Russian Journal of Pediatric Hematology and Oncology最新文献

{"title":"Palivizumab immunization of premature infants with bronchopulmonary dysplasia in a day hospital","authors":"N. Kharitonova, M. Basargina, I. Davydova, E. Zimina, M. Mitish, Marina I. Nesterovich, Mariya S. Illarionova, A. A. Seliverstova, T. V. Potekhina, V. Bondar","doi":"10.46563/1560-9561-2023-26-1-27-31","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-27-31","url":null,"abstract":"Introduction. To date, Рalivizumab is the only approved monoclonal antibody preparation used to prevent the development of respiratory syncytial virus (RSV) infection. The aim of the work is to evaluate the benefits of immunization with Palivizumab in premature infants with bronchopulmonary dysplasia in a day hospital of the Federal Center. \u0000Materials and methods. One hundred seven infants of different gestational age at birth were immunized with Palivizumab in the day patient department of hospital-replacing technologies. The preparation was administered to infants at risk for the formation of severe consequences of an RSV infection. \u0000Results. Of the 107 children hospitalized in the day hospital, 74 premature babies were diagnosed with bronchopulmonary dysplasia (69%). Before immunization all infants were consulted by pediatrician, pulmonologist, and if necessary, other specialists. Discussion. The length of stay of children in a day hospital ranged from 2 to 3.5 hours on average. Each child stayed with their parents in a separate room. During this time period, the patient received the full range of the services associated with immunization. \u0000Conclusion. Thus, immunization with Palivizumab in a day hospital of the Federal Center allows implementing a comprehensive multidisciplinary and individual approach to each infant, without exposing him to an undesirable risk of infection, in compliance with the principle of staged nursing of premature infants for patients with a new form of bronchopulmonary dysplasia who need a long follow-up observation.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80315116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a health-saving space for education of children with disabilities and handicapped children","authors":"S. Lazurenko, S. Konova, A. Fisenko, R. Terletskaya, T. Solovyova, I. Nurlygayanov","doi":"10.46563/1560-9561-2023-26-1-39-45","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-39-45","url":null,"abstract":"The goal is to assess the health of students studying according to adapted basic general education programs and the conditions of health saving in the educational institution. \u0000Materials and methods. A monitoring research in some educational institutions that provide education according to adapted basic general education programs in eight federal districts of the Russian Federation. The factors influencing on the state of children’s health in the training process were as follows: management of medical, hygienic, psychological, and pedagogical and health saving procedures. To objectivize the experimental data, questionnaire survey of teaching staff and parents, qualitative and quantitative analysis were carried out. \u0000Results. Currently, in educational institutions, regardless of the form of implementation of the educational process (in special or inclusive education), different categories of students are included in education. So far, education is carried out according to several versions of the basic general education curriculum. Such necessity is caused by the reduction of the number of children of one category and increase of another one. Education of children of different psychological and pedagogical categories in one educational institution requires creation of optimal educational conditions, taking into account the special educational needs of each student. The spatial environment that supports the health of students is created in most schools for children with musculoskeletal disorders, and less often in schools for children with hearing and vision disorders. Complete compliance of classrooms and special technical equipment of the educational process with the special educational needs of children occurred not in all educational institutions. Factor analysis has identified the most important components of a school health environment, and the data of the cluster analysis has formed its typological variants. Science-intensive health-saving technologies are used only for the correction of posture and the prevention of visual overexertion. The most acute gaps are insufficient educational and methodological equipment, material and technical condition of institutions, the volume and management of medical care for students. Existing legislative and normative legal documents do not fully regulate the management of health saving measures and technologies for students with special educational needs and children with disabilities, the process of health saving in the education system, which negatively affects their health status. \u0000Conclusion. The problems identified in the activities of educational institutions, in which children with special educational needs and children with disabilities study, to create a health-saving environment should be taken into account when supplementing and improving the content of legislative acts.