ASM case reports最新文献_第10页

Urinary tract infection in a cat and cholangiohepatitis in a dog caused by the same strain of CTX-M-14 extended-spectrum beta-lactamase-producing Escherichia coli ST162 in a household: case report. 由同一株产CTX-M-14广谱β -内酰胺酶大肠杆菌ST162引起的猫尿路感染和狗胆管肝炎：病例报告

ASM case reports Pub Date : 2025-08-26 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00069-25

Tessa E LeCuyer, Alexandra S Fox, Amanda A Carbonello, Diamond McClendon, Timothy Bolton

{"title":"Urinary tract infection in a cat and cholangiohepatitis in a dog caused by the same strain of CTX-M-14 extended-spectrum beta-lactamase-producing Escherichia coli ST162 in a household: case report.","authors":"Tessa E LeCuyer, Alexandra S Fox, Amanda A Carbonello, Diamond McClendon, Timothy Bolton","doi":"10.1128/asmcr.00069-25","DOIUrl":"10.1128/asmcr.00069-25","url":null,"abstract":"Background: Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales can be disseminated within households, including sharing of strains between people and pets, posing a public health risk. This case report demonstrates that household dissemination can also lead to antimicrobial-resistant infections in other pets in the household.Case summary: A 14-year-old domestic shorthair cat with a subcutaneous ureteral bypass system was diagnosed with a urinary tract infection caused by Escherichia coli ST162 with CTX-M-14 ESBL. The cat was successfully treated. Seven months later, a 16-year-old mixed-breed dog in the same household was diagnosed with cholangiohepatitis caused by E. coli ST162 with CTX-M-14. Genomic comparison of the feline urine and canine bile isolates showed that they were highly genetically similar, despite months passing between resolution of the cat's infection and the beginning of the dog's clinical signs.Conclusion: Dissemination of ESBL-producing E. coli to other pets, as well as to people, is possible when an animal in the household has an infection. In this case, cohabiting animals both developed clinical infections, highlighting the need for guidance to prevent pet-to-pet spread of antimicrobial-resistant pathogens.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct memory CD4⁺ T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor. 两种嗜ccr5型HIV-1在快速进展中的不同记忆性CD4+ T细胞亚群趋向性

ASM case reports Pub Date : 2025-08-26 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00101-25

Manukumar Honnayakanahalli Marichannegowda, Yasmine Farah, Meera Bose, Eric Sanders-Buell, David King, Leilani Francisco, Leigh Anne Eller, Abdur Rashid, Sodsai Tovanabutra, Nelson L Michael, Merlin L Robb, Hongshuo Song

{"title":"Distinct memory CD4+ T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor.","authors":"Manukumar Honnayakanahalli Marichannegowda, Yasmine Farah, Meera Bose, Eric Sanders-Buell, David King, Leilani Francisco, Leigh Anne Eller, Abdur Rashid, Sodsai Tovanabutra, Nelson L Michael, Merlin L Robb, Hongshuo Song","doi":"10.1128/asmcr.00101-25","DOIUrl":"10.1128/asmcr.00101-25","url":null,"abstract":"Background: Low HIV-1 infection level in the central memory CD4+ T cell subset is a hallmark of both non-progressive HIV infection and non-pathogenetic SIV infection in the natural hosts. However, an important gap in knowledge is whether CCR5-tropic HIV-1 variants have different memory CD4+ T cell subset preferences.Case summary: Here, we identified clear compartmentalization of two CCR5-tropic HIV-1 in different memory CD4+ T cell subsets in a rapid progressor. Participant 40512 was identified in the RV217 cohort. While the transmitted/founder (T/F) virus in 40512 was compartmentalized in the central memory CD4+ T cells, the superinfecting virus was compartmentalized in the effector memory CD4+ T cells. Both viruses rely on CCR5 to infect primary CD4+ T cells. The T/F virus is more than 100-fold more resistant to the CCR5 inhibitor Maraviroc than the superinfecting virus.Conclusion: This case report demonstrates that CCR5 HIV-1 variants have distinct memory CD4+ T cell subset preferences in vivo. Because CD4+ T cell subset targeting is highly relevant for HIV-1 pathogenesis, understanding the underlying molecular mechanisms may provide deeper insights into HIV-1 therapeutics and functional cure.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent meningitis due to Salmonella arizonae in an adult with AIDS: case presentation and next-generation sequencing analysis. 由于亚利桑那沙门氏菌在成人艾滋病复发性脑膜炎：病例介绍和下一代测序分析。

