Childhood kidney diseases最新文献_第2页

Prognostic stratification in congenital abnormalities of the kidney and urinary tract: beyond the antenatal ultrasound. 先天性肾脏和尿路异常的预后分层：超出产前超声。

Childhood kidney diseases Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.3339/ckd.26.019

Jiwon Jung

引用次数: 0

Kidney health in VACTERL association: structural vulnerability and surveillance. 与VACTERL相关的肾脏健康：结构脆弱性和监测。

Childhood kidney diseases Pub Date : 2026-06-01 Epub Date: 2026-04-13 DOI: 10.3339/ckd.26.012

Yo Han Ahn

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Kidney injury molecule-1 as a biomarker of diabetic kidney disease in children with type 1 diabetes: a systematic review and quantitative synthesis. 肾损伤分子-1作为1型糖尿病儿童糖尿病肾病的生物标志物：系统综述和定量综合

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.3339/ckd.25.035

Aristeidis Christakopoulos, Nikolaos Gkiourtzis, Anastasia Stoimeni, Assimina Galli-Tsinopoulou, Athanasios Christoforidis, Despoina Tramma

{"title":"Kidney injury molecule-1 as a biomarker of diabetic kidney disease in children with type 1 diabetes: a systematic review and quantitative synthesis.","authors":"Aristeidis Christakopoulos, Nikolaos Gkiourtzis, Anastasia Stoimeni, Assimina Galli-Tsinopoulou, Athanasios Christoforidis, Despoina Tramma","doi":"10.3339/ckd.25.035","DOIUrl":"10.3339/ckd.25.035","url":null,"abstract":"Tubulointerstitial damage is a common diabetic kidney disease (DKD) complication caused by diabetes mellitus. However, many patients may not present with albuminuria or impaired glomerular filtration rate (GFR), making it difficult to detect kidney dysfunction. Kidney injury molecule-1 (KIM-1) is an emerging biomarker of early DKD, reflecting tubular injury before glomerular dysfunction. We explored the association between KIM-1 and DKD in children and adolescents with type 1 diabetes (T1D). We included 10 studies with 842 participants published between 2016 and 2025. A literature search of MEDLINE/PubMed, Cochrane Library, and Scopus was conducted from inception through January 5, 2026. The mean difference with a 95% confidence interval (CI) was calculated, and a P-value of <0.05 was considered statistically significant. A quality assessment of the included studies was conducted using the Newcastle-Ottawa Scale. In the meta-analysis of four studies, the urinary KIM-1 (uKIM-1)/creatinine ratio was elevated before changes in estimated GFR (95% CI, 0.02-0.48; P=0.03). This review suggests that uKIM-1/creatinine ratio and uKIM-1 may act as promising tubular biomarkers associated with early kidney injury in pediatric patients with T1D. However, further data are needed to clarify their role in pediatric DKD.","PeriodicalId":524218,"journal":{"name":"Childhood kidney diseases","volume":"30 1","pages":"38-46"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and metabolomics insights into pediatric urinary tract infection: a narrative review. 微生物组学和代谢组学对儿童尿路感染的研究综述。

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-24 DOI: 10.3339/ckd.26.003

Jung Won Lee

引用次数: 0

Early genetic diagnosis of cystinosis before corneal crystal deposition: two case reports from South India. 角膜结晶沉积前胱氨酸病的早期遗传诊断：印度南部两例报告。

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.3339/ckd.25.032

Lubna K P, Rehna K Rahman, Preetha Remesh, Manjula Anand, Nirmal Jayadevan, Divya Pachat

引用次数: 0

Correction to "Tolvaptan: a possible preemptive treatment option in children with autosomal dominant polycystic kidney disease?" 更正“托伐普坦：常染色体显性多囊肾病儿童的一种可能的预防性治疗选择？”

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.3339/ckd.23.021.c1

Hee Sun Baek, Min Hyun Cho

引用次数: 0

Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition. 肾病患儿的饮食管理：韩国儿科肾病学会和韩国临床营养学会的建议

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-09 DOI: 10.3339/ckd.25.034

Yo Han Ahn, Hee Gyung Kang, Jiyoung Song, Sangmi Han, Eujin Park, Jin-Soon Suh, Jeong Yeon Kim, Min Ji Park, Keum Hwa Lee, Seon Hee Lim, Kyeong Hun Shin, Hyunji Ko, Hyun Joo Lee, Eunyoung Jeong, Jinsu Kim, Sohyun Park, Eonju Choi, Yuri Seo, Kyooyung Oh, Jin Kyoung Kim, Hyun Kyung Lee

