Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype-case report.

ASM case reports Pub Date : 2025-08-21 eCollection Date: 2025-11-01 DOI:10.1128/asmcr.00061-25
Frederik Juel Pontoppidan Børrild, Emil Fosbøl, Casper Roed, Melissa Hornbæk Øvre, Helle Brander Eriksen, Christian Kraef, Jannik Helweg-Larsen, Zitta Barrella Harboe, Christina Ekenberg
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Abstract

Background: Although rare, Austrian syndrome remains a life-threatening triad consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae.

Case summary: We present a case of Austrian syndrome, further complicated by spondylodiscitis and endophthalmitis, in an immunocompromised male receiving methotrexate treatment for rheumatoid arthritis. The infection was caused by a non-vaccine pneumococcal serotype (23B). Susceptibility testing showed reduced susceptibility towards benzylpenicillin, an uncommon finding in Denmark.

Conclusion: This case illustrates some of the challenges faced in managing invasive pneumococcal disease and underlines the importance of continued awareness of this disease, particularly in immunocompromised patients.

Abstract Image

非疫苗肺炎球菌血清型引起奥氏综合征多部位感染病例报告。
背景:虽然罕见,奥氏综合征仍然是一种危及生命的三联征,包括肺炎链球菌引起的肺炎、心内膜炎和脑膜炎。病例总结:我们报告一例奥氏综合征,进一步并发脊椎椎间盘炎和眼内炎,在一个免疫功能低下的男性接受甲氨蝶呤治疗类风湿关节炎。感染是由非疫苗肺炎球菌血清型(23B)引起的。药敏试验显示对青霉素的敏感性降低,这在丹麦并不常见。结论:该病例说明了管理侵袭性肺炎球菌疾病所面临的一些挑战,并强调了持续认识这种疾病的重要性,特别是在免疫功能低下的患者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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