Crystal Walker, Sonia Manjarrez Yanez, Alex Gallardo, Susanna Mayer
{"title":"Implementing Same-Day Long-Acting Injectable PrEP: A Program Brief Highlighting Integrated and Rapid HIV Prevention in the Southern United States.","authors":"Crystal Walker, Sonia Manjarrez Yanez, Alex Gallardo, Susanna Mayer","doi":"10.1097/JNC.0000000000000662","DOIUrl":"10.1097/JNC.0000000000000662","url":null,"abstract":"<p><strong>Abstract: </strong>This program brief details the implementation of same-day long-acting injectable PrEP (LAI-PrEP) program at a Southern U.S. community health center. Leveraging interdisciplinary coordination, protocol optimization, and sample medication access, the program enabled rapid transition from oral PrEP to injectable PrEP within 2 hours. Findings demonstrate feasibility of same-day LAI-PrEP and alignment with patient preferences. This model highlights critical structural and clinical components for scaling timely HIV prevention, offering actionable insights for health care providers and institutions aiming to reduce disparities and enhance intervention uptake in high-need populations.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"588-591"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emergency Department (ED) Leaders' Perspectives on Offering HIV Preexposure Prophylaxis (PrEP) in New York City EDs: A Qualitative Study.","authors":"Christine Tagliaferri Rael, Stefanie Mayorga, Tatiana Gonzalez-Argoti, Lilian Ha, Samantha Stonbraker, Yvette Calderon, Susie Hoffman, Ethan Cowan, Laurie J Bauman, Joanne E Mantell","doi":"10.1097/JNC.0000000000000577","DOIUrl":"10.1097/JNC.0000000000000577","url":null,"abstract":"<p><strong>Abstract: </strong>Offering preexposure prophylaxis (PrEP) in nontraditional settings, such as emergency departments (EDs), may be an opportunity to connect HIV-vulnerable people with PrEP. Our study aimed to identify the perspectives of N = 10 ED leaders on initiating PrEP in EDs in New York City. Leaders completed 30-min, audio-recorded, in-depth interviews through Zoom, covering challenges/benefits to offering PrEP in EDs, and how potential programs could be set up and managed. From interviews, we formed three key discussion points for designing and implementing PrEP in EDs: (a) ED leadership views PrEP as important, but resource/contextual barriers pose an implementation challenge, (b) interventions must leverage familiar clinical pathways for implementation and minimize burden to provider time/ED resources, (c) using telehealth and patient navigators to implement PrEP in ED interventions could overcome the challenges but may not be available everywhere. Building on relationships with referral partners could be a viable alternative in resource constrained settings.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"592-602"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Mickey Dhir, Steven J Clipman, Jason E Farley, Amteshwar Singh
{"title":"Systematic Review of Preferences for Preexposure Prophylaxis Among Persons Assigned Male at Birth in the United States.","authors":"Amit Mickey Dhir, Steven J Clipman, Jason E Farley, Amteshwar Singh","doi":"10.1097/JNC.0000000000000655","DOIUrl":"10.1097/JNC.0000000000000655","url":null,"abstract":"<p><strong>Abstract: </strong>Despite proven HIV prevention efficacy, preexposure prophylaxis (PrEP) uptake among individuals assigned-male-at-birth remains suboptimal; understanding their preferences is crucial. We conducted PRISMA-guided systematic review of stated-preference methods (i.e., discrete choice experiments [DCEs]; best-worst-scale [BWS], adaptive choice-based conjoint analysis [ACBCA]) through November 21, 2024. Of 648 records, 10 met inclusion (eight DCEs and two ACBCAs); all enrolled men who have sex with men (MSM; no studies with transgender women participants). Attributes included out-of-pocket cost, side effects, dosing frequency (daily oral vs. long-acting injectables), and accessibility. Cost, dosing frequency/method, and side effects most influenced MSM PrEP uptake. Uptake among MSM in the United States remains low due to stigma, misinformation, provider bias, cost, and limited affirming care; gender-diverse participants are underrepresented, and subgroup differences by race, age, and geography are seldom explored. Expanding culturally competent, gender-affirming care, peer-led education, and policy interventions is essential to strengthen PrEP engagement and equity.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"571-587"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alanna J Bergman, Emiko Kamitani, J Craig Phillips, Susan Silva, S Raquel Ramos, Allison R Webel
