{"title":"Limitations in clinical application of rapid measurements of macronutrients in human milk","authors":"Jianxing Zhu","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.07.003","DOIUrl":null,"url":null,"abstract":"Rapid measurements of macronutrients in human milk by infrared spectroscopy, particularly widely used mid-infrared at bed side, is undergoing rapid development in recent years. A recent published systematic review showed that the accurate rate of infrared spectroscopy for protein and fat measurement was only between 60% and 70%, while for carbohydrate/lactose was inconclusive. As for domestic used digital ultrasound techniques, only few studies were published based on small sample size and thus it is difficult to evaluate the results. The storage, temperature and container for milk samples may also affect the results. As individual human milk contents vary during the whole lactation period resulting in the instability of all contents, one single or few samples might not be representative. The proposed individualized fortification based on rapid measurement of human milk has failed to ensure a better growth though it might be true that the analysis made less error in determining the volume of fortifier. We concluded that routine clinical use of bedside or rapid measurement of human milk contents still lack of evidence and should not be recommended. \n \n \nKey words: \nMilk, human; Proteins; Carbohydrates; Spectrophotometry","PeriodicalId":52320,"journal":{"name":"中华围产医学杂志","volume":"22 1","pages":"441-444"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华围产医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.07.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
Rapid measurements of macronutrients in human milk by infrared spectroscopy, particularly widely used mid-infrared at bed side, is undergoing rapid development in recent years. A recent published systematic review showed that the accurate rate of infrared spectroscopy for protein and fat measurement was only between 60% and 70%, while for carbohydrate/lactose was inconclusive. As for domestic used digital ultrasound techniques, only few studies were published based on small sample size and thus it is difficult to evaluate the results. The storage, temperature and container for milk samples may also affect the results. As individual human milk contents vary during the whole lactation period resulting in the instability of all contents, one single or few samples might not be representative. The proposed individualized fortification based on rapid measurement of human milk has failed to ensure a better growth though it might be true that the analysis made less error in determining the volume of fortifier. We concluded that routine clinical use of bedside or rapid measurement of human milk contents still lack of evidence and should not be recommended.
Key words:
Milk, human; Proteins; Carbohydrates; Spectrophotometry
期刊介绍:
Chinese Journal of Perinatal Medicine was founded in May 1998. It is one of the journals of the Chinese Medical Association, which is supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by Peking University First Hospital. Perinatal medicine is a new discipline jointly studied by obstetrics and neonatology. The purpose of this journal is to "prenatal and postnatal care, improve the quality of the newborn population, and ensure the safety and health of mothers and infants". It reflects the new theories, new technologies, and new progress in perinatal medicine in related disciplines such as basic, clinical and preventive medicine, genetics, and sociology. It aims to provide a window and platform for academic exchanges, information transmission, and understanding of the development trends of domestic and foreign perinatal medicine for the majority of perinatal medicine workers in my country.