Rozhledy v Chirurgii最新文献

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Abdominal emergencies in surgical oncology. 外科肿瘤学中的腹部急诊。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.2.60-63
R Šefr, O Zapletal, P Krsička, I Novotný, M Pacal, L Němec, V Jedlička
{"title":"Abdominal emergencies in surgical oncology.","authors":"R Šefr,&nbsp;O Zapletal,&nbsp;P Krsička,&nbsp;I Novotný,&nbsp;M Pacal,&nbsp;L Němec,&nbsp;V Jedlička","doi":"10.33699/PIS.2023.102.2.60-63","DOIUrl":"https://doi.org/10.33699/PIS.2023.102.2.60-63","url":null,"abstract":"<p><strong>Introduction: </strong>In general, abdominal emergencies are urgent situations that require a prompt and correct diagnosis and treatment. They involve a broad spectrum of diagnoses and can occur in all age groups. The situation is often modified in oncologic patients according to the extent and level of progression of the primary oncological disease.</p><p><strong>Methods: </strong>A retrospective study was conducted to analyze the group of adult patients with abdominal emergencies treated in Masaryk Memorial Cancer Institute between 2011-2017.</p><p><strong>Results: </strong>In total, 601 patients underwent emergency surgery during the 7-year period. The causes included gastrointestinal obstruction (43%), intra-abdominal inflammatory complications (33%) and bleeding (17%). Acute appendicitis or cholecystitis was the cause in only less than 4% of all patients.</p><p><strong>Conclusion: </strong>The problems of acute abdominal emergencies in oncologic patients are substantially different from those in the general population, particularly in terms of the causes where gastrointestinal obstruction is the leading cause.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 2","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pneumoperitoneum, pneumomediastinum and subcutaneous emphysema following argon plasma coagulation treatment of colonic angioectasia. 氩离子凝固治疗结肠血管扩张后出现气腹、纵隔气肿及皮下气肿。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.3.130-133
P Horák, M Peregrinová, A Erbenová, T Žižková, J Fulík, J Fanta
{"title":"Pneumoperitoneum, pneumomediastinum and subcutaneous emphysema following argon plasma coagulation treatment of colonic angioectasia.","authors":"P Horák,&nbsp;M Peregrinová,&nbsp;A Erbenová,&nbsp;T Žižková,&nbsp;J Fulík,&nbsp;J Fanta","doi":"10.33699/PIS.2023.102.3.130-133","DOIUrl":"https://doi.org/10.33699/PIS.2023.102.3.130-133","url":null,"abstract":"<p><strong>Introduction: </strong>The paper presents unusual symptoms as a complication of therapeutic colonoscopy.</p><p><strong>Case report: </strong>A 70-year-old polymorbid female patient in chronic dialysis program underwent argon plasma coagulation treatment of leaking angioectasias in the cecum and ascending colon. Shortly after the procedure she presented with shortness of breath and subcutaneous emphysema of the neck which was initially misdiagnosed as swelling. Further tests revealed pneumoperitoneum, subcutaneous emphysema and pneumomediastinum. Considering the high risks for our patient (comorbidities, obesity), a laparoscopic approach was indicated. During laparoscopy neither peritonitis nor intestinal perforation were found. The patient recovered without complications after further complex treatment.</p><p><strong>Conclusion: </strong>Shortness of breath and subcutaneous emphysema are not typically among the first symptoms of colonoscopic perforation. Our case confirms that we should bear this complication in mind and when suspected, the diagnostic process should be started without delay.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 3","pages":"130-133"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Retroperitoneal abscess after urgent resection of the stomach in a geriatric patient treated with a surgical extraperitoneal approach - case report. 紧急胃切除术后腹膜后脓肿的治疗,手术腹膜外入路的老年患者-个案报告。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.1.37-41
J Šimo, P Babál, V Javorka
{"title":"Retroperitoneal abscess after urgent resection of the stomach in a geriatric patient treated with a surgical extraperitoneal approach - case report.","authors":"J Šimo,&nbsp;P Babál,&nbsp;V Javorka","doi":"10.33699/PIS.2023.102.1.37-41","DOIUrl":"https://doi.org/10.33699/PIS.2023.102.1.37-41","url":null,"abstract":"<p><p>Retroperitoneal abscess after abdominal and retroperitoneal surgery is a relatively rare but serious complication that most often occurs as a result of a healing disorder in the postoperative period. The incidence is not high, in the literature the cases are mostly reported as case reports with a serious clinical course, high morbidity and mortality. The most important factor of effective treatment, after successful diagnosis by CT examination is rapid evacuation of the abscess and retroperitoneal drainage, in which mini-invasive surgical or radiological drainage dominate as methods of choice. Surgical drainage, burdened by higher morbidity and mortality is considered the last resort after failure of mini-invasive methods. In our case report, we present a case of retroperitoneal abscess, arising as a complication after gastric resection, which was evacuated and drained primarily surgically due to unsuitability for radiological intervention.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10764920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative delirium. 术后谵妄。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.10.381-386
L Urbánek, P Urbánková, I Satinský, T Trávníček, I Penka, J Hruda
