Tumour Virus Research最新文献_第3页

Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease 分析中低收入国家宫颈癌的进展情况：从恶性前病变到浸润性疾病。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-12 DOI: 10.1016/j.tvr.2024.200299

Emma Robinson , Isabel Rodriguez , Victor Argueta , Yi Xie , Hong Lou , Rose Milano , Hyo Jung Lee , Laurie Burdett , Sambit K. Mishra , Meredith Yeager , Lisa Mirabello , Michael Dean , Roberto Orozco

{"title":"Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease","authors":"Emma Robinson , Isabel Rodriguez , Victor Argueta , Yi Xie , Hong Lou , Rose Milano , Hyo Jung Lee , Laurie Burdett , Sambit K. Mishra , Meredith Yeager , Lisa Mirabello , Michael Dean , Roberto Orozco","doi":"10.1016/j.tvr.2024.200299","DOIUrl":"10.1016/j.tvr.2024.200299","url":null,"abstract":"<div><div>To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer than stage 1 cancer and invasive cancer (p < 0.0001), and HPV16 increased in invasive disease (p < 0.0001). <em>CCNE1</em>, <em>MELTF</em>, and <em>ULBP2</em> were significantly increased in HPV16-positive compared to HPV31 precancers, while <em>NECTIN2</em> and <em>HLA-E</em> expression decreased. Markers of the innate immune system, DNA repair genes, and cell cycle genes are significantly increased during cancer progression (p = 0.0001). In contrast, the <em>TP53</em> and <em>RB1</em> tumor suppressor gene expression is significantly decreased in cancer cells. The T cell markers <em>CD28</em> and <em>FLT3LG</em> expression decreased in cancer while <em>FOXP3, IDO1</em>, and <em>ULBP2</em> expression increased. There is a significantly higher survival rate in individuals with increased expression of <em>CD28</em> (p = 0.0005), <em>FOXP3</em> (p = 0.0002), <em>IDO1</em> (p = 0.038), <em>FLT3LG</em> (p = 0.026), <em>APOBEC3B</em> (p = 0.0011), and <em>RUNX3</em> (p = 0.019), and a significantly lower survival rate in individuals with increased expression of <em>ULBP2</em> (p = 0.035). These results will help us elucidate the molecular factors influencing the progression of cervical precancer to cancer. Understanding the risk of progression of specific HPV types and sublineages may aid in the triage of positive patients, and better knowledge of the immune response may aid in developing and applying immunotherapies.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200299"},"PeriodicalIF":4.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblasts regulate the transcriptional signature of human papillomavirus-positive keratinocytes 成纤维细胞调控人类乳头瘤病毒阳性角质形成细胞的转录特征

IF 4.7

Tumour Virus Research Pub Date : 2024-12-10 DOI: 10.1016/j.tvr.2024.200302

Claire D. James , Rachel L. Lewis , Austin J. Witt , Christiane Carter , Nabiha M. Rais , Xu Wang , Molly L. Bristol

引用次数: 0

The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7 HPV101 E7蛋白与高危HPV16 E7具有相同的宿主细胞靶点和生物活性。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-05 DOI: 10.1016/j.tvr.2024.200300

Maya K. Gelbard , Miranda Grace , Annika von Schoeler-Ames , Ida Gnanou , Karl Munger

