{"title":"A pill for many ills.","authors":"Sigurd Ziegler","doi":"10.4045/tidsskr.22.0613","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0613","url":null,"abstract":"","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Øye Thorvaldsen, Anne Kristine Bergem, Øyvind Holst, Kristin Häikiö
{"title":"Coercion in the ambulance setting.","authors":"Nina Øye Thorvaldsen, Anne Kristine Bergem, Øyvind Holst, Kristin Häikiö","doi":"10.4045/tidsskr.22.0086","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0086","url":null,"abstract":"<p><strong>Background: </strong>Patients who resist medical assistance can undo the safety straps on the ambulance stretcher. Ambulance personnel have been known to make use of blankets, bandages and Velcro straps to restrain patients in transit. This study aims to establish how often this type of coercion is used.</p><p><strong>Material and method: </strong>In 2021, approximately 400 ambulance service personnel in the county of Innlandet were invited by email to take part in an online survey about the use of coercion vis-à-vis patients who resist medical assistance.</p><p><strong>Results: </strong>We received 85 responses, and 62 respondents (72.9 %) stated that they had used coercion. Of these, 38 (44.7 %) had restrained the arms/legs of patients using blankets, bandages or Velcro straps in order to keep them safe while in transit. A total of 36 respondents (42.4 %) had observed other personnel travelling in an ambulance without a fastened seatbelt in order to maintain patient safety during transit.</p><p><strong>Interpretation: </strong>The results clearly show that ambulance personnel regularly use coercion when patients who resist their help are transported by ambulance. There is a need to discuss how such ambulance services can be provided in a safe, secure and caring way.</p>","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Rolin, Rønnaug Astri Ødegård, Viktoria Vedeler Amundsen, Unni Mette Stamnes Köpp, Ane Kokkvoll, Pétur Benedikt Júlíusson, Jøran Hjelmesæth
{"title":"Supplementary drug treatment to reduce weight in adolescents with severe obesity.","authors":"Johannes Rolin, Rønnaug Astri Ødegård, Viktoria Vedeler Amundsen, Unni Mette Stamnes Köpp, Ane Kokkvoll, Pétur Benedikt Júlíusson, Jøran Hjelmesæth","doi":"10.4045/tidsskr.22.0540","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0540","url":null,"abstract":"In 2021, the Norwegian Medicines Agency approved the use of daily injection of liraglutide 3.0 mg (Saxenda) as a supplement to lifestyle treatment for weight control in children ≥ 12 years of age with obesity (isoBMI ≥ 30). We share the treatment experiences of six multidisciplinary obesity clinics in the specialist health service.","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jon Huge Hognestad, Stein Arve Lund, Svein Tore Baksaas
{"title":"Surgical treatment of infectious ulnar artery aneurysm.","authors":"Jon Huge Hognestad, Stein Arve Lund, Svein Tore Baksaas","doi":"10.4045/tidsskr.22.0137","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0137","url":null,"abstract":"<p><p>Infectious ulnar artery aneurysm is a rare condition with no standardised treatment. Our patient was treated with a simple proximal ligature without excision of the aneurysm.</p>","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Armika T Nyman, Vigdis Vindenes, Rune Tore Strøm, Sasa Katadzic, Ingebjørg Gustavsen, Stig Tore Bogstrand
{"title":"Systematic screening of substance use upon hospitalisation.","authors":"A Armika T Nyman, Vigdis Vindenes, Rune Tore Strøm, Sasa Katadzic, Ingebjørg Gustavsen, Stig Tore Bogstrand","doi":"10.4045/tidsskr.22.0481","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0481","url":null,"abstract":"Many people can improve their health by reducing their consumption of alcohol and habit-forming medications. By screening for this in connection with emergency hospital admissions, we can help to reduce use.","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A farewell to psychiatric diagnoses.","authors":"Trond F Aarre","doi":"10.4045/tidsskr.22.0386","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0386","url":null,"abstract":"Psychiatric diagnostic categories are neither valid nor stable. They tell us little about the causes of the problems, the prognosis or what treatment might be beneficial. A psychiatric diagnosis must not therefore be a prerequisite for providing proper health care.","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40377815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genotyping of patients treated with selective serotonin reuptake inhibitors.","authors":"Vigdis Solhaug, Tore Haslemo, Marianne Kristiansen Kringen, Espen Molden, Erik Sveberg Dietrichs","doi":"10.4045/tidsskr.22.0017","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0017","url":null,"abstract":"<p><strong>Background: </strong>Selective serotonin reuptake inhibitors (SSRIs) are used by over 180,000 people in Norway. The enzymes CYP2D6 and CYP2C19 are key in the metabolism of SSRI antidepressants. The serotonin transporter coded by SLC6A4 may be significant for the efficacy of the drugs.