Frederik Juel Pontoppidan Børrild, Emil Fosbøl, Casper Roed, Melissa Hornbæk Øvre, Helle Brander Eriksen, Christian Kraef, Jannik Helweg-Larsen, Zitta Barrella Harboe, Christina Ekenberg
{"title":"Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype-case report.","authors":"Frederik Juel Pontoppidan Børrild, Emil Fosbøl, Casper Roed, Melissa Hornbæk Øvre, Helle Brander Eriksen, Christian Kraef, Jannik Helweg-Larsen, Zitta Barrella Harboe, Christina Ekenberg","doi":"10.1128/asmcr.00061-25","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although rare, Austrian syndrome remains a life-threatening triad consisting of pneumonia, endocarditis, and meningitis caused by <i>Streptococcus pneumoniae</i>.</p><p><strong>Case summary: </strong>We present a case of Austrian syndrome, further complicated by spondylodiscitis and endophthalmitis, in an immunocompromised male receiving methotrexate treatment for rheumatoid arthritis. The infection was caused by a non-vaccine pneumococcal serotype (23B). Susceptibility testing showed reduced susceptibility towards benzylpenicillin, an uncommon finding in Denmark.</p><p><strong>Conclusion: </strong>This case illustrates some of the challenges faced in managing invasive pneumococcal disease and underlines the importance of continued awareness of this disease, particularly in immunocompromised patients.</p>","PeriodicalId":521101,"journal":{"name":"ASM case reports","volume":"1 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584194/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ASM case reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/asmcr.00061-25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Although rare, Austrian syndrome remains a life-threatening triad consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae.
Case summary: We present a case of Austrian syndrome, further complicated by spondylodiscitis and endophthalmitis, in an immunocompromised male receiving methotrexate treatment for rheumatoid arthritis. The infection was caused by a non-vaccine pneumococcal serotype (23B). Susceptibility testing showed reduced susceptibility towards benzylpenicillin, an uncommon finding in Denmark.
Conclusion: This case illustrates some of the challenges faced in managing invasive pneumococcal disease and underlines the importance of continued awareness of this disease, particularly in immunocompromised patients.