中华围产医学杂志最新文献

{"title":"Advances in perioperative management of intrauterine blood transfusion","authors":"Xiao Sun","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.05.012","url":null,"abstract":"With the fast development of fetal medicine in China, intrauterine transfusion, which is regarded as an effective treatment in certain conditions, has attracted more and more attention. In addition to the common seen red blood cell alloimmunization, the indications of intrauterine transfusion include parvovirus B19 infection, maternal-fetal blood transfusion syndrome, twin anemia-polycythemia sequence, placental chorionic hemangiomas and fetal sacrococcygeal teratomas. The recommended approach for intrauterine transfusion is umbilical vein or intraperitoneal transfusion depending on the gestational age, placental location, and presence of absence of fetal edema. However, umbilical artery and intracardiac transfusion are not recommended. In order to reduce the complications of intrauterine transfusion, routine fetal analgesia, avoidance of umbilical artery puncture and prior use of intrahepatic umbilical vein transfusion are recommended. Fetal middle cerebral artery-peak systolic velocity (MCA-PSV) >1.5 multiple of median (MOM) and 1.69 MOM can be a good indicators for the first and second intrauterine transfusions, respectively. For the third and subsequent transfusions, the rate of fetal hemoglobin decline is recommended to predict the timing of transfusion. \u0000 \u0000 \u0000Key words: \u0000Blood transfusion, intrauterine; Perioperative period; Fetal hemoglobin","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"353-356"},"PeriodicalIF":0.0,"publicationDate":"2019-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42155780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral congenital microphthalmia in newborn: a case report","authors":"Yanan Fu, Zhihua Zhang, Q. Cao, Jin Tian, Liqin Yue","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.05.011","url":null,"abstract":"Here, we reported a case of term infant with unilateral congenital microphthalmia (CM). Physical examination conducted on 2 d after birth showed that the left eye was barely open and the eye socket was deeper than the right. Meanwhile, the cornea of the left eye was not completely exposed and the light reflex could not be elicited. Ophthalmology consultation, ultrasound and CT scan were conducted, and CM was finally diagnosed since the infant was found to have a small eyeball and shortened axial length, accompanying by pathological changes in the lens, vitreous body and retina. This case suggested that detailed physical examination should be carried out, especially for the eyes, including orbit and eyelid, presence or absence of secretion or concealed eyeball, together with medical imaging techniques technology, to ensure an early detection and diagnosis of CM in neonates. \u0000 \u0000 \u0000Key words: \u0000Microphthalmos; Infant, newborn","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"350-352"},"PeriodicalIF":0.0,"publicationDate":"2019-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42334968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal ultrasonographic features of fetal total anomalous pulmonary venous connection","authors":"Juan Wu, Yun Liu, Ming Wang, Xinxia Wang, Shan Lin, R. Yuan, Hezhou Li, S. Cui","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.05.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.05.002","url":null,"abstract":"Objective \u0000To investigate the prenatal ultrasonographic features of fetal total anomalous pulmonary venous connection (TAPVC). \u0000 \u0000 \u0000Methods \u0000Forty-one cases who received prenatal ultrasound examination and then were diagnosed with TAPVC by postnatal surgery at the Third Affiliated Hospital of Zhengzhou University from June 2013 to June 2018 were enrolled. Echocardiography findings of all cases were analyzed retrospectively, and the prenatal imaging features were summarized. \u0000 \u0000 \u0000Results \u0000Among all cases, 21 were confirmed as supracardiac type, 14 as intracardiac type, four as infracardiac type and two as mixed type after surgery. The echocardiographic features of TAPVC were as follows: all 41 cases showed smooth posterior wall of left atrium without visible part of pulmonary venous connected to the left atrium in the-four chamber view; in 33 cases, the space between left atrium and descending aorta was