Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere最新文献

{"title":"Frische Parasitologie-Impulse in Berlin.","authors":"","doi":"10.1055/a-2874-0641","DOIUrl":"https://doi.org/10.1055/a-2874-0641","url":null,"abstract":"","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"361-363"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Thyroid hormone profiles in euthyroid, hypothyroid dogs, and dogs with defined non-thyroidal illness syndrome].","authors":"Judith Freudenberg, Theresa Schnelten, Holger Volk, Johanna Rieder, Marion Schmicke","doi":"10.1055/a-2894-2124","DOIUrl":"10.1055/a-2894-2124","url":null,"abstract":"<p><strong>Objective: </strong>Thyroxine (T4) is routinely measured in dogs by some laboratories, and the result may be misleading as total thyroxine values (TT4) below the reference range are frequently observed. This may be due to either hypothyroidism or a non-thyroidal illness (Non-Thyroidal Illness Syndrome, NTIS). The aim of this study was to systematically investigate and compare TT4, free T4 (fT4), thyroid-stimulating hormone (TSH), and total triiodothyronine (TT3) concentrations, as well as thyroglobulin autoantibodies (TgAA) in dogs affected by NTIS as well as healthy and known hypothyroid dogs.</p><p><strong>Material and methods: </strong>In this retrospective cross-sectional study, data from a medical database and 272 leftover serum samples from dogs presented at the Small Animal Clinic of the University of Veterinary Medicine Hannover between May 2021 and March 2023 were analyzed. In addition to samples from healthy dogs (n=40), a total of 463 diagnoses from 232 dogs were recorded and grouped. Multiple linear regression analyses were performed in the NTIS subsample, considering age as a covariate and various disease categories as predictors. Additionally, covariance analyses examined the effects of inflammation, multimorbidity, and hospitalization. Agreement between TT4 and fT4 was assessed by Spearman correlation and Bland-Altman analysis. The influence of phenobarbital therapy was investigated in the subgroup of dogs with epilepsy.</p><p><strong>Results: </strong>A total of 37 cases of hypothyroidism were diagnosed. Within the NTIS group, the most common diagnostic categories were nervous system diseases (n=125), gastrointestinal diseases (n=63), diseases of the urogenital tract (n=33), heart diseases (n=32), and oncologic diseases (n=31). Within 3 months, 6.6% of the dogs in all NTIS groups died. Lower TT4 and TT3 values were significantly associated with gastrointestinal diseases, hospitalization, more than 3 comorbidities, and inflammatory diseases, whereas fT4 was not. TT4 and fT4 levels were significantly reduced in dogs with NTIS and hypothyroidism compared to healthy dogs. Healthy dogs showed significantly lower log(TSH) values than dogs with hypothyroidism and significantly higher log(TSH) values than dogs with NTIS. Additionally, the log(TSH) values in dogs with hypothyroidism were significantly higher than those in NTIS dogs. For TT3 concentrations, the group comparison did not reveal any significant differences.</p><p><strong>Conclusions: </strong>The study shows that dogs with NTIS have significantly lower TT4 and fT4 levels compared to healthy dogs. TSH concentrations in dogs with NTIS are significantly lower than in hypothyroid and healthy dogs. In addition, different diseases have varying degrees of influence on thyroid parameters.</p><p><strong>Clinical relevance: </strong>The determination of TT4 and fT4 alone is not sufficient for the diagnosis of hypothyroidism, as NTIS may cause similar changes. The exclusion of","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"304-314"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expertenrunde zum Cushing-Syndrom.","authors":"Jennifer von Luckner","doi":"10.1055/a-2787-1768","DOIUrl":"https://doi.org/10.1055/a-2787-1768","url":null,"abstract":"","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"350-352"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Jennifer von Luckner, Astrid Wehner-Fleischberger","doi":"10.1055/a-2874-0594","DOIUrl":"https://doi.org/10.1055/a-2874-0594","url":null,"abstract":"","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"303"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establishment and validation of an LC-MS/MS-based determination method for 17-hydroxyprogesterone in canine serum].","authors":"Sebastian Naczenski, Ruth Klein, Andrea Hildebrand","doi":"10.1055/a-2854-7332","DOIUrl":"10.1055/a-2854-7332","url":null,"abstract":"<p><strong>Background and objective: </strong>A reliable determination of steroid hormones such as 17-hydroxyprogesterone has long been restricted by the limitations of immunological methods. Assays such as enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA) or chemiluminescence immunoassay (CLIA) show significant cross-reactions, interferences and pronounced variability depending on the test, which limits their diagnostic value.