Tumour Virus Research最新文献_第2页

Clinical indications for host-cell DNA methylation markers in cervical screening and management of cervical intraepithelial neoplasia: A review 宫颈上皮内瘤变筛查和治疗中宿主细胞DNA甲基化标志物的临床适应症综述

IF 4.7

Tumour Virus Research Pub Date : 2024-12-16 DOI: 10.1016/j.tvr.2024.200308

S. Dick , D.A.M. Heideman , J. Berkhof , R.D.M. Steenbergen , M.C.G. Bleeker

引用次数: 0

The adenoviral E4orf4 protein: A multifunctional protein serving as a guide for treating cancer, a multifactorial disease 腺病毒E4orf4蛋白：一种多功能蛋白，作为治疗癌症（一种多因素疾病）的指南。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-15 DOI: 10.1016/j.tvr.2024.200303

Amir Basis, Rakefet Sharf, Tamar Kleinberger

{"title":"The adenoviral E4orf4 protein: A multifunctional protein serving as a guide for treating cancer, a multifactorial disease","authors":"Amir Basis, Rakefet Sharf, Tamar Kleinberger","doi":"10.1016/j.tvr.2024.200303","DOIUrl":"10.1016/j.tvr.2024.200303","url":null,"abstract":"<div><div>Viruses exploit several cellular pathways to support their replication, and many of these virus-targeted pathways are also important for cancer growth. Consequently, studying virus-host interactions offers valuable insights into tumorigenesis and can suggest the development of novel anti-cancer therapies, with oncolytic viruses being one well-known example. The adenovirus E4orf4 protein, which disrupts several host regulatory pathways to facilitate viral infection, also functions as a potent anti-cancer agent when expressed independently. E4orf4 can selectively kill a wide range of cancer cell lines while sparing non-cancerous cells. Moreover, it effectively eliminated cancer in an <em>in vivo Drosophila</em> model without causing significant harm to normal tissues.</div><div>In this study we provide evidence that an E4orf4-mimicking drug cocktail, comprising sublethal doses of four FDA-approved drugs targeting the pathways disrupted by E4orf4, significantly enhanced cancer cell death in many cancer cell types compared with individual drugs or less inclusive drug combinations. The quadruple drug cocktail was not toxic in non-cancerous cells. These findings provide a proof-of-principle for the potential application of virus-host interaction studies to design an effective E4orf4-based cancer therapy. Further investigation of E4orf4 interactions with the host cell will likely improve this E4orf4-based therapy by adding drugs that disrupt additional pathways.</div><div>Crucially, the E4orf4-based approach offers a strategic advantage by avoiding the time-consuming development of novel drugs. Instead, it leverages existing drugs, including those that might be too toxic for use as monotherapies, by employing them at sublethal concentrations in combination. Thus, it provides a feasible and efficient method for advancing cancer therapy.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200303"},"PeriodicalIF":4.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyomavirus large T antigens: Unraveling a complex interactome 多瘤病毒大T抗原：揭示一个复杂的相互作用组。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-13 DOI: 10.1016/j.tvr.2024.200306

Matthew R. Googins, Ping An, Christian H. Gauthier, James M. Pipas

{"title":"Polyomavirus large T antigens: Unraveling a complex interactome","authors":"Matthew R. Googins, Ping An, Christian H. Gauthier, James M. Pipas","doi":"10.1016/j.tvr.2024.200306","DOIUrl":"10.1016/j.tvr.2024.200306","url":null,"abstract":"<div><div>All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and fish to mammals, including fourteen that infect humans. LT is among the most studied viral proteins with thousands of articles describing its functions in viral productive infection and tumorigenesis. However, nearly all knowledge of LT activities is based on the studies of simian virus 40 (SV40) and a few other viruses. Comparative studies of LT proteins of different polyomaviruses have revealed a remarkable diversity in the mechanisms by which LT proteins function across different polyomavirus species. This review focuses on human polyomaviruses highlights the similarities and differences between polyomavirus LTs and highlights gaps in our understanding of this protein family. The concentration of knowledge around SV40 LT and the corresponding lack of mechanistic studies on LT proteins encoded by other human and animal polyomaviruses severely constrains our understanding of the biology of this important virus family.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200306"},"PeriodicalIF":4.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease 分析中低收入国家宫颈癌的进展情况：从恶性前病变到浸润性疾病。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-12 DOI: 10.1016/j.tvr.2024.200299

