The Gulf journal of oncology最新文献

{"title":"Assessing the use of anti-PD-1/PD-L1 cancer therapies in the Middle-Eastern Country of Lebanon: a single-center study.","authors":"Reem El Hindi, Salim Moussa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy is an effective cancer treatment strategy. Immune checkpoint inhibitors (ICIs), such as anti-PD-1/PD-L1, have demonstrated promising clinical outcomes. In Lebanon, a lower-middle-income country with a history of economic collapse, oncologists began prescribing ICI therapy despite its high cost and the lack of clear evidence regarding the pattern of ICI clinical outcomes in Lebanese patients. The current status of ICIs use in Lebanon remains unclear.</p><p><strong>Methods: </strong>This retrospective study involved cancer patients treated with programmed cell death-1 (PD-1/PD-L1) inhibitors at the Central Military Hospital in Beirut, Lebanon. Demographic and clinical data were collected from patients' records from 2016 to 2024.</p><p><strong>Results: </strong>The study included 118 patients. The hospital covered the patient's treatment. Of those, 59.3% (n = 70) had received ICIs. They were distributed as follows: 58.6% received pembrolizumab; 24.3%, nivolumab; and 17.2%, atezolizumab. Of the patients, approximately 35.7% (n = 25) had undergone a PD-L1 immunohistochemistry (IHC) test prior to receiving the ICI. All PD-L1-positive patients responded to ICI treatment: three showed no tumor progression and 11 showed tumor size regression.</p><p><strong>Conclusion: </strong>The study provided an overview of the use of ICIs at a single center in Lebanon. It revealed that ICI prescriptions were not consistently preceded by a PDL1 positivity test. A significant proportion of patients responded to ICIs, and no association was found between demographics, clinical variables, and clinical outcomes to ICIs.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 50","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-oncology Burden in Developing Countries: A Retrospective Cost-Analysis Study.","authors":"Said Nassier Said Alsenani, Rawan Nasser Almaskari, Yusra Abid Shah, Balqees Yousuf Hussain Al Mujaini, Alshifa Khalifa Alsaidi, Maryam Saud Mohammed AlBalushi, Fatema Dawood Mulla Hasan Almualem, Tariq Al-Saadi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Brain tumours are a significant economic burden on patients and health systems.</p><p><strong>Objectives: </strong>This research aims to study the cost associated with management of brain tumour and its impact on healthcare.</p><p><strong>Methods and material: </strong>This is a retrospective observational study involving 280 patients with brain tumours at the Neurosurgery Department at Khoula Hospital in Oman. Data on patient demographics, type of brain tumour, diagnosis, treatment, cost of imaging and laboratory investigations, and length of hospital stay were collected from medical records.</p><p><strong>Results: </strong>The average cost of imaging and laboratory investigations was $276,293.33, with imaging accounting for $208,168.7 and laboratory tests accounting for $68,124.63. CT scan was the most expensive imaging investigation, followed by MRI and X-ray. RFT, MDR, and MRSA screening were the most expensive laboratory tests. The most common diagnosis was meningioma (18% of cases). The average length of hospital stay was 16 days.</p><p><strong>Conclusion: </strong>The cost of brain tumour management in Oman is significant. Further research is needed to understand the full economic burden of brain tumour management in Oman, including the costs of surgical and non-surgical interventions.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 50","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective observational comparative study of radiotherapy induced toxicities (xerostomia, skin reaction, and mucositis) between three-dimensional conformal radiotherapy and intensity modulated radiotherapy technique to oral cavity cancer of head and neck.","authors":"Mhendr Dhakar, Hameeduzzafar Ghori, Atal Singh Parihar, Raju Prajapati, Om Prakash Singh, Vineeta Yogi, Vivek Tiwari, Rakesh Mahawar, Tushar Jassal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity cancers often require radiotherapy (RT), leading to toxicities such as xerostomia, skin reactions, and mucositis. This study aims to compare these toxicities between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques.</p><p><strong>Methods: </strong>This prospective observational study included 60 patients with primary oral cavity squamous cell carcinoma. Patients were divided into two groups: 30 underwent 3D-CRT, and 30 underwent IMRT. Toxicities were assessed weekly during RT and bi-monthly up to one year post-RT using Radiotherapy Oncology Group (RTOG) criteria.</p><p><strong>Results: </strong>The mean age was 46.60 ± 11.58 years for 3D-CRT and 48.0 ± 11.38 years for IMRT patients. Both groups had a majority of male patients. No significant difference was observed in mucositis and skin reactions. However, xerostomia was significantly higher in the 3D-CRT group from 6 to 10 months post-RT.</p><p><strong>Conclusion: </strong>IMRT is preferable for treating oral cavity cancer to reduce long-term xerostomia compared to 3D-CRT, despite similar rates of acute mucositis and skin reactions.