The International journal of risk & safety in medicine最新文献

{"title":"ATC/DDD analysis of expired and unused medicines collected through separate collection.","authors":"Odina Makhmudova, Rasima Tukhtaeva, Pavel Vasilyev, Daniyar Khaziakhmetov, Olga Bagdanova, Lyayla Muradimova, Veronika Khaziakhmetova","doi":"10.1177/09246479251410821","DOIUrl":"10.1177/09246479251410821","url":null,"abstract":"<p><p>IntroductionIrrational use and improper disposal of medicines lead to environmental pollution. There is compelling evidence of the negative impact of medications on biological systems. In Russia, there is no legislation regarding the disposal of expired medications at home. Expired medications generated at home are considered household waste.ObjectiveTo study the effectiveness of separate collection of medicines and analyze unused medicines discarded by patients.MethodsWe organized separate collection of expired and unused medicines in two polyclinics in Kazan. An ATC/DDD (Anatomical Therapeutic Chemical/Defined Daily Dose) analysis was conducted to estimate how many drugs are not consumed by people and are thrown away in the general waste.ResultsFrom November 2022 to April 2024, a total of 4737 trade names of medicines or 707 INNs (International Nonproprietary Names) and 195 dietary supplements were collected, totaling 243 kg of medicines and supplements that were subsequently sent for proper disposal. The ATC/DDD analysis showed that the largest number of DDDs collected were medicines for treating cardiovascular system disorders, digestive system and metabolism disorders, and blood and hematopoietic system disorders.ConclusionsTo assess the rationality of medicine use, it is important to conduct qualitative and quantitative evaluation of disposed medicines. Such analysis can be part of actual consumption analysis, as not all medicines dispensed to patients in pharmacies are actually consumed by them.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"229-234"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Cochrane methodology into medical education: Experience and outcomes.","authors":"Victoria Kovalevskaya, Taisiia Turankova, Daria Varganova, Daria Teplyuk, Beatrice Volel, Chavdar Pavlov","doi":"10.1177/09246479261418868","DOIUrl":"10.1177/09246479261418868","url":null,"abstract":"<p><p>BackgroundModern medical education faces the challenges of digitalization, the implementation of evidence-based medicine, the development of research skills, and interdisciplinarity. In response, Sechenov University has developed a curriculum based on Cochrane methodology aimed at training professionals capable of making clinical decisions under uncertainty and data deficit, while taking into account both scientific validity and ethical standards.MethodsA cross-sectional online survey was conducted among 3rd- to 6th-year medical students to assess their knowledge in evidence-based medicine methodology, research skills, and satisfaction with the program.ResultsA total of 359 students were surveyed. Study year significantly affected knowledge level, with systematic knowledge accumulation occurring over time (<i>p</i> < 0.001). Senior students demonstrated higher proficiency with evidence-based medicine tools and research skills, although even in years 5-6, a considerable proportion of students were initially unsure of specific topics. Overall, 87.5% of all respondents reported increased knowledge, and 95.8% were fully satisfied with the course.ConclusionsTo develop clinical and critical thinking in medical students-enabling them to act reasonably in complex and changing clinical situations with incomplete or conflicting data and strict adherence to bioethical norms-it is necessary to expand practical training based on Cochrane methodology.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"160-167"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How I contributed to Cochrane Crowd and why it matters for evidence synthesis.","authors":"Vladimir Kataev","doi":"10.1177/09246479261441446","DOIUrl":"10.1177/09246479261441446","url":null,"abstract":"<p><p>Robust evidence depends on disciplined methods rather than slogans. This commentary draws on my experience with Cochrane Crowd to show how brief, well-structured micro-tasks can strengthen the evidence pipeline. Two features are central: the platform logs every screening decision for audit, and hidden calibration items help maintain contributor accuracy. In routine queues, volunteers identify randomised controlled trials and tag Population, Intervention, Comparison and Outcome (PICO) elements, reducing noise and prioritising relevant records. When publication volume surges, this volunteer triage preserves high recall without sacrificing precision, giving review teams a cleaner starting point. Regular exposure to trial anatomy also sharpens bias detection in peer review and teaching. Individually, each task is modest; collectively, these tasks provide a practical defence against distortions in the research record. I encourage colleagues to devote a brief, focused session each week to Cochrane Crowd and help make trustworthy evidence more visible.