Tumour Virus Research最新文献_第2页

Transcriptomic profile of the immune genes, oncogenes, and tumor suppressor genes in HPV associated Cervical Intraepithelial Neoplasia 3 (CIN 3) and Cervical Squamous Cell Carcinoma (CSCC): Comparable expressions indicative of invasive potential. HPV相关宫颈上皮内瘤变3 （CIN 3）和宫颈鳞状细胞癌（CSCC）中免疫基因、癌基因和肿瘤抑制基因的转录组学特征：侵袭潜力的可比表达

IF 8.1

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.tvr.2025.200327

Maaweya Awadalla, Halah Z Al Rawi, Reham M Alahmadi, Osamah T Khojah, Samia T Al-Shouli, Mansour I Almansour, Bandar Alosaimi

{"title":"Transcriptomic profile of the immune genes, oncogenes, and tumor suppressor genes in HPV associated Cervical Intraepithelial Neoplasia 3 (CIN 3) and Cervical Squamous Cell Carcinoma (CSCC): Comparable expressions indicative of invasive potential.","authors":"Maaweya Awadalla, Halah Z Al Rawi, Reham M Alahmadi, Osamah T Khojah, Samia T Al-Shouli, Mansour I Almansour, Bandar Alosaimi","doi":"10.1016/j.tvr.2025.200327","DOIUrl":"10.1016/j.tvr.2025.200327","url":null,"abstract":"<p><p>Cervical cancer is the fourth most common cancer among women globally, with a woman dying every 2 min. Despite the need to understand the tumor microenvironment (TME) transcriptome of cervical squamous cell carcinoma (CSCC) and cervical intraepithelial neoplasia grade 3 (CIN 3), studies remain limited. This study compares the TME transcriptome of HPV-positive CSCC and CIN 3, analyzing 168 genes involved in tumor cell interactions with inflammatory and immune mediators, transcription, signal transduction, oncogenesis, tumor suppression, angiogenesis, and apoptosis. Co-expressed genes identified in HPV + CSCC and CIN 3 were analyzed using computational biology. Gene Ontology and KEGG enrichment identified relevant biological pathways and cancer hallmarks. Fifty-five co-expressed genes were linked to cancer pathways, inflammatory responses, cell migration, and development. KEGG enrichment highlighted viral protein interactions involving cytokines, IL-17 signaling, and chemokine receptor interactions. These genes were associated with cancer hallmark pathways, including angiogenesis, inflammation, proliferation, genomic instability, invasion, and metastasis. Their similar expression in CSCC and CIN 3 suggests a potential prognostic value and that CIN 3 progression may involve changes in gene expression. We propose the term \"CSCC-like carcinoma,\" indicating CIN 3's increased invasive potential at the molecular level.</p>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":" ","pages":"200327"},"PeriodicalIF":8.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication 组蛋白伴侣HIRA的染色质组装促进了人乳头瘤病毒的复制。

IF 8.1

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI: 10.1016/j.tvr.2025.200329

Ashley N. Della Fera, Dan Chen, Alison A. McBride

{"title":"Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication","authors":"Ashley N. Della Fera, Dan Chen, Alison A. McBride","doi":"10.1016/j.tvr.2025.200329","DOIUrl":"10.1016/j.tvr.2025.200329","url":null,"abstract":"<div><div>The circular, double-stranded DNA genomes of Human papillomaviruses (HPV) exist in a nucleosomal state throughout the infectious cycle and rely on host histone epigenetic modifications and chromatin assembly processes to promote various phases of the viral life cycle. Here, we show that the histone H3.3 chaperone HIRA and its associated complex members are recruited to HPV replication factories during the late phase of the HPV life cycle. HIRA is also recruited to HPV replication factories generated by amplification of a replicon with a minimal origin and expression of the viral replication proteins E1 and E2, demonstrating that the E1 and E2 proteins are sufficient for HIRA recruitment. Downregulation of HIRA expression reduces HPV31 DNA amplification and viral transcription in differentiated keratinocytes. Histone H3.3 that is highly phosphorylated on serine residue 31 is also enriched at sites of HPV replication and this modification links the <span>DNA</span> damage response to chromatin that supports rapid gene activation. We propose that deposition of histone H3.3 generates viral minichromosomes which are highly primed to support the late stages of the HPV life cycle.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"20 ","pages":"Article 200329"},"PeriodicalIF":8.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial board member 编委会成员

IF 8.1

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-12-13 DOI: 10.1016/S2666-6790(25)00022-9

引用次数: 0

Dysregulation of histone methylation in SV40 chromosomes during replication results in aberrant transcription and chromatin structure. SV40染色体在复制过程中组蛋白甲基化失调导致转录和染色质结构异常。

IF 8.1

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-07-31 DOI: 10.1016/j.tvr.2025.200326