widened and the pulmonary venous confluence was observed in the four-chamber view; ten cases showed a dilated coronary sinus in the four-chamber view and 27 cases showed vertical vein in the three vessels and trachea or the upper abdomen view. None of the 41 cases was complicated by other structural intracardiac abnormalities. However, seven cases were complicated by obstruction of blood flow, and the blood flow velocity measured by Doppler ultrasound was 0.76 m/s to 1.25 m/s. \u0000 \u0000 \u0000Conclusions \u0000Blood flow in pulmonary veins should be carefully observed in prenatal ultrasonography, and anomalous pulmonary venous connection should be considered when pulmonary veins do not connect to the left atrium. \u0000 \u0000 \u0000Key words: \u0000Pulmonary veins; Congenital abnormalities; Scimitar syndrome; Ultrasonography, prenatal","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"296-302"},"PeriodicalIF":0.0,"publicationDate":"2019-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42025667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of regular exercise during pregnancy on overweight and obese gravidas: one-year follow-up of a previous randomized controlled trial","authors":"Xiaoming Zhang, Qianqian Xu, Chen Wang, Yumei Wei, Yue Zhang, Huixia Yang","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.005","url":null,"abstract":"Objective \u0000To investigate the long-term effects of regular exercise during pregnancy on overweight and obese gravidas. \u0000 \u0000 \u0000Methods \u0000This study was based on a previous randomized controlled trial (RCT) regarding Effect of Regular Exercise Commenced in Early Pregnancy on the Incidence of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women conducted at Peking University First Hospital from December 2014 to July 2016. Totally 265 women whose prepregnant body mass index (BMI) ≥24.0 kg/m2 were enrolled in the RCT and were randomly assigned to exercise group (n=132) and control group (n=133). This study was a follow-up of all the participants at one year after delivery from March 2016 to August 2017. Body weight, body fat, fasting and 2 h glucose level in 75 g oral glucose tolerance test (OGTT), insulin resistance index and lipid profiles were compared. We also evaluated their physical activities with International Physical Activity Questionnaire (IPAQ), their dietary habits with modified Adult Dietary Behavior Assessment Scale and depression condition with Postpartum Depression Screen Scale (PDSS). Two independent samples t-test, Mann-Whitney U test and Chi-square test were used for statistical analysis. \u0000 \u0000 \u0000Results \u0000The overall follow-up rate was 51.7% (137/265), while 64.4% (85/132) in the exercise group and 39.1% (52/133) in the control group. No significant difference in body weight loss [2.3 (-6.0 to 5.0) vs 1.0 (-1.3 to 4.7) kg], body fat percentage [(38.04±4.54)% vs (37.51±4.90) %], 2 h glucose level in 75 g OGTT [(7.30±2.80) vs (7.32±1.61) mmol/L], abnormal glucose tolerance ratio [30.0% (9/30) vs 28.8% (17/59)] or insulin resistance index (2.92±1.77 vs 2.86±1.92) was found between the control and exercise group (t or Z=-0.940, 0.312, 3.415, 0.005, 1.743, all P>0.05). However, the fasting blood glucose in 75 g OGTT was higher in the control group [(5.53±0.92) vs (5.28±0.43) mmol/L, t=9.268, P=0.003]. The two groups showed no significant difference (exercise group vs control group) in physical activity level [219 (99-504) vs 195 (99-351)], total score of dietary habits [79.00 (72.50-87.50) vs 76.00 (70.00-82.00)] or PDSS score of depression [55.00 (41.00-77.00) vs 70.00 (46.25-84.75)] at follow-up (Z=-0.808, -1.822, -1.620, all P>0.05). Moreover, there was no significant difference in the level of serum triglyceride [(1.25±1.04) vs (1.42±0.85) mmol/L], total cholesterol [(4.56±0.71) vs (4.40±0.67) mmol/L], high density lipoprotein-cholesterol [(1.32±0.29) vs (1.22±0.21) mmol/L] or low density lipoprotein-cholesterol [(2.67±0.56) vs (2.55±0.52) mmol/L] between the exercise and control group (t=0.001, 0.020, 3.255, 0.303, all P>0.05). \u0000 \u0000 \u0000Conclusions \u0000Regular exercise during pregnancy has no long-term effect on maternal health in the absence of continuing lifestyle intervention after delivery. Therefore, postpartum follow-up and continued education on healthy lifestyle should be emphasized. \u0000 \u0000 \u0000Key words: \u0000High body mass