿对铂螺旋藻水中镉离子的去除作用

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-21 DOI: 10.21608/eajbsc.2023.321788

Khitam Mushtaq, Sadiq Alzurfi

{"title":"Biochar and Biochar Magnetite of Spirulina platensis to Remove Cadmium Ions from Aqueous Solutions","authors":"Khitam Mushtaq, Sadiq Alzurfi","doi":"10.21608/eajbsc.2023.321788","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.321788","url":null,"abstract":"An investigation was conducted using both biochar and magnetic biochar. Have been utilized as an effective, affordable, secure, and ecologically friendly way to get rid of heavy metals like cadmium. Microalgae from Spirulina platensis were used to make biochar by burning it. We mix biochar with hydrogen peroxide to create functional groups on the surface by using ice bath sonication which is biochar activate (BC). Also, magnetic biochar (MBC) has been prepared by mixing biochar activated with Fe 3 O 4 (2:1 mole ratio) respectively. Two concentrations of aqueous solutions (5 ppm and 10 ppm) were mixed with two weights of biochar and magnetic biochar (0.1 and 0.5 g) for 10, 20, and 40 minutes. The concentration of cadmium (5 ppm) with 0.5 g of biochar (BC) after 40 minutes removed 97.58% of cadmium ion from the aqueous solution. On the other hand, magnetic biochar (MBC) (0.5 g) with 5 ppm of cadmium solution after 40 minutes could remove 100% of cadmium ions. We character BC, MBC, and biochar treated with cadmium ions by using FTIR, FESEM, EDX, and XRD studies. These analytical results indicate that the effective groups in biochar and magnetic biochar can adsorb heavy metals by carboxyl, hydroxyl, and carbonyl groups. The findings of the investigation on magnetic biochar revealed that, in addition to carbonyl, hydroxyl, and carboxylic groups, the substance also included magnetite. The findings made it very clear that removing cadmium with biochar reduced their risk and did it in a quick, inexpensive, and environmentally beneficial manner.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine 一种新的分光光度法测定药物制剂中非甾体抗炎药(NSAIDs)的新方法

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-18 DOI: 10.21608/eajbsc.2023.321259

Ali Nayef, Alaa Hussain, Dakhil Taha

{"title":"A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine","authors":"Ali Nayef, Alaa Hussain, Dakhil Taha","doi":"10.21608/eajbsc.2023.321259","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.321259","url":null,"abstract":"A novel, simple, accurate, sensitive, reproducible, economical method for spectrophotometric approach for measuring MFA in Pharmaceutical Drug formulations was successfully developed and verified. A novel analytical technique for estimating MFA 250 mg in capsule pharmaceutical formulations for different brands was established. The method suggested is based on the reduction of Cu(II)-2,9DMP complex to colored Cu(I)- 2,9DMP complex. The optimum experimental conditions have been achieved. Beer'ss Law holds true in the concentration levels 5.0-60 μg/mL with accurate molar absorptivity of 0.238 L/mol.cm at 454 nm and “detection limit” was 0.5882 μg/mL and the limit of quantification was 1.7825 μg/mL and correlation coefficient obtained has been near to one. The Effect of pH, reaction time, Buffer Solutions, Volume of Cu(ІІ), Volume of 2,9.DMP reagent, temperature, Order of Addition, and Effect of Acid on the determination of MFA, have been examined. The proposed method has been successfully utilized for quantitative assessment of commercially produced dosage modes. Our research sought to develop a fresh, accurate, and sensitive technique for measuring MFA as a pure pharmacological product and as a hard dosage. The creation of a metal complex of MFA with a copper ion is a prerequisite for the spectrophotometric approach.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135942971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Licorice Root Aqueous Extract, Glycyrrhiza glabra (Linnaeus): (Fabaceae) against Peach Fruit Fly, Bactrocera zonata (Saunders), (Diptera: Tephritidae) on Three Fruits, Guava, Peach And Apricot At Qulioubia Governorate And Enzymes Effect Of The Treated Adults On Its Behavior Under Laboratory Conditions 甘草根水提物、甘草根水提物(豆科)对贵州番石榴、桃、杏三种水果的防治效果及酶制剂对其行为的影响

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-15 DOI: 10.21608/eajbsc.2023.320872