Barry Milavetz, Ranna Dawlaty, Jacob Haugen

引用次数: 0

Oncolytic virus and immunogenic cell death in cancer therapy 溶瘤病毒和免疫原性细胞死亡在癌症治疗中的应用

IF 8.1

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-11-26 DOI: 10.1016/j.tvr.2025.200333

GuoXiu Cao , Chan Ding , Jun Dai , Xusheng Qiu

{"title":"Oncolytic virus and immunogenic cell death in cancer therapy","authors":"GuoXiu Cao , Chan Ding , Jun Dai , Xusheng Qiu","doi":"10.1016/j.tvr.2025.200333","DOIUrl":"10.1016/j.tvr.2025.200333","url":null,"abstract":"<div><div>As a promising cancer treatment strategy, oncolytic viruses (OVs) selectively replicate and kill tumor cells while sparing normal cells. They improve the tumor immunosuppressive microenvironment through multiple mechanisms, including direct infection, replication, and lysis of tumor cells—leading to the release of tumor-associated antigens (TAAs), chemokines, and cytokines, which in turn induce immunogenic cell death (ICD) and trigger sustained antitumor immune responses. Currently, while OVs have demonstrated therapeutic efficacy in multiple preclinical and clinical studies, their monotherapy fails to benefit a broad spectrum of cancer patients. Therefore, there remains a need to fully understand the biological mechanisms of OVs and optimize immunotherapeutic strategies to benefit more cancer patients and enhance therapeutic efficacy. In this review, we discuss how the immune responses induced by OVs maintain a balance between antiviral and antitumor immunity, as well as their unique characteristics in inducing ICD. In addition, we describe how to enhance the efficacy of cancer immunotherapy by combining OVs therapy with ICD inducers, aiming to provide valuable insights to guide the development of clinical OVs -based therapies.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"20 ","pages":"Article 200333"},"PeriodicalIF":8.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise identification of viral–host integration events in HPV-positive cervical cancers by targeted long-read sequencing 通过靶向长读测序精确鉴定hpv阳性宫颈癌病毒-宿主整合事件。

IF 4.7

Tumour Virus Research Pub Date : 2025-12-01 Epub Date: 2025-07-17 DOI: 10.1016/j.tvr.2025.200325

Preetiparna Parida , Nivedita Mukherjee , Agastya Singh , Shirley Lewis , Krishna Sharan , Sandeep Mallya , Ashima Singh , Surya Sarathi Das , Mahadev Rao , Daniel S. Higginson , Radhakrishnan Sabarinathan , Rama Rao Damerla

{"title":"Precise identification of viral–host integration events in HPV-positive cervical cancers by targeted long-read sequencing","authors":"Preetiparna Parida , Nivedita Mukherjee , Agastya Singh , Shirley Lewis , Krishna Sharan , Sandeep Mallya , Ashima Singh , Surya Sarathi Das , Mahadev Rao , Daniel S. Higginson , Radhakrishnan Sabarinathan , Rama Rao Damerla","doi":"10.1016/j.tvr.2025.200325","DOIUrl":"10.1016/j.tvr.2025.200325","url":null,"abstract":"<div><div>Human papillomaviral (HPV) integrations into host human genome, a frequently observed event in HPV associated cervical cancer, are currently mapped through expensive Whole Genome sequencing (WGS) or RNA sequencing (RNA-seq) methodologies. This study aims to develop a targeted sequencing assay to determine HPV integrations in cervical tumors without the need for WGS or RNA-seq. We employed a library preparation strategy using tiled single primers that bind to HPV genome as a template and possibly extend HPV sequences into adjacent host human genomic sequences resulting in HPV and human chimeric sequences. Using this strategy, we sequenced known HPV integrations in HPV18 positive HeLa and HPV16 positive SiHa cell lines. We further used this method to detect HPV integration sites in four HPV-positive cervical cancer patients and confirmed these integration breakpoints by WGS and Sanger sequencing. Functional impact of HPV integrations was explored through differentially expressed genes within or near topologically associating domain (TAD) boundaries, possibly disrupted by respective integration events in these patients. We found <em>ZFP36L1, CPA3, CPB1</em> and <em>CXCL8</em> as some of the differentially expressed genes within disrupted TADs, which are known cancer associated genes. Our approach also reduced the cost of HPV integration detection by 90 % compared to WGS while also minimizing sequencing data volume. We believe that this method captures HPV integrations at significantly reduced costs and lesser sequencing data volume leading to better understanding of disease progression and monitoring cancer treatment.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"20 ","pages":"Article 200325"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment 致瘤性HPV对极光激酶的去调控作用对癌症发展和治疗的影响。

IF 4.7

Tumour Virus Research Pub Date : 2025-06-01 Epub Date: 2025-02-07 DOI: 10.1016/j.tvr.2025.200314