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 50","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of mental toughness training program on psychological well-being and resilience in cancer patients: A Randomized Controlled Trial.","authors":"Negin Hemmati, Kourosh Zarea, Samira Beiranvand, Saeed Ghanbari, Mehran Hosseinzadeh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the effects of a mental toughness education program on the psychological well-being and resilience of cancer patients.</p><p><strong>Method: </strong>This randomized clinical trial recruited 32 adults with cancer from Baqayi Hospital 2 in Ahvaz. The participants were divided into two groups: an intervention group and a control group. The intervention group received the psychological resilience-based educational intervention. Data were collected using four questionnaires, including the Ryff Psychological Well- Being Scale, the Connor-Davidson Resilience Scale, and the Clough Mental Toughness Scale. Data analysis was performed using SPSS software version 25.</p><p><strong>Results: </strong>The average age of the participants in this study was 46.47 ± 10.21 years. The mean mental toughness scores before the intervention were 120.5 and 110.81 in the intervention and control groups, respectively. After the intervention, the mean scores increased to 164 and 111.88, respectively, and this difference was statistically significant (P<0.001). The overall mean resilience scores before and after the intervention in the intervention group were 49.56 and 108.63, respectively, with a statistically significant difference (P<0.001). The overall psychological well-being score decreased immediately after the intervention but increased one month later. However, this change was not statistically significant.</p><p><strong>Conclusion: </strong>Based on the results of this study, psychological resilience education has a positive impact on resilience, psychological well-being, and certain dimensions of social well-being in patients with cancer. Therefore, interventions focused on developing psychological resilience, with an emphasis on increasing resilience and psychological well-being, can lead to positive outcomes in patients with cancer.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 50","pages":"7-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review Article | Histopathological and Molecular Features of the Mammary Sclerosing Adenosis Lesions and Their association with breast carcinoma: Review of literature.","authors":"Rabab Ahmed Mohammed, Amina Ismaeel, Fayek Al Hilli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sclerosing adenosis (SA) is one of the findings seen in breast biopsies both in symptomatic and asymptomatic patients. Accurate diagnosis of this lesion is sometimes challenging for pathologists and radiologists. The lesion is characterized by proliferation of irregular glands with excess sclerosis in the surrounding stroma giving the lesion the features of invasive carcinomas. Will SA evolve into carcinoma? How long will it take for this transformation to occur? Can we distinguish between lesions that will undergo malignant transformation and those won't? These are all questions that have been raised about SA for years. Management of SA is not a straightforward decision; it differs from patient to another according to several factors. The following review article shed light on the recent updates about SA of the breast, its morphological histopathological characteristics, features that distinguish it from malignant tumors, radiological features, molecular mechanisms underlying this process and its management. Keywords: Sclerosing adenosis, radial scar, breast carcinoma, risk.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a correlation between estrogen receptor expression level and early breast cancer survival? A Retrospective Study.","authors":"Ayman Rasmy, Ahmed Zeeneldin, Walid Abozeed, Saeed Al-Ghamdi, Shereef Elsamany","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal cut-off of ER-positivity is still debatable; however, adjuvant hormonal therapy is usually given if ER expression = 1%. The present study aims to assess clinicopathological features and survival outcome of patients with low compared to higher ER expression level.</p><p><strong>Methods: </strong>In this retrospective, we checked nonmetastatic hormonal receptors-positive, HER2 negative breast cancer patients who presented to three Hospitals in Egypt and Saudi Arabia between 2020-2022. Different clinicopathological factors and data of relapse were checked in patients' medical records. These data were compared in patients with ER-Low (1-10%) Vs. ER-High (>10%) expression level.</p><p><strong>Results: </strong>We included 419 patients who met the eligibility criteria of the study. Only 3.3% of patients had ER-Low. Compared to ER-High group, the ER-Low expression were more likely to have grade 3 tumours (64.3% vs. 21.0%, p=<0.0001), PR-negative (64.3% vs. 16.3%, p= <0.0001). Furthermore, younger age (= 50 years) was more frequent in ER-Low group compared to ERHigh patients (71.4% vs. 42.5%, respectively, p=0.032). Likewise, ER-High patients were more likely to have high ER-staining intensity (74.1% vs. 0.0%, p<0.0001). Disease free survival (DFS) was numerically improved in patients with ER-High, but without statistical significance. After adjustment of different clinicopathological prognostic factors, DFS benefit in ER-High group was more definite (HR=3.59, 95% CI 1.11-11.55, p=0.032).