Mervat El-Genaidy, Mohamed Hindy

引用次数: 0

Genotypic Detection of New-Delhi Metallo-β-Lactamase Producing Carbapenem Resistant Escherichia coli in Holy Karbala Province-Iraq 伊拉克圣卡尔巴拉省产耐碳青霉烯类耐药新德里金属β-内酰胺酶大肠杆菌基因型检测

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-14 DOI: 10.21608/eajbsc.2023.320708

Rasol Taqi, Oday Hadi

{"title":"Genotypic Detection of New-Delhi Metallo-β-Lactamase Producing Carbapenem Resistant Escherichia coli in Holy Karbala Province-Iraq","authors":"Rasol Taqi, Oday Hadi","doi":"10.21608/eajbsc.2023.320708","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.320708","url":null,"abstract":"Background: Carbapenem is a beta-lactam antibiotic that works similarly to Penicillins and Cephalosporins by binding to Penicillin-binding sites and subsequently inhibiting cell wall synthesis. Due to their high potency and extraordinarily broad antibacterial action, Carbapenem antibiotics, which belong to the most recent generation of β-lactam antibiotics, are frequently used in clinics to treat bacterial infections. The current study aimed to shed light on Escherichia coli 's resistance to β-lactam antibiotics, especially Carbapenem, and the potential link between Carbapenem resistance and the production of β-lactamase variants bla (NDM-1, NDM-2, NDM-3, NDM-4, NDM-5, GIM-1, VIM-1, SPM-1, and IMP-1) in Karbala province, Iraq. Materials and methods: Four hundred-eight isolates have been identified according to traditional methods (colonial morphology on MacConkey and Eosin methylene blue (EMB) agar, and biochemical reactions), and confirmed by the Vitek2® system. Carbapenem susceptibility was assayed by using the Vitek2® system. Isolates were subjected to multiplex PCR targeting β-lactamase variants genes. Results: Out of a total of 408 samples randomly collected from different clinical sources, 24 (19.51%) Escherichia coli isolates were diagnosed. Four (16.67%) of the Escherichia coli isolates tested positive for imipenem and meropenem resistance. PCR experiments indicated that only two (50%) isolates contained the blaNDM-1 gene and four (100%) carried the blaNDM-3 gene; no additional beta-lactamases were found.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135766918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Diagnosis of Some Isolated Bacterial Types of Psoriasis Patients and Measurement of Some Immunological Parameters Such as Il-17 And Complements C3 and C4 银屑病部分分离菌型的分离诊断及Il-17、补体C3、C4等免疫学指标的测定

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-09 DOI: 10.21608/eajbsc.2023.320128

Dalida Hussin, Asmaa Mahmood

{"title":"Isolation and Diagnosis of Some Isolated Bacterial Types of Psoriasis Patients and Measurement of Some Immunological Parameters Such as Il-17 And Complements C3 and C4","authors":"Dalida Hussin, Asmaa Mahmood","doi":"10.21608/eajbsc.2023.320128","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.320128","url":null,"abstract":"aureus, 33.3% of the 60 bacterial isolates were isolated, it isolated 18 isolates of Staph epidermidis with 30% of the total isolates and Staphylococcus hominas isolated by 15%, gram-negative isolates included 13.3% of P. aeruginosa and five isolates of E. coli (8.3%), some immune markers were compared between a group of psoriasis patients and a healthy (control) group, the estimated C3 supplement level for patients is 265.1 ± 215.77, while the rate for healthy people is 652.18 ± 102.3, it is noted that this indicator is higher in patients with psoriasis compared to healthy people, it also indicates that the estimated C4 supplement level for patients is 392.92 ± 63.7, while the rate for healthy people is 167.94 ± 38.7. It is noted that this indicator is higher in patients with psoriasis compared to healthy people, the IL-17 level of interleukin was 765.29 ± 85.4, while the rate for healthy people is 212.37 ± 39.6. It is noted that this indicator is higher in patients with psoriasis compared to healthy people, the results also showed significant differences between the levels of immune indicators between patients and healthy people at a probability level (p value = 0.05).","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Esterase Activity on Benzothiazole Based Probe In Biological Samples 苯并噻唑探针测定生物样品中酯酶活性

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-10-07 DOI: 10.21608/eajbsc.2023.319900

Haider Abdulhadi El-Ali, Sami Radhi

引用次数: 0