{"title":"Postoperative delirium.","authors":"L Urbánek, P Urbánková, I Satinský, T Trávníček, I Penka, J Hruda","doi":"10.33699/PIS.2023.102.10.381-386","DOIUrl":"10.33699/PIS.2023.102.10.381-386","url":null,"abstract":"<p><p>Postoperative delirium is a serious complication occurring mainly in patients over 65 years. This complication is common in the above mentioned age group and has been described in up to 50% of patients. Postoperative delirium has a significant impact both on postoperative morbidity and mortality. Systematic and early detection of at-risk patients is essential to reduce the risk of postoperative delirium. Targeted efforts are then developed in thus identified patients to reduce the risk factors for developing delirium. An individualized approach to anesthesia is adopted during the surgery. Procedures that contribute to reducing the risk of developing delirium are preferred in the postoperative period. If this complication does occur, it is primarily preferred to manage any potential cause of the condition using non-pharmacological procedures. Pharmacological interven- tion should be reserved only for patients with a hyperactive form of delirium. The aim of the article was to shed more light on measures that help to prevent the delirium and on the therapeutic procedures used.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 10","pages":"381-386"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biportal robotic pulmonary lobectomy, initial experience - case report. 双门机器人肺叶切除术,初步经验--病例报告。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.11.430-432
J Kolařík, J Tavandžis, R Novysedlák, J Vachtenheim, M Švorcová, J Pozniak, J Šimonek, J Schützner, R Lischke
{"title":"Biportal robotic pulmonary lobectomy, initial experience - case report.","authors":"J Kolařík, J Tavandžis, R Novysedlák, J Vachtenheim, M Švorcová, J Pozniak, J Šimonek, J Schützner, R Lischke","doi":"10.33699/PIS.2023.102.11.430-432","DOIUrl":"10.33699/PIS.2023.102.11.430-432","url":null,"abstract":"<p><strong>Introduction: </strong>Thanks to perfect visualization and high maneuverability of instruments, the robotic technique is a preferable type of lung resection, even though the number of required incisions is usually higher compared to the video-assisted approach. This case report presents our initial experience with the reduced-port approach in performing robotic biportal lobectomy.</p><p><strong>Case report: </strong>The 72-years-old female, examined for hemoptysis, was diagnosed with a carcinoid tumor of the left lower lobe bronchus based on bronchoscopy. The patient underwent a biportal fully robotic left lower lobectomy. The time of operation was 235 minutes, longer compared to the average time of multiportal procedures, i.e. 190±52 minutes, and the blood loss of 100 mL was higher compared to 43±54 mL. The patient was discharged without complications on the third postoperative day. Histological analysis confirmed the diagnosis of a typical carcinoid with tumor free margins and seven tumor free lymph nodes. The patient continues to be followed at the Department of Pneumology, showing no signs of disease recurrence for eight months.</p><p><strong>Conclusion: </strong>The robotic biportal approach offers a reduction in chest wall traumatization while maintaining oncological radicality. Although this approach is safe and feasible, limitations in instrument movements necessitate specific training.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 11","pages":"430-432"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally-invasive pancreatic surgery in high volume centers in the Czech Republic - current status and possible implementations. 捷克共和国高容量中心的微创胰腺手术 - 现状和可能的实施方案。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.11.416-421
M Loveček, P Záruba, J Ulrych, J Froněk, M Oliverus, F Čečka, J Hlavsa, J Šimša, L Sirotek, P Hladík, V Liška, P Kožnar, M Straka, Z Kala, M Rybář, D Klos, P Skalický
{"title":"Minimally-invasive pancreatic surgery in high volume centers in the Czech Republic - current status and possible implementations.","authors":"M Loveček, P Záruba, J Ulrych, J Froněk, M Oliverus, F Čečka, J Hlavsa, J Šimša, L Sirotek, P Hladík, V Liška, P Kožnar, M Straka, Z Kala, M Rybář, D Klos, P Skalický","doi":"10.33699/PIS.2023.102.11.416-421","DOIUrl":"10.33699/PIS.2023.102.11.416-421","url":null,"abstract":"<p><strong>Introduction: </strong>Minimally-invasive surgical methods have been becoming ever more common also in the segment of pancreatic surgery. The aim of this paper was to analyze the current state of minimally-invasive surgery in the Czech Republic and the justification and potential of implementing such procedures.</p><p><strong>Methods: </strong>Analysis of high volume centers using healthcare providers´ and payers´ data.</p><p><strong>Results: </strong>Thirteen pancreatic surgical centers meet the proposed criteria for being called a high volume center - a center of highly specialized care in pancreatic surgery based on the annual number of at least 17 major resections of the pancreas. According to data from healthcare payers, laparoscopy was used in 0.6%-65.7% of procedures in individual centers. However, these are not resection procedures. The centers themselves report a significantly smaller number of minimally-invasive pancreatic resection procedures. The actual numbers of minimally-invasive resection procedures in the current system are practically impossible to verify. The potential for implementing minimally-invasive pancreatic surgery in the Czech Republic can be estimated based on the identification of candidate patients.</p><p><strong>Conclusion: </strong>Due to the fragmentation of this operative segment, its costs and small numbers of patients suitable for minimally-invasive pancreatic surgery even among high volume centers, the implementation rate of these methods is very slow. The need to centralize this segment of care appears to be very urgent from all points of view.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 11","pages":"416-421"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic-assisted minimally invasive esophagectomy - our first experience. 机器人辅助微创食管切除术--我们的初次体验。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.11.422-429
