CONTINUUM Lifelong Learning in Neurology最新文献_第2页

Key Points for Issue. 问题的关键点。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/01.cont.0001278628.99653.47

引用次数: 0

Spinal Muscular Atrophy. 脊髓性肌萎缩症。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001750

Bo Hoon Lee, Emma Ciafaloni

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Amyotrophic Lateral Sclerosis. 肌萎缩侧索硬化症。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001753

Mark B Bromberg

{"title":"Amyotrophic Lateral Sclerosis.","authors":"Mark B Bromberg","doi":"10.1212/cont.0000000000001753","DOIUrl":"https://doi.org/10.1212/cont.0000000000001753","url":null,"abstract":"Objective: This article describes the nerve loss underlying amyotrophic lateral sclerosis, its clinical manifestations, examination findings leading to the diagnosis, the expanding role of genetics, and available treatment and patient management.Latest developments: The cause of neuron death in patients with amyotrophic lateral sclerosis is not known, but many genes are strongly linked to the disease, in both patients with a family history and those with no history. A multistep pathologic process helps to explain the onset of symptoms later in life, even in patients with associated genes. Posttranslational and epigenetic changes are also important factors. Current clinical trials are based on putative pathologic mechanisms, and some newer therapies are gene-based.Essential points: Amyotrophic lateral sclerosis has distinctive features and can be diagnosed largely from the history and examination, and true mimics are rare. While the cause of neuronal death is not known, pathogenic and risk factor gene variations are present in a number of patients, and posttranscriptional and epigenetic changes are likely major causative factors. Environmental factors likely contribute, but specific avoidable factors have not been identified. Drugs to slow the progress of the disease are currently limited, but trials for all patients with amyotrophic lateral sclerosis continue, including a focus on genetic factors. Patient management is optimized in multidisciplinary amyotrophic lateral sclerosis clinics, and interventions for nutrition with gastric feeding tubes and respiratory insufficiency by noninvasive ventilation enhance patient comfort.","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"32 5","pages":"1529-1544"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guillain-Barré Syndrome. 格林-巴利综合征。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001764

Mamatha Pasnoor

{"title":"Guillain-Barré Syndrome.","authors":"Mamatha Pasnoor","doi":"10.1212/cont.0000000000001764","DOIUrl":"https://doi.org/10.1212/cont.0000000000001764","url":null,"abstract":"Objective: This article reviews the epidemiology, clinical symptoms, examination findings, pathogenesis, diagnostic criteria, and recent guidelines of Guillain-Barré syndrome (GBS) and its variants, including information on outcome measures, management, and ongoing research.Latest developments: CSF examination and electrodiagnostic testing are useful in some cases to support the diagnosis, particularly when GBS variants are suspected. Antibody testing is of limited value in typical sensorimotor GBS, but useful when GBS variants and nodopathies are considered. According to evidence-based guidelines for the diagnosis and treatment of GBS developed by the European Academy of Neurology and Peripheral Nerve Society, IV immunoglobulin (IVIg) or plasma exchange are the recommended treatment options. The guidelines recommend against using a second IVIg course, or corticosteroids or plasma exchange followed immediately by IVIg. For treatment of pain, gabapentinoids, tricyclic antidepressants, or carbamazepine have been recommended. The Modified Erasmus GBS outcome score and Modified Erasmus GBS Respiratory Insufficiency Score have been recommended. Research is ongoing to find new treatment options.Essential points: GBS is a life-threatening neuromuscular emergency seen frequently worldwide. Symptom progression for less than 4 weeks and findings of sensorimotor deficits and areflexia are required to make the diagnosis. Some patients may present with pain, cranial nerve involvement, autonomic dysfunction, or respiratory insufficiency. If progression continues after 8 weeks from onset, consider the diagnosis of acute-onset chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which is seen in 5% of patients initially diagnosed with GBS. Approximately 20% of patients have significant residual deficits and poor prognosis despite receiving available treatments.","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"32 5","pages":"1392-1415"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Overview. 问题概述。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/01.cont.0001278624.70894.4c

引用次数: 0

Wellness and Career Sustainability in Neurology. 神经病学的健康和职业可持续性。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001751

Jeffrey Dewey, Jennifer Bickel

{"title":"Wellness and Career Sustainability in Neurology.","authors":"Jeffrey Dewey, Jennifer Bickel","doi":"10.1212/cont.0000000000001751","DOIUrl":"https://doi.org/10.1212/cont.0000000000001751","url":null,"abstract":"This article reviews drivers of well-being in neurology, using the practice of neuromuscular neurology as an example and high-yield interventions to enhance professional fulfillment. Neurologist burnout, once viewed as a consequence of insufficient personal resilience and poor stress coping strategies, is now recognized as an occupational syndrome resulting from a mismatch between demands and resources. Expert consensus now recognizes that even highly resilient physicians can experience low professional well-being when faced with long-term exposure to human suffering and death, which are common in both neuromuscular practice and neurology in general. Despite rising awareness of this issue in health care workers and the general public, research demonstrates persistently high rates of burnout and related indicators of low well-being among neurologists. Professional fulfillment is the opposite of burnout on the spectrum of neurologist well-being. Although wide-reaching systemic change is necessary to address high-level extrinsic drivers, every neurologist can learn to recognize when they or a colleague is struggling with the demands of practice and respond with evidence-based interventions.","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"32 5","pages":"1564-1576"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic Neuropathies. 糖尿病神经病变。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001744

Vera Fridman

{"title":"Diabetic Neuropathies.","authors":"Vera Fridman","doi":"10.1212/cont.0000000000001744","DOIUrl":"10.1212/cont.0000000000001744","url":null,"abstract":"Objective: This article provides an update on the biological mechanisms and risk factors for the varied manifestations of diabetes-associated nerve injury, and reviews current diagnostic and treatment approaches.Latest developments: Diabetic peripheral neuropathy was recently identified as one of the top five leading global neurologic causes of disease burden. Multiple metabolic derangements beyond hyperglycemia, such as the metabolic syndrome, drive diabetic peripheral neuropathy pathogenesis. Social determinants of health are also increasingly seen as important contributors. The biological effects of diabetes are detrimental to both peripheral nerve axons and Schwann cells, and disruptions to the intricate Schwann cell-axon relationship in the diabetic environment are becoming better understood. With improved technology and larger data sets, genetic and epigenetic contributors to diabetic peripheral neuropathy and neuropathic pain are also emerging.Essential points: Diabetes-associated nerve injury is highly prevalent and results in a marked reduction in quality of life and increased mortality. Despite this disease burden, screening for its many manifestations remains insufficient. Disease-modifying treatments are also limited, necessitating the early implementation of preventative measures. To reduce nerve injury burden in people with diabetes, clinicians must work in multidisciplinary teams and tailor treatments to the patient's symptoms and risk factors.","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"32 5","pages":"1317-1339"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SELF-ASSESSMENT AND CME. 自我评估和继续教育。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001759

引用次数: 0

Learning Objectives and Core Competencies. 学习目标和核心竞争力。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-10-01 Epub Date: 2026-10-02 DOI: 10.1212/cont.0000000000001760

引用次数: 0

Issue Overview. 问题概述。

CONTINUUM Lifelong Learning in Neurology Pub Date : 2026-08-01 Epub Date: 2026-08-03 DOI: 10.1212/01.cont.0001238760.57280.23

引用次数: 0