The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease最新文献_第9页

Rifamycin-, macrolide-, and ethambutol-free combinations to treat Mycobacterium avium complex lung disease. 无利福霉素、大环内酯和乙胺丁醇联合治疗鸟分枝杆菌复杂肺部疾病。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0320

G D Boorgula, A Shrivastava, S Singh, R-A Galvez, P J McShane, M Devine, T Gumbo, S Srivastava

{"title":"Rifamycin-, macrolide-, and ethambutol-free combinations to treat Mycobacterium avium complex lung disease.","authors":"G D Boorgula, A Shrivastava, S Singh, R-A Galvez, P J McShane, M Devine, T Gumbo, S Srivastava","doi":"10.5588/ijtld.25.0320","DOIUrl":"10.5588/ijtld.25.0320","url":null,"abstract":"<sec><title>OBJECTIVE</title>Poor sustained sputum culture conversion with guidelines-based therapy for Mycobacterium avium complex lung disease highlights the need for new and improved multidrug combinations.</sec><sec><title>DESIGN</title>We tested eight drugs by performing minimum inhibitory concentration (MIC) experiments with the ATCC#700898 strain and 49 clinical isolates, followed by single and multidrug combination studies.</sec><sec><title>RESULTS</title>MIC90 of rifabutin, rifampin, azithromycin, and ethambutol were 4, 16, 256, and 128 mg/L, respectively. Among other drugs, MIC90 (mg/L) in lowest to highest rank order were for bedaquiline (0.25), tedizolid (16), tebipenem (64), and minocycline (128). As monotherapy, none of the drugs had better MAC kill compared to rifampin. While minocycline alone killed 1.76 ± 0.33 log10 CFU/mL MAC, replacement of rifabutin in the standard therapy resulted in 6.27 ± 0.28 log10 CFU/mL MAC kill, showing minocycline's synergistic effect with azithromycin and ethambutol. An example of a macrolide-rifamycin-ethambutol-free oral regimen, the azithromycin-minocycline-tedizolid combination killed 4.35 ± 0.42 log10 CFU/mL MAC. The tebipenem-tedizolid-minocycline combination killed 4.82 ± 0.42 log10 CFU/mL; however, addition of bedaquiline resulted in a lower kill of 2.71 ± 0.22 log10 CFU/mL, suggesting a likely antagonism.</sec><sec><title>CONCLUSION</title>We tested eight different drugs to identify several rifamycin-, macrolide-, and ethambutol-free oral multidrug combinations. The minocycline-based regimens warrant further preclinical and clinical testing.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"127-133"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory health of conch shell workers: insights from West Bengal, India. 海螺工人的呼吸健康：来自印度西孟加拉邦的见解。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0554

D Chakraborty, A Dey, K Manna, I Saha, S Sahu

引用次数: 0

Casting light on TB: a community awareness, screening, testing, and treatment campaign. 照亮结核病：社区认识、筛查、检测和治疗运动。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0247

M Bamuloba, S C Mukama, M G Nabukenya-Mudiope, S Zawedde-Muyanja, P Tumwesigye, I Senteza, A Burua, R M Mugabe, D Lukanga, S Muchuro, M Murungi, S Dejene, E Rutta, P Tusiime, D Kyabayinze, H Mwebesa, S Turyahabwe, D Atwine