{"title":"Centering People, Sustaining Prevention: Nursing Advances in PrEP Care.","authors":"Alanna J Bergman, Emiko Kamitani, J Craig Phillips, Susan Silva, S Raquel Ramos, Allison R Webel","doi":"10.1097/JNC.0000000000000684","DOIUrl":"10.1097/JNC.0000000000000684","url":null,"abstract":"","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"529-532"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Strength of ANAC Is Our People.","authors":"Darcel M Reyes","doi":"10.1097/JNC.0000000000000682","DOIUrl":"10.1097/JNC.0000000000000682","url":null,"abstract":"","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"617-619"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Kipkurui, Gerald Owuor, Dorothy Oketch, Alloys K'Oloo, Scholastica Wanjiru, Kawango Agot, Alison C Roxby
{"title":"Willingness to Test for HIV and Initiate Post-exposure Prophylaxis Among Adolescent Girls and Young Women Seeking Emergency Contraceptive Pills in Pharmacies in Nairobi and Kisumu, Kenya: A Longitudinal Study.","authors":"Nicholas Kipkurui, Gerald Owuor, Dorothy Oketch, Alloys K'Oloo, Scholastica Wanjiru, Kawango Agot, Alison C Roxby","doi":"10.1097/JNC.0000000000000626","DOIUrl":"10.1097/JNC.0000000000000626","url":null,"abstract":"<p><strong>Abstract: </strong>Adolescent girls and young women (AGYW) often seek emergency contraceptive pills (ECP) within 72 hr of condomless sex, a critical period for HIV exposure prevention through testing and postexposure prophylaxis (PEP). Pharmacies, where most AGYW obtain ECP, provide an ideal setting for timely HIV prevention services. From May to October 2023, a longitudinal study was conducted among AGYW ages 15-24 years seeking ECP in five pharmacies in Nairobi and Kisumu. Eligible participants were not on preexposure prophylaxis and provided consent. Baseline and 10-day optional follow-up phone data assessed HIV testing history, risk perception, and willingness to test or start PEP. Of 297 screened, 200 enrolled (mean age = 22 years). Nearly all (97.5%) had previously tested for HIV; 79% were interested in pharmacy-based testing and 73% in PEP. By follow-up, 50.7% tested for HIV, and 10.5% initiated PEP. These findings suggest that pharmacies offer a promising avenue to link ECP users to timely HIV prevention service.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"560-570"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Anne Barr, Nathaniel Albright, Gamji Rabiu Abu-Ba'are, Moka Yoo-Jeong, Stephen Bonett, Julie Schexnayder, Joseph De Santis
{"title":"The Proposed U.S. Office of Management and Budget Uniform Guidance Revisions: Implications for Scientific Integrity and HIV Research.","authors":"Emily Anne Barr, Nathaniel Albright, Gamji Rabiu Abu-Ba'are, Moka Yoo-Jeong, Stephen Bonett, Julie Schexnayder, Joseph De Santis","doi":"10.1097/JNC.0000000000000688","DOIUrl":"10.1097/JNC.0000000000000688","url":null,"abstract":"<p><strong>Abstract: </strong>Federal investment in HIV research has transformed HIV from a fatal disease into a manageable chronic condition through advances in prevention, treatment, implementation, and care. On May 29, 2026, the U.S. Office of Management and Budget proposed revisions to the Uniform Guidance governing federal financial assistance that could influence how federally funded HIV research is reviewed, awarded, and sustained. This commentary examines the proposed revisions from the perspective of the Association of Nurses in AIDS Care (ANAC), emphasizing the importance of scientific integrity, independent peer review, and sustained federal investment in advancing HIV research and improving health outcomes. HIV research demonstrates that long-term, community-engaged, interdisciplinary science has produced substantial public health benefits across the lifespan. ANAC supports responsible stewardship of federal resources while urging policymakers to preserve the scientific principles that have enabled decades of progress in HIV prevention, treatment, and care.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"620-623"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamal Gautam, Kiran Paudel, Frederick L Altice, David Vlahov, Antoine Khati, Jeffrey A Wickersham, Timothy E Moore, Eric Bae, Sandesh Bhusal, Md Safaet Hossain Sujan, Natalie Kil, Roman Shrestha