</p><p><strong>Background and objective: </strong>The aim of this work was the methodological establishment and validation of an LC-MS/MS-based determination method for 17-hydroxyprogesterone in order to provide a specific and robust alternative to immunological test systems.</p><p><strong>Material and methods: </strong>The method was developed using stable isotope standards and included systematic testing of linearity, sensitivity, precision, recovery, and matrix effects. Subsequently, initial canine serum samples were analyzed as part of routine diagnostics to illustrate its applicability in a veterinary setting.</p><p><strong>Results: </strong>The method demonstrated excellent analytical performance with a detection limit of 0.044 ng/ml, high linearity (R²>0.999) and low coefficients of variation (<5%). Cross-reactions, as observed with immunological systems, were ruled out.</p><p><strong>Conclusion and clinical relevance: </strong>With the establishment of a LC-MS/MS-based 17-hydroxyprogesterone determination method, a highly specific and precise technique is available, which is in contrast to immunologically based test systems. It thus provides a reliable basis for canine endocrinologic diagnostics and steroid hormone analysis.</p>","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":" ","pages":"344-349"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical presentation and diagnostic procedures in canine hypoadrenocorticism].","authors":"Deborah Anna Dobosz, Astrid Wehner","doi":"10.1055/a-2854-7290","DOIUrl":"10.1055/a-2854-7290","url":null,"abstract":"<p><strong>Abstract: </strong>Hypoadrenocorticism (HA) is a rare endocrinopathy in dogs that may occur in a primary form, characterized by a combined deficiency of glucocorticoids and mineralocorticoids or isolated glucocorticoid deficiency, or in a secondary form with an isolated glucocorticoid deficiency. In addition, iatrogenic HA may also occur. The primary form represents the most frequent type of the disease. Clinical signs are variable and often nonspecific, ranging from lethargy, inappetence, vomiting, and weight loss to polyuria/polydipsia or acute, life-threatening adrenal crises associated with hypovolemia and electrolyte imbalances.</p><p><strong>Abstract: </strong>Typical laboratory findings include the absence of a stress leukogram, hyponatremia, hyperkalemia, azotemia, and hypoglycemia, although not all parameters are necessarily altered.</p><p><strong>Abstract: </strong>The ACTH stimulation test (ACTHST) remains the gold standard to confirm the diagnosis, as it reliably demonstrates glucocorticoid deficiency. Classic electrolyte abnormalities such as hyperkalemia and hyponatremia indicate a concurrent mineralocorticoid deficiency indirectly. In the absence of electrolyte disturbances, however, no reliable conclusions can be drawn regarding mineralocorticoid deficiency, and differentiation of the form of HA is therefore not possible. Measurement of endogenous adrenocorticotropic hormone (eACTH) can help to distinguish between primary and secondary HA, whereas aldosterone determination is currently not yet recommended for routine diagnostic use to identify mineralocorticoid deficiency in dogs with normal electrolytes.</p>","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"315-323"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feliner Hyperaldosteronismus in Frage und Antwort.","authors":"Jennifer von Luckner, Nadja Sieber-Ruckstuhl","doi":"10.1055/a-2787-1734","DOIUrl":"https://doi.org/10.1055/a-2787-1734","url":null,"abstract":"","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"354-358"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diabetic ketoacidosis in cats: pathogenesis and diagnosis].","authors":"Lea Swoboda, René Dörfelt, Astrid Wehner","doi":"10.1055/a-2894-2205","DOIUrl":"10.1055/a-2894-2205","url":null,"abstract":"<p><strong>Abstract: </strong>Diabetic ketoacidosis represents a serious complication of diabetes mellitus. In 1/3 to 2/3 of reported cases, diabetes mellitus is known beforehand. At presentation, affected cats are severely ill. Anorexia, vomiting and dehydration are the most common signs and affected cats usually present with volume depletion. Hepatic lipidosis and pancreatitis are frequent concurrent conditions. It is necessary for the disease to be promptly recognized and diagnosed in order to initiate necessary therapeutic measures as rapidly as possible in order to improve the prognosis of affected animals. Diagnostic criteria include the documentation of severe hyperglycemia and the detection of elevated blood ketone bodies or ketonuria. In case of euglycemic diabetic ketoacidosis under treatment with SGLT2 inhibitors, blood glucose levels are within normal range. Blood gas analysis is required to assess metabolic acidosis resulting from ketosis and to determine its severity. The aim of this article is to provide a detailed overview of the pathogenesis of diabetic ketoacidosis, to offer guidance for the identification of affected cats and to present diagnostic guidance as well as to address advantages and disadvantages of the different diagnostic tests.