</p><p><strong>Conclusion: </strong>ER-low (1-10 %) expression was rare in the study group. Low ER expression was linked with more aggressive features at diagnosis and seems to have worse DFS which was more pronounced after adjustment for different clinic-pathological factors.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"54-65"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Outcome Analysis of Preoperative chemoradiation in Esophageal carcinoma.","authors":"Shuchita Pathak, Santhosh Kd, Parikshith J, Rasmi Palassery, Vinayak V Maka","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The incidence of esophageal cancer (EC) is increasing now-a-days and the management of EC has changed dramatically with the widespread adoption of mixed modality therapy. Although many Indian centres use combined modality therapy with neoadjuvant chemoradiation (nCRT), published data are scarce. This study assessed the feasibility of trimodality therapy in terms of safety and pathological complete response (pCR) among newly diagnosed patients with EC.</p><p><strong>Patients and methods: </strong>This ambispective study included the retrospective data of patients with locally advanced resectable carcinoma of the middle and lower thoracic oesophagus who were diagnosed and treated between January 2018 and December 2020 along with the prospective data of patients who were diagnosed between January 2021 and January 2023. The clinicodemographic details, radiation technique delivered along with the total dose planned, the dose received and chemotherapy details along with haematological toxicities and non-haematological toxicities were noted. The surgical details and aspects such as the interval between completion of neoadjuvant chemoradiation and surgery, postoperative mortality, pulmonary and cardiac complications, anastomotic leaks and length of hospital stay were recorded. The main outcome was the pCR of patients who received nCRT and underwent surgery.</p><p><strong>Results: </strong>Out of 250 cases retrieved, 100 eligible cases were included, in that, 50 patients received nCRT. About 84% of them underwent surgery after receiving nCRT and 30 patients (60%) post-surgery develop pCR. There were no grade 3 or 4 haematological toxicity noted and only few pateints developed non-haematological toxicities. Also, 16 patients developed postoperative complications. The median follow-up was 24 months, and the 1-year overall survival rate was 62 % among patients who received nCRT followed by surgery.</p><p><strong>Conclusion: </strong>Neoadjuvant chemoradiotherapy followed by surgery was tolerable and safe in the majority of patients with locally advanced EC with lower incidence of Grade 3 and 4 haematological, non-haematological toxicity and post-surgical complications.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Centre Experience of Treating Children with Cancer in the United Arab Emirates.","authors":"Mehnaz Aabideen, Arya Ashokan, Sagar Mohan Nivargi, Mohammed Ramzan, Deepthi Boddu, Fouzia Aboobacker, Abdullah Odat, Mohammed Taher, Rawia Mohamed, Rajasekhar Cingapagu, Humaid O Al Shamsi, Zainul Aabideen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer is a leading cause of death in children. Advancements in medical sciences have significantly improved childhood cancer outcome. However, the pattern of malignancy and outcomes of childhood cancer in the UAE have not been published in the literature in the recent period. Therefore, we aim to investigate this in a leading cancer institute in Abu Dhabi, United Arab Emirates (UAE).</p><p><strong>Methodology: </strong>This is a retrospective study. We collected data including diagnosis; age at diagnosis; treatments used e.g., chemotherapy, radiation, surgery, immunotherapy and bone marrow transplant (BMT) and outcomes. Overall survival (OS) and Event-Free Survival (EFS) were estimated using the Kaplan Meier method.</p><p><strong>Results: </strong>There are 82 children with cancer. The male-tofemale ratio is 1.2. Most patients (45%) were diagnosed between one to five years of age. The most common malignancies are B cell Acute Lymphoblastic Leukaemia (32, 39%), brain tumours (12, 15%); Neuroblastoma (9, 10%), Hodgkin Lymphoma (8, 9%) and Wilms Tumour (5, 6%); Acute Myeloid Leukaemia (3, 4%); Non-Hodgkin Lymphoma (3, 4%); Ewing Sarcoma (3, 4%); T ALL (2, 2%); Osteosarcoma (2, 2%); Angiosarcoma (1, 1%); Synovial Sarcoma (1, 1%). 28 (34%) of patients had completed all treatment at Burjeel Cancer Institute (BCI); 15 (18%) had completed their treatment at another centre and attending follow-up at BCI; and 5 (6%) commenced their treatment at BCI and were transferred to another centre. 34 (41%) but currently still undergoing treatment at BCI. The abandonment rate is 0%. Overall survival is 94% and event-free survival is 90%.</p><p><strong>Discussion: </strong>The rapid progression of UAE cancer care over the past four decades has contributed massively to our favourable survival outcomes. Radiation therapy, bone marrow stem cell transplantation, strict medication regulation and monitoring by the UAE Department of Health have been established in recent years to further enhance treatment for cancer patients in the UAE.