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"273-274"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of safety reports on oral anticoagulants in the Russian state pharmacovigilance database. A cross-sectional study for 2017-2022.","authors":"Aleksandr V Matveev, Sergey V Glagolev, Elena A Kruglova, Dmitry A Sychev","doi":"10.1177/09246479251410804","DOIUrl":"10.1177/09246479251410804","url":null,"abstract":"<p><p><b>Background:</b> Quality of individual cases of safety reports (ICSR) is a challenge for modern drug safety studies. <b>Purpose and Research Design:</b> In this cross-sectional study of the safety database, we studied reports completeness for direct oral anticoagulants (DOAC) received in 2017-2022. <b>Study sample:</b> A total of 1428 ICSRs were selected for analysis. <b>Results:</b> The largest number of reports was received for rivaroxaban (638), and the number of records for apixaban and dabigatran was 454 and 336, respectively. The number of reports in the reporting period increased for apixaban only. The number of empty fields per report was 47.5% (52.5% for apixaban, 47.5% for rivaroxaban, and 37.5% for dabigatran). The worst-filled field was the dose of the drug (8.96%). The VigiGrade (VG) score for all reports was 0.268 (rivaroxaban-0.268, apixaban-0.233, and dabigatran-0.353). The VG index was higher for reports received from healthcare professionals (0.441) and authorized authorities (0.397). The proportion of well-documented cases decreased between 2017 and 2022, accounting for 1.82% overall. The average median score (0.44) was achieved in 22.34% cases. Possible main reasons for the decline in quality include the COVID-19 pandemic and the coinciding transition to a new version of the database. <b>Conclusions:</b> Solutions to the problem of low-quality reports may include increasing the staffing, trainings, and introducing electronic control systems.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"275-283"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoepidemiological analysis of antiplatelet drug consumption in outpatient practice.","authors":"Dariya V Ivanova, Ayrat Usmanovich Ziganshin, Rustem N Khairullin, Liliya Eugenevna Ziganshina","doi":"10.1177/09246479251409027","DOIUrl":"10.1177/09246479251409027","url":null,"abstract":"<p><p>BackgroundAcute coronary syndrome remains a leading cause of mortality, making antiplatelet therapy crucial for the treatment and secondary prevention of this condition. PurposeWe aimed to analyze consumption of antiplatelet drugs in the outpatient segment of the pharmaceutical market in the Republic of Tatarstan in 2018 and 2023. Research DesignWe conducted a descriptive study based on sales data for antiplatelet drugs from two major suppliers. Data Collection and AnalysisConsumption was calculated in milligrams and defined daily doses. To assess therapy coverage, we calculated standard course doses for dual antiplatelet therapy and monotherapy based on clinical guidelines.ResultsDuring the study period, we identified a significant increase in the consumption of all antiplatelet drugs. Acetylsalicylic acid consumption doubled. Among P2Y₁₂-receptor inhibitors, clopidogrel showed the highest absolute increase (2.5 times), while ticagrelor (3.2 times) and prasugrel (4 times) showed the highest relative growth rates. The estimated number of patients who could have been treated with the sold volumes of antiplatelet drugs in 2018 was 15.4 times, and in 2023 was 35.2 times higher than the official number of registered ACS patients.ConclusionsWe observe a significant increase in outpatient antiplatelet drug consumption, reflecting current trends toward expanding indications and increasing therapy duration.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"265-272"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trusted evidence for better health: Achievements and barriers over the 10 years of Cochrane Russia.","authors":"Liliya Eugenevna Ziganshina","doi":"10.1177/09246479261442605","DOIUrl":"10.1177/09246479261442605","url":null,"abstract":"","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"157-159"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publication notice.","authors":"","doi":"10.1177/09246479261423804","DOIUrl":"10.1177/09246479261423804","url":null,"abstract":"","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"284"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety profile of linezolid in the elderly: National database analysis.","authors":"Olga Butranova, Victoria Koval, Sergey Zyryanov, Irina Asetskaya, Elizaveta Terekhina, Vitaly Polivanov, Anastasia Gorbacheva","doi":"10.1177/09246479251401400","DOIUrl":"10.1177/09246479251401400","url":null,"abstract":"<p><p>BackgroundLinezolid is one of the most used antibacterials to treat resistant gram-positive infections, though its use may result in a number of toxic effects, especially in the older adults. There is lack of data derived from the real-world studies regarding safety of linezolid in the elderly.The aimTo disclose the structure of adverse drug reactions (ADRs) associated with linezolid in patients ≥60 years.Materials and methodsRetrospective analysis of spontaneous reports (SRs) from the Russian Pharmacovigilance database (April 2019-December 2024).ResultsSRs of patients ≥60 years accounted up to 19.9% in the total structure of SRs. Top-5 system-organ classes (SOCs) were blood and lymphatic system disorders (24.4%, <i>n</i> = 68), gastrointestinal disorders (17.6%, <i>n</i> = 49), investigations (11.1%, <i>n</i> = 31), skin and subcutaneous tissue disorders (9.7%, n = 27), and general disorders and administration site conditions (6.1%, <i>n</i> = 17). Top-5 preferred terms (PTs) were thrombocytopenia (7.9%, <i>n</i> = 22), anemia (7.2%, <i>n</i> = 20), nausea 4.3% (<i>n</i> = 12), diarrhea (3.6%, <i>n</i> = 10), vomiting (3.6%, <i>n</i> = 10), and leukopenia (3.6%, <i>n</i> = 10).ConclusionsLinezolid-induced myelosuppression was identified as the most significant safety concern in patients ≥60 years, underscoring the necessity for careful laboratory and clinical monitoring in this population.