Emma Robinson , Isabel Rodriguez , Victor Argueta , Yi Xie , Hong Lou , Rose Milano , Hyo Jung Lee , Laurie Burdett , Sambit K. Mishra , Meredith Yeager , Lisa Mirabello , Michael Dean , Roberto Orozco

{"title":"Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease","authors":"Emma Robinson , Isabel Rodriguez , Victor Argueta , Yi Xie , Hong Lou , Rose Milano , Hyo Jung Lee , Laurie Burdett , Sambit K. Mishra , Meredith Yeager , Lisa Mirabello , Michael Dean , Roberto Orozco","doi":"10.1016/j.tvr.2024.200299","DOIUrl":"10.1016/j.tvr.2024.200299","url":null,"abstract":"<div><div>To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer than stage 1 cancer and invasive cancer (p < 0.0001), and HPV16 increased in invasive disease (p < 0.0001). <em>CCNE1</em>, <em>MELTF</em>, and <em>ULBP2</em> were significantly increased in HPV16-positive compared to HPV31 precancers, while <em>NECTIN2</em> and <em>HLA-E</em> expression decreased. Markers of the innate immune system, DNA repair genes, and cell cycle genes are significantly increased during cancer progression (p = 0.0001). In contrast, the <em>TP53</em> and <em>RB1</em> tumor suppressor gene expression is significantly decreased in cancer cells. The T cell markers <em>CD28</em> and <em>FLT3LG</em> expression decreased in cancer while <em>FOXP3, IDO1</em>, and <em>ULBP2</em> expression increased. There is a significantly higher survival rate in individuals with increased expression of <em>CD28</em> (p = 0.0005), <em>FOXP3</em> (p = 0.0002), <em>IDO1</em> (p = 0.038), <em>FLT3LG</em> (p = 0.026), <em>APOBEC3B</em> (p = 0.0011), and <em>RUNX3</em> (p = 0.019), and a significantly lower survival rate in individuals with increased expression of <em>ULBP2</em> (p = 0.035). These results will help us elucidate the molecular factors influencing the progression of cervical precancer to cancer. Understanding the risk of progression of specific HPV types and sublineages may aid in the triage of positive patients, and better knowledge of the immune response may aid in developing and applying immunotherapies.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200299"},"PeriodicalIF":4.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblasts regulate the transcriptional signature of human papillomavirus-positive keratinocytes 成纤维细胞调控人类乳头瘤病毒阳性角质形成细胞的转录特征

IF 4.7

Tumour Virus Research Pub Date : 2024-12-10 DOI: 10.1016/j.tvr.2024.200302

Claire D. James , Rachel L. Lewis , Austin J. Witt , Christiane Carter , Nabiha M. Rais , Xu Wang , Molly L. Bristol

引用次数: 0

The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7 HPV101 E7蛋白与高危HPV16 E7具有相同的宿主细胞靶点和生物活性。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-05 DOI: 10.1016/j.tvr.2024.200300

Maya K. Gelbard , Miranda Grace , Annika von Schoeler-Ames , Ida Gnanou , Karl Munger