T Haruštiak, S Jaroščiaková, M Šnajdauf, A Pazdro, R Lischke
{"title":"Robotic-assisted minimally invasive esophagectomy - our first experience.","authors":"T Haruštiak, S Jaroščiaková, M Šnajdauf, A Pazdro, R Lischke","doi":"10.33699/PIS.2023.102.11.422-429","DOIUrl":"10.33699/PIS.2023.102.11.422-429","url":null,"abstract":"<p><strong>Introduction: </strong>Minimally invasive esophagectomy is associated with lower postoperative morbidity and better quality of life compared to open esophagectomy in patients with comparable oncological outcomes. Robotic-assisted surgery represents the next step in the development of mini- mally invasive surgery. We aim to present the results of a pilot cohort of patients undergoing robotic-assisted minimally invasive esophagectomy (RAMIE).</p><p><strong>Methods: </strong>An initial cohort of patients with RAMIE was retrospectively analyzed. Operative characteristics, histopathological results, postoperative course, incidence of complications, and postoperative mortality were evaluated.</p><p><strong>Results: </strong>From 3/2022 to 6/2023, a total of 31 patients underwent RAMIE at our institution, including hybrid RAMIE (robotic abdomen, open chest) in 11 and total RAMIE in 20 patients. Most patients were male, had locally advanced tumors, predominantly adenocarcinoma and neoadjuvant treat- ment. Thirty patients had Ivor-Lewis and one patient had McKeown esophagectomy. The median total operative time was 495 minutes and median blood loss was 200 mL. R0 resection was achieved in 87% of patients. A median of 26 lymph nodes were removed. Postoperative Clavien-Dindo ≥3 complications occurred in 9 (29%) patients. Four (13%) patients required reoperation. Anastomotic leak was found in 5 (16%) and pneumonia in 9 (29%) patients. The median hospital stay was 9 days. One patient died in the postoperative period. Thirty-day and 90-day mortality rates were 0% and 3.2%, respectively.</p><p><strong>Conclusion: </strong>Our initial experience shows that RAMIE is a safe surgical procedure and we consider its implementation at our institution to be success- ful. After overcoming the learning curve, we hope to reduce the operative time and increase the medical benefit for the patient.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 11","pages":"422-429"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fresh arterial allograft as a replacement for an infected common femoral prosthetic graft and recurrent false aneurysm. 新鲜动脉同种异体移植物替代感染的股骨假体移植物和复发性假动脉瘤。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.2.75-79
M Pluchova, J Chlupac, L Janousek, J Froněk
{"title":"Fresh arterial allograft as a replacement for an infected common femoral prosthetic graft and recurrent false aneurysm.","authors":"M Pluchova,&nbsp;J Chlupac,&nbsp;L Janousek,&nbsp;J Froněk","doi":"10.33699/PIS.2023.102.2.75-79","DOIUrl":"https://doi.org/10.33699/PIS.2023.102.2.75-79","url":null,"abstract":"<p><p>Replacing an infected vascular prosthetic conduit with an allograft is a possible solution of this complication given the low recurrence of infection. It is most commonly utilized for cases where the use of autologous tissue is not an option. We present the case of a 70-year-old patient who had undergone repeated vascular reconstructions in the right lower limb. He was admitted to our department due to a progressively growing mass in the right groin and subsequently placed on the waiting list for a fresh allograft. The patient had the infected false aneurysm and prosthetic material of the femoral bifurcation replaced with an arterial allograft. The previous femoral popliteal autovenous bypass graft was reimplanted into the allograft. There were signs of sepsis during the operation; however, the blood culture was negative. Cultures from neither the wound nor the drain revealed the presence of any bacteria. The patient was discharged on the seventh post-operative day with prophylactic antibiotics. An early followup confirmed that there were no signs of recurrent infection and that the reconstruction remained patent. Seven and half months after the surgery, the femoral popliteal bypass graft became occluded and a conservative approach was chosen. A small thrombosed false aneurysm of the graft was revealed two years after the surgery due to transient non-compliance of the patient to immunosuppression therapy. It was treated conservatively. Two and a half years after the surgery, the allograft still remains open and the limb is preserved.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 2","pages":"75-79"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical practice guidelines for perioperative care in bariatric surgery 2023: Adapted ERAS (enhanced recovery after surgery) guidelines with consensual voting of the working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery…. 2023 年减肥手术围手术期护理临床实践指南:经捷克外科减肥和代谢外科联合工作组一致投票通过的ERAS(术后恢复强化)指南修订版....