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"201-212"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based medicine as an educational discipline-experience of implementation in undergraduates and doctors training.","authors":"Volha Haliuchenka, Ivan Zhyltsou, Yelena Skreblo","doi":"10.1177/09246479251390453","DOIUrl":"10.1177/09246479251390453","url":null,"abstract":"<p><p><b>Background:</b> Studying of evidence-based approach in medicine by future health professionals and medical practitioners is an essential part of their life-long education that leads to improvement of quality of healthcare in total.<b>Purpose:</b> To analyze and share the experience in evidence-based medicine teaching of the Chair of evidence-based medicine and clinical diagnostics of the Faculty of advanced training and retraining, Vitebsk State order of Peoples' friendship Medical University.<b>Research Design, Study Sample, Data Collection and/or Analysis:</b> Internet searches of the literature were conducted to find information about approaches to studying evidence-based medicine (EBM) in different medical universities in the Republic of Belarus and other countries. An analysis of questionnaires for doctors and pharmacists who took advanced training courses was carried out.<b>Results:</b> In the educational process educational institutions (including our University) use various teaching modalities. Despite a huge variability of teaching approaches, no significant difference in teaching results as knowledge and attitudes were revealed; practical skills and EBM-related behavior were formed more successfully when using practically oriented teaching modalities. Students and doctors shown the great interest for studying EBM. Discussing of issues related to EBM is of interest to the participants of the training courses and is noted by them as an essential part of the training of doctors.<b>Conclusions:</b> Studying of EBM as a separate discipline in a university allows to use science-based approach in the process of education, to make the knowledge more structured and qualitative. General principles of EBM should be reflected in the content of professional training courses for doctors. Understanding of general principles of EBM makes the interpretation of medical information and its implementation in clinical practice by doctors more reasonable and helps to achieve better results in the of patient management process.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"182-184"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why national consumption of direct oral anticoagulants over the rise of COVID-19 pandemic exceeded all potential recommendations: A qualitative analysis of textual details of Russian clinical practice guidelines.","authors":"Elena A Baybulatova, Mikhail S Chenkurov, Sergey K Zyryanov, Liliya E Ziganshina","doi":"10.1177/09246479251401348","DOIUrl":"10.1177/09246479251401348","url":null,"abstract":"<p><p>BackgroundCOVID-19-associated thrombotic complications became a major problem of pandemic. Clinical practice guidelines are meant to present approaches to preventing and managing them. In our previous studies, we found that direct oral anticoagulants (DOACs) consumption and expenditure in Russia through COVID-19 pandemic was extensive, exceeding CPGs' recommendations in 2020 and 2021, particularly in outpatient settings.ObjectiveTo analyze Russian clinical practice guidelines on the use of DOACs for COVID-19.MethodsWe conducted thematic content analysis of Russian guidelines using qualitative research methods. Purposive sampling allowed including all existing guidelines on the use of DOACs in COVID-19 pandemic. The sample size was limited to the results of our previous searches of the Russian guideline and bibliographic databases. We focused on indications, contraindications, dosing regimens, monitoring, and drug interactions and compared with international recommendations.ResultsOnly one guideline advised against outpatient DOAC use for COVID-19, aligning with international standards. The guidelines lacked clarity on indications, dosing, and treatment duration. Only two of six guidelines included safety monitoring recommendations, while four provided precautions.ConclusionWe conclude that the found textual problems could potentially cause the established excessive consumption of direct oral anticoagulants in outpatients with COVID-19 on the rise the pandemic.</p>","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"249-256"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}