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87963532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience in management of a child with enterocolitis syndrome induced by proteins from products of complementary foods","authors":"M. Galitskaya, S. Makarova, O. Ereshko, Ayina M. Lebedeva","doi":"10.46563/1560-9561-2023-26-1-75-78","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-75-78","url":null,"abstract":"Enterocolitis syndrome induced by dietary proteins occupies a special place in the structure of allergic diseases in children of the first years of life. This is primarily due to the difficulties of diagnosing the syndrome, since there are currently no specific laboratory tests confirming the diagnosis, and the similarity of the clinical picture with the symptoms of other diseases of the gastrointestinal tract. Most often, the diagnosis is established according to the clinical picture and is confirmed by a positive provocative test with a suspected food trigger. The article briefly describes the enterocolitis syndrome induced by dietary proteins, and presents a clinical case of the syndrome in a child of 11 months. This syndrome was suspected at the first appointment of a nutritionist-allergist after analyzing the clinical picture of the disease and confirmed at a repeat appointment after 1 month. The significant role in the diagnosis by the provocative introduction of a causally significant product is shown, as well as the importance of prescribing an elimination diet to achieve remission of the disease.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72765688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in external respiration in patients with cystic fibrosis with various infectious pathogens and structural damage to the lungs","authors":"S. Bystrova, O. Simonova, O. V. Kustova, Elina E. Akhmedova, Anna V. Lazareva","doi":"10.46563/1560-9561-2023-26-1-14-21","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-14-21","url":null,"abstract":"The progression of lung failure in children with cystic fibrosis (CF) is associated with chronic lung infection (Staphylococcus aureus, Pseudomonas aeruginosa, Achromobacter spp., etc.). Functional pulmonary tests (PFTs), spirometry and body plethysmography, computed tomography (CT) of the lungs and analysis of the lung microbiota are used for monitoring of lung condition of CF patients. Several studies have been devoted to assessing the correlation of structural changes in CT and pulmonary function tests (PFT), but at the moment there is not enough data on the relationship of these indicators and their differences depending on the respiratory microbiota in CF children in the Russian population. \u0000Materials and methods. Data was collected for CF 8–17.9 years children patients. We retrospectively analyzed genotype, body mass index, results of PFTs and CT scan of the chest (score by the Brody scale), deep throat cultures in all patients, and the capillary blood gas — in 56 children. \u0000Results. Significant correlations between functional tests and structural changes in the lungs were found. A trend towards impairment of PFTs and CT scores with age due to infectious pathogens was shown, and the most significant negative impact was exerted by the mucoid species Pseudomonas aeruginosa and, especially, Achromobacter spp. The last one was associated with the worst lung parameters in CF children. \u0000Conclusion. Pirometry, body plethysmography, and CT of the lungs are necessary for a comprehensive assessment of the lung condition, and a study of the lung microbiome due to its influence on structural and function changes in patients with CF.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75180602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern aspects of Helicobacter pylori infection","authors":"Nataliya V. Yakovleva, G. I. Smirnova, Anatoliy A. Korsunsky","doi":"10.46563/1560-9561-2023-26-1-67-74","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-67-74","url":null,"abstract":"A systematic review of current data on the structure and functions of Helicobacter pylori (Hp), pathogenesis, diagnosis and treatment of Hp-infection is presented. The relevance of the topic of helicobacteriosis is due to the proven connection of this infection with chronic, widespread diseases of the digestive organs among the population. The review used materials from the databases including PubМed, Medline, EMBASE, Scopus, Google Scholar, RSCI. A systematic review based on studies with a high degree of evidence has shown significant progress in the diagnosis and treatment of Hp-infection in recent years in adults and children. Coordination of the scientific search for the regularities of the formation of Hp-associated forms of pathology, continuous improvement of diagnostic technologies and