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.7.283-297
I Satinský, M Hrubý, P Šrámková, J Patka, M Čierný, P Babiak, I Šimonik, P Schwarz, M Haluzík
{"title":"Clinical practice guidelines for perioperative care in bariatric surgery 2023: Adapted ERAS (enhanced recovery after surgery) guidelines with consensual voting of the working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery….","authors":"I Satinský, M Hrubý, P Šrámková, J Patka, M Čierný, P Babiak, I Šimonik, P Schwarz, M Haluzík","doi":"10.33699/PIS.2023.102.7.283-297","DOIUrl":"10.33699/PIS.2023.102.7.283-297","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, bariatric surgery is the most effective treatment for the morbid obesity. It provides sustained weight loss as well as demonstrated positive effects on obesity-related comorbidities. The number of procedures performed worldwide has seen a sharp increase in the past twenty years. Therefore, an effort has been developed to establish a consensus in perioperative care based on best evidence.</p><p><strong>Methods: </strong>The working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery Society and Czech Society of Obesitology prepared clinical practice guidelines for the ERAS (enhanced recovery after surgery) concept in perioperative care in bariatric surgery. The working group based its guidelines on ERAS guidelines published in 2021. The working group adopted the original text and then adapted the text and added its comments to specific items as appropriate. Electronic voting of all members of the working group was the final phase, by which the strength of consensus was expressed with respect to individual elements of the guidelines.</p><p><strong>Results: </strong>The Czech working group reached a consensus with ERABS (enhanced recovery after bariatric surgery) guidelines for most elements. The quality of evidence is low for some interventions of the ERAS protocol for bariatric surgery. Therefore, extrapolation from other surgeries and fields is needed for evidence-based practice.</p><p><strong>Conclusion: </strong>The guidelines are intended for clinical practice in bariatric surgery with the ERAS protocol based on updated evidence and guidelines. It is based on recent and comprehensive ERAS guidelines adopted and adapted by the Czech working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery Society and Czech Society of Obesitology. Some supplementations and specifications are reflected in comments added to the Czech version.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 7","pages":"283-297"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and clinical significance of circulating tumour cells in patients with colorectal carcinoma. 大肠癌患者循环肿瘤细胞的检测和临床意义。
Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI: 10.33699/PIS.2023.102.10.376-380
P Ihnát, J Srovnal, J Hrubovčák, L Martínek
{"title":"Detection and clinical significance of circulating tumour cells in patients with colorectal carcinoma.","authors":"P Ihnát, J Srovnal, J Hrubovčák, L Martínek","doi":"10.33699/PIS.2023.102.10.376-380","DOIUrl":"10.33699/PIS.2023.102.10.376-380","url":null,"abstract":"<p><p>Circulating tumour cells (CTCs) are tumour cells identified in the peripheral blood of patients with malignant disease. CTCs present a very interesting biomarker with promising potential for use in the treatment management of patients with colorectal cancer. Unlike other tumour biomarkers, CTCs are living tumour cells that carry molecular and biological information about the tumour as a whole and reflect ongoing mutational changes. Detection of CTCs from peripheral blood presents a simple and easily repeatable method of liquid biopsy. However, various techniques of CTC selection and detection render clinical use of CTC as a clinical biomarker difficult. The presence/amount of CTCs correlates very well with prognosis and patients ́ survival. Since CTCs have metastatic potential, knowledge of the effect of different treatment modalities on the amount of CTCs in the blood appears to be very important. It can be expected that a more effective treatment regimen will be associated with a reduction in blood CTC levels, and also with a better prognosis. Conversely, an increase or persistence of CTC levels will be associated with resistance to the applied treatment. Routine use of CTCs in clinical practice is limited predominantly by price and very high variability of available scientific evidence. Recently published studies demonstrated the promising potential of CTCs; however, further research will be required for their routine use in clinical practice.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"102 10","pages":"376-380"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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