{"title":"Casting light on TB: a community awareness, screening, testing, and treatment campaign.","authors":"M Bamuloba, S C Mukama, M G Nabukenya-Mudiope, S Zawedde-Muyanja, P Tumwesigye, I Senteza, A Burua, R M Mugabe, D Lukanga, S Muchuro, M Murungi, S Dejene, E Rutta, P Tusiime, D Kyabayinze, H Mwebesa, S Turyahabwe, D Atwine","doi":"10.5588/ijtld.25.0247","DOIUrl":"10.5588/ijtld.25.0247","url":null,"abstract":"<sec><title>BACKGROUND</title>As part of its recovery from the COVID-19 pandemic, the Uganda National TB and Leprosy Program (NTLP) undertook a country-wide community-based active TB and leprosy case-finding intervention, the CAST-TB campaign. We aim to describe the process and results from this intervention over 2 years of implementation.</sec><sec><title>METHODS</title>The NTLP carried out preparatory activities including orientation of national and regional stakeholders, training and equipping of health facility and community teams, and setting up data collection mechanisms. The NTLP then supported health facility teams to review their TB notification data and map locations with the highest case notifications within their catchment area (TB hotspots). Active TB case-finding interventions were then carried out in each of these TB hotspots.</sec><sec><title>RESULTS</title>Three episodes of the CAST-TB campaign were carried out from March 2022 to March 2023. Overall, 6,715,810 individuals were screened for TB. Of these, 696,940 (10%) had presumptive TB, 480,522 (69%) received a TB diagnostic test, and 14,560 were diagnosed with TB (including 253 with rifampicin-resistant TB). Of 4,302 individuals with skin patches, 5% (196) were diagnosed with leprosy.</sec><sec><title>CONCLUSION</title>Targeted community-based active TB case finding can exponentially improve TB case finding and treatment initiation in high-TB-burden settings like Uganda.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"93-99"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB infection in the incarcerated population of Catalonia, Spain. 西班牙加泰罗尼亚被监禁人群的结核病感染。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0333

N Solé, R Prieto-García, E Turu, J P Millet, A Marco

{"title":"TB infection in the incarcerated population of Catalonia, Spain.","authors":"N Solé, R Prieto-García, E Turu, J P Millet, A Marco","doi":"10.5588/ijtld.25.0333","DOIUrl":"10.5588/ijtld.25.0333","url":null,"abstract":"<sec><title>OBJECTIVE</title>To determine the prevalence of TB infection (TBI) among individuals admitted to Catalan prisons and assess the concordance between the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs).</sec><sec><title>METHODS</title>A prospective, multicentre, population-based observational study was conducted in all nine Catalan prisons from 1 March to 30 June 2023. New admissions were classified based on history of TB or tuberculin testing. TBI was defined using TST thresholds adjusted for immunosuppression or Bacillus Calmette-Guérin vaccination. IGRAs were used in TST-positive or immunocompromised individuals. Logistic regression identified associated factors, and TST-IGRA concordance was assessed with the Kappa coefficient.</sec><sec><title>RESULTS</title>Among 1,679 participants, 38 (2.3%) had prior TB. Mean age was 38 years; 93.5% were male, 64.1% foreign-born, 23.2% homeless, and 3.4% living with HIV. TBI was found in 494 individuals (30.1%), and one case of active TB was detected. TBI was associated with older age, male sex (odds ratio [OR]: 2.05), foreign origin (OR: 3.92), injecting drug use (OR: 1.39), and smoking (OR: 2.06). TST-IGRA concordance was 64.5%. Prevalence adjusted for discordance was 25.2%.</sec><sec><title>CONCLUSION</title>TBI prevalence in Catalan prisons is high. Given the moderate agreement between TST and IGRA, relying solely on TST may be insufficient. Improved screening and treatment are essential for TB control in prison populations.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"120-126"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extra-pulmonary TB: a comparison between migrants and populations born in a low-incidence country. 肺外结核：移民和低发病率国家出生人口的比较。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0400