index","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48389318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of mammalian target of rapamycin signaling pathway in placental tissues of gravidas with gestational diabetes mellitus","authors":"Li Lin, Wanyi Zhang, Guanlin Li, R. Su, Huixia Yang","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.007","url":null,"abstract":"Objective \u0000To investigate the activation of mammalian target of rapamycin (mTOR) signaling pathway in placental tissues of gestational diabetes mellitus (GDM) women and in JEG3 cells after high glucose treatment. \u0000 \u0000 \u0000Methods \u0000Placental tissues were collected from 60 singleton pregnant women at term, who underwent elective cesarean section in Peking University First Hospital from December 2016 to June 2017, including 30 GDM women (GDM group) and 30 normal glucose tolerance (NGT) women (NGT group). Expressions of mTOR, Rictor, Raptor, S6 kinase (S6K) and phosphorylated-S6K (p-S6K), which were mTOR signaling pathway-related molecules in those placental tissues were detected by real-time fluorescence quantitative polymerase chain reaction, Western blotting and immunohistochemistry. At the same time, JEG3 cells were treated with glucose of different concentrations (5.5, 10.0, 15.0, 25.0 and 50.0 mmol/L) for 24 h, and the expressions of mTOR, S6K and p-S6K were detected by Western blotting. Two independent samples t-test, one-way analysis of variance test and Spearman correlation analysis were used for statistical analysis. \u0000 \u0000 \u0000Results \u0000Compared with the NGT group, the pre-pregnancy body mass index(BMI), neonatal birth weight, fasting blood glucose(FBG), and 1 h and 2 h post-load blood glucose in oral glucose tolerance test (OGTT) of the GDM group were significantly increased [pre-pregnant BMI: (21.6±2.7) vs (23.4±3.5) kg/m2, t=-2.192; neonatal birth weight: (3 337.5±347.7) vs (3 618.3±580.9) g, t=-2.727; FBG: (4.6±0.4) vs (5.2±0.8) mmol/L, t=-3.947; 1 h glucose level: (7.4±1.2) vs (9.6±1.9) mmol/L, t=-5.332; 2 h glucose level: (6.3±1.0) vs (8.1±1.5) mmol/L, t=-5.314; all P<0.05]. The mRNA expressions of mTOR, Rictor and Raptor were significantly higher in the GDM group than in the NGT group (0.051±0.015 vs 0.031±0.011, t=-5.635; 0.038±0.017 vs 0.026±0.010, t=-3.485; 0.036±0.012 vs 0.025±0.011, t=-3.312; all P<0.05). The expression of mTOR, Rictor, Raptor and p-S6K protein in the GDM group were enhanced as compared with those in the NGT group (0.834±0.432 vs 0.386±0.361, t=-2.249; 0.589±0.236 vs 0.262±0.075, t=-3.726; 0.767±0.345 vs 0.323±0.109, t=-3.472; 1.847±1.025 vs 0.834±0.432, t=-2.575; all P<0.05). The results of immunohistochemistry also showed that the p-S6K in the placental tissues of the GDM group was higher than that of the NGT group (0.29±0.09 vs 0.18±0.08, t=-3.122, P=0.004). The expressions of mTOR protein (0.190±0.085, 0.301±0.089, 0.419±0.065, 0.562±0.108, 0.412±0.058, F=18.351, P<0.05) and p-S6K protein (0.753±0.150, 1.146±0.289, 2.148±0.188, 2.248±0.115, 2.134±0.214, F=66.242, P<0.05) in JEG3 cells treated with different concentrations of glucose (5.5, 10.0, 15.0, 25.0 and 50.0 mmol/L) were significantly different and increased with increasing concentrations of glucose (r=0.314, P=0.035; r=0.457, P=0.002). \u0000 \u0000 \u0000Conclusions \u0000The up-regulated expressions of mTOR signaling pathway-related molecules in GDM placenta and high glucose-tre","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"240-246"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44566465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D receptor in subcutaneous adipose tissue and serum vitamin D levels relate to gestational diabetes mellitus in overweight/obese pregnant women","authors":"Guangtong She, Huiyan Wang, Wenbo Zhou, Cai-Feng Sun, Yin-Pin Wang, Hao Lu, Kezhuo Liu, Jun Miao, Hui-Hui Ju","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.008","url":null,"abstract":"Objective \u0000To investigate the differences in the expression of vitamin D receptor (VDR) and serum vitamin D levels in subcutaneous adipose tissue between overweight/obese and normal-weight gravidas, and the relationship between these two indicators and gestational diabetes mellitus (GDM). \u0000 \u0000 \u0000Methods \u0000Women with full-term singleton pregnancies who underwent elective cesarean section in Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University from January 2015 to April 2017 were enrolled. Among