ASM case reports Pub Date : 2025-08-26 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00095-25

Jairo Lizarazo, Catering Rodriguez, Efrain Montilla-Escudero, Carolina Duarte

引用次数: 0

Sudden deaths of two dogs in a breeding colony associated with enteropathogenic Escherichia coli and necrotoxigenic Escherichia coli. 饲养群中两只狗的突然死亡与肠致病性大肠杆菌和坏死性产毒素大肠杆菌有关。

ASM case reports Pub Date : 2025-08-25 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00064-24

Maho Okumura, Nathan Helgert, Katharine Tuohy, Donna J Kelly, Stephen D Cole

{"title":"Sudden deaths of two dogs in a breeding colony associated with enteropathogenic Escherichia coli and necrotoxigenic Escherichia coli.","authors":"Maho Okumura, Nathan Helgert, Katharine Tuohy, Donna J Kelly, Stephen D Cole","doi":"10.1128/asmcr.00064-24","DOIUrl":"10.1128/asmcr.00064-24","url":null,"abstract":"Background: This case report describes the peracute deaths of two healthy pups in a breeding facility associated with enteropathogenic Escherichia coli (EPEC) and a distinct strain of necrotoxigenic E. coli (ExP-NTEC) co-infection. When E. coli is recovered from post-mortem samples, the role of the organism can be challenging to elucidate. In this case, the use of whole-genome sequencing (WGS) uncovered the virulence factors associated with isolates from both cases and a molecular epidemiological connection between the two deaths.Case summary: A 7-week-old male and an 8-week-old female intact mixed-breed dogs were found deceased, shortly after routine examination with no preceding clinical signs. Post-mortem examination revealed multiple organ abnormalities, including bronchopneumonia with alveolar collapse, hepatic lipidosis, gastrointestinal inflammation, and bacterial colonization in the lungs and intestines. Bacterial cultures from the lungs and intestines of both pups yielded multiple bacterial species. WGS of six E. coli isolates from both pups identified ST5683 and ST127 strains, possessing two different morphotypes and virulence factors that distinguished them as EPEC ExP-NTEC.Conclusion: The findings suggest a role of EPEC and ExP-NTEC in the sudden deaths of neonatal dogs, possibly exacerbated by a naïve immune system. It is challenging to fully characterize the pathogenesis and potential risk factors as E. coli is present in the gastrointestinal system of healthy and asymptomatic carrier animals; however, these cases highlight the importance of comprehensive diagnostic approaches, including tools such as WGS.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype-case report. 非疫苗肺炎球菌血清型引起奥氏综合征多部位感染病例报告。

ASM case reports Pub Date : 2025-08-21 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00061-25

Frederik Juel Pontoppidan Børrild, Emil Fosbøl, Casper Roed, Melissa Hornbæk Øvre, Helle Brander Eriksen, Christian Kraef, Jannik Helweg-Larsen, Zitta Barrella Harboe, Christina Ekenberg

引用次数: 0

A case of enterovirus D68-associated acute flaccid myelitis in an immunocompromised adult, Australia. 一例肠病毒d68相关急性弛缓性脊髓炎在免疫功能低下的成年人，澳大利亚。

ASM case reports Pub Date : 2025-08-21 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00074-25

Nathaniel Lizak, Grace Butel-Simoes, Eike Steinig, Belinda Cruse, Edrich Rodrigues, Kirsty Buising, Joe Sasadeusz, Marcelina Krysiak, Bruce Thorley, Matthew Kaye, Leon Caly, Jean Moselen, Ivana Savic, Andrew W Roberts, Katherine Bond, Chuan Kok Lim, Deborah A Williamson, Prashanth Ramachandran