C R Khaw, A M Malhotra, S Tehranchi, A Rahman, V White, S Tiberi, H Kunst

{"title":"Extra-pulmonary TB: a comparison between migrants and populations born in a low-incidence country.","authors":"C R Khaw, A M Malhotra, S Tehranchi, A Rahman, V White, S Tiberi, H Kunst","doi":"10.5588/ijtld.25.0400","DOIUrl":"10.5588/ijtld.25.0400","url":null,"abstract":"<sec><title>BACKGROUND</title>The proportion of TB cases attributable to extra-pulmonary TB (EPTB) is increasing in high-income countries, including England. We sought to describe the burden of EPTB in East London, an area with a large migrant population and high TB incidence.</sec><sec><title>METHODS</title>A retrospective analysis of individuals with TB was conducted and compared to national data.</sec><sec><title>RESULTS</title>1,262 patients were diagnosed with TB between 2016 and 2019. 52.7% had EPTB, 32.6% isolated pulmonary TB (PTB), and 14.7% concurrent disease. This compares to 43.8% of individuals nationally with isolated EPTB. In our cohort, of those with EPTB, 83.6% were non-UK-born (migrants). Multivariate analysis demonstrated that migrants had significantly higher odds of EPTB compared to UK-born individuals after adjusting for age and sex (adjusted odds ratio: 1.55, 95% confidence interval: 1.16-2.09, P = 0.003). Median time since entry to the UK among migrants who were diagnosed with EPTB was 11 years (interquartile range: 5-21). Treatment outcomes were worse in migrants with EPTB, mainly due to higher mortality.</sec><sec><title>CONCLUSION</title>Our data reports a higher proportion of EPTB compared to national data. EPTB was more common in migrants than UK-born individuals.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 2","pages":"77-83"},"PeriodicalIF":3.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-based TB screening using hybrid acoustic features of a patient's cough. 基于人工智能的结核病筛查，利用患者咳嗽的混合声学特征。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0431

A Kawadia, M Moitra, H Patel

引用次数: 0

Lower FEV₁ and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis. 低肺活量1和革兰氏阴性杆菌分离是结核后支气管扩张恶化的独立危险因素。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0336

W-F Ou, C-H Chu, C-C Sheu, C-L Chang, P-H Wang, M-H Hsieh, W-H Hsu, M-T Chen, Y-F Wei, T-M Yang, C-C Lan, C-Y Wang, C-B Lin, M-S Lin, Y-T Wang, C-H Lin, S-F Liu, M-H Cheng, Y-F Chen, W-C Cheng, C-K Peng, C-Y Chen, L-Y Jao, Y-H Wang, Y-H Wang, S-P Chen, Y-H Tsai, H-C Wang, S-L Cheng, H-C Lin, J-Y Chien, M-C Chan

{"title":"Lower FEV1 and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis.","authors":"W-F Ou, C-H Chu, C-C Sheu, C-L Chang, P-H Wang, M-H Hsieh, W-H Hsu, M-T Chen, Y-F Wei, T-M Yang, C-C Lan, C-Y Wang, C-B Lin, M-S Lin, Y-T Wang, C-H Lin, S-F Liu, M-H Cheng, Y-F Chen, W-C Cheng, C-K Peng, C-Y Chen, L-Y Jao, Y-H Wang, Y-H Wang, S-P Chen, Y-H Tsai, H-C Wang, S-L Cheng, H-C Lin, J-Y Chien, M-C Chan","doi":"10.5588/ijtld.25.0336","DOIUrl":"10.5588/ijtld.25.0336","url":null,"abstract":"<sec><title>BACKGROUND</title>Post-TB bronchiectasis is a recognised but under-investigated category of bronchiectasis. This study evaluated its clinical features and identified risk factors for acute exacerbations (AEs).</sec><sec><title>METHODS</title>This retrospective observational cohort study analysed data from the Taiwan Bronchiectasis Registry. Patients with bronchiectasis were included, and those with post-TB bronchiectasis were identified for subgroup analysis. We collected demographics, symptoms, lung function, microbiological data, and modified Reiff scores to assess risk factors for AEs.</sec><sec><title>RESULTS</title>A total of 1,444 patients were analysed, including 222 (15%) with post-TB bronchiectasis. Among them, 54 (24%) experienced at least one AE during the study period. Post-TB bronchiectasis patients had more frequent AEs, higher FACED and modified Reiff scores, lower body mass index (BMI) and forced expiratory volume in 1 s (FEV1), and more symptoms than non-post-TB cases. Post-TB bronchiectasis patients with AEs had higher FACED and Reiff scores, lower BMI and FEV1, and higher rates of positive sputum cultures for gram-negative bacilli (GNB). Multivariable analysis identified FEV1 ≤ 60% predicted (adjusted odds ratio [aOR]: 2.334, 95% CI: 1.192-4.572) and positive GNB cultures (aOR: 3.075, 95% CI: 1.362-6.942) as independent risk factors for AEs.</sec><sec><title>CONCLUSION</title>Post-TB bronchiectasis is associated with a higher risk of exacerbations. Reduced FEV1 and positive GNB cultures are independent risk factors for AEs.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 2","pages":"63-69"},"PeriodicalIF":3.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low TB1 and TB2 antigen-nil is associated with increased QuantiFERON Gold Plus reversions. 低TB1和TB2抗原零与QuantiFERON Gold Plus逆转增加有关。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0308