{"title":"Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition.","authors":"Yo Han Ahn, Hee Gyung Kang, Jiyoung Song, Sangmi Han, Eujin Park, Jin-Soon Suh, Jeong Yeon Kim, Min Ji Park, Keum Hwa Lee, Seon Hee Lim, Kyeong Hun Shin, Hyunji Ko, Hyun Joo Lee, Eunyoung Jeong, Jinsu Kim, Sohyun Park, Eonju Choi, Yuri Seo, Kyooyung Oh, Jin Kyoung Kim, Hyun Kyung Lee","doi":"10.3339/ckd.25.034","DOIUrl":"10.3339/ckd.25.034","url":null,"abstract":"Pediatric kidney disease has a relatively lower prevalence than do other pediatric conditions and has a notably different etiology from kidney diseases observed in adults. Furthermore, the pediatric population is unique in that they experience ongoing growth and development, distinguishing them from adult patients. Consequently, pediatric patients with kidney disease require more specialized and meticulous nutritional management than do adults. To address this need and promote optimal dietary practices for pediatric patients with kidney disease, pediatric nephrologists from the Korean Society of Pediatric Nephrology and nutritionists from the Korean Society of Clinical Nutrition have collaborated to establish nutritional guidelines specifically tailored to Korean dietary patterns. These guidelines offer detailed, nutrient-specific recommendations covering energy, protein, calcium, phosphorus, and potassium consumption while providing practical, culturally relevant guidance intended to support both pediatric patients and their caregivers.","PeriodicalId":524218,"journal":{"name":"Childhood kidney diseases","volume":"30 1","pages":"4-14"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric acute kidney injury: what do we know about etiology and recovery? 小儿急性肾损伤：我们对病因和恢复了解多少？

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.3339/ckd.26.001

Jeesu Min

引用次数: 0

Autosomal dominant polycystic kidney disease in children and adolescents. 儿童和青少年常染色体显性多囊肾病。

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.3339/ckd.25.041

Eunji Mun, Hee Sun Baek

{"title":"Autosomal dominant polycystic kidney disease in children and adolescents.","authors":"Eunji Mun, Hee Sun Baek","doi":"10.3339/ckd.25.041","DOIUrl":"10.3339/ckd.25.041","url":null,"abstract":"Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder and primarily arises from mutations in either the polycystic kidney disease 1 (PKD1) or 2 (PKD2) gene. Although traditionally categorized as an adult-onset disease, cystogenesis often begins in utero, and structural changes may become evident during childhood. Although most pediatric patients with ADPKD remain asymptomatic, hypertension occurs in 20%-40% of cases, and albuminuria may also be present. Both findings represent early, treatable manifestations that can significantly influence long-term prognosis. Ultrasonography is the preferred diagnostic modality; however, genetic testing is indicated in very-early-onset or atypical cases. The cornerstone of disease management is rigorous blood pressure control using renin-angiotensin system inhibitors, along with lifestyle modifications such as sodium restriction and adequate hydration. Early diagnosis and intervention are essential for optimizing long-term clinical outcomes in pediatric patients with ADPKD. This study aimed to provide a comprehensive review of the genetics, pathophysiology, clinical manifestations, diagnosis, treatment, and future management of pediatric ADPKD.","PeriodicalId":524218,"journal":{"name":"Childhood kidney diseases","volume":"30 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of corticosteroid-induced cataracts in children with nephrotic syndrome: a cross-sectional study in Pakistan. 患有肾病综合征的儿童中皮质类固醇诱发的白内障患病率：巴基斯坦的一项横断面研究。

Childhood kidney diseases Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.3339/ckd.25.036

Saima Kashif, Khemchand N Moorani

{"title":"Prevalence of corticosteroid-induced cataracts in children with nephrotic syndrome: a cross-sectional study in Pakistan.","authors":"Saima Kashif, Khemchand N Moorani","doi":"10.3339/ckd.25.036","DOIUrl":"10.3339/ckd.25.036","url":null,"abstract":"Purpose: Idiopathic nephrotic syndrome (NS) often necessitates prolonged or repeated corticosteroid treatment, which increases the risk for steroid-induced posterior subcapsular cataract (SI-PSC). Previous research on its burden remains limited. Here, we aimed to determine the prevalence and predictive risk factors of SI-PSC in children with NS.Methods: This cross-sectional study was conducted in the Pediatric Nephrology Department of The Kidney Centre, Karachi, Pakistan, from October 2023 to October 2025. The study included 150 children with NS, aged 2-16 years, who had received oral prednisolone for more than 6 months. Demographic and clinical information were collected through caregiver interviews and medical record review. All participants underwent a detailed slit-lamp examination by the same ophthalmologist. Associations between cataract formation and demographic or treatment-related variables were analyzed statistically. A P-value of ≤0.05 was considered significant.Results: Cataracts were detected in 23 children (15.3%). Most patients had early lenticular changes, but only two required surgical intervention. Other ocular abnormalities were uncommon (4.7%). Cataracts occurred more frequently in males and in children younger than 10 years. Cumulative corticosteroid doses were nearly identical in patients with and without cataracts. Children with frequently relapsing NS accounted for the highest proportion of those with SI-PSC. Systemic hypertension was the adverse effect most strongly associated with cataract development.Conclusions: SI-PSC is a notable complication in children receiving long-term corticosteroid therapy. Our findings underscore the importance of routine ophthalmologic screening. Individual susceptibility, including potential genetic factors, might play a role in cataract development and warrant further investigation.","PeriodicalId":524218,"journal":{"name":"Childhood kidney diseases","volume":"30 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0