them, there were 70 cases GDM women, including 35 normal-weight (NW-GDM group) and 35 overweight/obese women (OW-GDM group). During the same period, another 70 pregnant women with normal glucose tolerance who underwent scheduled cesarean delivery were selected as the control group, including 35 normal weight women (NW-control group) and 35 obese/overweight women (OW-control group). Fasting blood samples were collected before operation to determine the levels of different biomarkers, including vitamin D, lipid, fasting blood glucose, fasting insulin and adiponectin, and to calculate the homeostasis model assessment-insulin resistance (HOMA-IR). Two subcutaneous adipose tissue samples of the abdominal wall were taken during the operation to detect the expression and distribution of VDR protein with immunohistochemistry. Meanwhile, VDR mRNA transcription level was quantitatively analyzed using real-time fluorescence quantitative polymerase chain reaction. One-way analysis of variance, LSD, Kruskal-Wallis test, Mann-Whitney U test, Chi-square test and logistic regression analysis were used for statistical analysis. \u0000 \u0000 \u0000Results \u0000(1) The body mass index (BMI) of the OW-control group and the OW-GDM group before pregnancy and delivery were all higher than that of the NW-control group and the NW-GDM group [BMI before pregnancy: (29.2±2.9), (29.4±3.8) vs (21.1±2.3) and (21.9±2.0) kg/m2, F=87.766; BMI before delivery: (35.2±3.4), (35.1±4.3) vs (27.9±2.8) and (28.8±3.3) kg/m2, F=44.827; all P<0.001]. Newborn birth weight and the proportion of diabetic family history in the OW-GDM group were higher comparing to the NW- and OW- control group [(3 893±498) vs (3 501±402) and (3 625±332) g, F=4.751; 22.9%(8/35) vs 5.7%(2/35) and 5.7%(2/35), χ2=7.869; all P<0.05]. (2) In the OW-control group, the fasting insulin level and HOMA-IR were higher and the adiponectin and vitamin D concentration were lower than those in the NW-control group [13.3(12.3-14.5) vs 12.0(10.4-13.3) mmol/L, 2.7(2.4-3.0) vs 2.2(2.0-2.7), (61.8±20.4) vs (74.9±29.3) ng/ml, (21.6±7.2) vs (25.9±7.3) ng/ml; all P<0.05], and similar results were found between the OW-GDM group and the NW-GDM group [15.3(12.3-19.5) vs 12.0(10.1-15.8) mmol/L, 3.4(2.6-4.1) vs 2.6(2.1-3.2), (50.3±22.3) vs (62.1±23.2) ng/ml, (17.1±6.7) vs (20.6±7.9) ng/ml, all P<0.05]. Compared with the NW-control group, the NW-GDM group had higher fasting glucose and lower high density lipoprotein-cholesterol (HDL-","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"247-254"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47358571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal lupus erythematosus: clinical analysis of 13 cases","authors":"Yirong Zheng, Changyi Yang, W. Xiu","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.013","url":null,"abstract":"Objective \u0000To summarize the clinical features of neonatal lupus erythematosus (NLE) and to have a better clinical understanding. \u0000 \u0000 \u0000Methods \u0000We retrospectively analyzed the clinical data of 13 patients with NLE who were hospitalized in Fujian Provincial Maternity and Children's Hospital from September 2010 to September 2017. The pathogenesis, clinical manifestations, laboratory examinition, management and long term outcomes of these babies were summarized, and the relevant literatures were also reviewed. Descriptive statistical analysis was performed. \u0000 \u0000 \u0000Results \u0000The 13 NLE cases included eight boys and five girls. Among them, skin lesions, cardiac impairment, hematological problems, hepatobiliary system damage, central nervous system involvement and renal function damage occurred in eight, seven (six cases were atrioventricular block), seven, three, one and one case, respectively. Antinuclear antibodies and anti-Sjogren's syndrome antigen A antibodies were positive in all neonates, anti-Sjogren's syndrome antigen B antibodies were positive in 11, and anti-double-stranded DNA antibodies were positive in two cases. Among the 13 mothers, three were diagnosed with Sjogren's syndrome and two had systemic lupus erythematosus(SLE) before pregnancy, two were diagnosed with Sjogren's syndrome and one developed SLE during pregnancy. Eight babies with skin lesions were asked to avoid light and the skin rash all gradually receded within 1-6 months after birth. Five cases with thrombocytopenia were treated with intravenous immunoglobulin and one anemic baby received