Kemi Hannah Oladipo , Joanna L. Parish

{"title":"De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment","authors":"Kemi Hannah Oladipo , Joanna L. Parish","doi":"10.1016/j.tvr.2025.200314","DOIUrl":"10.1016/j.tvr.2025.200314","url":null,"abstract":"<div><div>Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs are the cause of almost all cervical cancers and a sub-set of other epithelial malignancies including head and neck cancers, specifically within the oropharynx. The oncogenic properties of HPV are largely mediated through the viral oncoproteins E6 and E7, which disrupt many cellular pathways to drive uncontrolled cell proliferation. One family of proteins targeted by HPV is the Aurora kinase family. Aurora kinases are serine/threonine kinases including Aurora kinase A (AURKA), B (AURKB), and C (AURKC) which are often dysregulated in many cancer types, including HPV driven cancers. All three family members play essential roles in mitotic regulation and accurate cell division.</div><div>The deregulation of Aurora kinases by HPV infection highlights their potential as therapeutic targets in HPV-associated malignancies. Targeting Aurora kinase activity, in combination with current HPV therapies, may provide new avenues for treating HPV-induced cancers and reducing the burden of HPV-related diseases. Combinatorial inhibition targets distinct but overlapping functions of these kinases, thereby reducing the potential for cancer cells to develop resistance. This broad impact emphasizes the capability for Aurora kinase inhibitors not only as anti-mitotic agents but also as modulators of multiple oncogenic pathways. This review explores the combinatorial effects of Aurora kinase inhibition, offering insights into novel therapeutic strategies for the treatment of HPV-driven cancers.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200314"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the performance of the Xpert HPV assay in detecting HPV positive cases in Morocco 评估Xpert HPV检测在摩洛哥检测HPV阳性病例中的表现

IF 4.7

Tumour Virus Research Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1016/j.tvr.2025.200318

Said Ali Yerim , Youssef Chami Khazraji , Rachid Bekkali , Maria Bennai , Nassiba Bahra , Imane Chaoui , Fatima Zahra Chellat , Zineb Gaizi , Nabil Tachfouti , Anas Benabdellah , Bouchra Belkadi , Mohammed Attaleb , Mohamed Amine Berraho , Mohammed El Mzibri

{"title":"Evaluating the performance of the Xpert HPV assay in detecting HPV positive cases in Morocco","authors":"Said Ali Yerim , Youssef Chami Khazraji , Rachid Bekkali , Maria Bennai , Nassiba Bahra , Imane Chaoui , Fatima Zahra Chellat , Zineb Gaizi , Nabil Tachfouti , Anas Benabdellah , Bouchra Belkadi , Mohammed Attaleb , Mohamed Amine Berraho , Mohammed El Mzibri","doi":"10.1016/j.tvr.2025.200318","DOIUrl":"10.1016/j.tvr.2025.200318","url":null,"abstract":"<div><div>Recently, the World Health Organization recommended integrating HPV testing into cervical cancer screening programs globally. This study aimed to compare the GeneXpert assay with PCR-sequencing for HPV detection and genotyping to assess the feasibility of incorporating HPV molecular testing into cervical cancer screening. A total of 1000 women aged 30 or 40 from rural and urban areas across four regions in Morocco with high sexually transmitted infection prevalence were recruited. After excluding 21 invalid tests, DNA testing on the remaining 979 samples showed an HPV prevalence of 4.0 % (39/979) by PCR and 5.0 % (49/979) by Xpert, with an overall prevalence of 5.7 % (56/979) when combining both techniques. The concordance rate between the tests was 97.5 %. Notably, the Xpert HPV assay was highly efficient in detecting HPV, with nearly all identified HPVs being high-risk oncogenic types, predominantly HPV16, 18, 31, 35, and 45.</div><div>The Xpert HPV assay has demonstrated excellent analytical performance, making it a reliable option for HPV detection in vaginal and cervical swabs. Its integration into primary cervical cancer screening programs could significantly enhance the early detection of HPV-positive cases, thereby strengthening the screening framework and potentially reducing both the incidence and mortality of cervical cancer. Future studies should focus on confirming these results and exploring the utility of this method in conjunction with other diagnostic tools such as visual inspection with acetic acid (VIA) for a comprehensive assessment of its effectiveness in real-world settings.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200318"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Tumour Virus Research on Virus Host Interactions and Cell Transformation 社论：肿瘤病毒在病毒宿主相互作用和细胞转化方面的研究。

IF 4.7

Tumour Virus Research Pub Date : 2025-06-01 Epub Date: 2024-12-20 DOI: 10.1016/j.tvr.2024.200310

Lawrence Banks, Peter Stern

引用次数: 0

Rapid-onset cancer 迅速发生癌症。

IF 4.7

Tumour Virus Research Pub Date : 2025-06-01 Epub Date: 2025-01-02 DOI: 10.1016/j.tvr.2024.200312

Andrea Bilger, Paul F. Lambert

引用次数: 0