the search for new therapies, periodic well-organized international revisions of standard methods of Hp diagnosis and treatment contribute to the creation of effective methods of Hp eradication, preservation of the optimal composition of the microbiota of the gastrointestinal tract and prevention of antibiotic resistance. Of particular importance for the prevention of complications of Hp-infection are original diagnostic algorithms using specialized endoscopic and molecular technologies before and after Hp eradication with long-term follow-up and the determination of the leading factors correlating with a high risk of stomach cancer. The review indicates the emergence of potentially effective and promising areas for the diagnosis and treatment of Hp-infection, including genetic modification of the Hp genome to ensure its existence as a human symbiont and a significant reduction in its pathogenic properties. At the same time, sequencing of a new generation reveals mutations in Hp genes associated with its pathogenicity and antibiotic resistance, which contributes to the creation of new classes of drugs to increase the effectiveness of Hp eradication with a decrease in the proportion of antibiotics and an increase in pathogenetically significant inhibitors of its pathogenic factors for the prevention of side effects, a significant reduction in the empirical use of several antibiotics and increased compliance to treatment.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86575636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotavirus infection in children: clinical and etiological structure and analysis of vaccine prophylaxis","authors":"D. V. Sutovskaya, A. Burlutskaya, Daria R. Krylova, Anastasia A. Tetenkova, Marina A. Litvinskaya, G. V. Naumenko, Alena A. Epinetova","doi":"10.46563/1560-9561-2023-26-1-22-26","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-22-26","url":null,"abstract":"Among all hospitalizations of children with acute enteral infection (AEI), 20 to 60% are associated with rotavirus infection (RVI). The high intensity of the spread of the epidemic process and mortality from RVI indicates to the need for vaccination. \u0000Aim: to assess the state of vaccination and study the clinical and etiological structure of RVI in children in-patients in the city of Krasnodar. \u0000Materials and methods. There was performed the single-stage retrospective analysis of 505 case histories of acute AEI 0– \u000018 years children (boys/girls: 267/238) admitted to the Children’s City Clinical Hospital in Krasnodar (2020). The state of vaccination (2013–2020) was studied on the base of the vaccination center in the Children’s City Clinical Hospital in Krasnodar. \u0000Results. The number of immunized 6552 increased from 10 (2013) to 1460 (2020). Vaccination coverage in 2020 was 5.9% of the target cohort. Less than 1% of adverse events after immunization have been reported. In the AEI structure, 140 cases of RVI (27.7%) were registered: mono-RVI 50 (35.7%), mixed-RVI 90 (64.3%). Mixed-RVI included noro-RVI (67.9% cases), noro-adeno-RVI (17.8%), adeno-RVI (3.3%), salmonella-noro-RVI (3.3%), salmonella-RVI, salmonella-noro-adeno-RVI, campylobacteria-noro-RVI (2.2%) and escherichio-RVI (1.1%). The age structure of the Republic of Ingushetia was dominated by children under 1 year — 59.3%, \u00001–3 years old — 21.4%, 4–6 years old — 7.2%, 7–18 years old — 12.1%. Mono-RVI occurred in the form of gastroenteritis in moderate (78%) and severe (22%) forms with varying degrees of dehydration (stage I — 74%, stage II — 4%, stage III — 22%). Mixed RVI occurred in the form of gastroenteritis 80 (88.9%) and enterocolitis 10 (11.1%) in moderate (81%) and severe (19%) forms with stage I exsicosis (63%), II Art. (18%), III Art. (19%). Among all hospitalized children, none were as vaccinated against RVI. \u0000Conclusion. The high intensity of the spread of the epidemic process in RVI indicates the need for vaccination.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89239356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of thrombogenic risk factors in children in the Altai krai","authors":"V. Ponomarev, Evgeny V. Skudarnov, L. Strozenko, N. Dorokhov, O. Malyuga, O. Zenchenko","doi":"10.46563/1560-9561-2023-26-1-61-66","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-61-66","url":null,"abstract":"Introduction. One of the urgent problems of modern pediatrics is the risk of developing vascular complications in children, among which thrombosis is not uncommon. For early diagnosis and thromboprophylaxis of strokes and other vascular complications, the identification of thrombogenic risk factors is indicated. \u0000The purpose of the study. Based on the screening, to establish predictors of thrombogenic risk in children living in urban and rural areas of the Altai Territory for the timely prevention of vascular complications. \u0000Materials and methods. The results of a screening study of two hundred seventeen aged 12–17 years children living in the city of Barnaul, Zarinsk and Klyuchevsk districts of the