erythrocyte transfusion. Within 2 to 3 months, the impaired blood system in these babies were back to normal. For the three babies with abnormal liver functions, hepatic protectants and jaundice relieving agents were given, and 2 to 6 months later they recovered. The 13 patients were followed up for five months to seven years, among which, seven improved with normal growth and development; five still had grade Ⅲ atrioventricular block; one installed an atrial pacemaker at 11 months. Three mothers who were asymptomatic during pregnancy were found to have autoimmune diseases after their babies were diagnosed with NLE, including one case of Sjogren's syndrome and two of SLE. \u0000 \u0000 \u0000Conclusions \u0000NLE is mainly characterized by skin lesions and congenital heart block, while liver, blood system, central nervous system and other organs may also be involved. For high-risk mothers and babies, timely autoantibody screening and relevant examinations are suggested for early diagnosis and interventions. In addition, long term follow-up is required for affected cases. \u0000 \u0000 \u0000Key words: \u0000Lupus erythematosus, systemic; Infant, newborn","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"278-283"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43814237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and clinical characteristics in diagnosis and treatment of amniotic fluid embolism","authors":"A. Lin, Ye Feng, Yun Lu, Huixia Yang, Lingqun Hu","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.002","url":null,"abstract":"Amniotic fluid embolism(AFE) is a fatal intrapartum complication. Typical AFE is characterized by respiratory and circulatory failure, followed by disseminated intravascular coagulation(DIC), while atypical AFE, which had a higher survival possibility, presents with unexplained DIC only. Recent findings support an anaphylactoid inflammatory mechanism underlying the pathophysiology of AFE. Milrinone is currently the first choice for AFE due to its several functions, such as reducing pulmonary artery pressure, and improving right ventricular function through lowering heart rate and positive inotropic action. A multidisciplinary team is required in the rescue of AFE and medical staff who are skilled in critical medicine (such as anesthesiologists) often play a pivotal role. \u0000 \u0000 \u0000Key words: \u0000Embolism, amniotic fluid; Mastocytosis; Hypersensitivity","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"220-222"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45825484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA expression profiles in women with gestational diabetes mellitus: a nested case-control study","authors":"Ruihua Chen, Hongling Yang, R. Chen,, Jun Ma, Y. Long, Chunyan Zhu","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.009","url":null,"abstract":"Objective \u0000To investigate the expression of circular RNA (circRNA) in peripheral blood of gravidas with gestational diabetes mellitus (GDM) using gene chip technology, and to provide evidence for studying pathogenesis of GDM. \u0000 \u0000 \u0000Methods \u0000A prospective cohort-based nested case-control study was used to select 1 018 pregnant women who were examined and delivered in Guangzhou Women and Children's Medical Center from September 2014 to April 2016. The information of prenatal examination was recorded and the outcome of delivery was followed up. Six pregnant women diagnosed as GDM were selected as the GDM group. Six normal pregnant women who were collected blood samples by 1∶1 were selected as the control group. The difference of gestational week was less than 7 days, the number of previous pregnancies was less than 2 times, and the difference of previous delivery times as same as the control group. The expression of circRNA in maternal peripheral blood was analyzed by chromosome microarray technique, and the function and the regulation network forecast were analyzed by GO (http://www.geneontology.org/), KEGG PATHWAY (http://www.genome.jp/kegg/pathway.html) and CircNet(http://circnet.mbc.nctu.edu.tw/). t-test was used for data analysis. \u0000 \u0000 \u0000Results \u0000Compared to the normal pregnant women, 2 678 circRNAs were identified to be differentially expressed >2.0 times in GDM women, among which 1 532 were up-regulated and 1 146 were down-regulated. Functional analysis showed that the up-regulated circRNA was enriched in the biological