{"title":"The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7","authors":"Maya K. Gelbard , Miranda Grace , Annika von Schoeler-Ames , Ida Gnanou , Karl Munger","doi":"10.1016/j.tvr.2024.200300","DOIUrl":"10.1016/j.tvr.2024.200300","url":null,"abstract":"<div><div>Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully sequenced. They are classified into five phylogenetic genera: alpha, beta, gamma, mu, and nu. The high-risk alpha HPVs, such as HPV16, have been studied the most extensively due to their medical significance as cancer-causing agents. However, while nearly 70% of all HPVs are members of the gamma genus, they are almost entirely unstudied. This is because gamma HPVs have been considered medically irrelevant commensals as most of them infect the skin and are not known to cause significant clinical lesions in immunocompetent individuals. Members of the gamma 6 HPVs, however, have been detected in the anogenital tract mucosa and HPV101 has been isolated from a premalignant cervical lesion. Moreover, gamma 6 HPVs have a unique genome structure. They lack E6 proteins but in place of E6, they encode unique, small hydrophobic proteins without any close viral or cellular homologs that have been termed E10. Here, we report that HPV101 E7 shares biochemical activities with the high-risk alpha HPV16 E7, including the ability to target the pRB and PTPN14 tumor suppressors for degradation. This study underscores the importance of further characterizing HPV101 and other unstudied HPV species.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"19 ","pages":"Article 200300"},"PeriodicalIF":4.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oncogenic role of the NSD histone methyltransferases in head and neck and cervical cancers NSD组蛋白甲基转移酶在头颈部和宫颈癌中的致癌作用。

IF 4.7

Tumour Virus Research Pub Date : 2024-12-05 DOI: 10.1016/j.tvr.2024.200301

Lavinia Ghiani, Susanna Chiocca

引用次数: 0

JC virus small tumor antigen promotes S phase entry and cell cycle progression JC 病毒小肿瘤抗原促进 S 期进入和细胞周期进展

IF 4.7

Tumour Virus Research Pub Date : 2024-12-01 DOI: 10.1016/j.tvr.2024.200298

Renato Biffi , Stefanie W. Benoit , Ilker K. Sariyer , Mahmut Safak

{"title":"JC virus small tumor antigen promotes S phase entry and cell cycle progression","authors":"Renato Biffi , Stefanie W. Benoit , Ilker K. Sariyer , Mahmut Safak","doi":"10.1016/j.tvr.2024.200298","DOIUrl":"10.1016/j.tvr.2024.200298","url":null,"abstract":"<div><div>The early coding region of JC virus (JCV) encodes several regulatory proteins including large T antigen (LT-Ag), small t antigen (Sm t-Ag) and T’ proteins because of the alternative splicing of the pre-mRNA. LT-Ag plays a critical role in cell transformation by targeting the key cell cycle regulatory proteins including p53 and pRb, however, the role of Sm t-Ag in this process remains elusive. Here, we investigated the effect of Sm t-Ag on the cell cycle progression and demonstrated that it facilitates S phase entry and exit when cells are released from G0/G1 growth arrest. Examination of the cell cycle stage specific expression profiles of the selected cyclins and cyclin-dependent kinases, including those active at the G1/S and G2/M transition state, demonstrated a higher level of early expression of these regulators such as cyclin B, cycling E, and Cdk2. In addition, analysis of the effect of Sm t-Ag on the growth promoting pathways including those active in the PI3K/Akt/mTOR axis showed substantially higher levels of the phosphorylated-Akt, -Gsk3-β and -S6K1 in Sm t-Ag-positive cells. Collectively, our results demonstrate that Sm t-Ag promotes cell cycle progression by activating the growth promoting pathways through which it may contribute to LT-Ag-mediated cell transformation.</div></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":"18 ","pages":"Article 200298"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial board member

IF 4.7

Tumour Virus Research Pub Date : 2024-12-01 DOI: 10.1016/S2666-6790(24)00028-4

引用次数: 0

Modulation of epithelial homeostasis by HPV using Notch and Wnt 人乳头瘤病毒利用 Notch 和 Wnt 调节上皮细胞的稳态。

IF 4.7

Tumour Virus Research Pub Date : 2024-11-13 DOI: 10.1016/j.tvr.2024.200297

June See Chong, John Doorbar

引用次数: 0