{"title":"The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7","authors":"Maya K. Gelbard , Miranda Grace , Annika von Schoeler-Ames , Ida Gnanou , Karl Munger","doi":"10.1016/j.tvr.2024.200300","DOIUrl":"10.1016/j.tvr.2024.200300","url":null,"abstract":"<div><div>Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully sequenced. They are classified into five phylogenetic genera: alpha, beta, gamma, mu, and nu. The high-risk alpha HPVs, such as HPV16, have been studied the most extensively due to their medical significance as cancer-causing agents. However, while nearly 70% of all HPVs are members of the gamma genus, they are almost entirely unstudied. This is because gamma HPVs have been considered medically irrelevant commensals as most of them infect the skin and are not known to cause significant clinical lesions in immunocompetent individuals. Members of the gamma 6 HPVs, however, have been detected in the anogenital tract mucosa and HPV101 has been isolated from a premalignant cervical lesion. Moreover, gamma 6 HPVs have a unique genome structure. They lack E6 proteins but in place of E6, they encode unique, small hydrophobic proteins without any close viral or cellular homologs that have been termed E10. Here, we report that HPV101 E7 shares biochemical activities with the high-risk alpha HPV16 E7, including the ability to target the pRB and PTPN14 tumor suppressors for degradation. This study underscores the importance of further characterizing HPV101 and other unstudied HPV species.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200300"},"PeriodicalIF":4.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oncogenic role of the NSD histone methyltransferases in head and neck and cervical cancers NSD组蛋白甲基转移酶在头颈部和宫颈癌中的致癌作用。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-05 DOI: 10.1016/j.tvr.2024.200301

Lavinia Ghiani, Susanna Chiocca

引用次数: 0

JC virus small tumor antigen promotes S phase entry and cell cycle progression JC 病毒小肿瘤抗原促进 S 期进入和细胞周期进展

IF 4.7

Tumour Virus Research Pub Date : 2024-12-01 DOI: 10.1016/j.tvr.2024.200298

Renato Biffi , Stefanie W. Benoit , Ilker K. Sariyer , Mahmut Safak

{"title":"JC virus small tumor antigen promotes S phase entry and cell cycle progression","authors":"Renato Biffi , Stefanie W. Benoit , Ilker K. Sariyer , Mahmut Safak","doi":"10.1016/j.tvr.2024.200298","DOIUrl":"10.1016/j.tvr.2024.200298","url":null,"abstract":"<div><div>The early coding region of JC virus (JCV) encodes several regulatory proteins including large T antigen (LT-Ag), small t antigen (Sm t-Ag) and T’ proteins because of the alternative splicing of the pre-mRNA. LT-Ag plays a critical role in cell transformation by targeting the key cell cycle regulatory proteins including p53 and pRb, however, the role of Sm t-Ag in this process remains elusive. Here, we investigated the effect of Sm t-Ag on the cell cycle progression and demonstrated that it facilitates S phase entry and exit when cells are released from G0/G1 growth arrest. Examination of the cell cycle stage specific expression profiles of the selected cyclins and cyclin-dependent kinases, including those active at the G1/S and G2/M transition state, demonstrated a higher level of early expression of these regulators such as cyclin B, cycling E, and Cdk2. In addition, analysis of the effect of Sm t-Ag on the growth promoting pathways including those active in the PI3K/Akt/mTOR axis showed substantially higher levels of the phosphorylated-Akt, -Gsk3-β and -S6K1 in Sm t-Ag-positive cells. Collectively, our results demonstrate that Sm t-Ag promotes cell cycle progression by activating the growth promoting pathways through which it may contribute to LT-Ag-mediated cell transformation.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"18 ","pages":"Article 200298"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial board member 编委会成员

IF 4.7

Tumour Virus Research Pub Date : 2024-12-01 DOI: 10.1016/S2666-6790(24)00028-4

引用次数: 0

Modulation of epithelial homeostasis by HPV using Notch and Wnt 人乳头瘤病毒利用 Notch 和 Wnt 调节上皮细胞的稳态。

IF 4.7

Tumour Virus Research Pub Date : 2024-11-13 DOI: 10.1016/j.tvr.2024.200297

June See Chong, John Doorbar

引用次数: 0

Modulation of connexin 43 in viral infections 在病毒感染中调节连接蛋白 43

IF 4.7

Tumour Virus Research Pub Date : 2024-11-08 DOI: 10.1016/j.tvr.2024.200296

Harry Scott , Patricia E. Martin , Sheila V. Graham

引用次数: 0

The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas 病毒癌蛋白对人类乳头瘤病毒相关口咽鳞状细胞癌不同临床表现的影响。