</p><p><strong>Material and method: </strong>All patients who had undergone genotyping for CYP2D6, CYP2C19 and SLC6A4 at the Centre for Psychopharmacology in 2020 were included, irrespective of indication. For those patients where data were available, CYP2C19 genotype was linked to serum concentration measurement of escitalopram, which is the most commonly used SSRI drug.</p><p><strong>Results: </strong>Out of 3,492 patients, 432 (12.4 %) had a combination of genotypes of CYP2D6, CYP2C19 and SLC6A4 considered to lead to the most favourable metabolism and efficacy of SSRI antidepressants. The dose requirement in patients with poor CYP2C19 metabolism was more than halved to achieve the same concentration of escitalopram compared to patients with normal metabolism.</p><p><strong>Interpretation: </strong>Our findings demonstrate the low prevalence of the most favourable genotype combination for response to SSRIs. Genotype combinations probably contribute to the wide variation between individuals in the efficacy of these drugs and the fact that treatment does not produce the desired outcome in many patients.</p>","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40377814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measurements below the detection limit.","authors":"Guro F Giskeødegård, Stian Lydersen","doi":"10.4045/tidsskr.22.0439","DOIUrl":"https://doi.org/10.4045/tidsskr.22.0439","url":null,"abstract":"Let's start with an example: Figure 1 shows a fictional dataset of measurements of serum levels of a substance in two patient groups. The crosses indicate the actual values, but only those above the lower detection limit can be measured. We know how many values are below the detection limit, but not the actual values. These data are missing not at random (MNAR) because the probability depends on the non-observed values being below the detection limit (1).","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40377816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ole-Gunnar Olsen, Rasmus Dehli Thorkildsen, Olga Zaikova, Ingvild Victoria Koren Lobmaier, Ingeborg Taksdal, Magne Røkkum
{"title":"A woman in her fifties with a lump in the palm of her hand.","authors":"Ole-Gunnar Olsen, Rasmus Dehli Thorkildsen, Olga Zaikova, Ingvild Victoria Koren Lobmaier, Ingeborg Taksdal, Magne Røkkum","doi":"10.4045/tidsskr.21.0830","DOIUrl":"https://doi.org/10.4045/tidsskr.21.0830","url":null,"abstract":"<p><p>A previously healthy woman in her fifties contacted her general practitioner due to a troublesome lump on her hand that had progressed over the course of a year. The final diagnosis surprised those involved and serves as a reminder to both general practitioners and specialists.</p>","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40353193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gunnar Mouland, Christian Lie Berg, Mohammad Nouri Sharikabad, Hilchen Thode Sommerschild
{"title":"Fylkesforskjeller i utredning og behandling av vitamin B12-mangel.","authors":"Gunnar Mouland, Christian Lie Berg, Mohammad Nouri Sharikabad, Hilchen Thode Sommerschild","doi":"10.4045/tidsskr.21.0749","DOIUrl":"https://doi.org/10.4045/tidsskr.21.0749","url":null,"abstract":"<p><strong>Background: </strong>Severe vitamin B12 (cobalamin) deficiency is rare, but international reports show that up to 26 % of the general population may have subclinical vitamin B12 deficiency. The prevalence of vitamin B12 deficiency has not been investigated in Norway. Since 2017, treatment with vitamin B12 tablets has represented an alternative to traditional treatment with intramuscular injections in Norway. When we studied the transition from injection to tablet treatment, we discovered an unexpected difference in the counties' use of vitamin B12 supplements, which we wished to investigate in more detail.</p><p><strong>Material and method: </strong>Data on the dispensing of vitamin B12 supplements from pharmacies in 2020, broken down by the patients' county of residence, were retrieved from the Norwegian Prescription Database. The Norwegian Health Economics Administration (Helfo) provided figures on the number of reimbursed vitamin B12-related laboratory tests in 2020, classified by patients' municipality of residence.</p><p><strong>Results: </strong>In 2020, the sale of vitamin B12 supplements on prescription in Norway amounted to 12 defined daily doses (DDD) per inhabitant and varied from 7 to 15 between the counties. The number of laboratory analyses that were performed varied by county from 26 to 46 per 100 inhabitants for total vitamin B12, and from 21 to 37 for folate. The number of analyses varied correspondingly from 1 to 12 per 100 inhabitants for homocysteine, from 1 to 13 for methylmalonic acid and from 0.01 to 8.13 for active vitamin B12.</p><p><strong>Interpretation: </strong>Our study showed large intercounty differences in the consumption of vitamin B12 supplements. These differences may have a number of explanations. Variations in the number of vitamin B12-related laboratory analyses requisitioned may indicate that doctors' assessment and diagnosis of vitamin B12 deficiency could be a contributory factor.</p>","PeriodicalId":520817,"journal":{"name":"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40353196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}