A Tabackman, C Acuña-Villaorduña, M Canning, M Karoly, M R Dauphinais, R Michaud, T C Bouton, D L Bourque, K A Reifler, V Sabharwal, K Traber, A N Gupte, K R Jacobson, P Sinha

引用次数: 0

Incidence of Mycobacterium tuberculosis infection in an African city with endemic TB. 非洲一个城市地方性结核病的结核分枝杆菌感染发生率。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0299

N Kiwanuka, H T Quach, R Kakaire, S Zalwango, J P Jingo, S Nalukwago, K Chervenak, J Sekandi, W H Boom, C C Whalen, C M Bark

{"title":"Incidence of Mycobacterium tuberculosis infection in an African city with endemic TB.","authors":"N Kiwanuka, H T Quach, R Kakaire, S Zalwango, J P Jingo, S Nalukwago, K Chervenak, J Sekandi, W H Boom, C C Whalen, C M Bark","doi":"10.5588/ijtld.25.0299","DOIUrl":"10.5588/ijtld.25.0299","url":null,"abstract":"<sec><title>BACKGROUND</title>Transmission of Mycobacterium tuberculosis often occurs in the community before diagnosis of TB is made. To measure the force of infection in an African city with endemic TB, we conducted a prospective cohort study of adults in Kampala, Uganda, to estimate the incidence of M. tuberculosis infection.</sec><sec><title>METHODS</title>Consenting volunteers with both a negative interferon-γ release assay (IGRA) and a negative tuberculin skin test were enrolled and followed for 18 months with quarterly IGRAs. New M. tuberculosis infection was defined as IGRA conversion and further classified by sustained positive assays after conversion.</sec><sec><title>RESULTS</title>In 998 eligible adults, the median age was 26 years, 61% were women, 62% had received bacille Calmette-Guérin vaccination, 12% were HIV-infected, and 25% drank alcohol. The overall annual risk of M. tuberculosis infection was 3.3%. Older age, male sex, and drinking alcohol outside the home were associated with an increased risk of incident M. tuberculosis infection (rate ratio: 3.7).</sec><sec><title>CONCLUSION</title>This prospective cohort study found a high rate of annual TB infection in an African city with endemic TB, especially among older men who drank alcohol outside the home. Screening for M. tuberculosis among men in the community could lead to novel case-finding interventions.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 2","pages":"70-76"},"PeriodicalIF":3.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired pulmonary function and ineffective endobronchial valve placement in patients with TB. 结核患者肺功能受损和支气管内瓣膜置入术无效。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-01-30 DOI: 10.5588/ijtld.25.0234

M I Chushkin, E A Shergina, N A Chernyh, A S Polyakova, A M Tikhonov, L D Kiryukhina, V V Romanov, N L Karpina

引用次数: 0