{"title":"Nurse Practitioner-Led, Same-Day, Pre-exposure Prophylaxis Delivery Program for People Who Inject Drugs in the United States: Findings From a Pilot Randomized Controlled Trial.","authors":"Kamal Gautam, Kiran Paudel, Frederick L Altice, David Vlahov, Antoine Khati, Jeffrey A Wickersham, Timothy E Moore, Eric Bae, Sandesh Bhusal, Md Safaet Hossain Sujan, Natalie Kil, Roman Shrestha","doi":"10.1097/JNC.0000000000000657","DOIUrl":"10.1097/JNC.0000000000000657","url":null,"abstract":"<p><strong>Abstract: </strong>Pre-exposure prophylaxis (PrEP) is effective for HIV prevention, yet uptake remains suboptimal among people who inject drugs. A pilot randomized controlled trial examined the feasibility, acceptability, and preliminary efficacy of a nurse practitioner-led, same-day PrEP model (iRaPID) within a syringe services program. Forty-four people who inject drugs who were HIV-seronegative were randomized 1:1 to iRaPID or treatment-as-usual. In iRaPID, 12 of 22 participants filled a PrEP prescription at baseline, including nine on the same day. Only three participants refilled prescriptions at both the 30- and 90-day follow-ups. Acceptability was high (scale 1-5), with mean ratings of 3.9 at 30 days and 4.2 at 90 days. PrEP uptake at 30 days was significantly higher in iRaPID (odds ratio: 5.40; 95% confidence interval, 1.37-21.26; p = .016) but not sustained at 90 days (odds ratio: 0.19; 95% confidence interval, 0.02-1.67; p = .133). Findings support the feasibility and acceptability of nurse practitioner-led, same-day PrEP delivery through a syringe services program while highlighting challenges to sustaining uptake.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"533-546"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Mickey Dhir, Colleen Hanrahan, Rose P Kaptchuk, Amteshwar Singh, Jason E Farley, Steven J Clipman
{"title":"Systematic Development of Discrete Choice Experiment Attributes to Assess PrEP Preferences Among MSM and Transgender Women in Baltimore: A Qualitative Study.","authors":"Amit Mickey Dhir, Colleen Hanrahan, Rose P Kaptchuk, Amteshwar Singh, Jason E Farley, Steven J Clipman","doi":"10.1097/JNC.0000000000000653","DOIUrl":"10.1097/JNC.0000000000000653","url":null,"abstract":"<p><strong>Abstract: </strong>Men who have sex with men (MSM) and transgender women (TGW) in the United States face a high burden of HIV, but the uptake of preexposure prophylaxis (PrEP) remains low. With long-acting injectable PrEP, now with Food and Drug Administration-approved and newer formulations entering clinical use, our study developed attributes for a discrete choice experiment to capture PrEP access preferences in Baltimore. Nested within a mixed method project, five focus groups (21 MSM and two TGW) informed attribute development using a four-step framework: data collection, thematic coding, attribute reduction, and refinement. Guided by the Gelberg-Andersen model and a systematic review, 50 themes were reduced to six attributes. Choice sets were pilot tested with nine participants. The six attributes were modality/effectiveness, side effects, provider environment, dispensing location, support monitoring, and cost/insurance. Pilot testing confirmed usability. This rigorous, community-informed process produced attributes, reflecting structural and personal factors influencing PrEP decision making, now integrated into a cross-sectional survey to guide equitable service delivery.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"603-616"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José I Gutierrez, Adam Yates, Patrick W Hickey, Valentine Sing'oei, John Owuoth, Christina S Polyak, Trevor A Crowell
{"title":"Factors Associated With Interest in HIV Pre-exposure Prophylaxis Among Men and Women in Kisumu County, Kenya: A Secondary Analysis of the RV393 Cohort Study.","authors":"José I Gutierrez, Adam Yates, Patrick W Hickey, Valentine Sing'oei, John Owuoth, Christina S Polyak, Trevor A Crowell","doi":"10.1097/JNC.0000000000000573","DOIUrl":"10.1097/JNC.0000000000000573","url":null,"abstract":"<p><strong>Abstract: </strong>Pre-exposure prophylaxis (PrEP) decreases HIV acquisition, but uptake in sub-Saharan Africa is suboptimal. We identified correlates of PrEP interest among men and women at risk for HIV in Kisumu County, Kenya, to inform tailored interventions to prevent HIV. Between February 2017 and August 2021, 389 participants answered questions about PrEP interest. Of these, 53.7% were female, 72.2% were single, 55.5% completed secondary education, and 37.5% reported previous sex work. Their median age was 24 years. Overall, 45.8% expressed interest in PrEP and 18.0% reported previous PrEP use. Key correlates of PrEP interest included transactional sex, overnight travel, knowing someone in their social network taking PrEP, and belief in PrEP's efficacy. These findings highlight the importance of addressing behavioral and social drivers of PrEP interest. Efforts to increase PrEP awareness through social networks, emphasize PrEP efficacy, and tailor interventions toward people with high mobility and transactional sex may enhance uptake in high-burden regions.</p>","PeriodicalId":520809,"journal":{"name":"The Journal of the Association of Nurses in AIDS Care : JANAC","volume":" ","pages":"547-559"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}