</p><p><strong>Conclusion: </strong>The results of our study are comparable to the international standard. More studies involving multiple centres in the UAE are needed to ascertain the exact pattern of paediatric malignancy and outcomes in the UAE.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"80-84"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of size of ovoids with Intra-cavitary Brachytherapy on dose to point A in patients with Cancer Cervix.","authors":"Tanvir Pasha, Nikhila Radhakrishna, Rekha Reddy Buchapudi, Saritha Sunny Pullan, Hamsini R S, Elna Jerod, Naveen Thimmaiah, Sridhar Poojar, Uday Krishna, Siddanna Rudrappa Palled, Thejaswini B, Lokesh Viswanath","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Intracavitary Brachytherapy(ICBT) applications alone offer suboptimal coverage in some patients with medial parametrial(<2cms) residual disease after optimization. This retrospective study aims to identify the commonly accommodated size of ovoids in ICBT to identify the dose delivered to the parametrial disease and organs at risk (OARs).</p><p><strong>Methods: </strong>Cancer cervix Patients treated with concurrent chemoradiotherapy and High Dose Rate(HDR) BT of 6-7 Gy in 3-4 fractions prescribed to point A were identified. Dosimetric details were documented from BT plans.</p><p><strong>Results: </strong>219 ICBT applications were performed for 142 patients. 115 (52%) with semi-small (20mm), 69 (32%) small (25mm) and 35 (16%) medium (30mm) ovoids. Mean distance of 100% isodose curve obtained by above ovoids were 3.48 ± 0.53cm, 3.57 ± 0.45cm and 3.80 ± 0.44cm respectively (p = 0.005). Point A doses for respective ovoids were 5.40 ± 0.71 Gy, 5.59 ± 0.75 Gy and 5.79 ± 0.70 Gy (p=0.016) and Total Reference Air Kerma(TRAK) was 4137.35 ± 509.35, 4433.60 ± 554.80 and 4604.72 ± 381.45 mGy m2 h-1 (p < 0.001). No significant impact was observed in the OAR doses.</p><p><strong>Conclusion: </strong>Majority of our patients could accommodate semi-small ovoids. This compromises the distance covered by 100% isodose curve at the level of Point A and the dose to medial parametrial disease (<2cms) as well. Such patients may be receive higher dose within medial parametrium by use of Intracavitary + Interstitial Brachytherapy (IC + ISBT) Keywords: Intra-cavitary Brachytherapy, Size of Ovoids.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Recurrence and Long-Term Outcomes of Intracranial Meningiomas: A Retrospective Multicenter Study from Saudi Arabia.","authors":"Afnan Alkhotani, Rothaina Saeedi, Haneen Alomar, Fahad Alghamdi, Joudah Almaghrabi, Mohammed Binmahfoodh, Saleh Baeesa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Meningioma is the second most prevalent primary tumor of the central nervous system. The World Health Organization (WHO) categorizes meningiomas into three grades, with the less frequent higher grades (2 and 3) demonstrating a high local recurrence rate even after complete resection. This study aims to elucidate the tumor recurrence predictors and treatment outcomes associated with various histopathological types of intracranial meningiomas.</p><p><strong>Methods: </strong>A retrospective study was conducted to analyze the electronic medical records of histopathologically confirmed meningioma patients at two tertiary centers in Jeddah, Saudi Arabia, from 2005 to 2015. The primary objective was to delineate the clinical and radiological characteristics associated with various histopathological types of meningioma, as well as to ascertain the longterm outcomes and risk factors for tumor recurrence.</p><p><strong>Results: </strong>A comprehensive review of 255 patients demonstrated a predominance of females (72.9%) and a mean age at presentation of 51.8 years. The follow-up period had a minimum duration of five years. The most prevalent clinical manifestation was headache, occurring in 41.6% of cases. Notably, 90.6% of cases did not exhibit apparent preoperative sensory-motor neurological deficits, while 5.5% presented with marked hemiparesis. The histopathologic pattern predominantly consisted of meningothelial meningioma (47.1%). The overall tumor recurrence rate during follow-up was observed in 26 patients (10.2%). This rate varied depending on the WHO grade: 13 patients (5.1%) with grade 1, 9 patients (3.5%) with grade 2, and 5 patients (1.6%) with grade 3 meningiomas. The recurrence rate exhibited a statistically significant correlation with the extent of resection. Notably, there was a higher recurrence rate associated with Simpson's grade 3 and 4 resections (p<0.008 and <0.003, respectively). The radiological findings, including peritumoral edema (56.2%), midline shift (17.9%), calcification (14.3%), and central necrosis (6.3%), exhibited no significant correlation with recurrence. Notably, there was a substantial correlation between tumor size and the probability of recurrence, with a likelihood ratio of 1.75 (p<0.04).</p><p><strong>Conclusion: </strong>Our study presents comparable findings to international data pertaining to clinical behaviors, radiological, and histopathological characteristics. Its significance lies in underscoring the statistically significant coefficients for recurrence, encompassing WHO grading, extent of resection, and tumor size.</p>","PeriodicalId":523894,"journal":{"name":"The Gulf journal of oncology","volume":"1 49","pages":"40-52"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}