引用次数: 0

Chronic Cyclospora infection in a heart transplant patient with intestinal malabsorption: a case report. 慢性环孢子虫感染的心脏移植患者肠道吸收不良：1例报告。

ASM case reports Pub Date : 2025-08-08 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00062-25

Katie Ambrose, Robert Hamilton-Seth, Mollie Jackson, Rachel Sigler, Daffolyn Rachael Fels Elliott

{"title":"Chronic Cyclospora infection in a heart transplant patient with intestinal malabsorption: a case report.","authors":"Katie Ambrose, Robert Hamilton-Seth, Mollie Jackson, Rachel Sigler, Daffolyn Rachael Fels Elliott","doi":"10.1128/asmcr.00062-25","DOIUrl":"10.1128/asmcr.00062-25","url":null,"abstract":"Background: Cyclosporiasis is a rare cause of chronic diarrhea and malabsorption in immunosuppressed patients.Case summary: We report an unusual case of chronic Cyclospora infection in a heart transplant patient with a five-month history of watery diarrhea and weight loss. Initial stool testing failed to discover a causative pathogen. Duodenal biopsy showed histologic findings of intraepithelial lymphocytosis and partial villous blunting, raising the possibility of celiac disease. A repeat duodenal biopsy five months later revealed intracellular parasites with gametocyte, meront, and schizont forms, and the diagnosis of Cyclospora infection was confirmed by BIOFIRE Gastrointestinal (GI) Pathogen Panel.Conclusion: Morphologic diagnosis of enteric parasite infections is challenging and requires a high level of clinical suspicion in immunosuppressed patients. In addition to significant exposures and travel history, chronic immunosuppression should prompt extensive microbial testing, including stool ova and parasite, acid-fast testing, and/or multiplex PCR for GI pathogens in post-transplant patients with unexplained diarrhea.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichosporon inkin meningitis in a pediatric patient diagnosed via metagenomic sequencing. 通过宏基因组测序诊断的儿童患者的三磷酸丝状蛋白脑膜炎。

ASM case reports Pub Date : 2025-08-08 eCollection Date: 2026-01-01 DOI: 10.1128/asmcr.00053-25

Kathryn Phillips, Karen P Acker, Jin-Young Han, Christine M Salvatore, Sallie R Permar, Rebecca Marrero Rolón, Jamie Marino, Claire Dysart, David M Berman, Charles Y Chiu, Sarah E Kidd, Lars F Westblade, Melanie M Dubois

{"title":"Trichosporon inkin meningitis in a pediatric patient diagnosed via metagenomic sequencing.","authors":"Kathryn Phillips, Karen P Acker, Jin-Young Han, Christine M Salvatore, Sallie R Permar, Rebecca Marrero Rolón, Jamie Marino, Claire Dysart, David M Berman, Charles Y Chiu, Sarah E Kidd, Lars F Westblade, Melanie M Dubois","doi":"10.1128/asmcr.00053-25","DOIUrl":"10.1128/asmcr.00053-25","url":null,"abstract":"Background: Trichosporon has emerged as an important cause of invasive fungal infections in immunocompromised patients. There are limited data on invasive Trichosporon infections in children.Case summary: We report a case of culture-negative Trichosporon inkin meningitis diagnosed via metagenomic next-generation sequencing of plasma and cerebrospinal fluid in an infant with retinoblastoma. In addition, we highlight the role of β-1,3-D-glucan in the diagnosis and therapeutic monitoring of trichosporonosis, and cross-reactivity of the cryptococcal antigen lateral flow assay with T. inkin.Conclusion: This diagnosis, which was challenging to make in the absence of a positive culture, highlights the utility of metagenomic sequencing methods and fungal biomarkers in identifying infectious agents and ensuring timely diagnosis and management of patients with rare fungal infections of the central nervous system.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the mold: a case of invasive Medicopsis romeroi pulmonary infection with innovative granulocyte treatment strategy. 打破常规：采用创新的粒细胞治疗策略治疗侵袭性Medicopsis romeroi肺部感染一例。

