Respiratory research & clinical practice最新文献

{"title":"Patient and author diversity and representation in studies supporting the European Respiratory Society/European Society of Intensive Care Medicine/European Society of Clinical Microbiology and Infectious Diseases/Asociación Latinoamericana de Tórax severe community-acquired pneumonia guidelines.","authors":"Guilherme H C Zonis, Melissa Tassano Pitrowsky, Mariana Balbi, Bruno Adler Maccagnan Pinheiro Besen, Antonio Paulo Nassar, Gloria A R Martins, Giulliana Moralez, Jorge I F Salluh","doi":"10.36416/1806-3756/e20250376","DOIUrl":"10.36416/1806-3756/e20250376","url":null,"abstract":"<p><strong>Objective: </strong>Insufficient diversity is common among patients and authors in studies supporting guidelines. We hypothesized that the latest severe community-acquired pneumonia (CAP) guidelines suffered from such bias.</p><p><strong>Methods: </strong>We reviewed all original studies supporting the latest severe CAP guidelines. We assessed whether there were language restrictions in the search for studies to be included in each recommendation and recorded the following: the proportion of female patients included in the studies; ethnicity (when available); year of publication; and study location, which was classified by income in accordance with the World Bank classification. We also compiled data on the sex and affiliation of the first and last authors.</p><p><strong>Results: </strong>The guidelines included 115 references in eight sections; 74 unique references supported the recommendations. There was language restriction in the selection of studies in 3 of 8 questions. The proportion of female patients ranged from 4.7% to 70.5% (mean, 36%). Most of the patients were White (72.2-91.2%), and 80.5% of the studies were conducted in high-income countries. Only 6 (5.2%) of the 115 references included patients from low- or middle-income countries. Most of the first and last authors were male (75.6-88.3%) and were based in high-income countries (96.1%).</p><p><strong>Conclusions: </strong>The studies supporting the severe CAP guidelines were found to have insufficient diversity and representativeness of patients, sex, and country of origin of the authors. To enhance the generalizability of severe CAP guidelines, strategies must be devised to increase the diversity of patients and authors.</p>","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20250376"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive clinical trials: key concepts for clinical researchers.","authors":"Victor Zuniga Dourado, Cecilia Patino, Juliana Carvalho Ferreira","doi":"10.36416/1806-3756/e20260412","DOIUrl":"10.36416/1806-3756/e20260412","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260412"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Button battery or coin ingestion? A diagnostic challenge.","authors":"Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti","doi":"10.36416/1806-3756/e20260312","DOIUrl":"10.36416/1806-3756/e20260312","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260312"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central hypoventilation with hypercapnia: the silent face of ventilatory control.","authors":"Izabella M Brito Marques, Mariana Lima Lafetá, Eloara V M Ferreira","doi":"10.36416/1806-3756/e20260320","DOIUrl":"10.36416/1806-3756/e20260320","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260320"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac bronchus with a well-formed accessory cardiac lobe-a supernumerary lung?","authors":"Ester Labrunie, Gláucia Zanetti, Edson Marchiori","doi":"10.36416/1806-3756/e20260158","DOIUrl":"10.36416/1806-3756/e20260158","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260158"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking chronic bone cement pulmonary embolism: acute hypoxia two years post-vertebroplasty.","authors":"Guoping Yang, Weiwei Liao","doi":"10.36416/1806-3756/e20260058","DOIUrl":"10.36416/1806-3756/e20260058","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260058"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond typical pathogens: pleural empyema caused by <i>Aggregatibacter aphrophilus</i>.","authors":"Beatriz Dias, Ana Correia, Teresa Belo, Ana Filipa Matos, António Reis","doi":"10.36416/1806-3756/e20260094","DOIUrl":"10.36416/1806-3756/e20260094","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260094"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-pyroptosis-associated long noncoding RNAs as prognostic biomarkers in lung cancer: a systematic review and meta-analysis.","authors":"Chaonan Ma, Misbah Ullah Khan","doi":"10.36416/1806-3756/e20250525","DOIUrl":"10.36416/1806-3756/e20250525","url":null,"abstract":"<p><strong>Objective: </strong>Hypoxia-pyroptosis-associated long noncoding RNAs (HP-lncRNAs) may contribute to cancer progression and treatment resistance, but their prognostic and mechanistic roles in lung cancer remain unclear. We conducted a systematic review and meta-analysis to evaluate their prognostic value and regulatory networks in lung cancer.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically searched five scientific databases up to November 20, 2025, for studies evaluating HP-lncRNA expression and survival outcomes. Hazard ratios (HRs) were pooled by using random-effects models, with heterogeneity being assessed by I². Subgroup analyses examined histology, tumor stage, and study design. Mechanistic evidence and protein-interaction networks were also synthesized.</p><p><strong>Results: </strong>A total of 27 studies were included, with 14 providing quantitative data for meta-analysis. High expression of HP-lncRNA signatures was significantly associated with poorer overall survival (pooled adjusted HR = 1.50; 95% CI, 1.23-1.84), with a pronounced effect in lung adenocarcinoma (adjusted HR = 1.64; 95% CI, 1.34-1.99). Subgroup analyses supported a consistent adverse association across cohort designs and showed that the association remained evident in the advanced-stage subgroup (adjusted HR = 1.60; 95% CI, 1.44-1.77), although clear stage-specific effect modification was not demonstrated. Mechanistic evidence linked some lncRNAs to hypoxia-related regulation and others to pyroptosis-related signaling. Although direct evidence of a single lncRNA connecting both pathways is limited, findings support possible hypoxia-pyroptosis crosstalk. HIF-1a and caspase-1 emerged as central hub genes.</p><p><strong>Conclusions: </strong>Our findings suggest that HP-lncRNA signatures may have prognostic relevance and therapeutic potential in lung cancer; however, the marked between-study heterogeneity indicates that further standardization and external validation are required before clinical application.</p>","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20250525"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of medical thoracoscopy: five-year experience at a tertiary care center.","authors":"Pedro Fernandes, Tito Abrantes, Carla António, Joana Correia, Ana Luís Correia, Beatriz Dias, António Reis, Teresa Belo","doi":"10.36416/1806-3756/e20260200","DOIUrl":"10.36416/1806-3756/e20260200","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260200"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the cross-sectional snapshot: longitudinal trends, regional disparities, and the pandemic-related disruption of spirometry in Brazil.","authors":"Marcos Brum-Antunes, Alícia Viana Tavares, Jordana Henz Hammes, Marcia Margaret Menezes Pizzichini, Marcus Herbert Jones","doi":"10.36416/1806-3756/e20260202","DOIUrl":"10.36416/1806-3756/e20260202","url":null,"abstract":"","PeriodicalId":524203,"journal":{"name":"Respiratory research & clinical practice","volume":"52 4","pages":"e20260202"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}