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More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues. Brugada 综合征 30 多年：对成就和未决问题的批判性评估。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2023-12-12 DOI: 10.1007/s00399-023-00983-y
Lars Eckardt, Christian Veltmann
{"title":"More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues.","authors":"Lars Eckardt, Christian Veltmann","doi":"10.1007/s00399-023-00983-y","DOIUrl":"10.1007/s00399-023-00983-y","url":null,"abstract":"<p><p>Over the last three decades, what is referred to as Brugada syndrome (BrS) has developed from a clinical observation of initially a few cases of sudden cardiac death (SCD) in the absence of structural heart disease with ECG signs of \"atypical right bundle brunch block\" to a predominantly electrocardiographic, and to a lesser extent genetic, diagnosis. Today, BrS is diagnosed in patients without overt structural heart disease and a spontaneous Brugada type 1 ECG pattern regardless of symptoms. The diagnosis of BrS is less clear in those with an only transient or drug-induced type 1 Brugada pattern, but should be considered in the presence of an arrhythmic syncope, family history of BrS, or family history of sudden death. In addition to survived cardiac arrest, syncope is probably the single most decisive risk marker for future arrhythmias. For asymptomatic BrS, risk stratification remains challenging. General recommendations to lower the risk in BrS include avoidance of drugs/agents known to induce and/or increase right precordial ST-segment elevation, including treatment of fever with antipyretic drugs. Several ECG markers that have been associated with an increased risk of SCD have been incorporated into a recently published risk score for BrS. The aim of this article is to provide an overview of the status of risk stratification and to illustrate open issues und gaps in evidence in BrS.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[You can only understand today if you know yesterday : The history of rhythmology in Germany]. [只有了解昨天，才能理解今天：德国韵律学的历史]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-03-08 DOI: 10.1007/s00399-024-01013-1
M Borggrefe, F de Haan, C W Israel
{"title":"[You can only understand today if you know yesterday : The history of rhythmology in Germany].","authors":"M Borggrefe, F de Haan, C W Israel","doi":"10.1007/s00399-024-01013-1","DOIUrl":"10.1007/s00399-024-01013-1","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":"35 Suppl 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetics in atrial fibrillation and malignant arrhythmia syndromes]. [心房颤动和恶性心律失常综合征的遗传学]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1007/s00399-024-00998-z
Rainer Schimpf, Ursula Ravens
{"title":"[Genetics in atrial fibrillation and malignant arrhythmia syndromes].","authors":"Rainer Schimpf, Ursula Ravens","doi":"10.1007/s00399-024-00998-z","DOIUrl":"10.1007/s00399-024-00998-z","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":"35 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Perioperative management for cardiovascular implantable electronic devices]. [心血管植入式电子设备的围手术期管理]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-01-30 DOI: 10.1007/s00399-023-00989-6
Konstantin Krieger, Innu Park, Till Althoff, Sonia Busch, K R Julian Chun, Heidi Estner, Leon Iden, Tilman Maurer, Andreas Rillig, Philipp Sommer, Daniel Steven, Roland Tilz, David Duncker
{"title":"[Perioperative management for cardiovascular implantable electronic devices].","authors":"Konstantin Krieger, Innu Park, Till Althoff, Sonia Busch, K R Julian Chun, Heidi Estner, Leon Iden, Tilman Maurer, Andreas Rillig, Philipp Sommer, Daniel Steven, Roland Tilz, David Duncker","doi":"10.1007/s00399-023-00989-6","DOIUrl":"10.1007/s00399-023-00989-6","url":null,"abstract":"<p><p>Cardiovascular implantable electronic devices (CIED) are an important part of modern cardiology and careful perioperative planning of these procedures is necessary. All information relevant to the indication, the procedure, and the education of the patient must be available prior to surgery. This provides the basis for appropriate device selection. Preoperative antibiotic prophylaxis and perioperative anticoagulation management are essential to prevent infection. After surgery, postoperative monitoring, telemetric control, and device-based diagnostics are required before discharge. These processes need to be adapted to the increasing trend towards outpatient care. This review summarises perioperative management based on practical considerations.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"83-90"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10879261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Historical development of diagnosis of bradyarrhythmias : The early years of clinical electrophysiology in Germany]. [诊断缓慢性心律失常的历史发展 ：德国临床电生理学的早期发展]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-02-28 DOI: 10.1007/s00399-024-01006-0
Günter Breithardt
{"title":"[Historical development of diagnosis of bradyarrhythmias : The early years of clinical electrophysiology in Germany].","authors":"Günter Breithardt","doi":"10.1007/s00399-024-01006-0","DOIUrl":"10.1007/s00399-024-01006-0","url":null,"abstract":"<p><p>The introduction of His bundle electrography by Benjamin Scherlag (New York) in 1969, together with programmed stimulation of the heart by Philip Coumel (Paris) in 1967, and Hein Wellens (Amsterdam) in 1972, were decisive turning points on the way to invasive electrophysiology and the development of an independent, now distinctly interventional subspecialty of cardiology. The main topic of the 1970s was bradycardic arrhythmias, promoted by pacemaker therapy, which had been introduced just over 10 years earlier. The recording of the potentials of the bundle of His and other recording locations in the atria and ventricles allowed a differentiated assessment of the excitation process and the refractory periods. High-rate atrial stimulation to determine sinus node recovery time and premature stimulation to determine sinoatrial conduction time were developed to analyze sinoatrial node function. This article describes the introduction of His bundle electrography in a gradually increasing number of centers in Germany and their scientific contribution.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"5-17"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How everything started: the beginning and development of clinical electrophysiology in Germany]. [一切是如何开始的：德国临床电生理学的起步与发展]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-02-29 DOI: 10.1007/s00399-024-01002-4