ASM case reports Pub Date : 2025-08-05 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00060-25

Caitlin Raymond, Amir Seyedmousavi, Adrian M Zelazny, Jennifer D Treat, Chioma Aneke, Roya Zarpak, Kamille West-Mitchell, Steven M Holland, Christa S Zerbe

{"title":"Breaking the mold: a case of invasive Medicopsis romeroi pulmonary infection with innovative granulocyte treatment strategy.","authors":"Caitlin Raymond, Amir Seyedmousavi, Adrian M Zelazny, Jennifer D Treat, Chioma Aneke, Roya Zarpak, Kamille West-Mitchell, Steven M Holland, Christa S Zerbe","doi":"10.1128/asmcr.00060-25","DOIUrl":"10.1128/asmcr.00060-25","url":null,"abstract":"Background: Medicopsis romeroi only rarely causes infection in immunocompromised individuals. We report a rare case of invasive infection in a specific primary immunodeficiency not arising from primary cutaneous infection.Case summary: A 16-year-old male with chronic granulomatous disease (CGD) developed progressively enlarging diffuse pulmonary nodules in the setting of admission with obstructive hydrocephalus. A transthoracic biopsy grew a dematiaceous mold, identified as Medicopsis romeroi through DNA sequencing of the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA). The nodules progressed despite a combination of posaconazole, isavuconazole, terbinafine, and liposomal amphotericin B. A course of HLA-compatible granulocytes was initiated, resulting in stabilization of the infection.Conclusion: This is a rare case of M. romeroi causing an invasive fungal infection of a visceral organ, the second documented M. romeroi infection in a CGD patient, and a report of a novel treatment regimen for this pathogen.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical presentation of occupational mpox: a case report from Brazil. 职业性m痘的非典型表现：巴西一例报告。

ASM case reports Pub Date : 2025-08-01 eCollection Date: 2025-11-01 DOI: 10.1128/asmcr.00104-24

Guilherme S Lira, Mariana Q S Melo, Isabela C Leitão, Matheus V Andrade, Anna C Castiñeiras, Diana Mariani, Cássia C A Gonçalves, Lendel C Costa, Danielle A S Rodrigues, André M Vale, Filipe R R Moreira, Carolina M Voloch, Débora S Faffe, Luiza M Higa, Rafael M Galliez, Clarissa R Damaso, Amilcar Tanuri, Terezinha M P P Castiñeiras

{"title":"Atypical presentation of occupational mpox: a case report from Brazil.","authors":"Guilherme S Lira, Mariana Q S Melo, Isabela C Leitão, Matheus V Andrade, Anna C Castiñeiras, Diana Mariani, Cássia C A Gonçalves, Lendel C Costa, Danielle A S Rodrigues, André M Vale, Filipe R R Moreira, Carolina M Voloch, Débora S Faffe, Luiza M Higa, Rafael M Galliez, Clarissa R Damaso, Amilcar Tanuri, Terezinha M P P Castiñeiras","doi":"10.1128/asmcr.00104-24","DOIUrl":"10.1128/asmcr.00104-24","url":null,"abstract":"Background: After decades of circulating predominantly in Africa, mpox caused a public health emergency of international concern between 2022 and 2023. Even outside of the epidemic period, the virus still circulates, with threats of reemergence, and different clinical presentations must be brought to attention for optimal surveillance.Case summary: We report a case of monkeypox virus (MPXV) infection in a previously healthy physician with an atypical clinical presentation and a single identified exposure. Diagnosis was confirmed by PCR. Viral isolation was employed to reinforce diagnosis. Plaque reduction neutralization assays and semiquantitative ELISA were used to evaluate the antibody response.Conclusion: Our report has two main messages: atypical symptoms of mpox can hinder diagnosis, making adequate suspicion and testing fundamental; and the risk of occupational exposure must be considered when designing policies for healthcare workers.","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0