Altai Territory, were analyzed. Screening examination of children without signs of thrombosis and bleeding was carried out at an outpatient appointment with a pediatrician in random sampling. The questionnaire included questions to clarify the family thrombotic history, personal thrombotic history, background somatic diseases. Clinical examination was performed for all interviewed patients. \u0000Results. According to the results of the study, it was revealed that in 65 (30%) of the 217 children surveyed, the closest relatives had thrombogenic risk factors, such as heart attacks, strokes, hypertension, coronary heart disease (CHD). After analyzing the personal thrombotic history, it was found that in the general group of patients, myocardial infarction was observed in 2 (0.9%) children. Strokes were noted in 5 (2.3%) respondents, and thrombosis and TIA in 2 (0.9%) subjects. When analyzing the results, it was found that a significant proportion of children had the following conditions, such as vegetative-vascular dystonia (VVD) of the hypertensive type, the presence of signs of undifferentiated connective tissue dysplasia (UCTD), smoking, obesity. \u0000Conclusion. According to screening data in children, the main predisposing factors in the development of thrombosis, strokes and heart attacks are a burdened family, thrombotic history, the presence of some somatic diseases. The combination of these factors justifies the need for additional examination for the prevention of vascular thrombosis.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80577175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and functional readiness for learning activities in first-graders","authors":"S. A. Chekalova, P. I. Khramtsov, E. V. Antonova, N. O. Berezina, E. Karpovich, Anastasia O. Marinina, A. M. Kurgansky, V. V. Katunova","doi":"10.46563/1560-9561-2023-26-1-54-60","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-1-54-60","url":null,"abstract":"Introduction. The modern system of primary education dictates high requirements to children, which determines the relevance of the study of the child’s functional readiness for schooling. The child’s readiness for school provides an ability to fully satisfy conditions of systematic education and includes intellectual, emotional and social aspects. The emotional state of the child and the level of anxiety are important factors reflecting the adequacy of school adaptation during this period. \u0000Objective: assessment of anxiety and functional readiness for being taugh tin first-graders. \u0000Materials and methods. There were conducted survey and testing of sixty one 7–8 years first-graders, including 31 boys (50.8%) and 30 girls (49.2%). The children were taught in different classes: two classes with a separate form of education (only boys \u0000(19 students) and only girls (20 students)) and one class of joint education (together boys and girls — 22 students). Anxiety was assessed according to the method of “Scale of socio-situational anxiety” by O. Kondash (1973) adapted by V.V. Katunova (2020). The assessment of functional readiness for school was carried out using the Kern–Irasek orientation test of the school maturity. \u0000Results. When analyzing school and self-assessment anxiety, a significant predominance of excessive calmness was noted among 62.3% and 65.6% of children, respectively (95% CI 50.1–74.5% and 53.7–77.5%). When assessing school anxiety, a significant prevalence of normal anxiety for girls studying in a separate form of education — 55% (95% CI 33,2–76.8) was revealed in comparison with children studying in a joint form of education — 13.6% (95% CI –0.7–8.0). When considering aggressiveness, a significant prevalence of a low level of aggressiveness among girls — 35% (95% CI 14.1–55.9), and a high level among boys — 68.4% (95% CI 47.5–89.3) in comparison with children studying in the joint form of education (4.5%; 95% CI –4.2–13.2 and 27.3%; 95% CI 8.7–45.9, respectively). Reliable risks of high interpersonal anxiety and a high level of aggressiveness for boys studying in a separate form of education have been identified, which, however, requires further research. \u0000Conclusion. The data obtained make it possible to identify a risk group among children for the formation of school maladaptation and inadequate response to the academic load.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77751824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Establishment of Newborn Service in the Samara Region: Milestones and Fortunes","authors":"N. Koltsova","doi":"10.15690/rpj.v4i1.2511","DOIUrl":"https://doi.org/10.15690/rpj.v4i1.2511","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87469765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outstanding Russian pediatrician Peter Mikhaylovich Argutinsky-Dolgorukov (1850–1911)","authors":"D. A. Letunovskaya","doi":"10.15690/rpj.v4i1.2515","DOIUrl":"https://doi.org/10.15690/rpj.v4i1.2515","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87064708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}