</p>","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"331-343"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment strategies for canine hypoadrenocorticism - a current overview].","authors":"Deborah Anna Dobosz, Astrid Wehner","doi":"10.1055/a-2811-5723","DOIUrl":"https://doi.org/10.1055/a-2811-5723","url":null,"abstract":"<p><strong>Abstract: </strong>Hypoadrenocorticism (HA) in dogs requires lifelong substitution therapy with glucocorticoids and, in most cases, also mineralocorticoids. For glucocorticoid replacement, prednisolone is administered at a maintenance dose of approximately 0.1 mg/kg/day. Alternative drugs such as hydrocortisone, dexamethasone, or methylprednisolone are used less frequently.</p><p><strong>Abstract: </strong>In veterinary medicine, desoxycorticosterone pivalate (DOCP) is the only parenteral preparation approved for the replacement of mineralocorticoid hormones in Europe.</p><p><strong>Abstract: </strong>The approved dosage is 2.2 mg/kg every 25-30 days (subcutaneously). One study demonstrated that a lower starting dose of 1.5 mg/kg may already achieve stable regulation.</p><p><strong>Abstract: </strong>Fludrocortisone acetate (FC) is a human drug possessing both mineralocorticoid and a certain degree of glucocorticoid activity. It was commonly used prior to the approval of DOCP and must be prescribed off-label for dogs. The usual dosage is 0.01-0.02 mg/kg/day, administered twice daily.</p><p><strong>Abstract: </strong>Studies indicate that DOCP is superior to FC, being associated with fewer adverse effects, better electrolyte control, improved clinical condition, and higher owner satisfaction. Close clinical and laboratory monitoring is essential to avoid over- or underdosage and to adjust therapy. With adequate treatment, the prognosis for dogs with HA is generally very good.</p>","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":"54 5","pages":"324-330"},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological abnormalities, treatment, and outcome in in a 45-day-old puppy with acute Babesia canis infection.","authors":"Ingo Schäfer, Sophia Stüwe, Kathrin Fürst, Christina Strube, Elisabeth Müller, Torsten J Naucke, Andreas Moritz","doi":"10.1055/a-2910-4836","DOIUrl":"10.1055/a-2910-4836","url":null,"abstract":"<p><strong>Abstract: </strong>The knowledge regarding <i>Babesia canis</i> infections in puppies is limited to 3 dogs aged 43-46 days. A 45-day-old, male intact German Shepherd dog was presented due to lethargy, inappetence, and gait disorders. An acute <i>Babesia canis</i> infection was diagnosed by PCR. Marked thrombocytopenia, anemia, and hyperbilirubinemia were noted. A subcutaneous injection of imidocarb dipropionate (ID, 2.0 mg/kg bodyweight) was applied. The puppy's general condition significantly improved, but vomitus was noted. A negative PCR and mild hematological abnormalities were seen 14 days later. A second subcutaneous injection of ID (4.2 mg/kg bodyweight) was applied. <i>Babesia canis</i> infections should be considered in puppies with fever, marked thrombocytopenia, and marked anemia in the immunological gap. Next to vectorial transmission, transplacental <i>Babesia canis</i> infections are reported but considered unlikely in the presented puppy. The puppy responded well to a lower-ranged dose of ID, but side effects were noted (vomiting). In adult dogs, treatment of acute <i>Babesia canis</i> infections using ID dosed 6.6 mg/kg bodyweight is recommended. No safety regulations are published by the manufacturer regarding the use of ID in puppies, but vomitus is reported as a potential side effect after the use in adult dogs. A second ID injection (4.2 mg/kg bodyweight) was applied to avoid a potential disease relapse. The case report highlights the significance of the immunological gap in puppies with <i>Babesia canis</i> infections and the need for ectoparasite prophylaxis in puppies, if vector contact is possible.</p>","PeriodicalId":520818,"journal":{"name":"Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}