Ludger Seipel, Fokko de Haan
{"title":"[How everything started: the beginning and development of clinical electrophysiology in Germany].","authors":"Ludger Seipel, Fokko de Haan","doi":"10.1007/s00399-024-01002-4","DOIUrl":"10.1007/s00399-024-01002-4","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiogenetics in Germany- a view and review]. [德国的心脏遗传学--观点与回顾]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-02-28 DOI: 10.1007/s00399-024-01008-y
E Schulze-Bahr
{"title":"[Cardiogenetics in Germany- a view and review].","authors":"E Schulze-Bahr","doi":"10.1007/s00399-024-01008-y","DOIUrl":"10.1007/s00399-024-01008-y","url":null,"abstract":"<p><p>The development of the cardiogenetics field in Germany has been increasing since the mid-1990s with many national contributions, some of them were really important and groundbreaking. The starting point was and still is the patient and his family, e.g. with a familial form of arrhythmia or cardiomyopathy, the clarification of the genetic cause and the personalized treatment of those being affected. The scientific, always translationally oriented interest in identifying a causative gene and uncovering the underlying pathomechanisms has led to notable contributions for Brugada syndrome, short QT syndrome and cardiac conduction disorders or sinus node dysfunction, but also in DCM or ARVC. What is important, however, is always the way back (bench > bed side): implementation of national and international recommendations for cardiogenetic diagnostics in daily cardiological routine and the personalized care and therapy of those being affected.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"127-137"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetic basis of atrial fibrillation-on the road to precision medicine]. 【精准医疗之路上心房颤动的遗传基础】。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2023-11-06 DOI: 10.1007/s00399-023-00974-z
Shinwan Kany, Renate B Schnabel
{"title":"[Genetic basis of atrial fibrillation-on the road to precision medicine].","authors":"Shinwan Kany, Renate B Schnabel","doi":"10.1007/s00399-023-00974-z","DOIUrl":"10.1007/s00399-023-00974-z","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the most common cardiac arrhythmia and has complex genetic underpinnings. Despite advancements in treatment, mortality of AF patients remains high. This review discusses the genetic basis of AF and its implications for diagnosis and therapy. Although AF pathology has long been known to include a hereditary component, the first genes associated with AF were not identified until the early 2000s. Subsequent research with genome-wide association studies (GWAS) has implicated other genes and numerous genetic variants in AF. These studies have revealed nearly 140 different regions in the DNA with genome-wide significance associated with AF. In addition to common variants, rare variants with large effects have also been identified. The integration of these genetic findings into clinical practice holds promise for improving AF diagnosis and treatment, moving us closer to precision medicine. However, challenges remain, including the need for more diverse genetic data of non-European ancestry and improved genetic analyses of responses to AF therapy.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10879292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[History of cardiac pacemaker therapy in Germany]. [德国心脏起搏器治疗的历史]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-02-29 DOI: 10.1007/s00399-024-01010-4
Bernd Lemke
{"title":"[History of cardiac pacemaker therapy in Germany].","authors":"Bernd Lemke","doi":"10.1007/s00399-024-01010-4","DOIUrl":"10.1007/s00399-024-01010-4","url":null,"abstract":"<p><p>Cardiac pacemaker therapy began with successful stimulation of human hearts already in the first half of the 20th century. Complete implantation of a pacemaker by the cardiac surgeon Åke Senning on October 8, 1958 at the Karolinska Hospital in Stockholm is considered the actual birth of today's pacemaker therapy. The first pacemaker implantation in Germany was performed by Hans-Joachim Sykosch on October 6, 1961 at the Surgical Clinic of the University of Düsseldorf. Two years later, the first implantation in East Germany (GDR) was carried out by Friedrich Flemming on September 2, 1963 at the Charité in East Berlin. The first pacemaker manufactured in West Germany arrived on the market 1963; East Germany started device production in 1978. In 1974, pacemaker therapy in West Germany showed a 50% survival rate after 6.3 years compared to < 1 year with drug therapy. After initially using bare metal wires, pacemaker leads have significantly improved in both quality and reliability. Development culminated in the leadless pacemaker. Battery development led to a variety of inventions: rechargeable pacemakers, biogalvanic cells, bioenergy sources, nuclear generators and lithium batteries, the latter ultimately prevailed. In the beginning, only fixed-rate ventricular pacemakers were available. Subsequently, systems adapted to physiological requirements were developed: on-demand pacemakers, atrial-based pacing and rate-adaptive systems. However, it was not until the return to direct stimulation of the conduction system that truly physiological stimulation of the heart became possible.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"18-54"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Annual Report of the German Cardiac Pacemaker and Defibrillator Register 2021-Part 1: Cardiac pacemakers]. [德国心脏起搏器和除颤器登记册 2021 年年度报告：第 1 部分：心脏起搏器]。
Herzschrittmachertherapie und Elektrophysiologie Pub Date : 2024-03-01 Epub Date: 2024-01-11 DOI: 10.1007/s00399-023-00985-w
Heiko Burger, Bernd Nowak, Uwe Wiegand, Carsten Israel, Bernd Lemke, Christof Kolb, Andreas Markewitz
{"title":"[Annual Report of the German Cardiac Pacemaker and Defibrillator Register 2021-Part 1: Cardiac pacemakers].","authors":"Heiko Burger, Bernd Nowak, Uwe Wiegand, Carsten Israel, Bernd Lemke, Christof Kolb, Andreas Markewitz","doi":"10.1007/s00399-023-00985-w","DOIUrl":"10.1007/s00399-023-00985-w","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":" ","pages":"46-60"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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