processes of insulin response, gene silencing regulation, glucagon response and cell senescence. Signal pathway analysis showed that circRNA involved in insulin pathway. Taking has_circ_0042852 and has_circ_0004001 as center, the possible GDM-related regulatory networks were predicted. \u0000 \u0000 \u0000Conclusions \u0000The peripheral blood of GDM women is rich in circRNAs, which might involve in many biological processes, insulin signaling pathway and possibly induding GDM-related regulatory networks. \u0000 \u0000 \u0000Key words: \u0000Diabetes, gestational; RNA; Gene expression profiling; Biomarkers","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"255-260"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49252706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences on accuracy of automated image-based estimation of neonatal serum bilirubin level using smartphone application under different circumstances","authors":"Di Huang, Bo Yang, Xiang-yu Gao, Huiying Wang, M. Su, Yi Ren, Min Li, Honglin Lei, Dandan Zhao","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.04.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.04.012","url":null,"abstract":"Objective \u0000To study the influence factors on the accuracy of a smartphone software application (APP) , which is an automated image-based bilirubin (AIB) testing technique for neonatal bilirubin. \u0000 \u0000 \u0000Methods \u0000This was a prospective study involving 179 jaundiced neonates admitted to the Department of Neonatology of the Affiliated Xuzhou Hospital of Southeast University from August to December, 2017. If blood sampling was required to determine total serum bilirubin (TSB), the transcutaneous bilirubin (TcB) and AIB on the sternum (glabella or the visible darkest yellow area were tested in 36 cases at the same time) were also tested. The concentrations of AIB were measured using a mobile phone-based neonatal jaundice monitoring APP with images taken by OPPO R11 smartphone (55 cases were also taken by Huawei Mate 8 and iPhone 6). The accuracy and non-inferiority of AIB comparing with TcB, the correlation and consistency between AIB and TSB and the value of AIB in predicting TSB were analyzed. Non-inferiority trial, student's t test, variance analysis, Pearson's correlation analysis, Bland-Altman plots and receiver operating characteristic (ROC) curve were used as statistical methods. \u0000 \u0000 \u0000Results \u0000A total of 179 neonates were enrolled in this study with the mean gestational age of (36.2±2.1) weeks and the mean birth weight of (2 871±735) g. Based on all data, the mean difference between the absolute value of AIB minus TSB (|AIB-TSB|) and the absolute value of TcB minus TSB (|TcB-TSB|) was 0.77 mg/dl (1 mg/dl=17.1 μmol/L) with the 95%CI of (0.60-0.95) mg/dl, suggesting that the accuracy of AIB was not inferior to that of the TcB. Furthermore, AIB was not inferior to TcB in its accuracy in different subgroups based upon the time after birth (≤48 h and >48 h), gestational age (≤35 weeks and >35 weeks) and in the daytime subgroup. In the nighttime subgroup, the mean difference between∣AIB-TSB∣and∣TcB-TSB∣was 1.47 mg/dl [95%CI: (1.08-1.87) mg/dl], which indicated that the accuracy of AIB was inferior to that of the TcB. There were good correlation (r=0.788) and highly consistency between AIB and TSB based on all data [96.4% (238/247) of the samples were within the 95% limits of agreement of (-4.75 to 5.71) mg/dl]. Such results were also found in different subgroups, such as smartphone brands, detection areas, the time after birth and gestational age. The correlation and consistency between AIB and TSB in daytime subgroup (r=0.924, 98.4%) were obviously stronger than those of the nighttime subgroup (r=0.727, 87.5%). The mean difference between the absolute value of ocular value minus TSB (|ocular value-TSB|) and |AIB-TSB| was 2.13 mg/dl [95%CI: (1.68-2.58) mg/dl], implying a superior accuracy of AIB than ocular estimation. The areas under the ROC curves, the sensitivity and the specificity of AIB for the prediction of TSB >10, >15 and >20 mg/dl were 0.94, 93% and 85%; 0.89, 75% and 87%; and 0.84, 50% and 88%, respectively. \u0000 \u0000 \u0000Conclusions \u0000AIB is not infer","PeriodicalId":52320,"journal":{"name":"Chinese Journal of Perinatal Medicine","volume":"22 1","pages":"269-277"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41635671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}