IF 4.7

Tumour Virus Research Pub Date : 2024-11-01 DOI: 10.1016/j.tvr.2024.200295

Malay K. Sannigrahi , Lovely Raghav , Ahmed Diab , Devraj Basu

{"title":"The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas","authors":"Malay K. Sannigrahi , Lovely Raghav , Ahmed Diab , Devraj Basu","doi":"10.1016/j.tvr.2024.200295","DOIUrl":"10.1016/j.tvr.2024.200295","url":null,"abstract":"<div><div>Human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) are variable in their progression, immune landscape, treatment responses, and clinical outcomes. Their behavior is impacted not only by differences in host genomic alterations but also by diversity in levels and activity of HPV-encoded oncoproteins. Striking differences in HPV mRNA levels are found among HPV+ OPSCCs and likely derive in part from variations in the structurally diverse mix of integrated and episomal HPV genomes they often contain. Viral oncoprotein levels and function are also impacted by differential splicing of the two long polycistronic transcripts of HPV16, the HPV type within most HPV+ OPSCCs. Further variation in viral oncoprotein function arises from the distinct lineages and sub-lineages of HPV16, which encode polymorphisms in functionally important portions of oncogenes. Here we review the limited current knowledge linking HPV mRNA expression and splicing to differences in oncoprotein function that likely influence OPSCC behavior. We also summarize the evolving understanding of HPV16 physical genome state and genetic variants and their potential contributions to HPV oncoprotein levels and function. Addressing considerable remaining challenges in defining the quantitative and qualitative imprint of HPV oncoproteins on each OPSCC holds promise to guide personalization of therapy for this disease.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"18 ","pages":"Article 200295"},"PeriodicalIF":4.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic diversity of HPV6 and HPV11 in recurrent respiratory papillomatosis: Association with malignant transformation in the lungs and clinical outcomes 复发性呼吸道乳头状瘤病中 HPV6 和 HPV11 的基因组多样性：与肺部恶性转化和临床结果的关系

IF 4.7

Tumour Virus Research Pub Date : 2024-10-29 DOI: 10.1016/j.tvr.2024.200294

Massilva Rahmoun , Audrey Aussel , Sarah Bouzidi , Vincent Pedergnana , Victor Malassigné , Julien Puech , David Veyer , Hélène Péré , Charles Lepine , Fabian Blanc , Nathalie Boulle , Valérie Costes-Martineau , Ignacio G. Bravo

{"title":"Genomic diversity of HPV6 and HPV11 in recurrent respiratory papillomatosis: Association with malignant transformation in the lungs and clinical outcomes","authors":"Massilva Rahmoun , Audrey Aussel , Sarah Bouzidi , Vincent Pedergnana , Victor Malassigné , Julien Puech , David Veyer , Hélène Péré , Charles Lepine , Fabian Blanc , Nathalie Boulle , Valérie Costes-Martineau , Ignacio G. Bravo","doi":"10.1016/j.tvr.2024.200294","DOIUrl":"10.1016/j.tvr.2024.200294","url":null,"abstract":"<div><div>Recurrent respiratory papillomatosis (RRP) is a rare, proliferative disease caused by human papillomavirus 6 (HPV6) and HPV11. RRP can occasionally spread and undergo malignant transformation.</div><div>We analysed samples across time for five RRP patients with malignant transformation and four with highly recurrent, non-malignant RRP by applying high-throughput sequencing.</div><div>Patients with malignant transformation were infected by HPV11_A1/A2, while most non-malignant cases were associated with HPV6. Transient multiple infections with HPV6 and HPV11 were found in two patients, and resolved later to single infections. Viral genome loads were homogeneous across groups (median = 78 viral genomes per human genome). Within-patient, we did not observe differences between the viral sequences in the papillomatous lesions and in the malignant tissue. Genetic analysis of the <em>NLRP1</em> gene revealed no known mutations linked to idiopathic RRP, though some novel variants merit to be explored in larger cohorts.</div><div>HPV11 infections appear associated with RRP malignant transformation in young patients. Multiple infections can occur in RRP, but within-patient viral diversity is minimal for a given genotype. Our results confirm the importance of viral genotype in disease prognosis and are consistent with growing evidence of HPV11 infections to be differentially associated with RRP malignant transformation in young patients.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"18 ","pages":"Article 200294"},"PeriodicalIF":4.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0